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库岸有限厚度粉质黏土冲蚀演化规律及预测

水科学进展 2023年第6期34卷 938-947页

作者：陈勇张书石 CHAN dave 三峡大学三峡库区地质灾害教育部重点实验室湖北宜昌443002 Department of Civil and Environmental Engineering University of AlbertaEdmontonAB T6G 2W2Canada

土体冲蚀流失是塌岸发展和库岸再造的重要诱发因素。为准确预测水流作用下岸坡土体流失进程,自主研制了能够实时精确量测土样质量变化的新型冲蚀试验装置,开展三峡库岸粉质黏土冲刷起动和冲蚀进程试验,分析有限厚度土体冲蚀演化规律和... 详细信息

土体冲蚀流失是塌岸发展和库岸再造的重要诱发因素。为准确预测水流作用下岸坡土体流失进程,自主研制了能够实时精确量测土样质量变化的新型冲蚀试验装置,开展三峡库岸粉质黏土冲刷起动和冲蚀进程试验,分析有限厚度土体冲蚀演化规律和影响机制,并建立预测模型。结果表明:有限厚度土体的总冲蚀量随时间增加但增速逐渐趋缓,冲蚀速率逐渐衰减,且冲蚀速率及其衰减程度均与孔隙比或流速成正比;将反映密实度的孔隙比和反映剪切力的水流速度嵌入预测模型能较好地拟合粉质黏土冲蚀演化进程曲线。建立的有限厚度土体冲蚀进程预测模型,为水流冲刷作用下岸坡形态变化趋势预测研究提供参考。

关键词：冲蚀试验有限厚度冲蚀比冲蚀速率预测模型

Fluidization and bubbling behavior of potash particles in a deep fluidized bed

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Particuology 2023年第9期80卷 103-114页

作者： Mojtaba Nabipoor Hassankiadeh Jingsi Yang Mark Berrey dave Jordison Lifeng Zhang Donald Bergstrom Raymond J.Spiteri Department of Chemical and Biological Engineering University of SaskatchewanSKS7N 5A9SaskatoonCanada The Mosaic Company Belle PlaineSKCanada Department of Mechanical Engineering University of SaskatchewanSaskatoonCanada Department of Computer Science University of SaskatchewanSaskatoonSKCanada

Most existing models for predicting bubble size and bubble frequency have been developed for freely bubbling fluidized *** prediction of bubbling behavior in deep fluidized beds,however,has been a challenge due to the higher degree of bubble coalescence and break up,high probability of the slugging regime,partial fluidization,and chaotic behavior in the bubbling *** this work,the bubbling and fluidization behavior of potash particles was investigated in a deep fluidized bed employing a twin-plane electrical capacitance tomography(ECT)*** volume fraction,average bubble velocity,average bubble diameter,and bubble frequency in both bubbling and slugging regimes were measured at two different bed height ratios(H/D=3.5 and H/D=3.78).This work is the first to illustrate a sequential view of bubbles at different superficial gas velocities in a fluidized *** results show that both the bubble diameter and rising velocity increased with increasing the superficial gas velocity for the two bed heights,with larger values observed in the deeper bed compared to the shallower *** values for bubble diameter,bubble rise velocity and bubble frequency from different models are compared with the experimental data obtained from the ECT system in this *** agreement has been achieved between the values predicted by the previous models and the experimental data for the bubble diameter and bubble rise velocity with an average absolute deviation of 16%and 15%for the bed height of 49 cm and 13%and 8%for the bed height of 53 cm,respectively.

关键词： Deep fluidized bed Potash particle Electrical capacitance tomography Image reconstruction Bubbling and slugging regime

Assessing support alternatives for longwall gateroads subject to changing stress

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International Journal of Mining Science and Technology 2021年第1期31卷 103-110页

作者： Gabriel S.Esterhuizen I.Berk Tulu dave F.Gearhart Heather Dougherty Mark Van Dyke National Institute for Occupational Safety and Health Pittsburgh Mining Research DivisionPittsburghPA 15236USA West Virginia University MorgantownWV 26506USA

