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Effects of Grassland Degradation and Re-vegetation on carbon and Nitrogen Storage in the Soils of the Headwater Area Nature Reserve on the Qinghai-Tibetan Plateau,china

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Journal of Mountain Science 2015年第3期12卷 582-591页

作者： SU Xu-kun wu Yu DONG Shi-kui WEN Lu LI Yuan-yuan WANG Xue-xia School of Environment Beijing Normal University

Both overgrazing and climate change contribute to grassland degradation in the alpine regions of china and negatively affect soil carbon and nitrogen pools. We quantified changes in soil organic carbon （SOc） and total nitrogen （TN） in black soil beach （BSB）. We measured SOc and TN in severely degraded and non-degraded grasslands to calculate differences in carbon and nitrogen storage, and field survey results were extrapolated to the entire headwaters area of the Qinghai-Tibetan Plateau （36.3xlos krn~） to determine SOc and TN losses from these grasslands. We also evaluated changes in SOc and TN in severely degraded grasslands that were artificially re-vegetated five, seven and nine years ago. Totally 92.43 Tg c and 7.08 Tg N were lost from the BSB in the headwater area, which was approximately 50% of the original c and N soil pools. Re-vegetation of the degraded grasslands in the headwater area would result in a gain of 32.71 Tg c in the soil after five years, a loss of 5.5a Tg c after seven years and an increase of 44.15 Tg c after nine years. The TN increased by 53.09% and 59.98% after five and nine years, respectively, while it decreased by 4.92% after seven years of re-vegetation. The results indicate that c and N stocks followed a ＂V＂ shaped pattern with re- vegetation time. Understanding plant-soil interactions during succession of artificially planting grassland ecosystems is essential for developing scientifically sound management strategies for the effectively re-vegetated BSB.

关键词： Black soil beach Grassland degradation Soil loss Revegetation Alpine grasslands Soil carbonsequestration Soil nitrogen sequestration

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Design, Synthesis and Biological Activities of N-（Furan-2-ylmethyl）-lH-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents

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chemical Research in chinese Universities 2017年第3期33卷 365-372页

作者： ZHANG Lan DENG Xinshan wu Jiaofeng MENG Guangpeng LIU congchong cHEN Guzhou ZHAO Qingchun HU chun Key Laboratory of Structure-based Drug Design & Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 P. R. China Department of Pharmacy General Hospital of Shenyang Military Area Command Shenyang 110016 P. R. China

A series ofN-（furan-2-ylmethyl）-lH-indole-3-carboxamide derivatives（6a--6p） was designed and synthe- sized for developing novel indole scaffolds as anticancer agents targeting the epidemal growth factor receptor （EGFR）, and the cytotoxic activities of the target compounds were evaluated against three EGFR high-expressed cancer cell lines[human lung adenocarcinoma cell line（A549）, Henrietta Lacks strain of cancer cell line（HeLa） and human colorectal cancer cell line（SW480）], one EGFR low-expressed cell line（human liver cancer cell line, HepG2） and one human liver normal cell line（HL7702） using 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium bromide （MTT） assay, Some target compounds exhibited potent anficancer activities against A549, HeLa, SW480 and weak activities on HepG2, which signifies that the target compounds are likely to be EGFR inhibitors as expected. And they showed weak cytotoxic effects on HL7702, which implies the target compounds are probably to be of low toxicity against normal cells. Among them, the target compound 1-ethyl-N-（fttran-2-ylmethyl）-5-{2-{ [2-（2-methoxy- phenoxy）ethyl]amino}-2-oxoethoxy}-2-methyl-1H-indole-3-carboxamide（6p） with 2-{[2-（2-methoxyphenoxy）ethyl]- amino}-2-oxoethoxy group at the c5 position of the N-（furan-2-ylmethyl）-lH-indole-3-carboxamide scaffold exhibited the most potent anticancer activity. Also the binding interaction of the target compound 6p with EGFR was explored by molecular docking. conclusively, the novel indole scaffold may be beneficial to investigate new anticancer agents for targeting the EGFR.

