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中华内科杂志 1957年第7期05卷 569-569,584页

作者： Moll,H.C. Stickler,g.B. daugherty,g.w. 邝贺龄

水与电解质平衡对于每个人都是重耍的;但需要医师处理的严重性平衡紊乱,则比较罕见。这是由于机体的巨大适应能力,借助于各项调节机转。虽没有

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Complex pathologies of angiotensin Ⅱ-induced abdominal aortic aneurysms

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第8期12卷 624-628页

作者： Alan daugherty Lisa A. CASSIS Hong LU Saha Cardiovascular Research Center University of KentuckyLexington KY40536-0509 USA graduate Center for Nutritional Sciences University of KentuckyLexington KY40536-0200 USA

Angiotensin II （Angll） is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases. Subcutaneous infusion of Angll into mice induces the development of abdominal aortic aneurysms （AAAs）. Like human AAAs, Angll-induced AAA tissues exhibit progressive changes and considerable heterogeneity. This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques. Therefore, while the mouse model of Angll-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans, meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue.

关键词： Abdominal aortic aneurysms Angiotensin II,Pathologies Mouse

THE OCCURRENCE OF CERCIS ASSOCIATED wITH THE REMAINS OF SINANTHROPUS

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地质学报 1933年 356-362页

作者： RALPH w.CHANEY LYMAN H.daugherty

In a short paper entitled "Evidences of the Use of Fire by Sinanthropus",*** Black has discussed the occurrence of burned bone fragments andcharcoal debris in association with the remains of Sinanthropus at Chou KouTi... 详细信息

关键词： THE OCCURRENCE OF CERCIS ASSOCIATED wITH THE REMAINS OF SINANTHROPUS

Sequencing and bacterial expression of a novel murine alpha interferon gene

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Science China(Life Sciences) 1997年第3期40卷 277-283页

作者：王焱王征宇周鸣南蔡菊娥孙兰英刘新垣 B.L.daugherty S.Pestka Shanghai Institute of Biochemistry Chinese Academy of Sciences Shanghai 200031 China Department of Molecular genetics and Microbiology UMDNJ-Robert Wood Johnson Medical School New Jersey USA

A murine new alpha interferon gene (mIFN-αB) was found by primer-based sequencing method in a murine genomic DNA library. The gene was cloned and its sequence was determined. It was expressed in Escherichia coli under the control of the PL promoter which resulted in antiviral activity on mouse L-cells. The sequence of mlFN-αB has been accepted by gENEBANK.

关键词： murine alpha interferon primer-based sequencing method prokaryotic expression.

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肾素血管紧张素系统与动脉粥样硬化

中华高血压杂志 2017年第6期25卷 511-512页

作者：徐银川陈晓锋 Alan daugherty 吕红王建安浙江省心血管病诊治重点实验室浙江大学医学院附属第二医院心血管内科浙江杭州310000 浙江省台州恩泽医疗集团浙江省台州医院美国肯塔基大学Saha心血管研究中心

动脉粥样硬化是脂质在血管壁的异常堆积而引起的慢性血管炎症,据估计,90%的心肌梗死,60%的缺血性脑卒中以及大多数的心力衰竭均可由其引起。经典的肾素血管紧张素系统（renin-angiotensin system,RAS）作为调节机体血压的关键内分泌系统... 详细信息

动脉粥样硬化是脂质在血管壁的异常堆积而引起的慢性血管炎症,据估计,90%的心肌梗死,60%的缺血性脑卒中以及大多数的心力衰竭均可由其引起。经典的肾素血管紧张素系统（renin-angiotensin system,RAS）作为调节机体血压的关键内分泌系统,目前认为它是调节动脉粥样硬化发生发展的重要因子。

关键词：肾素血管紧张素系统动脉粥样硬化缺血性脑卒中内分泌系统血管炎症心肌梗死心力衰竭血管壁

Sofosbuvir Use in the Setting of End-stage Renal Disease:A Single Center Experience

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Journal of Clinical and Translational Hepatology 2017年第1期5卷 23-26页

