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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

Science china Life Sciences 2025年第1期68卷 116-129页

作者： Jiangpeng wu Siyu Xia Wenting Ye Yan Sun Jing cai Fubing Yu Haiping Wen Xiuwei Yi Taikang Li Mingwei chen Jiayun chen Ge Song chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQcG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Investigation on the interaction of dispersed and elongated bubbles based on laser-induced fluorescence

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Optoelectronics Letters 2025年

作者： XUE Ting SHI Ruini LIU Jinshun WANG Haixia wu Yan School of Electrical and Information Engineering， Tianjin University

The purpose of this paper is to investigate the interaction between dispersed and elongated bubbles in horizontal slug flow utilizing the laser-induced fluorescence method. A Segmentation method based on the fuzzy c-mean (FcM) algorithm is proposed to effectively separate elongated bubbles from the liquid phase， and an extreme value extraction method is developed to calculate the number of dispersed bubbles in front of the nose of elongated bubbles. Moreover， the velocity offsets of elongated bubbles with and without dispersed bubbles are calculated separately based on contour extraction. In addition， the effect of dispersed bubbles on the fluctuating offsets of the nose tip position and velocity of elongated bubbles are statistically investigated under different flow velocities. The experimental results show that the increase of the gas-liquid flow velocity exacerbates the radial deviation of the nose tip and the fluctuation of axial velocity.

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The low-latitude sodium layer:comparative data from lidar observations at Hainan,china and São Paulo,Brazil

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Earth and Planetary Physics 2025年第1期9卷 39-53页

作者： Fang wu Jing Jiao GuoTao Yang LiFang Du ZhengKuan Liu HaoRan Zheng JiXin Guo ShaoHua Gong YaJun Zhu State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Hainan National Field Science Observation and Research Observatory for Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of chinese Academy of Sciences Beijing 100049China china-Brazil Joint Laboratory for Space Weather NSSC/INPESão Josédos Campos 12227-010Brazil School of Physics and Electronics Engineering Hainan Normal UniversityHaikou 571158China

Physical and chemical processes observed in the mesosphere and thermosphere above the Earth’s low latitudes are complex and highly interrelated to activity in the low-latitude *** sodium detected by lidar can yield clues to dynamic and chemical processes in these spatial layers above the Earth’s *** paper is based on sodium layer data collected at two low-latitude stations,one in the northern hemisphere and one in the *** low-latitude sodium layer exhibits conspicuous seasonal variations in shape,density,and altitude;these variations are similar between Earth’s hemispheres:sodium layer density at both stations reaches its seasonal maximum in autumn and minimum in ***,maximal Na density over Brazil is greater than that over *** variations of Na density above the two low-latitude stations are also similar;at both,maxima are observed before *** variations of the Na layer over Brazil that differ from those observed in the northern hemisphere may be related to the South Atlantic Magnetic Anomaly(SAMA)or fountain *** suggest that low-latitude Na layer data may provide useful additional evidence that could significantly improve the low-latitude part of the WAccM-Na model.

关键词： metallic sodium layer seasonal variation nocturnal variation lidar

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Deep-Sea Geohazards in the South china Sea

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Journal of Ocean University of china 2018年第1期17卷 1-7页

作者： wu Shiguo WANG Dawei VOKER david Laboratory of Marine Geophysics and Georeource Institute of Deep-Sea Science and EngineeringChinese Academy of SciencesSanya 572000China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266061China college of Earth Sciences University of Chinese Academy of SciencesBeijing 100049China MARUM center for Marine Environmental Sciences University of BremenBremen 28359Germany

Various geological processes and features that might inflict hazards identified in the South china Sea by using new technologies and *** features include submarine landslides,pockmark fields,shallow free gas,gas hydrates,mud diapirs and earthquake tsunami,which are widely distributed in the continental slope and reefal islands of the South china *** the study and assessment of geohazards in the South china Sea came into operation only recently,advances in various aspects are evolving at full speed to comply with National Marine Strategy and‘the Belt and Road’*** characteristics of geohazards in deep-water seafloor of the South china Sea are summarized based on new scientific *** progress is aimed to aid ongoing deep-water drilling activities and decrease geological risks in ocean development.