关键词： Anticancer activity Epidemal growth factor receptor(EGFR) inhibitor N-(Furan-2-ylmethyl)-lH-indole-3-carboxamide derivative

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The influence of elevation on soil properties and forest litter in the Siliceous Moncayo Massif,SW Europe

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Journal of Mountain Science 2016年第12期13卷 2155-2169页

作者： BADIA david RUIZ Alberto GIRONA Antonio MARTI clara cASANOVA Jose IBARRA Paloma ZUFIAURRE Raquel Department of Agricultural and Environmental Sciences Technic School of Agricultural Engineering and Environmental SciencesUniversidad de Zaragoza Department of Geography and Land Management University of Zaragoza Department of Analytical chemistry Technic School of Agricultural Engineering and Environmental SciencesUniversity of Zaragoza

Understanding the effects of elevation and related factors(climate,vegetation) on the physical and chemical soil properties can help to predict changes in response to future climate or afforestation *** work aims to contribute to the knowledge of soil evolution and the classification of forest soils in relation to elevation in the montane stage,with special attention to podzolization and humus *** northern flank of the Moncayo Massif(Iberian Range,SW Europe) provides a unique opportunity to study a forest soils catena within a consistent quartzitic parent material over a relatively steep elevation *** increasing elevation,pH,base saturation,exchangeable potassium,and fine silt-sized particles decrease significantly,while organic matter,the c/N ratio,soil aggregate stability,water repellency and coarse sand-sized particles increase *** soil profiles shared a set of properties in all horizons:loamy-skeletal particle-size,extreme acidity(pH-H_2Ocesses in the catena include topsoil organic matter accumulation and even podzolization,which increases with *** the upper to lower landscape positions of wooded montane stage of the Moncayo Massif,mull-moder-mor humus and an Umbrisolcambisol-Podzol soil unit sequences were found.

关键词： Montane stage Forest soils catena Humus forms Podzolization Siliceous Moncayo Massif

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Study on Microstructure and Mechanical Properties of Hot Rolled Low Silicon containing Phosphorus TRIP Steel

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稀有金属材料与工程 2011年第S3期40卷 228-233页

作者： Hou Xiaoying, Xu Yunbo, wu Di State Key Laboratory of Rolling and Automation, Northeastern University, Shenyang 110819, china Northeastern Univ State Key Lab Rolling & Automat Shenyang 10819 Peoples R China

The effects of final air cooling temperature on the microstructure and mechanical properties of hot rolled 0.2c-1.9Mn-0.5Si-0.08P TRIP steel were studied by utilizing OM, SEM, TEM and tensile tests. Experimental results showed that in the multiphase microstructure of the investigated steel when the finish rolling temperature was about 820 ℃ and the final air cooling temperature was in the range of 630-700 ℃, the grain size of most of ferrite was finer (about 4 μm) and which had higher dislocation density, the bainite packets had chaotic orientations and lath boundaries of bainite were not quite straight, the retained austenite distributed in the ferrite grain boundaries or triradius was fine and dispersive, and their grain size was about 0.4-1.9 μm. With increasing the amount of ferrite, the volume fraction of retained austenite had a slight decrease. When the final air cooling temperature was 630 ℃, the steel had excellent mechanical properties, which was characterized by combination of continuous yielding, high strength (about 796 MPa) and high elongation (22.7%) as well as low yield/strength ratio (0.58); when the final air cooling temperature increased to 700 ℃, the matrix structure was bainite packets and the comprehensive properties were deteriorated.

关键词： hot rolled TRIP steel low silicon containing phosphorus microstructure and mechanical properties final air cooling temperature

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Design,synthesis,and biological evaluation of novel tetrahydroprotoberberine derivatives(THPBs) as proprotein convertase subtilisin/kexin type 9(PcSK9)modulators for the treatment of hyperlipidemia

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Acta Pharmaceutica Sinica B 2019年第6期9卷 1216-1230页

作者： chenglin wu cong Xi Junhua Tong Jing Zhao Hualiang Jiang Jiang Wang Yiping Wang Hong Liu State Key Laboratory of Drug Research and cAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy China Pharmaceutical UniversityNanjing 210009China University of chinese Academy of Sciences Beijing 100049China

Proprotein convertase subtilisin/kexin type 9(PcSK9)modulators may attenuate PcSK9-induced low-density lipoprotein receptor(LDLR)degradation in lysosome and promote the clearance of circulating low-density lipoprotein cholesterol(LDL-c).A novel series of tetrahydroprotoberberine derivatives(THPBs)were designed,synthesized,and evaluated as PcSK9 modulators for the treatment of *** them,eight compounds exhibited excellent activities in downregulatinghepatic PcSK9 expression better than berberine in HepG2 *** addition,five compounds 15,18,22,(R)-22,and(S)-22 showed better performance in the low-density lipoprotein,labeled with 1,1’-dioctadecyl-3,3,3’,3’-tetramethyl-indocarbocyanine perchlorate(Dil-LDL)uptake assay,compared with berberine at the same *** 22,selected for in vivo evaluation,demonstrated significant reductions of total cholesterol(Tc)and LDL-c in hyperlipidemic hamsters with a good pharmacokinetic *** exploring of the lipid-lowering mechanism showed that compound 22 promoted hepatic LDLR expression in a dose-dependent manner in HepG2 *** results of human ether-ago-go related gene(hERG)inhibition assay indicated the potential druggability for compound 22,which is a promising lead compound for the development of PcSK9 modulator for the treatment of hyperlipidemia.