作者： Avin Aggarwal Eric R.Yoo Ryan B.Perumpail george Cholankeril Radhika Kumari Tami J.daugherty Alex S.Lapasaran Aijaz Ahmed Division of gastroenterology and Hepatology Stanford University School of MedicineStanfordCAUSA Department of Medicine University of Illinois College of MedicineChicagoILUSA Division of gastroenterology and Hepatology University of Tennessee Health Sciences CenterMemphisTNUSA Digestive Health Associates RenoNVUSA

Background and Aims:Patients with chronic hepatitis C (CHC) and end-stage renal disease (ESRD) who are dialysisdependent form a unique group,in which safety,tolerability and efficacy of sofosbuvir (SOF)-based direct-acting antivirals (DAAs) need further ***:we performed a retrospective analysis of 14 patients with CHC and ESRD on dialysis who received 15 courses of SOF-based *** evaluated dose escalation to standard-dose SOF in this proof-of-principle ***:Sustained virological response (defined as undetectable viral load at 12 weeks,SVR-12) was achieved in 13 out of the 15 (86.7%) treatment *** (46.6%) patients received reduced half dose as conservative proof-of-principal to mitigate potential *** 13 out of 15 treatment courses,patients completed the designated treatment *** patient was treated twice and developed SVR-12 with the *** patient was lost to follow-up and counted as a *** discontinuations were not due to DAA-related adverse *** were no reports of severe adverse effects or drug ***:we treated CHC patients with ESRD using dose escalation to standard-dose SOF in this proof-of-principle experience and achieved SVR rates comparable to general population.

关键词： Hepatitis C End-stage renal disease Sofosbuvir Direct-acting antivirals

Prominent Roles of the Renin Angiotensin System in Atherosclerosis

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中国动脉硬化杂志 2009年第7期17卷 573-573页

作者： Debra L. Rateri Alan daugherty Cardiovascular Research Center University of Kentucky

The renin angiotensin system (RAS) is emerging as a prominent factor in the development of experimental atherosclerosis. we have previously demonstrated that the RAS is profoundly activated in hypercholesterolemia. This was demonstrated in LDLR-/-mice fed a saturated fat enriched diet and manifested as increased plasma concentrations of angiotensinogen and angiotensin peptides; especially angiotensin Ⅱ (AngⅡ).

关键词：肾素动脉粥样硬化临床分析血管

Complex pathologies of angiotensin II-induced abdominal aortic aneurysms

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 687-687页

作者： Alan daugherty Lisa A. CASSIS Hong LU

Angiotensin II (AngII) is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases. Subcutaneous infusion of AngII into mice induces the development of abdominal aortic aneurysms (AAAs). Like human AAAs, AngII-induced AAA tissues exhibit progressive changes and considerable heterogeneity. This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques. Therefore, while the mouse model of AngII-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans, meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue.

关键词：血管紧张素Ⅱ 生物活性肽动脉瘤诱导病理免疫组化技术 AAAS 组织成分

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与素坦尼克号擦肩而过的七位名人

英语学习 2012年第6期 26-28页

作者： greg daugherty 陈锦麟（选注）

The sinking of the Titanic claimed some 1,500 lives, among them a gallery of early 20th-century A-list celebrities.1 Captains of industry John Jacob Astor IV and Benjamin guggenheim both went down with the ship, as di... 详细信息

关键词：中学英语课外阅读阅读材料

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现代子午线航空轮胎的动态性能研究(三)

现代橡胶技术 2014年第2期40卷 7-16页

作者：李汉堂 Robert H.daugherty

（接上期）6．4．3滚动阻力参看图10的俯视图，其未刹车、偏航的轮胎是朝页面的上方滚动的。无论偏航角如何，都可以在印痕看到其压力的中心（垂直地面反作用力的质量中心）向前移动。由垂直地面反作用力作用于压力的正向中心而产生的... 详细信息

（接上期）6．4．3滚动阻力参看图10的俯视图，其未刹车、偏航的轮胎是朝页面的上方滚动的。无论偏航角如何，都可以在印痕看到其压力的中心（垂直地面反作用力的质量中心）向前移动。由垂直地面反作用力作用于压力的正向中心而产生的力矩有助于减缓轮胎偏航，获得力矩的平衡，在地面产生牵引力。

关键词：航空轮胎动态性能子午线滚动阻力反作用力偏航角质量中心俯视图