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RAMAN SPECTROSCOPY FOR iN ViVO TiSSUE ANALYSiS AND DiAGNOSiS,FROM iNSTRUMENT DEVELOPMENT TO CLiNiCAL APPLiCATiONS

Journal of innovative Optical Health Sciences 2008年第1期1卷 95-106页

作者： HAiSHAN ZENG JiANHUA ZHAO MiCHAEL SHORT david i.mclean STEPHEN LAM ANNETTE MCWiLLiAMS HARVEY LUi Laboratory for Advanced Medical Photonics(LAMP)Cancer imaging Department British Columbia Cancer Research Centre 675 West 10th Avenue Vancouver BCV5Z 1L3Canada Photomedicine Institute Department of Dermatology and Skin Science University of British Columbia and Vancouver Coastal Health Research Institute 835 West 10th Avenue VancouverBCV5Z 4E8Canada

Raman spectroscopy is a noninvasive,nondestructive analytical method capable of determining the biochemical constituents based on molecular *** does not require sample preparation or ***,the use of Raman spectroscopy for in vivo clinical applications will depend on the feasibility of measuring Raman spectra in a relatively short time period(a few seconds).in this work,a fast dispersive-type nearinfrared(NiR)Raman spectroscopy system and a skin Raman probe were developed to facilitate real-time,noninvasive,in vivo human skin *** image aberration was corrected by a parabolic-line fiber array,permitting complete CCD vertical binning,thereby yielding a 16-fold improvement in signal-to-noise *** quality in vivo skin NiR Raman spectra free of interference from fiber fluorescence and silica Raman scattering can be acquired within one second,which greatly facilitates practical noninvasive tissue characterization and clinical ***,we are conducting a large clinical study of various skin diseases in order to develop Raman spectroscopy into a useful tool for non-invasive skin cancer *** data analysis results are ***,we have also successfully developed a technically more challenging endoscopic Laser-Raman probe for early lung cancer *** in vivo results from endoscopic lung Raman measurements are discussed.

关键词： Rapid Raman system in vivo skin Raman in vivo lung Raman endoscopic Raman probe early cancer detection

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Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson’s substantia nigra

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Signal Transduction and Targeted Therapy 2016年第1期1卷 75-80页

作者： Scott Ayton Peng Lei Catriona mclean Ashley i Bush david i Finkelstein The Florey institute for Neuroscience and Mental Health The University of MelbourneParkvilleVictoriaAustralia Department of Neurology State Key Laboratory of BiotherapyWest China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengduSichuanChina The Alfred Hospital Department of Anatomical PathologyMelbourneVictoriaAustralia

iron deposition in Parkinson’s disease(PD)is a potential disease-modifying *** previously showed that supplementation of the iron-exporter,ceruloplasmin,selectively corrected nigral iron elevation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)*** delivers iron to transferrin(Tf),the extracellular iron-transporting *** show that Tf protein levels are decreased in the nigra of post-mortem PD brains compared with controls(−35%;n=10 each).Because Tf traffics iron away from iron-replete tissues,we hypothesized that Tf supplementation could selectively facilitate iron export from the nigra in *** cultured neurons,Tf treatment corrected iron accumulation,and subcutaneous Tf to mice ameliorated iron accumulation and motor deficits in the MPTP model of *** these data support a role for Tf in the disease mechanism for PD,and its potential use for correcting disorders of iron overload,Tf therapy also caused systemic iron depletion,which could limit its application for PD.