Longwall gateroad entries are subject to changing horizontal and vertical stress induced by redistribution of loads around the extracted *** stress changes can result in significant deformation of the entries that may include roof sag,rib dilation,and floor *** operators install different types of supports to control the ground response and maintain safe access and ventilation of the longwall *** paper describes recent research aimed at quantifying the effect of longwall-induced stress changes on ground stability and using the information to assess support *** research included monitoring of ground and support interaction at several operating longwall mines in the U.S.,analysis and calibration of numerical models that adequately represent the bedded rock mass,and observation of the support systems and their response to changes in *** models were then used to investigate the impact of geology and stress conditions on ground deformation and support response for various depths of cover and geologic *** research results were summarized in two regression equations that can be used to estimate the likely roof deformation and height of roof yield due to longwall-induced stress *** information is then used to assess the ability of support systems to maintain the stability of the *** application of the method is demonstrated with a retrospective analysis of the support performance at an operating longwall mine that experienced a headgate roof *** method is shown to produce realistic estimates of gateroad entry stability and support performance,allowing alternative support systems to be assessed during the design and planning stage of longwall operations.

关键词： Longwall Gateroad Support design Coal Standing support

Design and evaluation of aceclofenac ocular inserts with special reference to cataracts and conjunctivitis

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Journal of Chinese Pharmaceutical Sciences 2013年第5期22卷 449-455页

作者： Vivek dave Sachdev Yadav Sarvesh Paliwal Swapnil Sharma Dhirendra Kumar Department of Pharmacy Banasthali University Manipal College of Pharmaceutical Sciences

The eyes present unique opportunities and challenges when it comes to the delivery of *** absorption by this route is bungling,there are a few side effects with conventional dosage *** inserts were prepared with prolonged release of drug and minimum swelling within cul-de-sac using *** work focused on treatment of conjunctivitis and cataracts by formulating ocular inserts of different polymeric combination of aceclofenac using hydroxypropyl methyl cellulose(HPMC,3% to 5%),chitosan(3% to 5%),poly vinyle alcohol(PVA,3% to 5%),methyl cellulose(MC,3% to 5%) as drug reservoir and ethyl cellulose(EC) polymer as rate controlling membrane by solvent casting technique with the objective of increasing contact time,achieving controlled release and greater therapeutic *** prepared ocular insert were then evaluated for physical appearances tensile strength,elongation at break(%),weight variation,uniformity of thickness,moisture absorption(%),pH,folding endurance,Fourier Transform Infrared spectroscopy,differential scanning *** characterization and in vitro transcorneal permeation studies reveals that,the prepared ocular insert formulations F2 and F8 containing HPMC and PVA had released their drug content,98.54% and 96.24%,respectively,over an extended period of 24 *** these formulations were selected as best optimized *** can be concluded that hydroxy propyl methyl cellulose is a good film forming hydrophilic polymer which shows potential agent for ocular drug delivery *** of polyethylene glycol enhances the permeability of aceclofenac ocular insert and has perfect zero order release,proving a promising controlled release delivery system.

关键词： Transcomeal Nasolacrimal Rate controlling membrane Drug reservoir

Lipid-polymer hybrid nanoparticles: Development & statistical optimization of norfloxacin for topical drug delivery system

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Bioactive Materials 2017年第4期2卷 269-280页

作者： Vivek dave Renu Bala Yadav Kriti Kushwaha Sachdev Yadav Swapnil Sharma Udita Agrawal Department of Pharmacy Banasthali UniversityBanasthaliRajasthanIndia Sagar Institute of Research and Technology-Pharmacy Bhopal462041India

