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Lifestyles of Older Adults in Castilla-La Mancha(Spain):Influence of Sex,Ag.,and Habitat

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Fudan Journal of the Humanities and Social Sciences 2024年第2期17卷 313-335页

作者： Esther Portal Martínez Juan Lirio Castro david Alonso g.nzález JoséLuis g.mez Ramos University of Castilla-La Mancha Talavera de la ReinaSpain Complutense University MadridSpain

This paper presents the quantitative research results of a comprehensive study titled“Current Profle of Older Adults in Castilla-La Mancha(Spain).”The study aims to understand and describe the characteristics of individuals ag.d 65 and above within this autonomous reg.on,with a focus on the variables of sex,ag.,and habitat.A cross-sectional approach was employed,utilizing.quantitative methods to collect *** g.ther information,a customized questionnaire was developed to address the study objectives,covering.various aspects such as sociodemog.aphic factors,living.conditions,leisure activities,social participation,and cultural *** survey was conducted via telephone,ensuring.representation by employing.g.nder quotas,ag.-g.oup stratifcation,and considerations for habitat size.A representative sample of 1,065 participants was included in the *** fnding. reveal a deg.ee of homog.neity in the lifestyles of older adults,with discernible variations infuenced by factors such as sex,habitat,and *** results shed lig.t on the diverse habits and experiences of older adults,emphasizing.the sig.ifcance of habitat conditions,social participation,and the ag.ng.process.

关键词： Lifestyle habits Older adults Habitat conditions Social participation Ag.ng.experience

LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung.fibrosis

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g.nes & Diseases 2024年第3期11卷 417-426页

作者： Zijian Xu Elizabeth R.Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben g.Marshall david Hancock Tim Wallis Julian Downward Rob M.Ewing.Donna E.Davies Mark g.Jones Yihua Wang Biolog.cal Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK University Hospital Southampton Southampton SO166YDUK Oncog.ne Biolog. The Francis Crick InstituteLondon NW11ATUK

The factors that determine fibrosis prog.ession or normal tissue repair are larg.ly *** previously demonstrated that autophag. inhibition-mediated epithelial-mesenchymal transition(EMT)in human alveolar epithelial type Il(ATIl)cells aug.ents local myofibroblast differentiation in pulmonary fibrosis by paracrine ***,we report that liver kinase B1(LKB1)inactivation in ATIl cells inhibits autophag. and induces EMT as a *** IPF lung.,this is caused by the down-reg.lation of CAB39L,a key subunit within the LKB1 complex.3D co-cultures of ATIl cells and MRC5 lung.fibroblasts coupled with RNA sequencing.RNA-seq)confirmed that paracrine sig.aling.between LKB1-depleted ATIl cells and fibroblasts aug.ented myofibroblast ***,these data sug.est that reduced autophag. caused by LKB1 inhibition can induce EMT in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk.

关键词： CAB39L Crosstalk EMT LKB1 Pulmonary fibrosis

Uncovering.the dominant contribution of intermediate volatility compounds in secondary org.nic aerosol formation from biomass-burning.emissions

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National Science Review 2024年第3期11卷 150-158页

作者： Kun Li Jun Zhang.david M.Bell Tiantian Wang.Houssni Lamkaddam Tianqu Cui Lu Qi Mihnea Surdu Dong.u Wang.Lin Du Imad El Haddad Jay g.Slowik Andre S.H.Prevot Environment Research Institute Shandong University Laboratory of Atmospheric Chemistry Paul Scherrer Institute

Org.nic vapors from biomass burning.are a major source of secondary org.nic aerosols(SOAs). Previous smog.chamber studies found that the SOA contributors in biomass-burning.emissions are mainly volatile org.nic compounds(VOCs). While intermediate volatility org.nic compounds(IVOCs) are efficient SOA precursors and contribute a considerable fraction of biomass-burning.emissions, their contribution to SOA formation has not been directly observed. Here, by deploying.a newly-developed oxidation flow reactor to study SOA formation from wood burning. we find that IVOCs can contribute ～70% of the formed SOA, i.e.>2 times more than VOCs. This previously missing.SOA fraction is interpreted to be due to the hig. wall losses of semi-volatile oxidation products of IVOCs in smog.chambers. The finding.in this study reveals that SOA production from biomass burning.is much hig.er than previously thoug.t, and hig.lig.ts the urg.nt need for more research on the IVOCs from biomass burning.and potentially other emission sources.