关键词： corrected sized deficient

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基于非线性静态分析和软件的公路桥抗震评估

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钢结构(中英文) 2008年第12期 89-90页

作者： Nasim K.Shattarat Michael D.Symans david i . mclean William F. Cofer

受地震扰动时,可以通过一系列方法对桥的响应进行评估。传统的方法是采用线性静态或动态分析结合适当的修正来说明非弹性响应,而现行的实践着重强调非线性静态分析方法。本研究采用线性动态分析程序,对两跨公路桥的初步地震响应进行分... 详细信息

受地震扰动时,可以通过一系列方法对桥的响应进行评估。传统的方法是采用线性静态或动态分析结合适当的修正来说明非弹性响应,而现行的实践着重强调非线性静态分析方法。本研究采用线性动态分析程序,对两跨公路桥的初步地震响应进行分析以确定潜在的非弹性响应。按照两个非线性静态分析方法对桥进行分析,评估了两种方法所预测的全部响应的差别以及采用各种软件进行非线性静态分析的效率。结果显示:所采用的两种不同非线性响应预测的非线性静态分析方法,由于存在大量的简化,都不能获得正确的结果。此外,研究还揭示在综合分析和提供破坏过程图方面,一些软件更适合进行非线性静态分析(如塑性铰的性能)。

关键词：抗震分析推覆分析非线性分析桥地震工程

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isolation and characterization of human polyreactive pneumococcal polysaccharide antibodies

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Open Journal of immunology 2012年第3期2卷 98-110页

作者： Rebecca S. Thompson Noor M. Khaskhely Kristin R. Malhotra david J. Leggat Jason Mosakowski Sadik Khuder Gary R. mclean M. A. Julie Westerink Department of Medical Microbiology and immunology University of Toledo Toledo USA Department of Medicine University of Toledo Toledo USA School of Human Sciences London Metropolitan University London UK

Natural antibodies serve as the body’s first line of defense against pneumococcal challenge. Polyreactive human pneumococcal polysaccharide igG antibodies have not been extensively studied. We analyzed human polyreactive antibodies that bind multiple pneumococcal polysaccharides, including PPS14 and PPS23F. These antibodies were isolated from single pneumococcal polysaccharide specific B cells allowing for the analysis of human immunoglobulins with natively paired variable regions. Although isolated individually, these antibodies demonstrated similar characteristics. Most antibodies possessed a variable light chain with a CDR3 length made up of nine amino acids and relatively high number of flexible amino acids in combined VH/VL. While these antibodies were polyreactive and structurally alike, kinetic analysis revealed unique KD values. Variable chains are responsible for antigen recognition whereas antibody fine specificity is affected by isotype structure. To investigate the contribution of the constant region of these isotypes and their effect on antibody avidity to pneumococcal polysaccharide, the polyreactive variable regions were expressed as igG1 or igG2 and subjected to kinetic analysis. The igG1 antibodies uniformly had a stronger avidity to PPS14 and PPS23F compared to igG2. To further document the importance of the constant region in antibody avidity and fine specificity, analysis of antibody F(ab)’2 fragment binding to PPS14 and PPS23F resulted in similar KD values. These studies suggest that antigen recognition by polyreactive antibodies is determined by a conserved variable light chain CDR3 length and longer, more flexible variable heavy CDR3s when compared to pneumococcal polysaccha-ride-specific sequences while differences in specific avidities are modulated by antibody isotype.

关键词： B Cell Pneumococcal Polysaccharide Polyreactive Natural isotype

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Standardization and identification of Minor Components of Silymarin (MK-001)

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Chinese Herbal Medicines 2012年第3期4卷 237-244页

作者： Yan-ze LiU[a][b] david Yue-wei LEE[a] Bioorganic and Natural Product Laboratory McLean Hospital/Harvard Medical SchoolMA 02478USA institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China

Objective To develop a highly effective HPLC method for standardization of silymarin and for characterization of minor components, which has not been reported previously. Methods An HPLC fingerprinting method and 1 H-NMR spectroscopy were employed to provide assurance for a standardized silymarin product (MK-001). Results A total of 18 marker compounds were identified and characterized including ten flavonolignans and eight small molecules including adenine, adenosine, uridine, and 3,5,7-trihydroxychromone which were first isolated and characterized from silymarin. The HPLC fingerprinting method and 1 H-NMR had been established for complete assignments of HPLC peaks with intensity over 1.0%. Conclusion The successfully established HPLC fingerprinting method and 1 H-NMR could be applied for the standardization of commercial silymarin products. MK-001 represents the first standardized silymarin with the highest content of flavonolignans ( > 90%).