关键词： deep-sea geohazards South china Sea

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Shaking table tests and dynamic analyses of masonry wall buildings with frame-shear walls at lower stories

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Earthquake Engineering and Engineering Vibration 2008年第3期7卷 271-283页

作者： Xiong Lihong david Xiong wu Ruifeng Xia Jingqian Institute of Engineering Mechanics China Earthquake Administration Harbin 150080 China Key Lab of Urban Security ＆ Disaster Engineering MOE Beijing University of Technology Beijing 100022 China Arup Engineering consultant Ltd Hong Kong Department of Engineering Mechanics Dalian University of Technology Dalian 116024 China

This paper describes shaking table tests of three eight-story building models： all are masonry structures in the upper stories, with or without frame-shear walls of one- or two- stories at the bottom. The test results of damage characteristics and seismic responses are provided and compared. Then, nonlinear response analyses are conducted to examine the reliability of the dynamic analysis. Finally, many nonlinear response analyses are performed and it is concluded that for relatively hard sites under a certain lateral stiffness ratio （i.e., the ratio of the stiffness of the lowest upper masonry story to that of the frame- shear wall story）, the masonry structure with one-story frame-shear wall at the bottom performs better than a structure built entirely of masonry, and a masonry structure with frame-shear wall of two stories performs better than with one-story frame- shear wall. In relatively soft soil conditions, all three structures have similar performane. In addition, some suggestions that could be helpful for design of masonry structures with ground story of frame-shear wall structure in seismic intensity region VII, such as the appropriate lateral stiffness ratio, shear force increase factor of the frame-shear wall story, and permissible maximum height of the building, are proposed.

关键词： masonry structure soft story seismic performance shaking table test nonlinear time history analysis

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A Multi-parametric Programming Based Analytic Method to compute consumer Offer curve for Reserves

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Journal of Modern Power Systems and clean Energy 2022年第2期10卷 542-546页

作者： Weiye Zheng david J.Hill Wenchuan wu the School of Electrical Power Engineering South China University of TechnologyGuangzhouChina the Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina the Department of Electrical Engineering Tsinghua UniversityBeijingChina

Abstract-An analytic method is proposed to compute the price-reserve offer curve at the consumer level in hierarchical direct load *** convexification of the consumer reserve provision is examined,and the analytic expression of the optimal solution within each critical region is ***,based on multi-parametric programming,a combinatorial enumeration method in conjunction with efficient reduction and pruning strategy is proposed to compute the optimal response of consumers in the whole price *** tests along with an application example in the bi-level aggregator pricing problem demonstrate the merit of this method.

关键词： Direct load control multi-parametric programming price-reserve offer curve analytic solution

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catalytic performances of cobalt-based catalysts for hydrogen generation with sodium borohydride solution

Catalytic performances of cobalt-based catalysts for hydroge...

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第九届全国氢能学术会议

作者： c.wu,F.wu,Y.Bai Beijing Institute of Technology,china

Hydrogen supply is one of the most important issues for wide practice of proton exchange membrane fuel cell(PEMFc).There are many ways to get *** instance,mass hydrogen production can be gained with chemical methods,from electrolysis of water,or by biologic ***,it is found that hydrogen generation from catalysis of sodium borohydride(NaBH) is flexible and controllable,and may be a promising way for on-site

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基于机器学习筛选猪活体肌内脂肪含量间接选育和构建预测模型的关键性状

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南京农业大学学报 2025年第1期48卷 161-170页

