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A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface

International Journal of Oral Science 2024年第2期16卷 225-237页

作者： William Macalester Asme Boussahel Rafael O.Moreno-Tortolero Mark R.Shannon Nicola West darryl hill Adam Perriman School of Cellular and Molecular Medicine Biomedical Sciences BuildingUniversity of BristolUniversity WalkBristolUnited Kingdom Bristol Centre for Functional Nanomaterials HH Wills Physics LaboratoryUniversity of BristolTyndall AvenueBristolUnited Kingdom Centre for Protolife Research School of ChemistryUniversity of BristolCantocks CloseBristolUnited Kingdom Max Planck-Bristol Centre for Minimal Biology School of ChemistryUniversity of BristolBristolUnited Kingdom Periodontology Bristol Dental SchoolUniversity of BristolLower Maudlin StreetBristolUnited Kingdom

Emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for minimally invasive surgery to treat small and spatially complex maxilla-oral ***,the oral cavity presents a unique and challenging environment for in vivo bone tissue engineering,exhibiting both hard and soft periodontal tissue as well as acting as key biocenosis for many distinct microbial communities that interact with both the external environment and internal body systems,which will impact on cell fate and subsequent treatment ***,we design and bioprint a facile 3D in vitro model of a human dentine interface to probe the effect of the dentine surface on human mesenchymal stem cells(hMSCs)encapsulated in a microporous hydrogel *** demonstrate that the dentine substrate induces osteogenic differentiation of encapsulated hMSCs,and that both dentine andβ-tricalcium phosphate substrates stimulate extracellular matrix production and maturation at the gel-media interface,which is distal to the gel-substrate *** findings demonstrate the potential for long-range effects on stem cells by mineralized surfaces during bone tissue engineering and provide a framework for the rapid development of 3D dentine-bone interface models.

关键词： interface den surface

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Gynecologic oncologists involvement on ovarian cancer standard of care receipt and survival

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World Journal of Obstetrics and Gynecology 2016年第2期5卷 187-196页

作者： Sun Hee Rim Shawn Hirsch Cheryll C Thomas Wendy R Brewster darryl Cooney Trevor D Thompson Sherri L Stewart Division of Cancer Prevention and Control National Center for Chronic Disease Prevention and Health PromotionCenters for Disease Control and Prevention Sci Metrika LLC University of North Carolina at Chapel hill

AIM： To examine the infuence of gynecologic oncolo-gists （GO） in the United States on surgical/chemothe-rapeutic standard of care （SOC）, and how this translates into improved survival among women with ovarian cancer （OC）.METHODS： Surveillance, Epidemiology, and End Result （SEER）-Medicare data were used to identify 11688 OC patients （1992-2006）. Only Medicare recipients with an initial surgical procedure code （n = 6714） were included. Physician specialty was identified by linking SEER-Medicare to the American Medical Association Masterfile. SOC was defined by a panel of GOs. Mul-tivariate logistic regression was used to determine predictors of receiving surgical/chemotherapeutic SOC and proportional hazards modeling to estimate the effect of SOC treatment and physician specialty on survival. RESULTS： About 34% received surgery from a GO and 25% received the overall SOC. One-third of women had a GO involved sometime during their care. Women receiving surgery from a GO vs non-GO had 2.35 times the odds of receiving the surgical SOC and 1.25 times the odds of receiving chemotherapeutic SOC （P 〈 0.01）. Risk of mortality was greater among women not receiving surgical SOC compared to those who did [hazard ratio = 1.22 （95%CI： 1.12-1.33）, P 〈 0.01], and also was higher among women seen by non-GOs vs GOs （for surgical treatment） after adjusting for covariates. Median survival time was 14 mo longer for women receiving combined SOC. CONCLUSION： A survival advantage associated with receiving surgical SOC and overall treatment by a GO is supported. Persistent survival differences, particularly among those not receiving the SOC, require further investigation.

关键词： Ovarian neoplasms Gynecologic oncologist Guidelines-based care Surveillance Epidemiology and End Result Medicare

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