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Unmodified autologous stem cells at point of care for chronic myocardial infarction

World Journal of Stem Cells 2019年第10期11卷 831-858页

作者： Alexander Haenel Mohamad Ghosn Tahereh Karimi Jody Vykoukal Dipan Shah Miguel Valderrabano daryl G Schulz Albert Raizner Christoph Schmitz Eckhard U Alt Heart and Vascular Institute Department of MedicineTulane University Health Science CenterNew OrleansLA 70112United States The Methodist Hospital Research Institute HoustonTX 77030United States Department of Radiology and Nuclear Medicine University Hospital Schleswig-HolsteinLübeck D-23562Germany Houston Methodist DeBakey Heart and Vascular Center HoustonTX 77030United States Department of Translational Molecular Pathology MD Anderson Cancer CenterThe University of TexasHoustonTX 77030United States Institute of Anatomy Faculty of MedicineLMU MunichMunich D-80336Germany Isar Klinikum Munich Munich D-80331Germany

BACKGROUND Numerous studies investigated cell-based therapies for myocardial infarction(MI).The conflicting results of these studies have established the need for developing innovative approaches for applying cell-based therapy for *** studies on animal models demonstrated the potential of fresh,uncultured,unmodified,autologous adipose-derived regenerative cells(UAADRCs)for treating acute *** contrast,studies on the treatment of chronic MI(CMI;>4 wk post-MI)with UA-ADRCs have not been published so *** several methods for delivering cells to the myocardium,retrograde delivery into a temporarily blocked coronary vein has recently been demonstrated as an effective *** To test the hypothesis that in experimentally-induced chronic myocardial infarction(CMI;>4 wk post-MI)in pigs,retrograde delivery of fresh,uncultured,unmodified,autologous adipose-derived regenerative cells(UA-ADRCs)into a temporarily blocked coronary vein improves cardiac function and *** The left anterior descending(lAD)coronary artery of pigs was blocked for 180 min at time point ***,either 18×106 UA-ADRCs prepared at“point of care”or saline as control were retrogradely delivered via an over-the-wire balloon catheter placed in the temporarily blocked lAD vein 4 wk after T0(T1).Effects of cells or saline were assessed by cardiac magnetic resonance(CMR)imaging,late gadolinium enhancement CMR imaging,and post mortem histologic analysis 10 wk after T0(T2).RESUlTS Unlike the delivery of saline,delivery of UA-ADRCs demonstrated statistically significant improvements in cardiac function and structure at T2 compared to T1(all values given as mean±SE):Increased mean lVEF(UA-ADRCs group:34.3%±2.9%at T1 vs 40.4±2.6%at T2,P=0.037;saline group:37.8%±2.6%at T1 vs 36.2%±2.4%at T2,P>0.999),increased mean cardiac output(UA-ADRCs group:2.7±0.2 l/min at T1 vs 3.8±0.2 l/min at T2,P=0.002;saline group:3.4±0.3 l/min at T1 vs 3.6±0.3 l/min at T2,P=0.798),increased mean mass of the

关键词： Adipose tissue-derived regenerative cells Chronic myocardial infarction Heart failure Stem cells Translational medicine Point of care cell therapy

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High mechanical strengths and ductility of stainless steel 304l fabricated using selective laser melting

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Journal of Materials Science & Technology 2019年第2期35卷 388-394页

作者： Q.B.Nguyen Z.Zhu F.l.Ng B.W.Chua S.M.l.Nai J.Wei Singapore Institute of Manufacturing Technology Institute of Research and Development Duy Tan University

Achieving not only high mechanical strengths but also high ductility is recently established using an additive manufacturing technique called selective laser melting. In the present study, stainless steel 304 l fully dense samples were successfully printed using the 3 D systems – ProX 300 printing machine. The ductility and tensile yield strength were almost two and three times higher compared to those of ASTM cast's alloy. Honey comb like nano-cellular structure with different orientation was observed in the fine grains(~4μm) due to fast cooling rate. In addition, the formation of martensite phase in random grains is also a contributor to the strengths. Furthermore, negative residual stresses in the build and horizontal directions were detected and assisted further increase in the tensile strength. Fractography revealed the ductile feature of plastic deformation and the crack openings at unmelted particles or pores.

关键词： Additive manufacturing Stainless steel Powder Selective laser melting

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel l.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Effect of Zn binding to phytate and humic substances on its uptake by wheat(Triticum durum l.)as affected by carbonates and Fe oxides

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Pedosphere 2022年第6期32卷 823-832页

作者： Ana M.GARCÍA-lÓPEZ Ramiro RECENA Antonio DElGADO Department of Agronomy ETSIAUniversity of SevilleSeville 41013(Spain)

