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Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease

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Journal of Sport and Health Science 2024年第3期13卷 398-408页

作者： Pedro L.Valenzuela Alfredo Santalla Lidia B.Alejo Andrea Merlo Asuncion Bustos Laura Castellote-Belles Roser Ferrer-Costa Nicola A.Maffiuletti david barranco-gil Tomas Pinos Alejandro Lucia Physical Activity and Health Research Group(“PaHerg”) Research Institute of Hospital“12 de Octubre”(“imas12”)Madrid 28041Spain Department of Systems Biology University of AlcalaMadrid 28871Spain Department of Sport and Computer Science Section of Physical Education and SportsFaculty of SportUniversidad Pablo de OlavideSevilla 41013Spain EVOPRED Research Group Universidad Europea de CanariasTenerife 38300Spain Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain Gait&Motion Analysis Laboratory Sol et Salus HospitalTorre Pedrera di Rimini(RN)47922Italy Department of Clinical Biochemistry Laboratoris ClınicsHospital Universitari Vall d’HebronBarcelona 08035Spain Human Performance Lab Schulthess ClinicZurich 8008Switzerland Biomedical Research Networking Center on Rare Disorders(CIBERER) Barcelona 08035Spain Mitochondrial and Neuromuscular Disorders Unit Vall d’Hebron Institut de RecercaUniversitat Autonoma de BarcelonaBarcelona 08035Spain

Background:This study aimed to determine the effect of different carbohydrate(CHO)doses on exercise capacity in patients with McArdle disease—the paradigm of“exercise intolerance”,characterized by complete muscle glycogen unavailability—and to determine whether higher exogenous glucose levels affect metabolic responses at the McArdle muscle cell(in vitro)***:Patients with McArdle disease(n=8)and healthy controls(n=9)underwent a 12-min submaximal cycling constant-load bout followed by a maximal ramp test 15 min after ingesting a non-caloric *** a randomized,double-blinded,cross-over design,patients repeated the tests after consuming either 75 g or 150 g of CHO(glucose:fructose=2:1).Cardiorespiratory,biochemical,perceptual,and electromyographic(EMG)variables were ***,glucose uptake and lactate appearance were studied in vitro in wild-type and McArdle mouse myotubes cultured with increasing glucose concentrations(0.35,1.00,4.50,and 10.00 g/L).Results:Compared with controls,patients showed the“classical”second-wind phenomenon(after prior disproportionate tachycardia,myalgia,and excess electromyographic activity during submaximal exercise,all p<0.05)and an impaired endurance exercise capacity(-51%ventilatory threshold and55%peak power output,both p<0.001).Regardless of the CHO dose(p<0.05 for both doses compared with the placebo),CHO intake increased blood glucose and lactate levels,decreased fat oxidation rates,and attenuated the second wind in the ***,only the higher dose increased ventilatory threshold(+27%,p=0.010)and peak power output(+18%,p=0.007).In vitro analyses revealed no differences in lactate levels across glucose concentrations in wild-type myotubes,whereas a doseresponse effect was observed in McArdle ***:CHO intake exerts beneficial effects on exercise capacity in McArdle disease,a condition associated with total muscle glycogen *** of these benefits are dose dependent.

关键词： Endurance Glycogen storage disease Glycogenosis Nutrition Supplement

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

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PERTURBATIONS OF ZEROS OF SOLUTIONS TO SECOND ORDER DIFFERENTIAL EQUATIONS WITH POLYNOMIAL COEFFICIENTS

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Acta Mathematica Scientia 2012年第3期32卷 1083-1092页

作者： Michael gil' Department of Mathematics Ben Gurion University of the NegevP.O.Box 653Beer-Sheva 84105Israel

Let P（z） and P（z） be polynomials of the same degree. We consider the equations u＂ = P（z）u and u＂ = P（z）u （z ∈ C） whose solutions are u（z） and u（z）, respectively. Let Zk（U） and zk（u）, k = 1, 2,..., be the zeros of u（z） and u（z）, respectively. We derive bounds for the quantity sup j inf k｜1/zk（u）-1/zj（u）｜

关键词： Complex differential equation zeros of solutions perturbation of zeros

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Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

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World Journal of Clinical Cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas Francisco Pozo Muñoz Rogelio Garcia Cisneros Maria Jose Garcia Larrosa Maria del Mar Callejon gil Ignacio Garcia Delgado Maria Belen Jimenez Martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management

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Development and transferability of two multiplexes nSSR in Scots pine(Pinus sylvestris L.)

