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RNA m^(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

Genes & Diseases 2024年第1期11卷 382-396页

作者： Zheng Zhang Keren Zhou Li han Andrew Small Jianhuang Xue Huilin Huang Hengyou Weng Rui Su Brandon Tan Chao Shen Wei Li Zhicong Zhao Ying Qing Xi Qin Kitty Wang Keith Leung Mark Boldin Chun-Wei Chen david Ann Zhijian Qian Xiaolan Deng Jianjun Chen Zhenhua Chen Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and Manella Graduate School of Biological Sciences Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr Family Center for Leukemia Research City of HopeDuarteCA 91010USA Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou Laboratory GuangzhouGuangdong 510005China Bioland Laboratory GuangzhouGuangdong 51005China Department of Liver Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes Complications and Metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Biochemistry and Molecular Biology University of FloridaGainesvilleFL 32603USA Tongji Hospital Affiliated to Tongji University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China School of Pharmacy China Medical UniversityShenyangLiaoning 110001China

As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including *** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTL3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its processing into precursor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to ***,we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia(AML)patients,especially in relapsed patients,and plays an onco-genic role in ***,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AML,through facilitating the processing of pre-miR-126 into mature ***,YTHDF2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA processing,to promote the maturation of ***2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AML patients,and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AML cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YTHDF2 in ***,our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AML and highlight the ther-apeutic potential of targeting this axis for AML treatment,but also suggest that m^(6)A plays a role in pre-miRNA processing that contributes to tumorigenesis.

关键词： AML miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2

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一种实用的PECVD腔体检漏工具设计方法

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液晶与显示 2015年第5期30卷 813-818页

作者：周梁韩大伟孙泉钦王丹名李华陈垚成都京东方光电科技有限公司设备技术部四川成都611731

在TFT-LCD行业,PECVD设备主要用于Array TFT基板工艺中的气相沉积;产生的非金属膜层,为金属电路提供保护、开关作用;在PECVD工艺制程中,腔体设计复杂,反应条件苛刻,产生的制程物会造成产品不良,故需要定期进行PM(pre maintenance预防性... 详细信息

在TFT-LCD行业,PECVD设备主要用于Array TFT基板工艺中的气相沉积;产生的非金属膜层,为金属电路提供保护、开关作用;在PECVD工艺制程中,腔体设计复杂,反应条件苛刻,产生的制程物会造成产品不良,故需要定期进行PM(pre maintenance预防性维护)。本文以PECVD PM作业为背景,针对设备PM耗时长的问题,制定了改善方法,并着重介绍了腔体检漏工具的设计过程。设计制作了一台国产化检漏工具,成功运用于量产。通过测试,检漏工具3min内达到10mT(1mT=0.133Pa),漏率为0.45mT/min,基本符合设备Spec.(标准)要求。

关键词： TFT-LCD PECVD 腔体检漏工具自主设计

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几种典型X80管线钢管及其环焊缝性能研究

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石油管材与仪器 2021年第2期7卷 55-61页

作者： david han 齐丽华霍春勇 José B.Bacalhau Marcos A.Stuart Nogueira Frank J.Barbaro 张永青国际焊接研究中心陕西西安710077 中国石油集团石油管工程技术研究院陕西西安710077 巴西冶矿公司圣保罗04538-133 澳大利亚伍伦贡大学新南威尔士伍伦贡2522 中信金属公司北京100004

环焊缝质量是影响高钢级长输管道安全的重要因素之一。国际焊接研究中心(IWTC)针对几种典型X80管线钢的焊接开展了大量研究,测试了钢管管体和环焊缝的组织及关键力学性能,分析了X80管线钢管环焊工艺及环焊缝性能影响因素,给出了推荐工... 详细信息

环焊缝质量是影响高钢级长输管道安全的重要因素之一。国际焊接研究中心(IWTC)针对几种典型X80管线钢的焊接开展了大量研究,测试了钢管管体和环焊缝的组织及关键力学性能,分析了X80管线钢管环焊工艺及环焊缝性能影响因素,给出了推荐工艺参数、控制措施等。采用焊接热模拟试验研究了2种不同Nb含量的X80钢管的焊接性,分析了Nb含量对焊缝区域微观组织的影响机制。结果表明,国内典型的X80管线钢管均具有良好的性能,其管体性能及焊接性满足工程需要;应采用合理的环焊工艺和质量控制措施以保证焊缝的性能;铌含量较高的X80管线钢具有更优越的焊接性,但必须严格遵从焊接工艺规范。