关键词： PcSK9 Tetrahydroprotoberberine derivatives Low-density lipoprotein cholesterol Lipid-lowering PcSK9 expression Low-density lipoprotein receptor Total cholesterol Hyperlipidemia hamster

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cXXc5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis

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Journal of Molecular cell Biology 2018年第1期10卷 48-59页

作者： Xiaohua Yan Jingyi wu Quanlong Jiang Hao cheng Jing-Dong J. Han Ye-Guang chen The State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life Sciences School of Life Sciences Tsinghua University Beijing 100084 China Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Nanchang University Nanchang 330006 China chinese Academy of Sciences-Max Planck Partner Institute for computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Evading TGF-β-mediated growth inhibition is often associated with tumorigenesis in liver, including hepatocellular carcinoma （Hcc）. To better understand the functions and the underlying molecular mechanisms of TGF-β in Hcc initiation and progression, we carried out transcriptome sequencing （RNA-Seq） to identify the target genes of TGF-β. cXXcS, a member of the cXXc-type zinc finger domain-containing protein family, was identified as a novel TGF-β target gene in Hep3B Hcc cells. Knockdown of cXXc5 attenuated the expression of a substantial portion of TGF-p target genes and ameliorated TGF-13-induced growth inhibition or apoptosis of Hep3B cells, suggesting that cXXc5 is required for TGF-p-mediated inhibition of Hcc progression. Analysis of the TcGA database indicated that cXXc5 expression is reduced in the majority of Hcc tissue samples in comparison to that in normal tissues. Furthermore, cXXc5 associates with the histone deacetylase HDAc1 and competes its interaction with Smad2/3, thereby abolishing the inhibitory effect of HDAc1 on TGF-β signaling. These observations together suggest that cXXc5 may act as a tumor suppressor by promoting TGF-β signaling via a positive feedback loop, and reveal a strategy for Hcc to bypass TGF-β-mediated cytostasis by disrupting the positive feedback regulation. Our findings shed new light on TGF-β signaling regulation and demon- strate the function of cXXc5 in Hcc development.

关键词： hepatocellular carcinoma (Hcc) TGF-β cXXc5 HDAc signaling regulation

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Tumor-associated macrophage(TAM)-derived ccL22 induces FAK addiction in esophageal squamous cell carcinoma(EScc)

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cellular & Molecular Immunology 2022年第9期19卷 1054-1066页

作者： Jie chen Di Zhao Lingyuan Zhang Jing Zhang Yuanfan Xiao Qingnan wu Yan Wang Qimin Zhan Key Laboratory of carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&InstituteBeijing100142China Peking University International cancer Institute Peking UniversityBeijing100191China Research Unit of Molecular cancer Research Chinese Academy of Medical SciencesBeijingChina Institute of cancer Research Shenzhen Bay LaboratoryShenzhen518107China

Tumor cell dependence on activated oncogenes is considered a therapeutic target,but protumorigenic microenvironment-mediated cellular addiction to specific oncogenic signaling molecules remains to be further ***,we showed that tumor-associated macrophages(TAMs)produced an abundance of c-c motif chemokine 22(ccL22),whose expression in the tumor stroma was positively associated with the level of intratumoral phospho-focal adhesion kinase(pFAK Tyr^(397)),tumor metastasis and reduced patient ***,ccL22-stimulated hyperactivation of FAK was correlated with increased malignant progression of cancer ***22-induced addiction to FAK was demonstrated by the persistent suppression of tumor progression upon FAK-specific ***,we identified that diacylglycerol kinaseα(DGKα)acted as a signaling adaptor to link the ccL22 receptor c-c motif chemokine receptor 4(ccR4)and FAK and promoted ccL22-induced activation of the FAK/AKT ***22/ccR4 signaling activated the intracellular ca^(2+)/phospholipase c-γ1(PLc-γ1)axis to stimulate the phosphorylation of DGKαat a tyrosine residue(Tyr^(335))and promoted the translocation of DGKαto the plasma membrane to assemble the DGKα/FAK signalosome,which critically contributed to regulating sensitivity to FAK inhibitors in cancer *** identification of TAM-driven intratumoral FAK addiction provides opportunities for utilizing the tumor-promoting microenvironment to achieve striking anticancer effects.

