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Analytically depicting the calcium diffusion for Alzheimer's affected cell

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International Journal of Biomathematics 2018年第7期11卷 109-121页

作者： Devanshi D.dave Brajesh Kumar Jha Department of Mathematics School of Technology Pandit Deendayal Petroleum UniversityRaisan GandhinagarGujarat 382007India

Brain is the most complex structure of the human *** processes going inside the brain and the mechanisms behind it have been unrevealed up to certain extent *** of the various physiological phenomena carried out by the brain,calcium signalling can be considered as one of the most *** being a second messenger plays an important role in transformation of various *** view of above,an attempt has been made here to study calcium signalling in presence of buffers,*** kind of proteins and endoplasmic reticulum (ER),which is also known as store house of the *** the store house of the cell,it has very high amount of calcium,whereas buffers decrease the level of free calcium ions by binding calcium ions to it.A two-dimensional mathematical model has been developed to see the impact of these parameters on cytosolic calcium *** mathematical model is solved analytically using Laplace transforms and similarity *** simulations are carried out using *** is observed that the impact of buffer and ER is significant on calcium *** obtained results are interpreted with the Alzheimeric condition of the nerve cells.

关键词： Calcium buffers endoplasmic reticulum Alzheimer's disease Laplace transforms

Congenital peritoneal encapsulation: A review and novel classification system

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World Journal of Gastroenterology 2019年第19期25卷 2294-2307页

作者： Aneesh dave James Mc Mahon Assad Zahid Department of Colorectal Surgery Royal Prince Alfred Hospital Sydney Medical School Edward Ford Building the University of Sydney

Congenital peritoneal encapsulation(CPE) is a very rare, congenital condition characterised by the presence of an accessory peritoneal membrane which encases a variable extent of the small bowel. It is unclear how CPE develops,however it is currently understood to be a result of an aberrant adhesion in the peritoneal lining of the physiological hernia in foetal mid-gut development. The condition was first described in 1868, and subsequently there have been only 45 case reports of the phenomenon. No formal, systematised review of CPE has yet been performed, meaning the condition remains poorly understood,underdiagnosed and mismanaged. Diagnosis of CPE remains clinical with important adjuncts provided by imaging and diagnostic laparoscopy. Two thirds of patients present with abdominal pain, likely secondary to sub-acute bowel obstruction. A fixed, asymmetrical distension of the abdomen and differential consistency on abdominal palpation are more specific clinical features present in approximately 10% of cases. CPE is virtually undetectable on plain imaging, and is only detected on 40% of patients with computed tomography scan. Most patients will undergo diagnostic laparotomy to confirm the *** of CPE includes both medical management of the critically-unstable patient and surgical laparotomy, partial peritonectomy and *** following prompt surgical treatment is excellent, with a majority of patients being symptom free at follow up. This review summarises the current literature on the aetiology, diagnosis and treatment of this rare disease. We also introduce a novel classification system for encapsulating bowel diseases, which may distinguish CPE from the commoner, more morbid conditions of abdominal cocoon and encapsulating peritoneal sclerosis.

关键词： Congenital Encapsulation Peritoneum Cocoon Sclerosis

Theoretical elastoplastic analysis for foundations with geosynthetic-encased columns

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第7期13卷 506-518页

作者： Yuan-yu DUAN Yi-ping ZHANG dave CHAN Ya-nan YU College of Civil Engineering and Architecture Zhejiang UniversityHangzhou 310058China Department of Civil and Environmental Engineering University of AlbertaEdmontonAlbertaCanada

As a new technique in ground improvement, geosynthetic-encased columns (GECs) have promising applications in soft soil foundation. By assuming yielding occurs in the columns while the surrounding soil and the geosynthetic remain elastic, an elastoplastic analytical procedure for foundations improved by GECs is proposed. The radial stresses that the geosynthetic provides and the elastoplastic deformations of the foundation resting on a rigid base are derived. A comparison with finite element analysis shows that the proposed method is effective and can provide a reasonable prediction of a GEC's deformation. Subsequent parametric analysis indicates that higher geosynthetic stiffness leads to better performance of the composite foundation. The optimum length of encasement is related to the load acting on the foundation and the permissible vertical and radial displacements of the column. Moreover, as the dilation angle of the column increases, the settlement decreases, especially under high loading. The influence of the encasement is more significant in soils with smaller elastic modulus.

