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Short neuropeptide F in integrated insect physiology

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期25卷 389-409页

作者： Marcin CHOLEWINski Szymon CHOWANski Jan LUBAWY Arkadiusz URBANski Karolina WALKOWIAK-NOWICKA Paweł MARCINIAK Department of Animal Physiology and Developmental Biology Adam Mickiewicz UniversityPoznan 61-614Poland

The short neuropeptide F(sNPF)family of peptides is a multifunctional group of neurohormones involved in the regulation of various physiological processes in *** have been found in a broad spectrum of species,but the number of isoforms in the precursor molecule varies from one to *** receptor for sNPF(sNPFR),which belongs to the G protein-coupled receptor family,has been characterized in various insect orders and was shown to be an ortholog of the mammalian prolactin-releasing peptide receptor(PrPR).The sNPF signaling pathway interacts with other neurohormones such as insulin-like peptides,SIFamide,and pigment-dispersing factors(PDFs)to regulate various *** main physiological function of sNPF seems to be involved in the regulation of feeding,but the observed effects are *** is also connected with the regulation of foraging behavior and the olfactory *** influence of sNPF on feeding and thus energy metabolism may also indirectly affect other vital processes,such as reproduction and *** addition,these neurohormones are involved in the regulation of locomotor activity and circadian rhythm in *** review summarizes the current state of knowledge about the sNPF system in insects.

关键词： Insect neuropeptide Invertebrate neurobiology Short neuropeptide F(sNPF) Feeding Neurohormone

The g-factor measurement as an ultimate test for nuclear chirality

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Frontiers of physics 2024年第3期19卷 1-10页

作者： Ernest Grodner Michał Kowalczyk Julian Srebrny Leszek Próchniak Chrystian Droste Jan Kownacki Maciej Kisieliński Krzysztof Starosta Takeshi Koike National Centre for Nuclear Research 05-540ŚwierkPoland Heavy Ion Laboratory University of WarsawPasteura 5a02-093 WarsawPoland Faculty of Physics University of WarsawPasteura 502-093 WarsawPoland Simon Fraser University 8888 University Drive BurnabyB.C.Canada V5A 1S6 Department of Physics Tohoku UniversitySendaiMiyagi 980-8577Japan

We present results of a series of experiments aimed at finding the most direct fingerprints of a phenomenon of nuclear chirality. These experiments brought a detailed knowledge of the so called partner bands in 132La, 128Cs and 126Cs including absolute values of E2 and M1 transition probabilities obtained through the DSA (Doppler Shift Attenuation) method. Considering the indirect character of observables such as energies and transition rates we proposed measurement of the g-factor of a chosen state as a direct, ultimate test of chirality. Our experiment on the bandhead of partner bands in 128Cs showed feasibility of this approach. Measured value of the g-factor which suggests non-chiral character of this state leads to another puzzle in the chirality studies — how the chirality emerges with increasing spin of levels along a partner band.

关键词： nuclear chirality electromagnetic transitions electromagnetic moments level lifetimes

昆虫生理中短神经肽F的功能研究进展（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期 389-410页

作者： Marcin CHOLEWI?ski Szymon CHOWA?ski Jan LUBAWY Arkadiusz URBA?ski Karolina WALKOWIAK-NOWICKA Pawe? MARCINIAK 亚当密茨凯维奇大学生物学院动物生理学和发育生物学系

短神经肽F(sNPF)肽家族是参与调控昆虫体内各种生理过程的多功能神经激素。它们广泛分布于生物体中，但前体分子中的异构体数量因物种而异，从一个到四个不等。sNPF受体（sNPFR）属于G蛋白偶联受体家族，在多种昆虫目中已有表征，并被... 详细信息

短神经肽F(sNPF)肽家族是参与调控昆虫体内各种生理过程的多功能神经激素。它们广泛分布于生物体中，但前体分子中的异构体数量因物种而异，从一个到四个不等。sNPF受体（sNPFR）属于G蛋白偶联受体家族，在多种昆虫目中已有表征，并被证明是哺乳动物泌乳素释放肽受体（PrPR）的同源物。sNPF信号通路通过与其他神经激素（例如类胰岛素肽、SIFamide和色素分散因子（PDFs））的相互作用以调控多种生理过程。其主要生理功能涉及摄食的调节，但观察到的效应因物种而异。sNPF还与觅食行为和嗅觉系统的调节相关。其对摄食及能量代谢的影响还可能间接影响其他重要过程，例如繁殖和发育。此外，这些神经激素还参与昆虫的运动活动和昼夜节律的调节。本文回顾并总结了昆虫中sNPF系统的现阶段研究进展。