Although complexation with soil organic matter may improve zinc(Zn)bioavailability to plants,the effect of Zn sorbent surface on the use of complexed Zn by plants remains *** objective of this research was to elucidate how Zn complexation with humic substances(HS)and phytate affects the uptake of Zn by wheat plants depending on the main sorbent surface in growth media,i.e.,carbonates and Fe *** this end,two pot experiments were performed,one using Fe oxide-coated siliceous as the siliceous growth medium sand and the other using a mixture of calcareous sand and siliceous sand as the calcareous growth *** experiment involved three Zn sources,Zn-HS complex,Zn phytate,and ZnSO_(4).All sources were applied with surface irrigation at two Zn rates(0.25 and 2 mg kg^(-1) growth medium).The Zn-HS complex significantly increased Zn uptake by plants in both media,relative to the other two Zn sources,but no significant difference was observed between Zn phytate and ZnSO_(4).In the calcareous medium,Zn-HS complex and Zn phytate resulted in significantly higher dry biomass yields of wheat than ZnSO_(4).In the siliceous medium,spike and shoot dry biomass yields with Zn-HS complex at the low rate and Zn phytate at both rates were not significantly different from those with ZnSO_(4) at the high *** harvest,approximately 50%of the Zn applied as Zn-HS complex remained extractable by diethylenetriaminepentaacetic acid(DTPA),while this proportion was less than 20%for the other Zn ***,Zn-HS complex and Zn phytate are sources of available Zn for plants,and they are more effective than ZnSO_(4) in increasing plant growth,particularly when carbonates are the main Zn sorbent surface.

关键词： calcareous growth medium micronutrient organic matter organic phosphorus Zn availability Zn deficiency Zn sorbent surface Zn source

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Experimental study on reduction of U (Ⅵ) by an anaerobic bacterium, Shewanella putrefaciens: Application to sandstone-hosted interlayer oxidation-zone type uranium deposits, China

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Science China Earth Sciences 2005年第3期48卷 346-352页

作者： l.l.Barton Department of Biology University of New Mexico Albuquerque NM 87131-1116USA

An experimental study on reduction of U (VI) by anaerobic bacteria, Shewanella putrefaciens, is first reported here in China. The experimental conditions were: 35℃ and pH = 7.0—7.4, corresponding to a physicochemical environments in which the sandstone-hosted in- terlayer oxidation-zone type uranium deposit formed in Northwest China’s Xinjiang. Bacteria adopted in the present experiment, Shewanella putrefaciens, occur extensively in natural envi- ronment. Our study shows that nano-crystal precipitates of uraninite quickly occurred on the surface of the cells within one week. It was found that the pitchblende was characterized by a random arrangement of uraninite nanocrystals (2—4 nm) in it, significantly different from natural pitchblende in which uraninite nanocrystals are arranged in order. Finally, a possible mechanism of uranium biomineralization by microorganisms in the deposits is discussed. Our investigation may supply a technical train of thoughts for bioremediation of nuclear-contaminated water envi- ronments and for underground dissolving extraction of the sandstone-hosted uranium ores.

关键词： anaerobic bacteria, reduction, pitchblende, sandstone-hosted uranium deposit, experimental study.

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NOD2 and ATG16l1 polymorphisms affect monocyte responses in Crohn's disease

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World Journal of Gastroenterology 2011年第23期17卷 2829-2837页

作者： Dylan M Glubb Richard B Gearry Murray l Barclay Rebecca l Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley Department of Medicine University of ChicagoIL 60637-1470United States Department of Medicine University of OtagoChristchurch8140New Zealand Department of Gastroenterology Christchurch HospitalChristchurch8140New Zealand Department of Biochemistry University of OtagoDunedin9054New Zealand Department of Pathology University of OtagoChristchurch8140New Zealand Department of Surgery University of OtagoChristchurch8140New Zealand Department of Haematology University of OtagoChristchurch8140New Zealand Department of Paediatrics University of OtagoChristchurch8140New Zealand

AIM： TO assess whether polymorphisms in NOD2 and ATG16l1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis （MAP） survival in monocytes from Crohn＇s disease （CD） patients METHODS： Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16l1, Monocytes were challenged with MAP and bacterial per- sistence assessed at subsequent time-points. Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines. RESUlTS： Monooltes heterozygous for a NOD2 polymorphism （R702W, P268S, or 1007fs） were more permissive for growth of MAP （P = 0.045） than those without. There was no effect of NOD2 genotype on subsequent cytokine expression. The T300A polymorphism of ATG16l1 did not affect growth of MAP in our model （P = 0.175）, but did increase expression of cytokines interleukin （Il）-10 （P = 0.047） and Il-6 （P = 0.019）. CONClUSION： CD-associated polymorphisms affected the eliminaUon of MAP from ex v/vo monooltes （NOD2）, or expression of certain oltokines （ATG16lI）, implying independent but contributory roles in the pathogenesis of CD.

