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Universal frequency engineering tool for microcavity nonlinear optics:multiple selective mode splitting of whispering-gallery resonances

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Photonics Research 2020年第11期8卷 1676-1686页

作者： Xiyuan Lu Ashutosh Rao Gregory Moille daron A.Westly Kartik Srinivasan Microsystems and Nanotechnology Division Physical Measurement LaboratoryNational Institute of Standards and TechnologyGaithersburgM aryland 20899USA Institute for Research in Electronics and Applied Physics and M aryland NanoCenter University of MarylandCollege ParkMaryland 20742USA Department of Chemistry and Biochemistry University of MarylandCollege ParkMaryland 20742USA Joint Quantum Institute NIST/University of MarylandCollege ParkMaryland 20742USA

Whispering-gallery microcavities have been used to realize a variety of efficient parametric nonlinear optical processes through the enhanced light–matter interaction brought about by supporting multiple high quality factor and small modal volume *** to such studies is the ability to control the relative frequencies of the cavity modes,so that frequency matching is achieved to satisfy energy *** this is done by tailoring the resonator cross *** so modifies the frequencies of all of the cavity modes,that is,the global dispersion profile,which may be undesired,for example,in introducing competing nonlinear ***,we demonstrate a frequency engineering tool,termed multiple selective mode splitting(MSMS),that is independent of the global dispersion and instead allows targeted and independent control of the frequencies of multiple cavity *** particular,we show controllable frequency shifts up to 0.8 nm,independent control of the splitting of up to five cavity modes with optical quality factors≳10^5,and strongly suppressed frequency shifts for untargeted *** MSMS technique can be broadly applied to a wide variety of nonlinear optical processes across different material platforms and can be used to both selectively enhance processes of interest and suppress competing unwanted processes.

关键词： resonator nonlinear splitting

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Photonic waveguide to free-space Gaussian beam extreme mode converter

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Light(Science & Applications) 2018年第1期7卷 346-358页

作者： Sangsik Kim daron A.Westly Brian J.Roxworthy Qing Li Alexander Yulaev Kartik Srinivasan Vladimir A.Aksyuk Center for Nanoscale Science and Technology National Institute of Standards and TechnologyGaithersburgMD 20899USA Maryland Nanocenter University of MarylandCollege ParkMD 20742USA Department of Electrical and Computer Engineering Texas Tech UniversityLubbockTX 79409USA

Integration of photonic chips with millimeter-scale atomic,micromechanical,chemical,and biological systems can advance science and enable new miniaturized hybrid devices and *** interaction via small evanescent volumes restricts performance in applications such as gas spectroscopy,and a general ability to photonically access optical fields in large free-space volumes is ***,conventional inverse tapers and grating couplers do not directly scale to create wide,high-quality collimated beams for low-loss diffraction-free propagation over many millimeters in free space,necessitating additional bulky collimating optics and expensive ***,we develop an extreme mode converter,which is a compact planar photonic structure that efficiently couples a 300 nm×250 nm silicon nitride high-index single-mode waveguide to a well-collimated near surface-normal Gaussian beam with an≈160μm waist,which corresponds to an increase in the modal area by a factor of>*** beam quality is thoroughly characterized,and propagation over 4mm in free space and coupling back into a single-mode photonic waveguide with low loss via a separate identical mode converter is *** achieve low phase error over a beam area that is>100×larger than that of a typical grating coupler,our approach separates the two-dimensional mode expansion into two sequential separately optimized stages,which create a fully expanded and well-collimated Gaussian slab mode before out-coupling it into free *** at 780 nm for integration with chip-scale atomic vapor cell cavities,our design can be adapted for visible,telecommunication,or other *** technique can be expanded to more arbitrary phase and intensity control of both large-diameter,free-space optical beams and wide photonic slab modes.

关键词： waveguide millimeter mode

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Integrating planar photonics for multi-beam generation and atomic clock packaging on chip

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Light(Science & Applications) 2023年第4期12卷 691-701页

作者： Chad Ropp Wenqi Zhu Alexander Yulaev daron Westly Gregory Simelgor Akash Rakholia William Lunden Dan Sheredy Martin MBoyd Scott Papp Amit Agrawal Vladimir Aksyuk Physical Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Department of Chemistry and Biochemistry University of MarylandCollege ParkMD 20742USA Vector Atomic Inc.PleasantonCA 94588USA Physical Measurement Laboratory National Institute of Standards and TechnologyBoulderCO 80305USA

The commercialization of atomic technologies requires replacing laboratory-scale laser setups with compact and manufacturable optical *** arrangements of free-space beams can be generated on chip through a combination of integrated photonics and metasurface *** this work,we combine these two technologies using flip-chip bonding and demonstrate an integrated optical architecture for realizing a compact strontium atomic *** planar design includes twelve beams in two co-aligned magneto-optical *** beams are directed above the chip to intersect at a central location with diameters as large as 1 *** design also includes two co-propagating beams at lattice and clock *** beams emit collinearly and vertically to probe the center of the magneto-optical trap,where they will have diameters of≈100μ*** these devices we demonstrate that our integrated photonic platform is scalable to an arbitrary number of beams,each with different wavelengths,geometries,and polarizations.