关键词：昆虫神经肽无脊椎动物神经生物学短神经肽F(sNPF) 摄食神经激素

Fabrication and comprehensive evaluation of Zr-based bulk metallic glass matrix composites for biomedical applications

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Science China Materials 2024年

作者： Mariusz Hasiak Beata Sobieszczańska Amadeusz ?aszcz Micha? Bia?y Jacek Ch?cmanowski Tomasz Zatoński Department of Mechanics Materials and Biomedical Engineering Wroc?aw University of Science and Technology Department of Microbiology Wroc?aw Medical University Department of Advanced Materials Technologies Wroc?aw University of Science and Technology Clinical Department of Otolaryngology Head and Neck Surgery Wroc?aw Medical University

The aim of this study is to fabricate Zr-based bulk metallic glass matrix composites（BMG-MCs） for biomedical usage and subject them to a comprehensive and farreaching analysis with respect to their mechanical properties,biocorrosion resistance, biocompatibility, and interactions with biofilms that all may arise from their chemical compositions and unusual disordered internal structure. In this study, we fabricate Zr40Ti15Cu10Ni10Be25, Zr50Ti15Cu10Ni10Be25,and Zr40Ti15Cu10Ni5Si5Be25alloys and confirm their glassy matrix nature through differential scanning calorimetry（DSC） and scanning electron microscopy（SEM） analyses. The mechanical properties, assessed via nanoindentation, demonstrate the high hardness, strength, and elasticity of the produced materials. Corrosion resistance is investigated in simulated body fluid, with Zr-based BMG-MCs exhibiting superior performance compared to conventional biomedical materials, including 316L stainless steel and Ti6Al4V *** is assessed using human fetal osteoblastic cell line hFOB 1.19, revealing low levels of cytotoxicity. The study also examines the potential for biofilm formation, a critical factor in the success of biomedical implantation, where bacterial infection is a major concern. Our findings suggest, as never reported before, that Zr-based BMG-MCs, with their unique composite glassy structure and excellent physicochemical properties, are promising candidates for various biomedical applications, potentially offering improved performance over traditional metallic biomaterials.

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Influence of processing history on microstructure， mechanical properties， and electrical conductivity of Cu-0.7Mg alloy

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Transactions of Nonferrous Metals Society of China 2024年

作者： Alireza KALHOR Kinga RODAK Marek TKOCZ Bartosz CHMIELA Ivo SCHINDLER ?ukasz POLOCZEK Krzysztof RADWA?ski Hamed MIRZADEH Marian KAMPIK Faculty of Materials Engineering， Silesian University of Technology V?B – Technical University of Ostrava， Faculty of Materials Science and Technology Materials Research Group， ?ukasiewicz Upper Silesian Institute of Technology School of Metallurgy and Materials Engineering， College of Engineering， University of Tehran Faculty of Electrical Engineering， Silesian University of Technology

The effects of forward extrusion as well as extrusion combined with reversible torsion (KoBo extrusion)， followed by additional deformation via the MaxStrain module of the Gleeble thermomechanical simulator， on the microstructure， mechanical properties， and electrical conductivity of a Cu-0.7Mg (wt.%) alloy， were investigated in this work. The simulation results highlighted the critical influence of processing history in determining the equivalent strain distribution. The sample subjected to forward extrusion at 400 ℃and subsequent MaxStrain processing (FM sample)， possessed 76% lower grain size compared to the sample processed solely with MaxStrain (AM sample). Likewise， the KoBo-extruded and MaxStrain-processed sample (KM sample) exhibited 66% smaller grain size compared to the AM sample. Tensile test results revealed that the AM， FM， and KM samples， respectively， possessed 251%， 288%， and 360% higher yield strength， and 95%， 121%， and 169% higher tensile strength compared to the initial annealed alloy， as a result of grain refinement as well as deformation strengthening. Finally， the electrical conductivity measurements revealed that AM， FM， and KM samples， respectively， possessed electrical conductivity values of 37.9， 35.6， and 32.0 (MS/m)， which， considering their mechanical properties， makes them eligible to be categorized as high-strength and high-conductivity copper alloys.