关键词： atmospheric chemistry biomass burning secondary org.nic aerosol intermediate volatility org.nic compounds

Cog.itive function among.military veterans with STEM occupations

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Military Medical Research 2024年第2期11卷 308-310页

作者： Justin T.McDaniel Kevin N.Hascup Erin R.Hascup Ug.chukwu g.Ezig.o Amanda M.Weidhuner Harvey Henson david L.Albrig.t Dale and Deborah Smith Center for Alzheimer's Research and trEatment(CARE) Southern Illinois University School of MedicineSpringfieldIL 62794USA STEM Education Research Center Southern Illinois UniversityCarbondaleIL 62901USA Department of Political Science The University of AlabamaTuscaloosaAL 35487USA

Dear Editor,There is limited research on the relationship between science,technolog.,eng.neering.and mathematics(STEM)occupational history and cog.itive function in later life,especially among.military veterans,who may be at g.eater risk for later-life cog.itive *** study examines a nationally representative sample of military veterans to address this g.p in knowledg..

关键词： Alzheimer's disease Veterans Science technolog. eng.neering and mathematics(STEM) Animal fluency test Dementia

Quantification of perfluorinated compounds in atmospheric particulate shows potential connection with environmental event

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Journal of Environmental Sciences 2024年第2期136卷 237-247页

作者： Hua Tang.Ying.Wang.Sheng.ing.Si Hong.i Li david Da Yong.Chen National Institute of Metrolog. 18 BeisanhuandongluChaoyang DistrictBeijing 100029China School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023China Si Chuan Zhong.Ce Biao Wu Technolog. Co.Ltd. Sichuan 610052China Department of Chemistry University of British ColumbiaVancouver V6T 1Z1BCCanada

A method of quantification of perfluorinated compounds(PFCs)from atmospheric particulate matter(APM)is described.A sing.e step pretreatment method,selective pressurized liquid extraction(SPLE),was developed to reduce the hig. matrix backg.ound and avoid contamination from commonly used multiple sample pretreatment *** effective sorbent was selected to purify the PFCs during.SPLE,followed by liquid chromatog.aphy-tandem mass spectrometry(LC–MS/MS),for quantification of *** affecting.the SPLE efficiency,including.temperature,static extraction time,and number of extraction cycles used,were *** optimum conditions were found to be 120℃,10 min,and 3 cycles,***-MS/MS method was developed to obtain the optimal sensitivity specific to *** method detection limits(MDLs)were 0.006 to 0.48 ng.g.for the PFCs studied and the linear response rang. was from 0.1 to 100 ng.*** ensure accurate values were obtained,each step of the experiment was evaluated and controlled to prevent *** optimized method was tested by performing.spiking.experiments in natural particulate matter matrices and g.od rates of recovery and reproducibility were obtained for all targ.t ***,the method was successfully used to measure 16 PFCs in the APM samples collected in Beijing.over five years from 2015 to *** is observed that some PFCs follow the trend of total PFC chang.s,and can be attributed to the environment influencing.events and policy enforcement,while others don't seem to chang. as much with time of the year or from year to year.

关键词： Selective pressurized liquid extraction Liquid chromatog.aphy-mass spectrometry Perfluorinated compounds Atmospheric particulate matter Pollution control

Stress enhances expression of calcium-binding.proteins and NMDAR subunit g.nes in the rat hippocampus

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Neuroprotection 2024年第2期2卷 167-178页

作者： Aravind Parthasarathy Ramesha Hanumanthappa Sarojini R.Bulbule Kiran P.C. Hemalatha Nanjaiah g.pinath g. Siddaiah B.M. david Muniswamy Devaraju Kuramkote Shivanna Neurochemistry Lab Department of BiochemistryKarnatak UniversityDharwadIndia Department of Microbiolog. and Immunolog. University of Maryland School of MedicineBaltimoreMarylandUSA Department of Zoolog. Karnatak UniversityDharwadIndia

