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路虎咖啡:疯狂的品牌扩张？

新营销 2013年第9期15卷 14-15页

作者： david taylor

博客主人/ david taylor http：//***：com.汽车品牌路虎推出了路虎咖啡品牌（LandRoverCoffee），在其网站上路虎宣称自己的咖啡“非常吸引人，是国际公认的咖啡品牌．以其高品质闻名，风味区别于其他咖啡品牌”。对于路虎而言，这种... 详细信息

博客主人/ david taylor http：//***：com.汽车品牌路虎推出了路虎咖啡品牌（LandRoverCoffee），在其网站上路虎宣称自己的咖啡“非常吸引人，是国际公认的咖啡品牌．以其高品质闻名，风味区别于其他咖啡品牌”。对于路虎而言，这种品牌扩张方式是否合理呢？

关键词：咖啡品牌品牌扩张疯狂汽车品牌 http 扩张方式博客国际

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TomTom:重新界定核心市场

新营销 2012年第9期14卷 40-41页

作者： david taylor

全球汽车导航第一品牌TomTom是品牌核心业务重振的一个有趣案例。该企业1991年创办于阿姆斯特丹，2004年推出汽车卫星导航设备，之后开始快速发展。

关键词：核心市场界定汽车导航阿姆斯特丹核心业务导航设备品牌企业

Substrate-specific structural rearrang.ments of human Dicer

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Substrate-specific structural rearrangements of human Dicer

Numerical Analysis and Desig. of an EMF Birdcag. Wearable Device for the Treatment of Alzheimer’s Disease: A Feasibility Study

第四届中国结构生物学学术讨论会

作者： david W.taylor Hideki Shig.matsu Hong.Wei Wang Department of Molecular Biophysics and Biochemistry Yale UniversityNew Haven CT 06530 USA Tsing.ua-Peking.Center for Life Sciences Center for Structural Biology School of Life Sciences Tsinghua University

Dicer plays a central role in RNA interference pathways by cleaving.double stranded RNAs(dsRNAs) to produce small reg.latory RNAs. Human Dicer can process both long.double-stranded and hairpin precursor RNAs to yield short interfering.RNAs(siRNAs) or microRNAs(miRNAs), respectively. Previous studies have shown that pre-miRNAs are cleaved much more rapidly than pre-siRNAs in vitro and are the predominant natural Dicer substrates in cells. We have used cryo-electron microscopy and sing.e particle analysis of Dicer-RNA complexes to g.in insig.t into the structural basis for human Dicer’s substrate preference. Our studies show that Dicer has a flexible architecture that traps pre-siRNA molecules in a non-productive conformation. Interactions of Dicer with pre-miRNAs and dsRNA binding.proteins induce structural chang.s in the enzyme that enable productive substrate recog.ition in the central catalytic channel. These finding. implicate RNA structure and cofactors in determining.substrate recog.ition and processing.efficiency by human Dicer.

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Journal of Biomedical Science and Eng.neering 2022年第8期15卷 219-227页

作者： Felipe P. Perez david Michael Arvidson Tyler Phoenix taylor Maryam Rahmani Maher Rizkalla Department of Medicine Division of General Internal Medicine and Geriatrics Indiana University School of Medicine Indianapolis USA Department of Electrical and Computer Eng.neering Indiana University-Purdue University Indianapolis USA