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Amylase intrapancreatic infusion delays insulin release during an intravenous glucose tolerance test,proof of acini–islet–acinar interactions

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World Journal of Experimental Medicine 2024年第3期14卷 101-107页

作者： Kateryna Pierzynowska Piotr Wychowański Kamil Zaworski Jarosław Woliński Janine Donaldson Dominika Szkopek Katarzyna Roszkowicz-Ostrowska Agata Kondej Stefan G Pierzynowski Department of Biology Lund UniversityLund 22362Sweden Department of Animal Physiology The Kielanowski Institute of Animal Physiology and NutritionPolish Academy of SciencesJabłonna 05110Poland Anara AB Trelleborg 23132Sweden Department of Head and Neck and Sensory Organs Division of Oral Surgery and ImplantologyInstitute of Clinical DentistryGemelli Foundation for the University PoliclinicCatholic University of the“Sacred Heart”Rome 00168Italy Department of Oral Surgery Medical University of GdańskGdańsk 80211Poland Laboratory of Large Animal Models The Kielanowski Institute of Animal Physiology and NutritionPolish Academy of SciencesJabłonna 05110Poland School of Physiology Faculty of Health SciencesUniversity of the Witwatersrand(WITS)Johannesburg 2050South Africa Department of Medical Biology Institute of Rural HealthLublin 20090Poland

BACKGROUND The possible existence of an acini–islet–acinar(AIA)reflex,involving mutual amylase and insulin interactions,was investigated in the current acute experiment on *** To confirm the existence of an AIA reflex and justify the placement of the exocrine and endocrine pancreatic components within the same *** The study was performed on six pigs under general *** intravenous glucose tolerance test was performed,with a bolus infusion of 50%glucose to the jugular vein,while amylase(5000 U/kg)or vehicle intrapancreatic infusions were administered via the pancreaticoduodenalis cranialis artery during 30 min with a 1 mL/min flow *** The amylase infusion to pancreatic arterial circulation inhibited and delayed the insulin release peak which is usually associated with the highest value of blood glucose and is typically observed at 15 min after glucose infusion,for>1 *** intrapancreatic infusion of the vehicle(saline)did not have any effect on the time frame of insulin *** of 1%bovine serum albumin changed the insulin release curve dramatically and prolonged the high range of insulin secretion,far beyond the glucose *** Intrapancreatic arterial infusion of amylase interrupted the integrated glucose–insulin *** confirms an AIA reflex and justifies placement of the exocrine and endocrine pancreatic components within the same organ.

关键词： Amylase Glucose-insulin-amylase interaction Intravenous glucose tolerance test Acini-islet-acinar axis Insulin

Risk of Flash Floods in Urban and Rural Municipalities Triggered by Intense Precipitation in Wielkopolska of Poland

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International Journal of Disaster Risk Science 2023年第3期14卷 440-457页

作者： Iwona Pińskwar Adam Choryński dariusz Graczyk Department of Land Improvement Environmental Development and Spatial ManagementFaculty of Environmental Engineering and Mechanical EngineeringPoznan University of Life Sciences60-649 PoznanPoland Meteorology Laboratory Department of Construction and GeoengineeringFaculty of Environmental Engineering and Mechanical EngineeringPoznan University of Life Sciences60-649 PoznanPoland

This research analyzed interventions of State Fire Service(SFS)units in the Wielkopolska region of Poland that were triggered by extreme precipitation for the period *** results demonstrated that the most populated and urbanized towns in the Wielkopolska(Greater Poland,west of Warsaw)region are at the most risk in the event of extreme precipitation occurrence as measured by the total number of interventions made by the *** number of SFS unit interventions in towns,standardized to 10,000 inhabitants,indicates that the highest proportional volume of interventions also occurred in smaller *** the rural municipalities the number of SFS unit interventions increases along with higher population density and proportion of infrastructure *** analyzed in this study,the 12 years from 2010 to 2021 were characterized by a higher number of days with heavy precipitation,for example,20,30,40,and 50 mm,in comparison to the previous periods 1961-2010 and *** databases collected by emergency services are a valuable source of information for hazard *** on those and other available data,a statistical model was created and factors influencing the local and regional occurrence of interventions were *** suburbanization,the rising proportion of impermeable surfaces,and the impact of climate change are of considerable importance in urban flood *** is necessary to help municipalities develop abilities to absorb larger amounts of rainwater.