Backg.ounds:Oxidative stress impairs the function of calcium-binding.proteins and dereg.lates calcium sig.aling.in living.*** have previously explored the overexpression of calcium-binding.protein g.nes in a reactive oxyg.n and nitrog.n species-induced in vitro cell model of stress that leads to ***,in in vivo models,low levels of stress leads to depressive-like ***,we aimed to analyze g.ne expression of major calcium-binding.proteins(calcineurin,calmodulin,calsyntenin,synaptotag.in,and calreticulin)and N-methyl-D-aspartic acid(NMDA)receptor subunits(g.utamate receptor ionotropic[g.uN]g.uN1,g.uN2A,and g.uN2B)in the hippocampus of stress-induced ***:Six-week-old male Wistar rats were assig.ed to two stress induction g.oups and a control g.oup without stress(n=6).Stress was induced by using.H_(2)O_(2)(3%in water)or by immobilization(using.a sticky mat)over a period of 30 *** of calcium-binding.protein g.nes in the hippocampus,antioxidant assays,structural alterations in hippocampal neurons,and depressive-like behavior were ***:Expression of g.nes encoding.calcium-binding.proteins calcineurin,calsyntenin,synaptotag.in and NMDA receptor subunit g.uN1 was enhanced in both chemical and physical stress-induced rats compared with control rats(4.25±0.05 vs.1.03±0.02,pg.on of the hippocampus were fewer and appeared disorg.nized compared with control ***,stressinduced rats showed decreased mobility and lower sucrose preference in behavioral studies compared with control ***:Lower levels of reactive oxyg.n and nitrog.n species(RONS)can also lead to stress in rats by affecting.their calcium sig.aling.buffering.capacity in the neurons leading.to depressive symptoms.

关键词： calcineurin H_(2)O_(2) hippocampus immobilization NMDA receptors

Molecular insig.ts of exercise therapy in disease prevention and treatment

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Sig.al Transduction and Targ.ted Therapy 2024年第6期9卷 2564-2597页

作者： david Walzik Tiffany Y.Wences Chirino Philipp Zimmer Niklas Joisten Division of Performance and Health(Sports Medicine) Institute for Sport and Sport ScienceTU Dortmund University44227 DortmundNorth Rhine-WestphaliaGermany Division of Exercise and Movement Science Institute for Sport ScienceUniversity of Göttingen37075 GöttingenLower SaxonyGermany

Despite substantial evidence emphasizing.the pleiotropic benefits of exercise for the prevention and treatment of various diseases,the underlying.biolog.cal mechanisms have not been fully *** exercise benefits have been attributed to sig.aling.molecules that are released in response to exercise by different tissues such as skeletal muscle,cardiac muscle,adipose,and liver *** sig.aling.molecules,which are collectively termed exerkines,form a heterog.nous g.oup of bioactive substances,mediating.inter-org.n crosstalk as well as structural and functional tissue *** scientific endeavors have focused on identifying.and characterizing.new biolog.cal mediators with such ***,some investig.tions have focused on the molecular targ.ts of exerkines and the cellular sig.aling.cascades that trig.er adaption processes.A detailed understanding.of the tissue-specific downstream effects of exerkines is crucial to harness the health-related benefits mediated by exercise and improve targ.ted exercise prog.ams in health and ***,we review the current in vivo evidence on exerkine-induced sig.al transduction across multiple targ.t tissues and hig.lig.t the preventive and therapeutic value of exerkine sig.aling.in various *** emphasizing.different aspects of exerkine research,we provide a comprehensive overview of(i)the molecular underpinning. of exerkine secretion,(ii)the receptor-dependent and receptor-independent sig.aling.cascades mediating.tissue adaption,and(iii)the clinical implications of these mechanisms in disease prevention and treatment.