In this study, we performed a numerical analysis of a novel EMF Birdcag. wearable device for the treatment of Alzheimer’s disease (AD). We desig.ed the new device to g.nerate and radiate a frequency of 64 MHz and a specific absorption rate (SAR) of 0.6 W/kg.to a simulated human brain tissue. We determined these parameters from our experimental studies on primary human brain cultures at the Indiana University School of Medicine (IUSM). We found that this frequency and SAR decreased the toxic Aβ levels in the cell cultures. The frequency of 64 MHZ has g.od skin depth penetration, which will easily pass throug. the various head layers, including.hair, skin, fat, dura, the cerebrospinal (CSF), and g.ey matter, and reach deeply into the brain tissues. The SAR of 0.6 W/kg.was achieved with lower power input and energ., decreasing.the probability of thermal injury. Therefore, these parameters enhance the safety of these potential treatments. This Birdcag. device emulates a small-scale MRI machine, producing.the same 64 MHz frequency at much lower operating.input power. In this work, we utilized a hig.-frequency simulation system (HFSS/EMPro) software to produce the birdcag. structure for the required EMF parameters. The 64 MHz radiating.frequency produced the scattering.S11 parameter of −15 dbs. We obtained a SAR of 0.6 W/kg.when an input power of 100 W was applied. The coil dimensions were found to be near 15 cm in heig.t and 22 cm in diameter, which fits in wearable systems. We found that the distribution of the electric field and SAR radiate homog.neously over the simulated human head with g.od penetration into the brain, which proves to be an appropriate potential therapeutic strateg. for Alzheimer’s disease.

关键词： Alzheimer Disease Birdcag. Treatment HFSS EMF Temperature

Current and future applications of mag.etic resonance imag.ng.and spectroscopy of the brain in hepatic encepha-lopathy

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World Journal of g.stroenterolog. 2006年第19期12卷 2969-2978页

作者： VP Bob g.aver M Alex Dresner Daniel M Forton Serena Counsell david J Larkman Nayna Patel Howard C Thomas Simon D taylor-Robinson Hepatolog. Section Division of Medicine A St Mary's CampusFaculty of MedicineImperial College LondonSouth Wharf StreetLondon W2 1NYUnited Kingdom Imaging Sciences DepartmentClinical Sciences DivisionFaculty of MedicineImperial College LondonHammersmith HospitalDu Cane RoadLondon W12 0HSUnited Kingdom Imag.ng.Sciences Department Clinical Sciences Division Faculty of MedicineImperial College LondonHammersmith HospitalDu Cane RoadLondon W12 0HSUnited Kingdom Hepatolog. Section Division of Medicine A St Mary's CampusFaculty of MedicineImperial College LondonSouth Wharf StreetLondon W2 1NYUnited Kingdom

Hepatic encephalopathy （HE） is a common neuropsychiatric abnormality, which complicates the course of patients with liver disease and results from hepatocellular failure and/or portosystemic shunting. The manifestations of HE are widely variable and involve a spectrum from mild subclinical disturbance to deep coma. Research interest has focused on the role of circulating.g.t-derived toxins, particularly ammonia, the development of brain swelling.and chang.s in cerebral neurotransmitter systems that lead to g.obal CNS depression and disordered function. Until recently the direct investig.tion of cerebral function has been difficult in man. However, new mag.etic resonance imag.ng.（MRI） techniques provide a non-invasive means of assessment of chang.s in brain volume （coreg.stered MRI） and impaired brain function （fMRI）, while proton mag.etic resonance spectroscopy （^1H MRS） detects chang.s in brain biochemistry, including.direct measurement of cerebral osmolytes, such as myoinositol, g.utamate and g.utamine which g.vern processes intrinsic to cellular homeostasis, including.the accumulation of intracellular water. The concentrations of these intracellular osmolytes alter with hyperammonaemia. MRS-detected metabolite abnormalities correlate with the severity of neuropsychiatric impairment and since MR spectra return towards normal after treatment, the technique may be of use in objective patient monitoring.and in assessing.the effectiveness of various treatment reg.mens.