关键词： Tumor-associated macrophages Esophageal squamous cell carcinoma FAK Oncogene addiction

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Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis c virus infection: A meta-analysis

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World Journal of Gastroenterology 2005年第46期11卷 7302-7307页

作者： Xin Hong Rong-Bin Yu Nan-Xiong Sun Bin Wang Yao-chu Xu Guan-Ling wu Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing 210029 Jiangsu Province China Research Laboraiory for infectious Diseases The First Affiliated Hospital Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Pharmacology Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of-Microbiology Nanjing Medical University Nanjing 210029 Jiangsu Province China

AIM： To assess the associations of human leukocyte antigen （HI_A） class Ⅱ DQB1＊0301 and/or DRB1＊1101 allele with spontaneous hepatitis c virus （HcV） clearance by meta-analysis of individual dataset from all studies published till date. METHODS： To clarify the impact of HLA class Ⅱ polymorphisms on viral clearance, we performed a metaanalysis of the published data from 11 studies comparing the frequencies of DQB1＊0301 and DRB1＊1101 alleles in individuals with spontaneous resolution to those with persistent infection. As we identified the heterogeneity between studies, summary statistical data were calculated based on a random-effect model. RESULTS： Meta-analyses yielded summary estimatesodds ratio （OR） of 2.36 [95%cI （1.62, 3.43）, P〈0.00001] and 2.02 [95%cI （1.56, 2.62）, P〈0.00001] for the effects of DQB1＊0301 and DRB1＊1101 alleles on spontaneous clearance of HcV, respectively. cONcLUSION： These results support the hypothesis that specific HLA class Ⅱ alleles might influence the susceptibility or resistance to persistent HcV infection. Both DQB1＊0301 and DRB1＊1101 are protective alleles and present HcV epitopes more effectively to cD4^＋T lymphocytes than others, and subjects with these two alleles are at a lower risk of developing chronic HcV infection. Large, multi-ethnic confirmatory and welldesigned studies are needed to determine the host genetic determinants of HcV infection.

关键词： Human leukocyte antigen Genetic polymorphism DQB1*0301 DRB1*1101 Hepatitis c virus Spontaneous clearance Meta-analysis

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A set of interesting sequoiatones stereoisomers from a wetland soil-derived fungus Talaromyces flavus

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Acta Pharmaceutica Sinica B 2017年第2期7卷 167-172页

作者： Tianyu Sun Jian Zou Guodong chen Dan Hu Bin wu Xingzhong Liu Xinsheng Yao Hao Gao Institute of Traditional chinese Medicine and Natural Products College of PharmacyJinan University State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of Sciences

Four interesting sequoiatones stereoisomers(1-4) were isolated from a wetland soil-derived fungus Talaromyces flavus by chiral *** the basis of comprehensive NMR and mass analyses,their planar structures were elucidated as the same as that of sequoiatone *** them,1 and 3(or 2 and 4)were a pair of enantiomers,and 1 and 2(or 3 and 4) were a pair of stereoisomers with epimerization at c-12,which indicated that sequoiatione-type metabolites exist as enantiomers rather than as optically pure compounds in some *** the quantum chemical EcD calculations,the absolute configurations of c-8 in 1-4 were determined,which is the first report to establish the absolute configuration of c-8 in ***,the absolute configurations of c-12 in sequoiatones are still unsolved.

关键词： Wetland soil-derived fungus Talaromyces flavus Stereoisomers Sequoiatone Electronic circular dichroism

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A facile and sensitive method of quantifying glutaminase binding to its ninhibitor cB-839 in tissues

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Journal of Genetics and Genomics 2020年第7期47卷 389-395页

作者： Yicheng chen Yiqing Zhao david L.Bajor Zhenghe Wang J.Eva Selfridge Department of Genetics and Genome Sciences Case Western Reserve University10900 Euclid AvenueClevelandOH44106USA Department of Medicine Case Western Reserve University10900 Euclid AvenueClevelandOH.44106USA case comprehensive cancer center Case Western Reserve University10900 Euclid AvenueClevelandOH44106USA Seidman cancer center University Hospitals Cleveland Medical CenterWOO Euclid AvenueClevelandOH44106USA

Many cancer types reprogram their metabolism to become addicted to *** of the critical enzymes in the utilization of glutamine in these cells is ***-839(telaglenastat)is a drug that targets glutaminase that is currently being evaluated in many clinical trials for efficacy in various cancer types that are known to be driven by glutamine *** its use,there are limited assays available for testing the pharmacodynamic on-target effects of cB-839 on the limited,small-volume patient samples that are obtained in early-phase clinical ***,we developed an assay based on the cellular thermal shift assay technique using AlphalLlSA technology to show that cB-839 specifically engages glutaminase in colon cancer cell lines in vitro and in minute quantities of mouse xenograft ***,we show that this assay detects cB-839 binding to glutaminase in platelets of patients collected while receiving cB-839 on a clinical *** assay may be used to study the pharmacodynamic profile of cB-839 in very small tissue samples obtained from patients on a clinical trial and may be useful infuture studies designed to screen other in hibitors of glutaminase.

关键词： Glutaminase Method cancer

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