关键词：管线钢环焊连续冷却组织转变铌含量韧性

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Iatrogenic opioid dependence is endemic and legal: Genetic addiction risk score (GARS) with electrotherapy a paradigm shift in pain treatment programs

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Health 2013年第11期5卷 16-34页

作者： Kenneth Blum david han Marlene Oscar-Berman Gary Reinl Nicholas DiNubile Margaret A. Madigan Anish Bajaj Bernard William Downs John Giordano Wayne Westcott Leonard Smith Eric R. Braverman Kristina Dushaj Mary Hauser Thomas Simpatico Thomas McLaughlin Joan Borsten Debmayla Barh Center for Psychiatric Medicine North Andover USA Centre for Genomics and Applied Gene Technology Institute of Integrative Omics and Applied Biotechnology (IIOAB) Nonakuri Purba Medinipur India Department of Addiction Research & Therapy Malibu Beach Recovery Center Malibu Beach USA Department of Executive Health Path Research Foundation NY New York USA Department of Exercise Science Quincy College Quincy USA Department of Holistic Medicine and Pain Track National Institute for Holistic Addiction Studies North Miami Beach USA Department of Management Science and Statistics The University of Texas at San Antonio San Antonio USA Department of Molecular Nutrition Impact Genomics Inc. Austin USA Igene LLC Austin USA Department of Psychiatry Anatomy & Neurobiology Boston VA and Boston University School of Medicine Boston USA Department of Psychiatry College of Medicine & McKnight Brain Institute University of Florida Gainesville USA Department of Executive Health Path Research Foundation NY New York USA Department of Psychiatry College of Medicine & McKnight Brain Institute University of Florida Gainesville USA Electronic Waveform Lab Department of Pain Research Huntington Beach USA Department of Orthopedic Surgery Hospital of the University of Pennsylvania Philadelphia USA Department of Molecular Nutrition Impact Genomics Inc. Austin USA Department of Executive Health Path Research Foundation NY New York USA Department of Holistic Medicine and Pain Track National Institute for Holistic Addiction Studies North Miami Beach USA Dominion Diagnostics LLC North Kingstown USA Department of Psychiatry Human Integrated Services Unit of Vermont Center for Clinical & Translational Science University of Vermont College of Medicine Burlington USA Department of Addiction Research & Therapy Malibu Beach Recovery Center Malibu Beach USA Centre for Genomics and Applied Gene Technology Institute of Integrative Omics and Applied Biotechnology (IIOAB) Nonakuri Purba Me

The mounting endemic of prescription iatrogenic opioid dependence in pain patients provoked this treatise about an alternative method that can be used to treat pain, improve function and reduce the risk of opioid dependence. It is well known that as well as the side effects reported for chronic opioid therapy, genetically predisposed individuals are at risk for opioid dependence. We propose the use of the Genetic Addiction Risk Score (GARS) assessment to identify patients early in treatment who should avoid narcotic pain medications. Primarily, this review will be an exploration of the mechanisms of action of an electrotherapeutic alternative to narcotic treatment that can be used to augment tissue healing and reduce the pain associated with human injuries and neuropathies. This particular electrotherapeutic device was developed at the Electronic Waveform Laboratory in Huntington Beach, California and is called the H-Wave? device. The primary effect of the H-Wave?device is stimulation (HWDS) of small diameter fibers of “red-slow-twitch” skeletal muscle. Mechanisms of action of HWDS have been investigated in both animal and human studies. They include edema reduction, induction of nitric oxide dependent augmented microcirculation and angiogenesis, small muscle contraction that eliminates transcapillary fluid shifts, reducing the painful effects of tetanizing fatigue and gradual loading of healing injured muscle tissue that helps repair and remodeling. A recent metaanalysis found a moderate-to-strong-positive effect of the HWDS in providing pain relief, reducing the requirement for pain medication, with the most robust effect being increased functionality. We are proposing that GARS can be used to identify those at risk of developing opioid dependence and that the need for opioid analgesia can be reduced by use of this electro therapeutic alternative to opioid analgesia in the treatment of pain and injuries.