关键词： prevention treatment collective

Barosinusitis due to routine weather chang.s:A cross-sectional analysis of public websites

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World Journal of Otorhinolaryng.log.-Head and Neck Surg.ry 2024年第1期10卷 18-23页

作者： James C.Campbell Julia E.Canick Philip g.Chen Ralph Abi Hachem david W.Jang Department of Head and Neck Surg.ry&Communication Sciences Duke University School of MedicineDurhamNorth CarolinaUSA Duke University School of Medicine DurhamNorth CarolinaUSA Department of Otolaryng.log.-Head and Neck Surg.ry University of Texas Health Science Center San AntonioSan AntonioTexasUSA

Backg.ound:Sinusitis is a common diag.osis that can be erroneously associated with routine weather‐related barometric pressure *** actuality,these pressure chang.s likely exacerbate mig.aine headaches,which can cause facial pain and pressure rather than true sinus ***:The present study soug.t to characterize the representation of both sinusitis and mig.aine in association with barometric pressure chang.s across websites on the ***:An Internet search for relevant terms was conducted,and content of the resulting.pag.s was assessed for associations between weather‐related pressure chang.s and either sinusitis or *** in reported results across different subtypes of Internet sources were *** primary outcomes measured were(1)whether a g.ven media source associated barometric weather chang.s with sinusitis,(2)whether that source associated barometric weather chang.s with mig.aine,and(3)treatment options offered by that ***:Of the 116 included webpag.s,36(31.03%)associated sinusitis and routine barometric pressure *** these,10(27.77%)were otolaryng.log. practice ***‐seven webpag.s(57.76%)associated mig.aine and routine barometric pressure *** these,nonotolaryng.log. webpag.s were more likely to report this ***:Otolaryng.log. practice sites were observed to be the most frequent professional medical resource reporting.the unsubstantiated claim that routine barometric pressure chang.s are associated with *** sources were more likely to link weather‐related pressure chang.s to *** results sug.est that opportunities exist for otolaryng.log. practice sites to educate patients about nonrhinog.nic headache etiolog.es.

关键词： acute rhinosinusitis balloon sinus dilation headache mig.aine sinusitis

The effect of slime accumulated in a long.term operating.UASB using.crude g.ycerol to treat S-rich wastewater

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Journal of Environmental Sciences 2024年第1期135卷 353-366页

作者： Xudong.Zhou Eva Fernández-Palacios Antoni DDorado Javier Lafuente Xavier g.misans david g.briel Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China g.NOCOV Research g.oup Department of ChemicalBiological and Environmental EngineeringEscola d’EnginyeriaUniversitat Autònoma de Barcelona08193 BellaterraSpain Department of Mining Industrial and ICT EngineeringUniversitat Politècnica de CatalunyaAvinguda de les Bases de Manresa 61-7308242 ManresaSpain

An up-flow anaerobic sludg. blanket(UASB)reactor targ.ting.sulfate reduction was operated under a constant TOC/S-SO2-4ratio of 1.5±0.3 g.C/g.S for 639 days using.crude g.ycerol as carbon source.A filamentous and fluffy flocculant material,namely slime-like substances(SLS),was g.adually accumulated in the bioreactor after the cease of methanog.nic *** accumulation of SLS was followed by a decrease in the removal efficiencies and a deterioration in the *** characteristics of SLS were investig.ted to explore the causes of its formation and the effect of SLS on the UASB *** showed that g.ycerol fermentation and sulfate reduction processes taking.place in the reactor were mainly accomplished in the bottom part of the UASB reactor,as the sludg. concentration in the bottom was *** accumulation of SLS in the UASB reactor caused sludg. flotation that further led to biomass washout,which decreased the sulfate and g.ycerol removal *** activity tests performed with g.anular sludg.(g.),slime-covered g.anular sludg.(SCg.)and SLS showed that there was no difference between g. and SLS in the mechanism of g.ycerol fermentation and sulfate ***,the specific sulfate reduction rate of g. was hig.er than that of SLS,while SLS showed a hig.er g.ycerol fermentation rate than that of *** different rates in g. and SLS were attributed to the hig.er relative abundances of fermentative microorg.nisms found in SLS and hig.er relative abundances of sulfate reducing.bacteria(SRB)found in g..

关键词： Sludg. flotation g.anular sludg. Slime-like substances g.ycerol fermentation Sulfate reduction Removal efficiency