关键词： adenine flavonolignans 1 H-NMR HPLC fingerprinting silymarin

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Video-based trajectory extraction with deep learning for High-Granularity Highway Simulation(HiGH-SiM)

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Communications in Transportation Research 2021年第1期1卷 111-120页

作者： Xiaowei Shi Dongfang Zhao Handong Yao Xiaopeng Li david K.Hale Amir Ghiasi Department of Civil and Environmental Engineering University of South FloridaTampaFL33620United States Leidos IncSaxton Transportation Operation LaboratoryMcLean22101VirginiaUnited States

High-granularity vehicle trajectory data can help researchers develop traffic simulation models,understand traffic flow characteristics,and thus propose insightful strategies for road traffic *** paper proposes a novel vehicle trajectory extraction method that can extract high-granularity vehicle trajectories from aerial *** proposed method includes video calibration,vehicle detection and tracking,lane marking identification,and vehicle motion characteristics *** particular,the authors propose a Monte-Carlo-based lane marking identification approach to identify each vehicle's *** is a challenging problem for vehicle trajectory extraction,especially when the aerial videos are taken from a high *** authors applied the proposed method to extract vehicle trajectories from several high-resolution aerial videos recorded from *** extracted dataset is named by the High-Granularity Highway Simulation(HiGH-SiM)vehicle trajectory *** demonstrate the effectiveness of the proposed method and understand the quality of the HiGHSiM dataset,we compared the HiGH-SiM dataset with a well-known dataset,the NGSiM US-101 dataset,regarding the accuracy and consistency *** comparison results showed that the HiGH-SiM dataset has more reasonable speed and acceleration distributions than the NGSiM US-101 ***,the internal and platoon consistencies of the HiGH-SiM dataset give lower errors compared to the NGSiM US-101 *** benefit future research,the authors have published the HiGH-SiM dataset online for public use.

关键词： Video analytics image processing Vehicle trajectory extraction Deep learning Microsimulation

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Can eastern wisdom resolve western epidemics? Traditional Chinese medicine therapies and the opioid crisis

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Journal of integrative Medicine 2021年第4期19卷 295-299页

作者： Thomas Efferth An-long Xu Roxana Damiescu Mita Banerjee Norbert W.Paul david Y.W.Lee Department of Pharmaceutical Biology Institute of Pharmacy and BiochemistryJohannes Gutenberg University55128 MainzGermany School of Life Science Beijing University of Chinese MedicineBeijing 100029China Obama institute of Transnational American Studies Department of English and LinguisticsJohannes Gutenberg University55128 MainzGermany institute for the History Philosophyand Ethics of MedicineJohannes Gutenberg University Medical Center55131 MainzGermany Harvard Medical School McLean HospitalBostonMA 02115USA

The widespread use of opioids to treat chronic pain led to a nation-wide crisis in the United States. Tens of thousands of deaths annually occur mainly due to respiratory depression, the most dangerous side effect of opioids. Non-opioid drugs and non-pharmacological treatments without addictive potential are urgently required. Traditional Chinese medicine(TCM) is based on a completely different medical theory than academic Western medicine. The scientific basis of acupuncture and herbal treatments as main TCM practices has been considerably improved during the past two decades, and large metaanalyses with thousands of patients provide evidence for their efficacy. Furthermore, opinion leaders in the United States favor non-pharmacological techniques including TCM for pain management to fight the opioid crisis. We advocate TCM as therapeutic option without addictive potential and without lifethreatening side effects(e.g., respiratory depression) to treat chronic pain patients suffering from opioid misuse. The evidence suggests that:(1) opioid misuse cannot be satisfactorily managed with standard medication;(2) opinion leaders in the United States favor to consider non-opioid and nonpharmacological treatment strategies including those from TCM to treat acute and chronic pain conditions;(3) large meta-analyses provide scientific evidence for the clinical activity of acupuncture and herbal TCM remedies in the treatment of chronic pain. Future clinical trials should demonstrate the safety of TCM treatments if combined with Western medical practices to exclude negative interactions between both modalities.

