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Nano Research 2020年第6期13卷 1586-1591页

作者： Seyyedesadaf Pournia Samuel Linser Giriraj Jnawali Howard E.Jackson leigh M.Smith Amira Ameruddin Philippe Caroff Jennifer Wong-Leung Hark Hoe Tan Chennupati Jagadish Hannah J.Joyce Department of Physics University of CincinnatiCincinnatiOH45221-0011USA Department of Electronic Materials Engineering Research School of PhysicsThe Australian National UniversityCanberraACT2601Australia Department of Engineering University of Cambridge9 JJ Thomson AvenueCambridgeCB30FAUK

Nano Research volume We use polarized photocurrent spectroscopy in a nanowire device to investigate the band structure of hexagonal Wurtzite *** of optical transitions between four valence bands and two conduction bands are observed which are consistent with the symmetries expected from group *** ground state transition energy identified from photocurrent spectra is seen to be consistent with photoluminescence emitted from a cluster of nanowires from the same growth *** the energies of the observed bands we determine the spin orbit and crystal field energies in Wurtzite *** information is vital to the development of crystal phase engineering of this important III-V semiconductor.

关键词： nanowires Wurtzite InAs photocurrent measurement optical selection rules energy band structure

Development and pilot implementation of a patient-oriented discharge summary for critically Ill patients

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World Journal of Critical Care Medicine 2022年第4期11卷 255-268页

作者： Anmol Shahid Bonnie Sept Shelly Kupsch Rebecca Brundin-Mather Danijela Piskulic Andrea Soo Christopher Grant Jeanna Parsons leigh Kirsten M Fiest Henry T Stelfox Department of Critical Care Medicine University of CalgaryCalgary T2N 4Z6AlbertaCanada Department of Psychiatry Hotchkiss Brain InstituteCalgary T2N 4Z6AlbertaCanada School of Health Administration Dalhousie UniversityHalifax B3H 4R2Nova ScotiaCanada

BACKGROUND Patients leaving the intensive care unit(ICU)often experience gaps in care due to deficiencies in discharge communication,leaving them vulnerable to increased stress,adverse events,readmission to ICU,and *** facilitate discharge communication,written summaries have been implemented to provide patients and their families with information on medications,activity and diet restrictions,follow-up appointments,symptoms to expect,and who to call if there are *** written discharge summaries for patients and their families are utilized frequently in surgical,rehabilitation,and pediatric settings,few have been utilized in ICU *** To develop an ICU specific patient-oriented discharge summary tool(PODS-ICU),and pilot test the tool to determine acceptability and *** Patient-partners(i.e.,individuals with lived experience as an ICU patient or family member of an ICU patient),ICU clinicians(i.e.,physicians,nurses),and researchers met to discuss ICU patients’specific informational needs and design the PODS-ICU through several cycles of discussion and iterative *** team nurses piloted the PODS-ICU with patient and family participants in two ICUs in Calgary,***-up surveys on the PODS-ICU and its impact on discharge were administered to patients,family participants,and ICU *** Most participants felt that their discharge from the ICU was good or better(n=13;87.0%),and some(n=9;60.0%)participants reported a good understanding of why the patient was in *** participants(n=12;80.0%)reported that they understood ICU events and impacts on the patient’s *** many patients and family participants indicated the PODS-ICU was informative and useful,ICU nurses reported that the PODS-ICU was“not reasonable”in their daily clinical workflow due to“time constraint”.CONCLUSION The PODS-ICU tool provides patients and their families with essential information as they discharge from the *** tool has

关键词： Discharge tool Patient discharge summary Patient communication Family communication Transitions in care Intensive care unit

Decreased incidence of febrile neutropenia in Michigan following masking and social distancing orders for the COVID-19 pandemic: A population based cohort study

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World Journal of Clinical Oncology 2022年第7期13卷 609-615页

作者： Michael Gerard Baracy Jr Karen Hagglund Sanjana Kulkarni Fareeza Afzal Katherine Arends Robert T.Morris leigh Ann Solomon Muhammad Faisal Aslam Logan Corey Department of Obstetrics and Gynecology Ascension St.John HospitalDetroitMI 48236United States Medical Research Ascension St John Hospital and Medical CenterDetroitMI 48236United States Surveillance and Infectious Disease Epidemiology Section Michigan Department of Health and Human ServicesLansingMI 48933United States Department of Obstetrics and Gynecology Wayne State University School of MedicineKarmanos Cancer InstituteDetroitMI 48201United States Female Pelvic Medicine and Reconstructive Surgery Ascension St.John HospitalDetroitMI 48236United States Department of Gynecologic Oncology Wayne State UniversityDetroitMI 48202United States