关键词： Inflammatory bowel disease Mycobacteriumavium subspecies paratuberculosis Cytokine CARD15 Autophagy

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Three-dimensional dynamics of supported pipes conveying fluid

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Acta Mechanica Sinica 2017年第6期33卷 1065-1074页

作者： l.Wang T.l.Jiang H.l.Dai Department of Mechanics Huazhong University of Science and Technology Wuhan 430074 China Hubei Key laboratory for Engineering Structural Analysis and Safety Assessment Wuhan 430074 China

This paper deals with the three-dimensional dynamics and postbuckling behavior of flexible supported pipes conveying fluid, considering flow velocities lower and higher than the critical value at which the buckling instability occurs. In the case of low flow velocity, the pipe is stable with a straight equilibrium position and the dynamics of the system can be examined using linear theory. When the flow velocity is beyond the critical value, any motions of the pipe could be around the postbuckling configuration(non-zero equilibrium position) rather than the straight equilibrium position, so nonlinear theory is required. The nonlinear equations of perturbed motions around the postbuckling configuration are derived and solved with the aid of Galerkin discretization. It is found, for a given flow velocity,that the first-mode frequency for in-plane motions is quite different from that for out-of-plane motions. However, the second-or third-mode frequencies for in-plane motions are approximately equal to their counterparts for out-of-plane motions, keeping almost constant values with increasing flow velocity. Moreover, the orientation angle of the postbuckling configuration plane for a buckled pipe can be significantly affected by initial conditions, displaying new features which have not been observed in the same pipe system factitiously supposed to deform in a single plane.

关键词： Pipe conveying fluid Three-dimensional dynamics Instability Natural frequency Postbuckling configuration

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INVERSION OF ElECTRON TOMOGRAPHY IMAGES USING l^2-GRADIENT FlOWS -- COMPUTATIONAl METHODS

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Journal of Computational Mathematics 2011年第5期29卷 501-525页

作者： Guoliang Xu Ming li Ajay Gopinath Chandrajit l. Bajaj lSEC ICMSEC Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 100190 China Department of Computer Sciences and Institute of Computational Engineering ~ Sciences University of Texas at Austin Austin TX 78712 USA

In this paper, we present a stable, reliable and robust method for reconstructing a three dimensional density function from a set of two dimensional electric tomographic images. By minimizing an energy functional consisting of a fidelity term and a regularization term, an l^2-gradient flow is derived. The flow is integrated by a finite element method in the spatial direction and an explicit Euler scheme in temporal direction. The experimental results show that the proposed method is efficient and effective.

关键词： Computational Inversion Reconstruction Electric Tomography.

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The interaction mechanism of nickel ions with l929 cells based on integrative analysis of proteomics and metabolomics data

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Regenerative Biomaterials 2022年第1期9卷 560-571页

作者： Yajing Zhang Yan Huang Rong Chen Shulin Chen Xiaoying lü State Key laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast University2#Si PailouNanjing 210096China

The aim of this article was to study the toxicity mechanism of nickel ions(Ni^(2+))on l929 cells by combining proteomics and ***,iTRAQ-based proteomics and lC/MS metabolomics analyses were used to determine the protein and metabolite expression profiles in l929 cells after treatment with 100μMNi^(2+)for 12,24 and 48 h.A total of 177,2191 and 2109 proteins and 40,60 and 74 metabolites were found to be differentially ***,the metabolic pathways in which both differentially expressed proteins and metabolites were involved were identified,and three pathways with proteins and metabolites showing upstream and downstream relationships were affected at all three time ***,the protein-metabolite-metabolic pathway network was constructed,and two important metabolic pathways involving 4 metabolites and 17 proteins were ***,the functions of the important screened metabolic pathways,metabolites and proteins were investigated and experimentally ***^(2+)mainly affected the expression of upstream proteins in the glutathione metabolic pathway and the arginine and proline metabolic pathway,which further regulated the synthesis of downstream metabolites,reduced the antioxidant capacity of cells,increased the level of superoxide anions and the ratio of GSSG to GSH,led to oxidative stress,affected energy metabolism and induced apoptosis.

关键词： nickel ion(Ni2t) proteomics metabolomics protein-metabolite-metabolic pathway network

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The dynamic compensation temperature in a kinetic spin-5/2 Ising model on a hexagonal lattice

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Chinese Physics B 2013年第3期22卷 471-480页

作者： mt Temizer Aysegl Ozkιlι Department of Physics Bozok University66200 YozgatTurkey Institute of Science Bozok University66200 YozgatTurkey

We present a study of the dynamic behavior of a two-sublattice spin-5/2 Ising model with bilinear and crystal-field interactions in the presence of a time-dependent oscillating external magnetic field on alternating layers of a hexagonal lattice by using the Glauber-type stochastic *** lattice is formed by alternate layers of spins σ=5/2 and S=5/*** employ the Glauber transition rates to construct the mean-field dynamic ***,we investigate the time variations of the average sublattice magnetizations to find the phases in the system and then the thermal behavior of the dynamic sublattice magnetizations to characterize the nature（first-or second-order） of the phase transitions and to obtain the dynamic phase transition（DPT） *** also study the thermal behavior of the dynamic total magnetization to find the dynamic compensation temperature and to determine the type of the dynamic compensation *** present the dynamic phase diagrams,including the dynamic compensation temperatures,in nine different *** phase diagrams contain seven different fundamental phases,thirteen different mixed phases,in which the binary and ternary combination of fundamental phases and the compensation temperature or the l-type behavior strongly depend on the interaction parameters.

关键词： kinetic Ising model dynamic phase transition dynamic compensation temperature

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