关键词： Microcirculation Angiogenesis Analgesic Therapy Electrical Device Stimulation Tissue Loading Remodeling Genetic Addiction Risk Score (GARS) Reward Deficiency Syndrome (RDS)

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Equation of motion for grain boundaries in polycrystals

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npj Computational Materials 2021年第1期7卷 580-587页

作者： Luchan Zhang Jian han david J.Srolovitz Yang Xiang Department of Mathematics The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong SARChina Hong Kong Institute for Advanced Study City University of Hong KongKowloonHong Kong SARChina

Grain boundary(GB)dynamics are largely controlled by the formation and motion of disconnections(with step and dislocation characters)along with the *** dislocation character gives rise to shear coupling;*** relative tangential motion of two grains meeting at the GB during GB *** a polycrystal,the shear coupling is constrained by the presence of other grains and GB junctions,which prevents large-scale sliding of one grain relative to the *** present continuum equations of motion for GBs that is based upon the underlying disconnection dynamics and accounts for this mechanical constraint in *** leads to a reduced-order(zero-shear constrained)model for GB motion that is easily implemented in a computationally efficient framework,appropriate for the large-scale simulation of the evolution of polycrystalline *** validated the proposed reducedorder model with direct comparisons to full multi-disconnection mode simulations.

关键词： grain motion dislocation

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Coherent and semicoherent α/β interfaces in titanium: structure, thermodynamics, migration

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npj Computational Materials 2023年第1期9卷 146-156页

作者： Siqi Wang Tongqi Wen Jian han david J.Srolovitz Department of Materials Science and Engineering City University of Hong KongHong Kong SARChina Department of Mechanical Engineering The University of Hong KongPokfulam RoadHong Kong SARChina

Theα/βinterface is central to the microstructure and mechanical properties of titanium *** investigate the structure,thermodynamics and migration of the coherent and semicoherent Tiα/βinterfaces as a function of temperature and misfit strain via molecular dynamics(MD)simulations,thermodynamic integration and an accurate,DFT-trained Deep *** structure of an equilibrium semicoherent interface consists of an array of steps,an array of misfit dislocations,and coherent *** determines the dislocation and step(disconnection)array structure and habit *** MD simulations show the detailed interface morphology dictated by intersecting disconnection *** steps are shown to facilitateα/βinterface migration,while the misfit dislocations lead to interface drag;the drag mechanism is different depending on the direction of interface *** results are used to predict the nature ofαphase nucleation on cooling through theα-βphase transition.

关键词： semicoherent microstructure interface

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Structural Properties of Homomorphism Dilation Systems

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Chinese Annals of Mathematics,Series B 2020年第4期41卷 585-600页

作者： Deguang han david R.LARSON Bei LIU Rui LIU Department of Mathematics University of Central FloridaOrlando 32816USA. Department of Mathematics Texas A&M UniversityCollege Station 77843USA. School of Science Tianjin University of TechnologyTianjin 300384China. Corresponding author.School of Mathematical Sciences and LPMC Nankai UniversityTianjin 300071China.

Inspired by some recent development on the theory about projection valued dilations for operator valued measures or more generally bounded homomorphism dilations for bounded linear maps on Banach algebras,the authors explore a pure algebraic version of the dilation theory for linear systems acting on unital algebras and vector *** introducing two natural dilation structures,namely the canonical and the universal dilation systems,they prove that every linearly minimal dilation is equivalent to a reduced homomorphism dilation of the universal dilation,and all the linearly minimal homomorphism dilations can be classified by the associated reduced subspaces contained in the kernel of synthesis operator for the universal dilation.