关键词： Geosynthetic-encased columns (GECs) Equal vertical strain Elastoplastic deformation Analytical procedure

New sedimentological and palynological data from the Yarkand-Fergana Basin(Kyrgyz Tian Shan): Insights on its Mesozoic paleogeographic and tectonic evolution

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Geoscience Frontiers 2021年第1期12卷 183-202页

作者： Julien Morin Marc Jolivet dave Shaw Sylvie Bourquin Elena Bataleva Univ Rennes CNRSGeosciences RennesUMR 6118CNRSF-35000RennesFrance Biostratigraphic Associates(UK)Ltd 17 Woodland AvenueNorton GreenStoke on TrentStaffsST68NEUK Research Station of the Russian Academy of Sciences BishkekKyrgyzstan

The Talas Fergana/Karatau Fault,is a major tectonic boundary separating the Kazakh-Turan domain to the west from the Tian Shan domain to the *** the Jurassic,movements along the fault led to the opening of several ***,the Mesozoic kinematics of the fault and the geodynamic mechanism that led to the opening of these basins are largely *** at its southwestern termination,the Yarkand-Fergana Basin is certainly the best exposed and however still poorly *** this study,we provide new sedimentological description of the Jurassic series from the northern part of the Yarkand-Fergana Basin as well as new palynological *** a Middle-Late Triassic period dominated by regional erosion,the onset of sedimentation in the Yarkand-Fergana Basin occurred during the Sinemurian(?)-*** basin opened as a half graben controlled by the Talas Fergana/Karatau Fault and separated from the Fergana Basin by basement *** persisted during the late Pliensbachian-Middle Jurassic,leading to a general widening of the YarkandFergana ***,Late Jurassic-Early Cretaceous renewed tectonic activity in the area led to the inversion of the north Yarkand-Fergana *** Early to Middle Jurassic timing of development of the Yarkand-Fergana Basin suggests that the coeval movements along the Talas Fergana/Karatau Fault are not associated to the collision of the Qiangtang block along the southern margin of *** favor the hypothesis of an opening controlled by transtension related to far field effects of back-arc extension along the Neo-Tethys subduction zone to the west.

关键词： Central Asia Talas Fergana/Karatau Fault Extension Jurassic

Metamorphic testing as a test case selection strategy

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Science China(Information Sciences) 2016年第5期59卷 24-25页

作者： dave TOWEY Yunwei DONG Chang-Ai SUN Tsong Yueh CHEN School of Computer Science The University of Nottingham Ningbo China School of Computer Science and Engineering Northwestern Polytechnical University School of Computer and Communication Engineering University of Science and Technology Beijing Department of Computer Science and Software Engineering Swinburne University of Technology

Software testing is a well-known and popular approach to ensuring quality *** involves execution of the software under test(SUT),in an attempt to either offer some degree of confidence that the software is relatively bug free,or to actually uncover bugs or problems(called failures).Software testing has been studied for many years,and has generated a large body of approaches,methods,and techniques[1].An assumption underlying many of these approaches,however,is

关键词： Oracle Metamorphic testing as a test case selection strategy MT test case

A revisit of three studies related to random testing

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Science China(Information Sciences) 2015年第5期58卷 49-57页

作者： CHEN Tsong Yueh KUO Fei-Ching TOWEY dave ZHOU Zhi Quan Department of Computer Science and Software Engineering Swinburne University of Technology School of Computer Science The University of Nottingham Ningbo China School of Computer Science and Software Engineering University of Wollongong

Software testing is an approach that ensures the quality of software through execution, with a goal being to reveal failures and other problems as quickly as possible. Test case selection is a fundamental issue in software testing, and has generated a large body of research, especially with regards to the effectiveness of random testing(RT), where test cases are randomly selected from the software’s input domain. In this paper, we revisit three of our previous studies. The first study investigated a sufficient condition for partition testing(PT)to outperform RT, and was motivated by various controversial and conflicting results suggesting that sometimes PT performed better than RT, and sometimes the opposite. The second study aimed at enhancing RT itself, and was motivated by the fact that RT continues to be a fundamental and popular testing technique. This second study enhanced RT fault detection effectiveness by making use of the common observation that failure-causing inputs tend to cluster together, and resulted in a new family of RT techniques: adaptive random testing(ART),which is random testing with an even spread of test cases across the input domain. Following the successful use of failure-causing region contiguity insights to develop ART, we conducted a third study on how to make use of other characteristics of failure-causing inputs to develop more effective test case selection strategies. This third study revealed how best to approach testing strategies when certain characteristics of the failure-causing inputs are known, and produced some interesting and important results. In revisiting these three previous studies, we explore their unexpected commonalities, and identify diversity as a key concept underlying their *** observation further prompted us to examine whether or not such a concept plays a role in other areas of software testing, and our conclusion is that, yes, diversity appears to be one of the most important concepts in the fie