关键词： Hepatic encephalopathy Mag.etic resonance imag.ng Mag.etic resonance spectroscopy Diffusion weig.ted imag.ng Arterial spin labeling Functional MRI

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有备无患

新理财（公司理财） 2006年第5期 54-56页

作者： david taylor 井明

现在人们大多已经意识到IT灾难恢复程序不能被孤立于核心商业活动之外,在IT

关键词：软件故障系统升级 IT部门灾难恢复应急计划成本费用检测系统系统使用硬件持续性

Development and first evaluation of an attractant impreg.ated adhesive tape ag.inst blood-sucking.flies

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Insect Science 2022年第2期29卷 603-612页

作者： Junwei J.Zhu g.ang.Hyun Roh Yosuke Asamoto Kujtim Bizati Jen-Chieh Liu Alexander Lehmann Kyle Harrison david Btaylor Hironao Otake Ag.oecosystem Manag.ment Research Unit US Department of AgricultureAgricultural Research ServiceLincolnNebraskaUSA US Pacific Basin Ag.icultural Research Center US Department of AgricultureAgricultural Research ServiceHiloHawaiiUSA Oak Ridg. Institute for Science and Education Oak RidgeTennesseeUSA Nitto Inc. TeaneckNew JerseyUSA Department of Entomolog. University of NebraskaLincolnNebraskaUSA

Stable flies are one of the most important arthropod pests of livestock that reduce cattle weig.t g.in and milk production leading.to annual economic losses in excess of$2 billion to the US cattle *** host-seeking.behavior is primarily mediated by associated odors from stable fly larval development environments and host *** present paper reports the development and evaluation of attractant-impreg.ated adhesive tapes to reduce stable fly attacks on *** bioassays showed that only m-cresol impreg.ated adhesive tapes caug.t sig.ificantly more stable flies(16±1)than the control tape without attractant added(7±1),with a 77%fly recapture ***-impreg.ated adhesive tapes deployed in cattle feedlots showed sig.ificant impacts in reducing.fly population,with a total of one million stable flies captured over a period of three weeks(mean catches from 57596 to 102088 stable flies per trap per week).It further relieved cattle stress with a sig.ificant reduction of biting.fly avoidance behavior,(6±0.4 cows observed with tail wag.ing.in control vs.3±0.4 from the trap-deployed).The efficacy of the developed tapes lasted up to 1-week long.vity,althoug. 70%of m-cresol was released starting.from the second *** m-cresol impreg.ated adhesive tape provided an 80%reduction in cattle stress due to stable fly *** is the first report of a technolog. developed by integ.ating.an attractant compound into an adhesive material on a plastic film with demonstrated effectiveness in trapping.biting.flies that attack livestock animals.

关键词： cattle stress reduction mass trapping m-cresol-impreg.ated adhesive tapes Stomoxys calcitrans

射频收发器为航空航天和防务应用提供突破性的SWaP解决方案

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今日电子 2016年第12期 50-52页

作者： Wyatt taylor david Brown ADI公司

新一代航空航天和防务平台将带来新的挑战，其需要的解决方案无法通过单独优化器件来实现。在无线电中集成更多的软件控制和认知能力，需要采用一种在频率和带宽方面更具灵活性的射频设计。

关键词：航空航天射频收发器 SWaP 防务突破性应用认知能力软件控制

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婴儿眼底出血

国外医学（眼科学分册） 1993年第2期17卷 99-105页

作者： Baljit Kaur david taylor 刘武

婴儿视网膜出血的位置和形态为眼底病的诊断提供重要线索。新生儿因产伤引起的视网膜出血常见,预后良好,为自限性。而婴儿的某些视网膜出血则可表明颅内动脉瘤、意外或非意外性损伤、和多种眼底病(如Coats病,残存性原始玻璃体增生症、... 详细信息

婴儿视网膜出血的位置和形态为眼底病的诊断提供重要线索。新生儿因产伤引起的视网膜出血常见,预后良好,为自限性。而婴儿的某些视网膜出血则可表明颅内动脉瘤、意外或非意外性损伤、和多种眼底病(如Coats病,残存性原始玻璃体增生症、早产儿视网膜病变、视网膜发育不良、高血压、近视)、或全身病(如血液病或心血管病变.感染、蛋白C缺乏)。本文根据视网膜出血的位置、形态和病因进行图解和分类。婴儿视网膜出血的及时诊断至为重要,因为通过治疗可预防早期剥夺性弱视和盲的发生。眼科体征亦为全身治疗提供有价值的评估。

关键词：视网膜出血诊断位置形态