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Journal of Forestry Research 2015年第2期26卷 361-368页

作者： Stefana Ganea Sonali S.Ranade david Hall Sara Abrahamsson Maria Rosario Garcia-gil Department of Forest Genetics and Plant Physiology SLU901 83 UmeaSweden Department of Genetics and Plant Breeding USAMV400372 Cluj-NapocaRomania

Single sequence repeat（SSR） multiplexing is a semi high-throughput PCR methodology for the analysis of multiple *** developed two SSR multiplexes selected from SSR loci previously reported in the pine literature and tested the transferability of both SSR multiplexes in nine other pine *** tested 234 nuclear SSR loci（n SSRs） previously described in the pine literature and selected ten n SSRs following the simple criteria of interpretability and *** nuclear loci were divided into two n SSRs multiplex sets and their amplification was optimized for three different multiplex PCR methods based on：（a） a custom PCR protocol,（b） a custom protocol with hotstart taq polymerase,and（c） a commercially available kit for SSR *** validate their performance,the level of genetic diversity was assessed in three Scots pine natural populations（Hungary,northern Sweden and southern Sweden）.In addition,we also tested the transferability of these multiplexes in nine other pine *** have developed two n SSRs multiplexes of five loci each that will contribute to reduce the costs of n SSR scoring,while increasing the capacity of n SSR loci *** was successful in all three populations（94 % success） and the level of polymorphism（7.1 alleles/marker） was similar to that previously reported for other Scots pine natural *** of both multiplexes was successful for those pine species closely related to Scots pine.

关键词： Genetic diversity Nuclear SSR SSR multiplex Scots pine

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Inequalities for Sums and Products of Complex Zeros of Solutions to ODE with Polynomial Right Parts

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Communications on Applied Mathematics and Computation 2023年第4期5卷 1524-1533页

作者： Michael gil’ The Department of Mathematics Ben-Gurion University of the NegevBeer-Sheva84105Israel

The paper is devoted to non-homogeneous second-order differential equations with polynomial right parts and polynomial *** derive estimates for the partial sums and products of the zeros of solutions to the considered *** estimates give us bounds for the function counting the zeros of solutions and information about the zero-free domains.

关键词： Ordinary differential equations Linear equations Zeros of solutions

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Effect of anaerobic digestion on the high rate of nitritation,treating piggery wastewater

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Journal of Environmental Sciences 2011年第11期23卷 1787-1793页

作者： Jiyeol Im Kyungik gil Department of Civil Engineering Seoul National University of Science and TechnologySeoulSouth Korea School of Civil Engineering Seoul National University of Science and TechnologySeoulSouth Korea

The amount of piggery wastewater as domestic livestock is *** volume of piggery wastewater produced is less than the volume of other wastewaters,but piggery wastewater has a heavy impact on wastewater streams due to an extremely high concentration of nitrogen and *** this study,laboratory reactors were operated using piggery wastewater and the effluent of anaerobic digester from piggery wastewater *** purpose of this study was to induce the nitritation process,which is an economically advantageous nitrogen removal method that converts ammonium nitrogen into *** results showed that the effluent of anaerobic digester from piggery wastewater was more efficient than raw piggery wastewater in terms of inducing *** can be deduced that nitritation is largely affected by an organic fraction of piggery *** can also be concluded that a small amount of biodegradable organic matter in piggery wastewater is efficient in inducing nitritation.

关键词： piggery wastewater anaerobic digestion nitritation nitrogen

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LENTICULAR NONCOMMUTATIVE TORI

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Acta Mathematica Scientia 2003年第1期23卷 83-94页

作者： Chun-gil Park Department of Mathematics Chungnam National University Daejeon 305-764 Korea

All C*-algebras of sections of locally trivial C* -algebra bundles over ∏i=1sLki(ni) with fibres Aw Mc(C) are constructed, under the assumption that every completely irrational noncommutative torus Aw is realized as an inductive limit of circle algebras, where Lki (ni) are lens spaces. Let Lcd be a cd-homogeneous C*-algebra over whose cd-homogeneous C*-subalgebra restricted to the subspace Tr × T2 is realized as C(Tr) A1/d Mc(C), and of which no non-trivial matrix algebra can be factored *** lenticular noncommutative torus Lpcd is defined by twisting in by a totally skew multiplier p on Tr+2 × Zm-2. It is shown that is isomorphic to if and only if the set of prime factors of cd is a subset of the set of prime factors of p, and that Lpcd is not stablyisomorphic to if the cd-homogeneous C*-subalgebra of Lpcd restricted to some subspace LkiLki (ni) is realized as the crossed product by the obvious non-trivial action of Zki on a cd/ki-homogeneous C*-algebra over S2ni+1 for ki an integer greater than 1.

关键词： Lens space homogeneous C*-algebra C*-algebra bundle twisted group C*-algebra noncommutative torus K-theory UHF-algebra Cuntz algebra

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Universal Jensen's Equations in Banach Modules over a C-Algebra and Its Unitary Group

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Acta Mathematica Sinica,English Series 2004年第6期20卷 1047-1056页

作者： Chun gil PARK Department of Mathematics Chungnam National University

In this paper,we prove the generalized Hyers-Ulam-Rassias stability of universal Jensen's equations in Banach modules over a unital C~*-*** is applied to show the stability of universal Jensen's equations in a Hilbert module over a unital C~*-***,we prove the stability of linear operators in a Hilbert module over a unitat C~*-algebra.

关键词： Banach module over C~*-algebra Universal Jensen's equation Stability Hilbert module over C~*-algebra Real rank O Unitary group

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