关键词： Traditional Chinese medicine Acupuncture Addiction Opioid crisis Pain

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A randomized trial comparing the Tennant Biomodulator to transcutaneous electrical nerve stimulation and traditional Chinese acupuncture for the treatment of chronic pain in military service members

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Military Medical Research 2020年第2期7卷 140-150页

作者： Kimberly S.Peacock Erika Stoerkel Salvatore Libretto Weimin Zhang Alice inman Michael Schlicher John D.Cowsar Jr david Eddie Joan Walter University of Texas Health San Antonio 7703 Floyd Curl DriveSan AntonioTX78229USA TLi Foundation 1750 Tysons BoulevardMcLeanVirginia22102USA Henry M.Jackson Foundation 6720A Rockledge DriveBethesdaMD20817USA BD Life Sciences 1 Becton DriveFranklin LakesNJ07417USA Brooke Army Medical Center 3551 Roger Brooke DriveFort Sam HoustonTX78234USA Madigan Army Medical Center 9040A Jackson AveJoint Base Lewis-McChordWA98431USA MedPost Urgent Care Center 513 Cibolo Valley DriveCiboloTX78108USA Massachusetts General Hospital Harvard Medical School151 Merrimac St.6th FloorBostonMA02114USA H&S Ventures Samueli Integrative Health Program1800 Diagonal RoadSuite 617AlexandriaVA22314USA

Background:The present investigation tested the efficacy of the Tennant Biomodulator,a novel pain management intervention that uses biofeedback-modulated electrical stimulation,to reduce chronic pain and its psychosocial sequelae in a sample of current and former military service *** Tennant Biomodulator used on its most basic setting was compared to two commonly used,non-pharmacological pain treatments—traditional Chinese acupuncture and transcutaneous electrical nerve stimulation(TENS)—in a comparative efficacy,randomized,open-label ***:Participants included 100 active duty and retired service men and women with chronic pain undergoing treatment at the Brooke Army Medical Center in Texas,USA,randomly assigned to receive six,weekly sessions of either Tennant Biomodulator treatment,traditional Chinese acupuncture,or TENS,in addition to usual *** was conducted between May 2010 to September *** measures were collected at intake,before and after each treatment session,and at a 1-month ***-to-treat analyses were used throughout,with mixed models used to investigate main effects of group,time,and group×time interactions with consideration given to quadratic *** measured included ratings of chronic pain,pain-related functional disability,and symptoms of post-traumatic stress disorder(PTSD)and ***:On average,regardless of their treatment group,participants exhibited a 16%reduction in pain measured by the Brooke Army Medical Center’s Clinic Pain Log[F(1,335)=55.7,Pion in pain-related disability measured by the Million Visual Analog Scale[MVAS:F(1,84)=28.3,Pine to the end of treatment,but no one treatment performed better than the other,and the reductions in pain and pain-related disability were largely lost by 1-month *** of PTSD and depression did not change significantly as a function of time or ***:Findings build on previ

关键词： Tennant biomodulator Acupuncture Transcutaneous electrical nerve stimulation Chronic pain Military service members

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Discussions on real-world acupuncture treatments for chroni clow-back pain in older adults

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Journal of integrative Medicine 2019年第2期17卷 71-76页

作者： Arthur Yin Fan Hui Ouyang Xinru Qian Hui Wei david Dehui Wang Deguang He Haihe Tian Changzhen Gong Amy Matecki Sarah Faggert Alemi American TCM Association (ATCMA) mclean Center for Complementary and Alternative Medicine PLC YiN & YANG Healthcare Rusk Rehabilitation at NYU Langone Health Wei’s Chinese Medical Center Ohio State integrative Medicine Wexner Medical Center Ohio State University New England School of Acupuncture Chinese Acupuncture and Herbs Center American Academy of Acupuncture & Oriental Medicine Division of integrative Medicine Alameda Health System Affiliated with School of Medicine University of California San Francisco Eastern Roots Wellness PLC