关键词： planar diameters atomic

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Effect of non-steroidal anti-inflammatory drugs on post-surgical complications against the backdrop of the opioid crisis

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Burns & Trauma 2018年第3期6卷 190-198页

作者： Hannah Zhao-Fleming Audrey Hand Kelly Zhang Robert Polak Armand Northcut daron Jacob Sharmila Dissanaike Kendra P.Rumbaugh Department of Surgery Texas Tech University Health Sciences Center3601 4th StreetSTOP 8312LubbockTX 79430USA Burn Center of Excellence Texas Tech University Health Sciences CenterLubbockTXUSA School of Medicine Texas Tech University Health Sciences CenterLubbockTXUSA

The USA is currently going through an opioid crisis, associated with tremendous economic and societal impacts. In response to this crisis, healthcare professionals are looking for alternative pain management methods, and non-steroidal anti-inflammatory drugs (NSAIDs) are a sensible choice because of their effectiveness after surgical procedures. However, before surgeons start prescribing NSAIDs in place of opioids, it is crucial to first understand their potential post-surgical complications. The goal of this review is to summarize the data obtained through both animal and human studies, which suggest how a dramatic increase in NSAID use may affect these post-surgical complications. We first provide a short review outlining the mechanisms of action of NSAIDs, followed by a summary of animal studies, which show a trend towards the negative effects of NSAIDs on wound healing and an association between NSAID use and wound infections. Lastly, we present evidence from human studies on the association of NSAIDs with the following complications:anastomotic leaks, necrotizing soft tissue infections, bleeding complications, orthopedic injuries, wound healing, and cancer care. The human studies are much more variable in their conclusions as to whether NSAIDs are beneficial or not, with the only strong evidence showing that NSAIDs inhibit bone healing. This may partially be explained by male and female differences in response to NSAIDs as many animal studies showing the inhibitory effects of NSAIDs were performed on females, while al the human studies were performed with both sexes. We conclude that strong caution should be used in the prescription of NSAIDs, especially in female patients, but larger scale studies are warranted before solid recommendations can be made.

关键词： NSAIDs Opioids Anastomotic leaks Necrotizing soft tissue infections Bleeding Orthopedic injuries Wound healing Cancer care non-steroidal anti-inflammatory

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Stricture Navigator-RT: Real-Time Structure-Based Query Service at PDBj

Stricture Navigator-RT: Real-Time Structure-Based Query Serv...

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The 4th ISGO International Conference on Structural Genomics

作者： daron M Standley Hiroyuki Toh Haruki Nakamura Institute for Protein Research （IPR） Osaka University Suita Osaka 565-0871Japanand JST-BIRDJapan Human Genome Center Institute of Bioregulation Kyushu University Kyushu Japan IPR Osaka University Japan

＜正＞Traditionally, the Protein Data Bank Japan （PDBj） has offered queries based on keywords such as the PDB ID, compound name, primary author, etc. Recently, queries can also be made based on the amino acid sequence or atomic coordinates. The later features are potentially useful as they do not require prior knowledge of

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苏格拉底之死

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英语学习 2013年第5期 21-23页

作者： daron Scofield

哲学家苏格拉底被称为是西方的孔子，他因“渎神”、＂蛊惑青年”和“反民主”而被处死。在面对审判团时他没有丝毫的畏惧,反而像是一个斗士。于是，一杯毒芹汁结束了这位伟大的哲学家的生命。

关键词：苏格拉底之死哲学家反民主孔子蛊

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Towards integrated photonic interposers for processing octave-spanning microresonator frequency combs

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Light(Science & Applications) 2021年第6期10卷 1099-1111页

作者： Ashutosh Rao Gregory Moille Xiyuan Lu daron A.Westly Davide Sacchetto Michael Geiselmann Michael Zervas Scott B.Papp John Bowers Kartik Srinivasan Physical Measurement Laboratory Microsystems and Nanotechno logy DivisionNational Institute of Standards and TechnologyGaithersburgMD 20899USA Maryland NanoCenter University of MarylandCollege Park 20742 MDUSA Joint Quantum Institute NIST/University of MarylandCollege ParkMD 20742USA Ligentec EPFL Innovation ParkBatiment CLausanneSwitzerland Physical Measurement Laboratory Time and Frequency DivisionNational Institute of Standards and TechnologyBoulderCO 80305USA Department of Physics University of ColoradoBoulderCO 80309USA Department of Electrical and Computer Engineering University of CaliforniaSanta BarbaraCA 93106USA

