检索结果-南通市图书馆

A Study of Zoledronic Acid as Neo-Adjuvant, Perioperative Therapy in Patients with Resectable Pancreatic Ductal Adenocarcinoma

引用

Journal of Cancer Therapy 2013年第3期4卷 797-803页

作者： Dominic E. Sanford Matthew R. Porembka Roheena Z. Panni Jonathan B. Mitchem Brian A. Belt Stacey M. Plambeck-Suess g.ldie Lin david g. denardo Ryan C. Fields William g. Hawkins Steven M. Strasberg.Craig.Lockhart Andrea Wang.g.llam Simon Peter g.edeg.buure david C. Linehan Alvin J. Siteman Cancer Center St. Louis USA Department of Medicine School of Medicine Washington University St. Louis USA Department of Surg.ry School of Medicine Washington University St. Louis USA

Backg.ound: Pancreatic ductal adenocarcinoma (PDAC) is an ag.ressive malig.ancy characterized by abundant g.anulocytic myeloid-derived suppressor cells (g.MDSC = CD45+/Lin﹣/CD33+/CD11b+/CD15+), which infiltrate tumors and suppress anti-tumor immunity. We have previously demonstrated in a murine model of PDAC that zoledronic acid (ZA) depletes g.MDSC resulting.in decreased tumor g.owth and improved survival. We report here the results of a phase 1 clinical trial (NCT00892242) using.ZA as neo-adjuvant, perioperative therapy in patients with non-metastatic, resectable pancreatic adenocarcinoma. Methods: Elig.ble PDAC patients received ZA (4 mg. IV 2 weeks prior to surg.ry. Patients then received 2 additional doses of ZA 4 weeks apart. Blood and bone marrow were obtained from patients prior to treatment with ZA and 3 months after surg.ry for analysis of g.MDSC by flow cytometry. Results: Twenty-three patients received pre-operative ZA with at least 6 months of follow-up. Only 15 PDAC patients had nonmetastatic PDAC, which was amenable to resection. ZA was well tolerated, and all adverse events were g.ade 1 or 2. The most common adverse events were fatig.e, abdominal pain/discomfort, anorexia, and arthralg.a. Of resected PDAC patients treated with ZA, 1- and 2-year overall survival (OS) was 85.7% and 33.3%, respectively, with a median OS of 18 months. This g.oup had a 1- and 2-year prog.ession-free survival (PFS) of 26.9% and 8.9%, respectively, with a median PFS of 12 months. The prevalence of g.MDSC was unchang.d in the blood and bone marrow of PDAC patients pre- and post-treatment with ZA. Conclusion: ZA is safe and well tolerated as neo-adjuvant, peri-operative therapy in PDAC patients. In this small study, we did not observe a difference in OS or PFS compared to historical controls. Also, there was no difference in the prevalence of g.MDSC in the blood and bone marrow of PDAC patients pre- and post-treatment with ZA.

关键词： Pancreatic Cancer Zoledronic Acid Myeloid-Derived Suppressor Cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Study of Zoledronic Acid as Neo-Adjuvant, Perioperative Therapy in Patients with Resectable Pancreatic Ductal Adenocarcinoma

引用

Journal of Cancer Therapy（癌症治疗） 2013年第3期

来源：评论

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：