BACKGROUND It has been theorized that 75%-80%of febrile neutropenia(FN)is caused by endogenous pathogens,while up to 20%of cases are thought to be caused by a viral *** is unknown if precautions such as masking and social distancing reduce the risk of FN in susceptible *** To determine whether coronavirus disease 2019(COVID-19)infection mitigation efforts,namely masking and social distancing,were associated with a reduction in the incidence of *** This was a retrospective population based cohort study comparing the incidence of FN in the 13 mo prior to(Year 0)and 13 mo following(Year 1)the public health executive orders(PHEO)in *** was queried for all emergency department(ED)visits from April 1,2019 to March 31,2021 from the National Syndromic Surveillance Program,a program which collects data that is voluntarily submitted by approximately 89%of Michigan *** primary study outcome was the incidence of FN as a proportion of ED visits in the 13-mo before and 13-mo after COVID-19 mitigations efforts,namely masking and social *** hypothesized that there would be a significant decrease in the incidence of FN in the period following the PHEO aimed at reducing the spread of the severe acute respiratory syndrome coronavirus 2 *** There was a total of 8979221 total ED visits captured during the study *** Year 0 there were 5073081 recorded ED visits and 3906140 in Year *** was a significant reduction in the proportion of total ED visits with a diagnosis of FN,decreasing 13.3%across periods(0.15%vs 0.13%,P=0.036).In patients with a hematologic malignancy a more impressive reduction in the incidence of FN was evident following PHEO(22%vs 17%,P=0.02).CONCLUSION We found a significant association between social distancing and mask guidelines implemented on a large public scale with decreased rates of FN,particularly in those with a hematologic *** findings may be useful in the design of future res

关键词： Febrile neutropenia COVID-19 SARS-CoV-2 Malignancy Hematology Public health

EGFR signaling promotes resistance to CHK1 inhibitor prexasertib in triple negative breast cancer

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Cancer Drug Resistance 2020年第4期3卷 980-991页

作者： Kevin J.Lee Griffin Wright Hannah Bryant leigh Ann Wiggins Michele Schuler Natalie R.Gassman Department of Physiology and Cell Biology University of South Alabama College of MedicineMobileAL 36688USA Mitchell Cancer Institute University of South AlabamaMobileAL 36604USA Department of Comparative Medicine University of South Alabama College of MedicineMobileAL 36688USA Department of Microbiology and Immunology University of South Alabama College of MedicineMobileAL 36688USA

Aim:Innate resistance to the CHK1 inhibitor prexasertib has been described,but resistance mechanisms are not *** aimed to determine the role epidermal growth factor receptor(EGFR)plays in innate resistance to prexasertib in triple negative breast cancer(TNBC).Methods:Using a panel of pre-clinical TNBC cell lines,we measured the sensitivity to *** examined the effect activation of EGFR had on prexasertib *** measured the synergy of dual blockade of EGFR with erlotinib and CHK1 with prexasertib in TNBC cell lines and ***:EGFR overexpression and activation increased resistance to CHK1 inhibition by *** promoted the phosphorylation of BCL2-associated agonist of cell death(BAD),inactivating its pro-apoptotic *** of EGFR reversed BAD phosphorylation,increasing sensitivity to ***:The use of prexasertib as a monotherapy in TNBC has been limited due to modest clinical *** demonstrated that EGFR activation contributes to innate resistance to prexasertib in TNBC and potentially other *** expression status should be considered in clinical trials examining prexasertib’s use as a monotherapy or combination therapy.

关键词： Triple negative breast cancer CHK1 replication apoptosis drug resistance epidermal growth factor receptor mitogenic signaling

Design Optimization of a Micro-Combustor for Lean, Premixed Fuel-Air Mixtures

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Journal of Power and Energy Engineering 2016年第6期4卷 13-26页

作者： leigh T. Powell Ralph C. Aldredge Department of Mechanical and Aerospace Engineering University of California-Davis Davis CA USA

Present technology has been shifting towards miniaturization of devices for energy production for portable electronics. Micro-combustors, when incorporated into a micro-power generation system, create the energy desired in the form of hot gases to power such technology. This creates the need for a design optimization of the micro-combustor in terms of geometry, fuel choice, and material selection. A total of five micro-combustor geometries, three fuels, and three materials were computationally simulated in different configurations in order to determine the optimal micro-combustor design for highest efficiency. Inlet velocity, equivalence ratio, and wall heat transfer coefficient were varied in order to test a comprehensive range of micro-combustor parameters. All simulations completed for the optimization study used ANSYS Fluent v16.1 and post-processing of the data was done in CFD Post v16.1. It was found that for lean, premixed fuel-air mixtures (φ= 0.6 - 0.9) ethane (C2H6) provided the highest flame temperatures when ignited within the micro-combustor geometries. An aluminum oxide converging micro-combustor burning ethane and air at an equivalence ratio of 0.9, an inlet velocity of 0.5 m/s, and heat transfer coefficient of 5 W/m2-K was found to produce the highest combustor efficiency, making it the optimal choice for a micro-combustor design. It is proposed that this geometry be experimentally and computationally investigated further in order to determine if additional optimization can be achieved.