Microcombs-optical frequency combs generated in microresonators-have advanced tremendously in the past decade,and are advantageous for applications in frequency metrology,navigation,spectroscopy,telecommunications,and microwave ***,microcombs promise fully integrated miniaturized optical systems with unprecedented reductions in cost,size,weight,and ***,the use of bulk free-space and fiber-optic comp on ents to process microcombs has restricted form factors to the *** microcomb-based optical frequency synthesis around 1550 nm as our target application,here,we address this challenge by proposing an integrated photonics interposer architecture to replace discrete components by collecting,routing,and interfacing octave-wide microcomb-based optical signals between photonic chiplets and heterogeneously integrated ***,we con firm the requisite performa nee of the individual passive elements of the proposed interposer一octave-wide dichroics,multimode interferometers,and tunable ring filters,and implement the octave-spanning spectral filteri ng of a microcomb,central to the in terposer,using silicon n itride phot ***,we show that the thick silicon nitride needed for bright dissipative Kerr soliton generation can be integrated with the comparatively thin silicon nitride interposer layer through octave-bandwidth adiabatic evanescent coupling,indicating a path towards future system-level *** ally,we numerically confirm the feasibility of operating the proposed in terposer synthesizer as a fully assembled *** interposer architecture addresses the immediate need for on-chip microcomb processing to successfully miniaturize microcomb systems and can be readily adapted to other metrology-grade applications based on optical atomic clocks and high-precision navigation and spectroscopy.

关键词： resonator interferometer synthesizer

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网络中的级联和总量波动

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理论经济学 2014年第3期 116-130页

作者： daron Acemoglu Asuman Ozdaglarz Alireza Tahbaz-Salehi

本文提供了一个研究级联效应的一般框架。通过研究由供应网络联系在一起的多部门经济，我们探究了供应网络结构特征如何决定总量波动是否随经济体中部门数目的增多而消失以及以何种速度消失的问题。本文的主要结果刻画了一阶互联和高阶... 详细信息

本文提供了一个研究级联效应的一般框架。通过研究由供应网络联系在一起的多部门经济，我们探究了供应网络结构特征如何决定总量波动是否随经济体中部门数目的增多而消失以及以何种速度消失的问题。本文的主要结果刻画了一阶互联和高阶互联与总量波动之间的关系。高阶互联刻画了一些供应商的低效率或失败通过供应网络向经济体中的其他供应商进行传导的级联效应。我们还把尾部事件发生的概率与具体部门的波动和供应网络的结构特征联系在一起。

关键词：总量波动级联效应供应网络

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合约和技术选择

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经济资料译丛 2010年第4期 27-49页

作者： daron Acemoglu Pol Antras Elhanan Helpman 张婉琼（译）不详上海对外贸易学院国际经贸学院 201600

为了分析合约不完全、技术互补和技术选择的关系,我们构建了一个可分析处理的理论模型。在我们的模型中,企业在与中间投入供应商达成的可置约活动中选择自己的技术和投资水平,供应商则选择在不可置约的活动中的投资水平,并从事后议价中... 详细信息

为了分析合约不完全、技术互补和技术选择的关系,我们构建了一个可分析处理的理论模型。在我们的模型中,企业在与中间投入供应商达成的可置约活动中选择自己的技术和投资水平,供应商则选择在不可置约的活动中的投资水平,并从事后议价中获得支付。本文表明,合约越不完全,企业采用的技术则越不先进:中间投入的互补性越大,合约不完全程度的影响就越大。我们考察了该模型的一些应用,结果发现:我们所提出的机制在不同的国家和不同签约制度中产生了很大的生产率差异,而由不同签约制度产生的生产率差异会导致相当大的比较优势差异。

关键词：比较优势经济增长不完全合约技术选择公司理论

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Structure and Functional Implications of Chaperone Chz1 Complexed with Histones H2A.Z-H2B

Structure and Functional Implications of Chaperone Chz1 Comp...

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第十二届北京分析测试学术报告会暨展览会(BCEIA2...

作者： Zheng Zhou Hanqiao Feng D.Flemming Hansen Ed Luk Hidenori Kato daron I.Freedberg Lewis E.Kay Carl Wu Yawen Bai Department of Medical Genetics Biochemistry and Chemistry University of Toronto

＜正＞The packaging of the genome into chromatin is essential for normal growth,development,and differentiation of eukaryotic *** chaperones play important roles in the assembly and disassembly of nucleosomes,the fundamental structural units of *** yeast Chz1 is a recently discovered,intrinsically-disordered histone chaperone of H2A-H2B and its variant

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