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Slope failure simulations with MPM

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Journal of Hydrodynamics 2017年第3期29卷 445-451页

作者： Philip J.Vardon Bin Wang Michael a.hicks Geo-Engineering Section Faculty of Civil Engineering and GeosciencesDelft University of Technology State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of Sciences

The simulation of slope failures,including both failure initiation and development,has been modelled using the material point method（MPM）.Numerical case studies involving various slope angles,heterogeneity and rainfall infiltration are *** is demonstrated that,by utilising a constitutive model which encompasses,in a simplified manner,both pre-and post-failure behaviour,the material point method is able to simulate commonly observed failure *** is a step towards being able to better quantify slope failure consequence and risk.

关键词： Heterogeneity material point method(MPM) rainfall-induced slope failure strain softening

SLP-2: a potential new target for improving mitochondrial function in Parkinson's disease

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Neural Regeneration Research 2017年第9期12卷 1435-1436页

作者： Alessandra Zanon Andrew a.hicks Peter P.Pramstaller Irene Pichler Institute for Biomedicine Eurac Research Affiliated Institute of the University of Lübeck

Parkinson＇s disease （PD） is a progressive neurodegenerative disease, which is generally considered a multifactorial disorder that arises owing to a combination of genes and environmental factors. While most cases are idiopathic, in about 10% of the patients a genetic cause can be detected, ascribable to mutations in more than a dozen genes. PD is characterized clinically by tremor, rigidity, reduced mo- tor activity （bradykinesia）, and postural instability and pathological- ly by loss of dopaminergic （DA） neurons in the substantia nigra pars compacta, loss of DA innervation in the striatum, and the presence of a-synuclein positive aggregates in the form of Lewy bodies. The symptomatic treatment of PD with levodopa, which aims at replac- ing dopamine, remains the gold standard, and no neuroprotective or disease-modifying therapy is available. During treatment, the disease continues to progress, and long-term use of levodopa has import- ant limitations including motor complications termed dyskinesias. Therefore, a pharmacological therapy able to prevent or halt the neu- rodegenerative process is urgently required.

关键词： SLP-2 a potential new target for improving mitochondrial function in Parkinson’s disease

Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Unavoidable disorder and entropy in multi-component systems

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npj Computational Materials 2019年第1期5卷 544-546页

作者： Cormac Toher Corey Oses david hicks Stefano Curtarolo Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA

The need for improved functionalities is driving the search for more complicated multi-component *** the factorially increasing composition space,ordered compounds with four or more species are ***,we unveil the competition between the gain in enthalpy and entropy with increasing number of species by statistical analysis of the AFLOW data repositories.A threshold in the number of species is found where entropy gain exceeds enthalpy *** that,enthalpy can be neglected,and disorder—complete or partial—is unavoidable.

关键词： materials. entropy enthalpy

A 3D morphometric perspective for facial gender analysis and classification using geodesic path curvature features

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Computational Visual Media 2018年第1期4卷 17-32页

作者： Hawraa Abbas Yulia.hicks david Marshall Alexei I.Zhurov StephenRichmond School of Engineering Kerbala UniversityKarbolaaIraq. School of Engineering Cardiff UniversityCardiffUK. School of Computer Science and Informatics Cardiff UniversityCardiffUK. School of Dentistry Cardiff UniversityCardiffUK.

The relationship between the shape and gender of a face, with particular application to automatic gender classification, has been the subject of significant research in recent years. Determining the gender of a face, especially when dealing with unseen examples, presents a major challenge. This is especially true for certain age groups, such as teenagers, due to their rapid development at this phase of life. This study proposes a new set of facial morphological descriptors,based on 3D geodesic path curvatures, and uses them for gender analysis. Their goal is to discern key facial areas related to gender, specifically suited to the task of gender classification. These new curvature-based features are extracted along the geodesic path between two biological landmarks located in key facial *** performance based on the new features is compared with that achieved using the Euclidean and geodesic distance measures traditionally used in gender analysis and classification. Five different experiments were conducted on a large teenage face database(4745 faces from the Avon Longitudinal Study of Parents and Children) to investigate and justify the use of the proposed curvature features. Our experiments show that the combination of the new features with geodesic distances provides a classification accuracy of 89%. They also show that nose-related traits provide the most discriminative facial feature for gender classification, with the most discriminative features lying along the 3D face profile curve.

关键词： ALSPAC dataset gender classification curvature features geodesic curve

Recent results from LEPS

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Chinese Physics C 2010年第9期34卷 1275-1280页

作者： K.hicks Department of Physics and Astronomy Ohio University

Photoproduction of baryons with strangeness,such as the Σ（1385）,Λ（1520） and possibly the Θ ＋,are described from measurements at the LEPS/SPring-8 facility in *** polarized photons in the energy range of 1.5–2.4 GeV,along with the forward-angle kinematics at LEPS,provide unique data to learn about these baryons,which are non-perturbative solutions of QCD.

关键词： photoproduction baryons mesons exotic pentaquark

Parametrically constrained geometry relaxations for high-throughput materials science

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npj Computational Materials 2019年第1期5卷 63-72页

作者： Maja-Olivia Lenz Thomas A.R.Purcell david hicks Stefano Curtarolo Matthias Scheffler Christian Carbogno Fritz-Haber-Institut der Max-Planck-Gesellschaft Faradayweg 4–6D-14195 BerlinGermany Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA

Reducing parameter spaces via exploiting symmetries has greatly accelerated and increased the quality of electronic-structure ***,many of the traditional methods fail when the global crystal symmetry is broken,even when the distortion is only a slight perturbation(e.g.,Jahn-Teller like distortions).Here we introduce a flexible and generalizable parametric relaxation scheme and implement it in the all-electron code *** approach utilizes parametric constraints to maintain symmetry at any *** demonstrating the method’s ability to relax metastable structures,we highlight its adaptability and performance over a test set of 359 materials,across 13 lattice *** we show how these constraints can reduce the number of steps needed to relax local lattice distortions by an order of *** flexibility of these constraints enables a significant acceleration of high-throughput searches for novel materials for numerous applications.

关键词： relaxation constraints distortion

AFLOW-XtalFinder:a reliable choice to identify crystalline prototypes

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npj Computational Materials 2021年第1期7卷 264-283页

作者： david hicks Cormac Toher Denise CFord Frisco Rose Carlo De Santo Ohad Levy Michael J.Mehl Stefano Curtarolo Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Center for Autonomous Materials Design Duke UniversityDurhamNC 27708USA Department of Physics NRCNP.O.Box 9001Beer-Sheva 84190Israel

The accelerated growth rate of repository entries in crystallographic databases makes it arduous to identify and classify their prototype *** open-source AFLOW-XtalFinder package was developed to solve this *** symbolically maps structures into standard designations following the AFLOW Prototype Encyclopedia and calculates the internal degrees of freedom consistent with the International Tables for *** ensure uniqueness,structures are analyzed and compared via symmetry,local atomic geometries,and crystal mapping techniques,simultaneously grouping them by *** software(i)distinguishes distinct crystal prototypes and atom decorations,(ii)determines equivalent spin configurations,(iii)reveals compounds with similar properties,and(iv)guides the discovery of unexplored *** operations are accessible through a Python module ready for workflows,and through command line *** the 4+million compounds in the *** repositories are mapped to their ideal prototype,allowing users to search database entries via symbolic ***,15,000 unique structures—sorted by prevalence—are extracted from the AFLOW-ICSD catalog to serve as future prototypes in the Encyclopedia.

关键词： Python symbolic crystalline