关键词： Linear systems Linearly minimal homomorphism dilation systems Principle and universal dilations Equivalent dilation systems

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Emission mechanism for the silicon He-α lines in a photoionization experiment

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High Power Laser Science and Engineering 2021年第1期9卷 86-93页

作者： Bo han Feilu Wang david Salzmann Jiayong Zhong Gang Zhao Department of Astronomy Beijing Normal UniversityBeijing 100875China College of Physics and Electronic Engineering Qilu Normal UniversityJinan 250200China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China Graduate School of China Academy of Engineering Physics Beijing 100196China Collaborative Innovation Center of IFSA(CICIFSA) Shanghai Jiao Tong UniversityShanghai 200240China

In this paper, we present a reanalysis of the silicon He-α X-ray spectrum emission in Fujioka et al.’s 2009 photoionization experiment. The computations were performed with our radiative-collisional code, RCF. The central ingredients of our computations are accurate atomic data, inclusion of satellite lines from doubly excited states and accounting for the reabsorption of the emitted photons on their way to the spectrometer. With all these elements included, the simulated spectrum turns out to be in good agreement with the experimental spectrum.

关键词： high-energy-density physics laboratory astrophysics laser–plasma interaction

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Finite-temperature screw dislocation core structures and dynamics in α-titanium

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npj Computational Materials 2023年第1期9卷 12-24页

作者： Anwen Liu Tongqi Wen Jian han david J.Srolovitz Department of Materials Science and Engineering City University of Hong KongHong Kong SARChina Department of Mechanical Engineering The University of Hong KongHong Kong SARChina

A multiscale approach based on molecular dynamics(MD)and kinetic Monte Carlo(kMC)methods is developed to simulate the dynamics of an(a)screw dislocation inα-*** free energy barriers for the core dissociation transitions and Peierls barriers for dislocation glide as a function of temperature are extracted from the MD simulations(based on machine learning interatomic potentials and optimization);these form the input to kMC *** random walk trajectories from kMC agree well with those predicted by *** some planes,dislocations move via a locking-unlocking ***,some dislocations glide in directions that are not parallel with the core dissociation *** MD/kMC multiscale method proposed is applicable to dislocation motion in simple and complex materials(not only screw dislocations in Ti)as a function of temperature and stress state.

关键词： dislocation dynamics locking

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基于生物信息学方法的2型糖尿病差异表达miRNA筛选及靶基因预测

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老年医学研究 2024年第2期5卷 28-33页

作者：韩壮福建中医药大学福建福州350108

目的基于生物信息学方法分析2型糖尿病(T2DM)患者肝脏组织中差异miRNA表达,并预测靶基因。方法通过GEO数据库下载T2DM与正常人群肝脏组织miRNA芯片数据集GSE176025,分为type-2-dabetic和non-diabetic两组,每组20例,利用GEOR2工具分析获... 详细信息

目的基于生物信息学方法分析2型糖尿病(T2DM)患者肝脏组织中差异miRNA表达,并预测靶基因。方法通过GEO数据库下载T2DM与正常人群肝脏组织miRNA芯片数据集GSE176025,分为type-2-dabetic和non-diabetic两组,每组20例,利用GEOR2工具分析获取差异miRNA,并制作火山图。通过TargetScan和miRWalk数据库对差异miRNA行靶基因预测,并利用david数据库对靶基因从生物过程(BP)、细胞成分(CC)、分子功能(MF)做基因本体论功能富集分析(GO)和京都基因组百科全书信号通路分析(KEGG)。利用STRING在线工具及Cytoscape软件构建靶基因蛋白质相互作用(PPI)网络,并筛选关键基因。结果筛选后获得差异miRNA 15个,包含12个上调miRNA和3个下调miRNA。预测差异miRNA靶基因318个,关键靶基因5个,分别为SMARCD3、BCL11A、BCL11B、ARID2、BICRA。GO及KEGG分析结果显示,BP包括调控RNA聚合酶Ⅱ启动子转录、DNA模板转录、蛋白质磷酸化等;CC包括细胞核、核质、细胞质、细胞溶质等;MF包括蛋白质结合、DNA结合、染色质结合等;KEGG包括调节干细胞多能性的信号通路、mTOR信号通路、Hippo信号通路等。结论与正常人群相比,T2DM患者肝脏组织中存在多个差异miRNA表达;这些差异miRNA及相关靶基因等有助于明确T2DM发病机制,为临床诊疗提供新的思路。

关键词： 2型糖尿病微小RNA 靶基因生物信息学

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