关键词： Flash flood risk Poland Risk exposure Social vulnerability State Fire Service Wielkopolska

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Application of a Lumped Multi-Section Model for Analyzing the Thermal Performance of a Small-Scale Biomass Boiler

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Journal of Thermal Science 2021年第3期30卷 1034-1045页

作者： POLESEK-KARCZEWSKA Sylwia WARDACH-ŚWIĘCICKA Izabela KARDAŚdariusz TURZYŃski Tomasz Renewable Energy Department Szewalski Institute of Fluid-Flow MachineryPolish Academy of SciencesFiszera 14PL 80-231 GdańskPoland

The stationary lumped-cell model was developed and used to simulate the thermal characteristics of domestic biomass boiler with helically coiled tube heat exchanger(HCHE).The device serves as the heat source for ORC(Organic Rankine Cycle)unit and utilizes the thermal oil as the medium transferring the heat to the *** of studies available in the literature refer to the CFD simulations for water flow in tube coils or in one-or two-turn coil *** investigations are basically focused on the determination of Nusselt *** proposed herein model aims at determining the thermal performance of flue gas-oil HCHE while providing low CPU *** demonstrate the model possibilities,it was used to predict the flue gas temperatures at the inlet and outlet from the heat exchange zone,based on measurement data regarding the outlet temperature of thermal *** test series were *** computation results appeared to be in satisfactory agreement with experimental results(the discrepancies do not exceed 12%).The investigations showed that the used approach may be recommended as an alternative method that allows for fast prediction of thermal parameters for units of complex geometries,in particular the multi-coil heat exchangers.

关键词： lumped cell-model biomass boiler helically coiled tube heat exchanger

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Bone graft incorporation failure with inappropriate limb load transfer can lead to aseptic acetabular loosening of metal-on-metal prosthesis: A case report

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World Journal of Orthopedics 2024年第7期15卷 668-674页

作者： RafałStanisław Domagalski Bogdan Dugiełło Sonia Rokicka Szymon Czech RafałSkowroński Dominika Rokicka Marta Patrycja Wróbel Krzysztof Strojek Tomasz Stołtny District Hospital of Orthopaedics and Trauma Surgery in PiekaryŚląskie PiekaryŚląskie 41-940Poland District Railway Hospital Medical University of SilesiaKatowice 40-760Poland Faculty of Medicine Medical University of GdańskGdańsk 80-210Poland “ALFA”Orthopaedics and Traumatology Center Białystok 15-763Poland Department of Internal Medicine Diabetology and Cardiometabolic DisordersFaculty of Medical Sciences ZabrzeMedical University of SilesiaZabrze 41-800Poland

BACKGROUND Aseptic acetabular loosening can result from various factors that can be categorized into groups:patient-related,surgeon-related and *** present a case of a 63-year-old patient who at first underwent a total hip arthro-plasty(THA)using a metal-on-metal bearing due to hip ***-up visits revealed no complications after the *** years after the THA,acetabular component loosening occurred due to subsequent trauma of the opposite hip,necessitating a revision THA using a ceramic-on-ceramic *** SUMMARY We aim to illustrate a rare case where the primary reason for undergoing THA revision was not only incomplete bone graft incorporation but also improper limb load *** the revision arthroplasty,a 9-year follow-up visit revealed improvements in all evaluation measures on questionnaire compared to the state before surgery:Harris Hip Score(before surgery:15;after surgery:95),Western Ontario and McMaster Universities Arthritis Index(before surgery:96;after surgery:0),and Visual Analogue Scale(before surgery:10;after surgery:1).CONCLUSION Opposite-hip trauma caused a weight transfer to the limb after a THA *** process led to a stress shielding effect,resulting in acetabular component loosening.

关键词： Acetabular loosening Limb load Stress shielding effect Revision hip arthroplasty Case report