作者：吴建杨文孟孜查成万吴望军南京农业大学动物科技学院江苏南京210095

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测... 详细信息

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测定初生重、断奶重、屠宰前活体重和IMF含量等14个性状,然后通过相关性分析从14个性状中初步筛选出影响IMF含量的性状因素,再通过随机森林模型评估各性状因素对IMF含量影响的重要性,进一步通过LASSO回归和逐步回归筛选出影响IMF含量的关键性状因素;在此基础上,利用广义线性模型(generalized linear model,GLM)分析关键性状因素不同水平对IMF含量的影响。[结果]相关性分析结果显示,猪IMF含量与断奶重(r=0.13, Pc*值也呈显著相关(P0.05)。胸腰椎结合处背膘厚大于26 mm组的平均IMF含量(2.73%)显著高于其他背膘厚组(P0.05)。[结论]本研究通过机器学习确定了性别、断奶重、屠宰前活体重和胸腰椎结合处背膘厚4个与IMF含量显著相关的活体可测定性状,并发现平均IMF含量随着屠宰前活体重和胸腰椎结合处背膘厚的增加呈明显的上升趋势。

关键词：猪肌内脂肪间接选择模型构建机器学习活体可测定性状

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人胚胎干细胞心肌定向分化的基因表达变化及功能的实验研究

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中华心血管病杂志 2009年第8期37卷 696-700页

作者：曹丰孙冬冬赵力谢小燕 Roger A.Wagner Joseph c.wu 第四军医大学西京医院心血管内科西安710032 中国人民解放军军事医学科学院输血研究所美国斯坦福大学医学院分子影像中心

缺血性心脏病的发病率和死亡率在我国居高不下。虽然目前缺血性心脏病的治疗手段多样，例如经皮冠状动脉介入治疗（PcI）、冠状动脉旁路移植术（cABG）、药物治疗等，但这些治疗方法仍不能从根本上逆转心肌缺血后心脏功能的进行性下降... 详细信息

缺血性心脏病的发病率和死亡率在我国居高不下。虽然目前缺血性心脏病的治疗手段多样，例如经皮冠状动脉介入治疗（PcI）、冠状动脉旁路移植术（cABG）、药物治疗等，但这些治疗方法仍不能从根本上逆转心肌缺血后心脏功能的进行性下降，许多患者仍不可避免地发生左心室病理性重构及心力衰竭。心脏移植是终末期心力衰竭患者惟一有效的根治手段，但是心脏器官供体缺乏以及左心室辅助装置伴随频繁感染等问题持续出现，使得只有少数患者能够从心脏移植中获益。胚胎干细胞（embryonic stem cell，ESc）来源于囊胚中分离出的内细胞团，是在体外培养获得的一种原始多能干细胞。它具有两个基本特点，即体外无限增殖和多向分化潜能。近年来，随者干细胞研究的深入以及细胞治疗的兴起，人们发现干细胞可体外分化为心肌细胞，并能应用于心肌损伤后修复期，这使其成为缺血性心脏病的理想治疗方法之一，具有广阔的应用前景。

关键词：人胚胎干细胞心肌细胞基因表达变化经皮冠状动脉介入治疗实验研究定向分化缺血性心脏病左心室辅助装置

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Measurement and Prediction of Insertion Force for the Mosquito Fascicle Penetrating into Human Skin

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Journal of Bionic Engineering 2009年第2期6卷 143-152页

作者： X Q Kong c W wu State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsDalian University of Technology

Mosquitoes are exceptional in their ability to pierce into human skin with a natural ultimate painless microneedle, named fascicle. Here the structure of the Aedes albopictus mosquito fascicle is obtained using a Scanning Electron Microscope (SEM), and the whole process of the fascicle inserting into human skin is observed using a high-speed video imaging technique. Direct measurements of the insertion force for mosquito fascicle to penetrate into human skin are reported. Results show that the mosquito uses a very low force (average 18 μN) to penetrate into the skin. This force is at least three orders of magnitude smaller than the reported lowest insertion force for an artificial microneedle with an ultra sharp tip to insert into the human skin. In order to understand the piercing mechanism of mosquito fascicle tip into human multilayer skin tissue, a numerical simulation is conducted to analyze the insertion process using a nonlinear finite element method. A good agreement occurs between the numerical results and the experimental measurements.

关键词： biomimetic microneedle mosquito fascicle mechanics penetration

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