Chronic low-back pain(CLBP) is one of the most common pain conditions. Current clinical guidelines for low-back pain recommend acupuncture for CLBP. However, there are very few high-quality acupuncture studies on CLBP in older adults. Clinical acupuncture experts in the American Traditional Chinese Medicine Association(ATCMA) were interested in the recent grant on CLBP research announced by the National Center for Complementary and integrative Health. The ATCMA experts held an online discussion on the subject of real-world acupuncture treatments for CLBP in older adults. Seven participants, each with more than 20 years of acupuncture practice, discussed their own unique clinical experience while another participant talked about the potential mechanism of acupuncture in pain management. As a result of the discussion, a picture of a similar treatment strategy emerged across the participants for CLBP in older adults. This discussion shows that acupuncture may have complicated mechanisms in pain management, yet it is effective for the treatment of chronic pain involving maladaptive neuroplasticity;therefore, it should be effective for CLBP in older adults.

关键词： Acupuncture Pragmatic clinical trials as topic Real world Treatment strategies Low-back pain Older adults Discussion

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Acupuncture price in forty-one metropolitan regions in the United States: An out-of-pocket cost analysis based on Ok ***

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Journal of integrative Medicine 2019年第5期17卷 315-320页

作者： Arthur Yin Fan david Dehui Wang Hui Ouyang Haihe Tian Hui Wei Deguang He Changzhen Gong Jipu Wen Ming Jin Chong He Sarah Faggert Alemi Sudaba Rahimi Acupuncture Profession Survey Project American Traditional Chinese Medicine AssociationViennaVA 22182USA Tongrentang Ming Qi Clinic New YorkNY 10016USA Oriental Asclepius LLCPlantationFL 33317USA Eastern Roots Wellness PLCMcLeanVA 22101USA mclean Center for Complementary and Alternative Medicine PIC.ViennaVA 22182USA Ohio State integrative Medicine Wexner Medical CenterOhio State UniversityColumbusOH 43221USA YiN & YANG Healthcare FriendswoodTX 77546USA Chinese Acupuncture and Herbs Center LargoFI 33778USA Wei's Chinese Medical Center Lake WorthFL 33467USA New England School of Acupuncture NewtonMA 02458USA American Academy of Acupuncture Oriental Medicine RosevilleMN 55113USA TCMzone TempeAZ 85281USA

Few studies have focused on the cost of acupuncture treatments although acupuncture has become popular in the United States(U.S.). The purpose of the current study was to examine the out-of-pocket costs incurred from acupuncture services based on an online website, Ok ***. We examined descriptive statistics(range, median and 20% intervals) for the cost of acupuncture "first-time visits"and "follow-up visits" in 41 metropolitan regions in the U.S. The acupuncture prices of 723 clinics throughout 39 metropolitan regions were included, except for Birmingham, Alabama and Detroit, Michigan as there was no online data available at the time of the study for these two regions. The cost range for a first-time acupuncture visit was $15–400;the highest median was $150 in Charleston, South Carolina,while the lowest was $45 in St. Louis, Missouri. The top 10 cities for the highest median were:Baltimore, Washington, D.C., New York, San Francisco, San Jose, Boston, Atlanta, Seattle, Portland and indianapolis, with the median $120, while the median for all 723 clinics was $112. For the follow-up visits,the cost range was $15–300;the highest median was $108 in Charleston, South Carolina, and the lowest$40 in Miami, Florida. The 10 cities with highest median follow-up acupuncture visit costs were: New York, Baltimore, New Orleans, Washington, D.C., Philadelphia, San Francisco, San Jose, Seattle, Boston and Atlanta, with the median $85, while for all 723 clinics the median price was $80. The estimation of the average gross annual income of each acupuncturist from the regions studied was $95,760, while the total annual cost of patients seeking acupuncture services in the U.S. was about $3.5 billion in 2018.

关键词： Acupuncture Price Out-of-pocket cost Annual cost City, United States

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