关键词： Micro-Combustor Combustion Computational Fluid Dynamics Ethane Efficiency

中国对东南亚的友好城市外交研究 ——以福建省为中心的考察

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中国对东南亚的友好城市外交研究 ——以福建省为中心的考察

作者： ZHANG HELEN leigh 厦门大学

学位级别：硕士

中国友好城市外交自1973年诞生伊始便是中国对外交流的一个重要工具。友城外交在提升缔结国外交关系、促进民间交往、文化交流、活跃地方关系、推动经贸联系等方面具有重要作用。在目前中国推行的“一带一路”倡议中,友城外交也是实现... 详细信息

中国友好城市外交自1973年诞生伊始便是中国对外交流的一个重要工具。友城外交在提升缔结国外交关系、促进民间交往、文化交流、活跃地方关系、推动经贸联系等方面具有重要作用。在目前中国推行的“一带一路”倡议中,友城外交也是实现这一愿景的重要内涵和渠道。特别是,在与中国一衣带水的东南亚,友城外交被赋予了更多的内涵。长期以来,中国因与东南亚有着悠久的历史交流、文化相通、地缘距离相近等共通点,双方具有亲密、频繁的互动关系。而福建省作为中国对东南亚友城外交的桥头堡,拥有丰富的华侨华人资源,因而以友城外交视角来拓展华侨华人的研究领域具有现实与学术的双重意义。在中国对东南亚开展友城外交的过程之中,友好城市外交不仅在形式、内容和意义上与中国与其他地区友城外交不同,而且最重要的节点在于双方奉行内政“互相不干涉”原则、维持地区和平安全以及重视华侨华人的桥梁作用。本文以福建省为中心来考察中国与东南亚友好城市外交的范围、内容、特点和成效,并通过与更邻近东南亚的云南省和广西壮族自治区进行横向比较,通过对比剖析福建省在友城外交中的独特优势与特点。中国-东南亚友城活动涵盖投资、贸易、旅游、文化、教育等广泛活动。中国和东南亚地理位置邻近虽然促成更频繁、友好的交流、也可能因为双边关系紧张出现波动。南海问题和其他领土纠纷引起的不信任感,导致东南亚国家对中国的公信力认可度降低。友城外交作为根植于软实力理念的外交工具、中国与东南亚的友好城市关系离不开中国与东南亚外交关系的大背景。尽管如此,友好城市可以起到一定的安抚作用,正如在2012-2016年黄岩岛紧张局势期间,某些中菲友好城市对之间可以看到这种功效。

关键词：东南亚城市外交友好城市中国

由实验设计优化工业原料注浆ZrO_2增韧Al_2O_3的工艺和性质

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硅酸盐通报 1992年第1期11卷 25-28,48页

作者：刘浩斌 H.D.leigh 咸阳陶瓷研究设计院美国Clemson大学陶瓷工程系

由先进工艺和高纯、超细原料制各的氧化锆增韧氧化铝陶瓷已得到广泛研究,但由工业原料生产的制品都未受到足够重视,注浆材料更是如此.本文用实验设计系统研究某些原料及工艺参数对泥浆及制品性质的影响.结果发现,优化Al_2O_3原料、提高Z... 详细信息

由先进工艺和高纯、超细原料制各的氧化锆增韧氧化铝陶瓷已得到广泛研究,但由工业原料生产的制品都未受到足够重视,注浆材料更是如此.本文用实验设计系统研究某些原料及工艺参数对泥浆及制品性质的影响.结果发现,优化Al_2O_3原料、提高ZrO_2含量.延长球磨时间及加入TiO_2均具有显著作用.

关键词：氧化铝陶瓷氧化锆增韧注浆

Asian-American elders’ health and physician use: An examination of social determinants and lifespan influences

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Health 2012年第11期4卷 1106-1115页

作者： Duy Nguyen leigh J. Bernstein Megha Goel Mailman School of Public Health Columbia University New York USA Silver School of Social Work New York University New York USA

While the Asian American population is growing rapidly, relatively little research has focused on intergroup health comparisons. The application of the life course perspective sheds new light on the inter-section of the ageing process and social determinants of health. This study compares physician use and health equity among Asian ethnic groups and non-Hispanic Whites. Data on Asian American and non-Hispanic White immigrants over 65 were extracted from the California Health Interview Survey. Weighted logistic regression models were tested applying the Commission on Social Determinants of Health model. Intergroup differences in physician use and health equity were observed. Furthermore, physician use and health varied among the groups by age. The diverse background of older Asian Americans and the differential effects of the ageing process point to the need for novel interventions to promote health among this population.

关键词： Immigrants Health Inequities Ageing Social Determinants of Health

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疯狂英语（初中天地） 2007年第1期 54-55页

作者： leigh Belz 叶雅诗

四名十多岁的美国少女指撰写了一本名为《高校女生日志》(The Notebook Girls)的书,一度成为轰动纽约文坛之作。该书已占据了《纽约时报》畅销书榜3个星期。书中真实反映出城市少女的日常生活,其内容充斥性爱、吸毒、喝酒及过度注重体... 详细信息

四名十多岁的美国少女指撰写了一本名为《高校女生日志》(The Notebook Girls)的书,一度成为轰动纽约文坛之作。该书已占据了《纽约时报》畅销书榜3个星期。书中真实反映出城市少女的日常生活,其内容充斥性爱、吸毒、喝酒及过度注重体型。本文让读者与之四名少年作家讲行了一次零距离的接触。

关键词：牛仔裤高校女生姐妹情谊朱莉娅