Poly lactic acid is a biodegradable, biocompatible, and non-toxic polymer, widely used in many pharmaceuticalpreparations such as controlled release formulations, parenteral preparations, surgicaltreatment applications, and tissue engineering. In this study, we prepared lipid-polymer hybrid nanoparticlesfor topical and site targeting delivery of Norfloxacin by emulsification solvent evaporationmethod (ESE). The design of experiment (DOE) was done by using software to optimize the result, andthen a surface plot was generated to compare with the practical results. The surface morphology, particlesize, zeta potential and composition of the lipid-polymer hybrid nanoparticles were characterized bySEM, TEM, AFM, and FTIR. The thermal behavior of the lipid-polymer hybrid nanoparticles was characterizedby DSC and TGA. The prepared lipid-polymer hybrid nanoparticles of Norfloxacin exhibited anaverage particle size from 178.6 ± 3.7 nm to 220.8 ± 2.3 nm, and showed very narrow distribution withpolydispersity index ranging from 0.206 ± 0.36 to 0.383 ± 0.66. The surface charge on the lipid-polymerhybrid nanoparticles were confirmed by zeta potential, showed the value from t23.4 ± 1.5 mVto t41.5 ± 3.4 mV. An Antimicrobial study was done against Staphylococcus aureus and Pseudomonasaeruginosa, and the lipid-polymer hybrid nanoparticles showed potential activity against these ***-polymer hybrid nanoparticles of Norfloxacin showed the %cumulative drug release of 89.72% in24 h. A stability study of the optimized formulation showed the suitable condition for the storage oflipid-polymer hybrid nanoparticles was at 4 ± 2 C/60 ± 5% RH. These results illustrated high potential oflipid-polymer hybrid nanoparticles Norfloxacin for usage as a topical antibiotic drug carriers.

关键词： Lipid-polymer hybrid nanoparticles Norfloxacin Antimicrobial activity Carbopol gel

Profit and gift in the digital economy

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Profit and gift in the digital economy

Magnetic resonance venography and liver transplant complications

作者： (author.)Elder-Vass dave

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World Journal of Gastroenterology 2013年第36期19卷 6110-6113页

作者： Evgeny Strovski dave Liu Charles Scudamore Stephen Ho Eric Yoshida Darren Klass Division of Interventional Radiology Department of RadiologyUniversity of British Columbia Vancouver General Hospital Division of Hepatobiliary Surgery Department of Surgery University of British Columbia Vancouver General Hospital Division of Gastroenterology Faculty of Medicine University of British Columbia Vancouver General Hospital

Hepatic vein stenosis is a rare but serious complication following liver *** modalities can be utilized to image the hepatic *** resonance venography(MRV)provides certain advantages over ultrasound,computed tomography angiography and digital subtraction *** utilizes the same imaging principles of magnetic resonance angiography in order to image the venous *** pool contrast agents,specifically gadofosveset trisodium,allow for steady state imaging up to 1 h following injection,with improved visualisation of vital venous structures by utilising delayed steady state ***,the inherent physics properties of magnetic resonance imaging also provide excellent soft tissue detail and thus help define the extent of complications that often plague the post-liver transplant *** case report describes the use of gadofosveset trisodium in a patient with hepatic venous stenosis following liver *** venography failed to outline the stenoses and thus MRV using a blood pool contrast agent was utilised in order to delineate the anatomy and plan a therapeutic endovascular procedure.

关键词： Magnetic resonance venography Blood pool Magnetic resonance angiography Nephrogenic systemic fibrosis Liver transplant Gadofosveset trisodium

N-acetylcysteine treats intravenous amiodarone induced liver injury

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World Journal of Gastroenterology 2015年第9期21卷 2816-2819页

作者： Matthew L Mudalel Kartikeya P dave James P Hummel Steven F Solga Department of Medicine Division of GastroenteorlogySt. Luke’s University Hospital and Temple School of MedicineBethlehemPA 18015United States Department of Medicine Montefiore Medical CenterBronxNY 10461United States Department of Medicine Division of Cardiology University of North Carolina Chapel Hill NC 27514United States

We report a case of intravenous(IV) amiodarone drug induced liver injury(DILI).The patient received IV N-acetylcysteine(NAC) which resulted in a rapid improvement in liver *** the specific mechanisms for the pathogenesis of IV amiodaroneDILI and the therapeutic action of IV NAC are both unknown, this case strongly implies at least some *** IV amiodarone is indicated for the treatment of serious cardiac arrhythmias in an intensive care unit setting, some degree of ischemic hepatitis is likely a cofactor in most cases.

关键词： N-acetylcysteine Amiodarone Drug induced liver inj

Changes in Soil Physicochemical Properties under Selected Climate-Smart Agricultural Practices in Central African Republic

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