关键词： adaptive random testing diversity metamorphic testing proportional sampling strategy random testing software testing

The Open Data Challenge:An Analysis of 124,000 Data Availability Statements and an Ironic Lesson about Data Management Plans

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Data Intelligence 2020年第4期2卷 554-568页

作者： Chris Graf dave Flanagan Lisa Wylie Deirdre Silver Wiley 9600 Garsington RoadOxford OX42DQUK

Data availability statements can provide useful information about how researchers actually share research *** used unsupervised machine learning to analyze 124,000 data availability statements submitted by research authors to 176 Wiley journals between 2013 and *** categorized the data availability statements,and looked at trends over *** found expected increases in the number of data availability statements submitted over time,and marked increases that correlate with policy changes made by *** open data challenge becomes to use what we have learned to present researchers with relevant and easy options that help them to share and make an impact with new research data.

关键词： Data availability statement(DAS) FAIR data Machine learning Trends Journal Policy

Impact Assessment and Mitigation Techniques for High Penetration Levels of Renewable Energy Sources in Distribution Networks:Voltage-control Perspective

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 450-458页

作者： Ahmed S.A.Awad dave Turcotte Tarek H.M.El-Fouly Natural Resources Canada Can-metENERGYVarennesCanadaon leave from the Electrical Power and Machines DepartmentFaculty of EngineeringAin Shams UniversityCairo 11566Egyp Natural Resources Canada CanmetENERGYVarennesCanada Advanced Power and Energy Center Khalifa UniversityAbu DhabiUnited Arab Emirates

The integration of renewable distributed generation(RDG)into distribution networks is promising and increasing ***,high penetration levels of distributed generation(DG)are often limited as they may have an adverse effect on the operation of distribution *** of the operation challenges is the interaction between DG and voltage-control equipment,e.g.,an under-load tap changer(ULTC),which is basically designed to compensate for voltage changes caused by slow load *** integration of variable DGs leads to rapid voltage fluctuations,which can negatively affect the tap operation of *** paper investigates the impact of high penetration levels of RDG on the tap operation of ULTC in distribution networks through *** mitigation techniques that can alleviate this impact are also *** these techniques,constant power-factor mode is regarded as the best trade-off between the simplicity and effectiveness of minimizing the number of tap *** are performed on a Canadian benchmark rural distribution feeder using OpenDSS software.

关键词： Renewable energy distributed generation(DG) voltage regulator load tap changer distribution network.

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远程化工作时代数字游民的内涵与类型探赜

阅江学刊 2024年第4期16卷 103-119页

作者： [美]戴夫·库克姚建华杨涵庚英国伦敦大学学院人类学系复旦大学新闻学院复旦大学马克思主义新闻观教学与研究基地

2010年以来,数字游牧在全球范围内逐步扩展。特别是新冠疫情暴发后,作为数字游牧基础条件的远程工作日渐增多,导致“数字游牧”这一概念的应用范围不断扩大。本文重新定义数字游牧的内涵,并对当代数字游民进行最新的分类,将数字游民细... 详细信息

2010年以来,数字游牧在全球范围内逐步扩展。特别是新冠疫情暴发后,作为数字游牧基础条件的远程工作日渐增多,导致“数字游牧”这一概念的应用范围不断扩大。本文重新定义数字游牧的内涵,并对当代数字游民进行最新的分类,将数字游民细分为五种不同类型,即自由职业数字游民、数字游民企业主、带薪数字游民、实验性数字游民和“扶手椅上”的数字游民。这一分类涉及六个关键变量:流动频率和自主性、以家庭为居住地的实践、国内与跨国旅行、法律合规性、工作与生活平衡以及使用共享工作空间。文章强调,探讨数字游民内涵和类型,不仅能为未来的相关研究提供学术方向,还能帮助研究人员和政策制定者更准确地理解和评估数字游民在现实世界中的背景、动机、实践和影响。

关键词：数字游民数字游牧远程工作士绅化共享工作空间