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Quality Evaluation of Fermented Mulberry Wine

Agricultural Biotechnology 2024年第3期13卷 48-54页

作者： Lei ZHANG Jiarui HUANG yu QI Yimin WANG Shuzhen WANG Feng HE Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie MountainsHuanggang Normal UniversityHuanggang 438000China LiShizhen Culture and Industry Research Center of Traditional Chinese Medicine Huanggang Normal University Huanggang 438000China

[Objectives]This study to conducted to clarify various nutritional components and the composition and contents of aromatic substances in mulberry wine prepared by fermentation,and promote the quality improvement and product development of mulberry wine.[Methods]Mulberry wine was prepared with mulberry Shengguo 1 as the material using Saccharomyces cerevisiae,and its contents of total sugars,total phenols,total acids,resveratrol,protein,dry extract,ethanol content,Fe,methanol,sulfur dioxide,volatile acids,total flavonoids and proanthocyanidins were *** substances were extracted by n-hexane,and their components and relative contents were determined by gas chromatography-mass spectrometry(GC-MS).[Results]The physical and chemical indexes of the mulberry wine prepared by fermentation were in accordance with the national standards,and it was rich in resveratrol(10.5±0.6 mg/L),protein(381±11 mg/L),total flavonoids(406±18 mg/L)and proanthocyanidins(855±22 mg/L),which were 8.95,19.49,3.76 and 1.63 times higher than those of grape wine,*** aromatic substances were mainly composed of ethyl formate(9.9%),ethyl acetate(7.6%),acetal(6.2%),propanol(5.7%),isobutanol(5.6%)and isoamyl acetate(5.3%).[Conclusions]The results of this study demonstrated that mulberry wine was rich in active substances,which suggested that mulberry wine has great potential in the fruit wine market.

关键词： Mulberry wine Resveratrol Proanthocyanidin Total flavonoid Aromatic substance

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BaTiO_(3)纳米单晶薄膜在外加电场作用下畴结构演化的相场研究

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人工晶体学报 2024年第7期53卷 1136-1149页

作者：李昊晴苏煜北京理工大学宇航学院北京100081

铁电薄膜的工作电场加载频率及基底失配应变可影响微观畴结构形态和材料宏观铁电性能。本文利用相场模拟方法分别研究了在-0.1%、-0.7%的失配应变下,0.1~100 kHz频率范围内BaTiO_(3)纳米单晶薄膜的铁电性能变化规律。研究发现,随着外加... 详细信息

铁电薄膜的工作电场加载频率及基底失配应变可影响微观畴结构形态和材料宏观铁电性能。本文利用相场模拟方法分别研究了在-0.1%、-0.7%的失配应变下,0.1~100 kHz频率范围内BaTiO_(3)纳米单晶薄膜的铁电性能变化规律。研究发现,随着外加电场频率的增大,薄膜电滞回线由四方形向椭圆形转变,标准蝶形曲线向腰果形曲线发生改变。在50 kHz以下的低频段,矫顽场随频率增加而快速升高,但剩余极化强度变化幅度不大;而在50 kHz以上的高频段,矫顽场随频率增加略有升高,剩余极化强度则呈下降趋势。在低频段下铁电性能的频率依赖性受失配应变的影响较大,而在高频段下则对失配应变不敏感。同时发现,压缩失配应变可导致剩余极化及矫顽场显著升高,而拉伸应变的效果相反。分析表明,BaTiO_(3)纳米单晶薄膜铁电性能的频率依赖性源自内部微结构演化速度与外电场施加速率的相互竞争。本研究可为铁电功能薄膜材料的实验设计提供理论基础,为其在高频电子器件中的应用提供有力支撑。

关键词：铁电薄膜相场方法钛酸钡纳米单晶薄膜金兹堡-朗道方程频率效应失配应变

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儿童遗传性胰腺炎的研究进展

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临床肝胆病杂志 2024年第8期40卷 1709-1714页

作者：于晓政吴捷国家儿童医学中心首都医科大学附属北京儿童医院消化科北京100045

遗传性胰腺炎是儿童胰腺炎的主要致病因素之一,成年后癌变风险高。本文综述了遗传性胰腺炎的研究进展,包括历史发展、流行病学、致病机制及相关致病基因、临床特征与诊断及治疗等,旨在为延缓儿童遗传性胰腺炎疾病进程及基础研究提供新... 详细信息

遗传性胰腺炎是儿童胰腺炎的主要致病因素之一,成年后癌变风险高。本文综述了遗传性胰腺炎的研究进展,包括历史发展、流行病学、致病机制及相关致病基因、临床特征与诊断及治疗等,旨在为延缓儿童遗传性胰腺炎疾病进程及基础研究提供新的参考信息。

关键词：遗传性胰腺炎体征和症状治疗学儿童

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基于深度学习的细骨料图像实时分割提取

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合肥工业大学学报（自然科学版） 2024年第5期47卷 712-720页

作者：宇周亮洪丽詹炳根余其俊合肥工业大学土木与水利工程学院安徽合肥230009 土木工程结构与材料安徽省重点实验室安徽合肥230009

文章基于深度学习算法对细骨料投影图像进行分割,通过对比传统阈值分割与PSPNet、DeepLab V3+、U-Net深度学习网络模型算法的分割结果对4种模型进行评价分析,同时实验对比细骨料2种等效粒径计算方法(单面投影法、双面投影法)的粒径和级... 详细信息

文章基于深度学习算法对细骨料投影图像进行分割,通过对比传统阈值分割与PSPNet、DeepLab V3+、U-Net深度学习网络模型算法的分割结果对4种模型进行评价分析,同时实验对比细骨料2种等效粒径计算方法(单面投影法、双面投影法)的粒径和级配分布结果。结果表明:深度学习模型算法中U-Net网络模型的准确率、召回率、F平衡分数和交并比分别达到99.8%、88.1%、84.9%、84.3%,均优于对比组模型;对于3种不同粒径的单粒段细骨料,采用双面投影法计算出的细骨料等效粒径D d与实际细骨料粒径的偏差分别为1.40%、2.10%、3.12%;对于混合粒段骨料,采用等效粒径D d计算出的级配分布曲线更接近筛分法的实验结果,具有普遍适用性。研究结果可为细骨料径粒径和粒型参数的计算提取提供新的思路。

关键词：细骨料阈值分割深度学习算法等效粒径细骨料粒型参数

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Percutaneous cervical cordotomy for managing refractory pain in a patient with a Pancoast tumor:A case report

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World Journal of Clinical Cases 2024年第21期12卷 4770-4776页

作者： Kuan-yu Lu Feng-Sheng Lin Chia-Shiang Lin Hsuan-Chih Lao Department of Anesthesiology MacKay Memorial HospitalTaipei 10449Taiwan Department of Anesthesiology National Taiwan University HospitalTaipei 10002Taiwan Department of Anesthesiology Shuang-Ho HospitalTaipei 23561Taiwan Institute of Brain Science College of MedicineNational Yang Ming Chiao Tung UniversityTaipei 11203Taiwan Department of Medicine MacKay Medical CollegeTaipei 23245Taiwan

BACKGROUND According to the World Health Organization analgesic ladder,cancer-related pain generally begins with pharmacotherapy in a stepwise ***,some patients continue to experience poorly controlled pain despite medications,particularly when considering adverse effects and self-care *** cervical cordotomy is an alternative interventional procedure for unremitting unilateral intractable cancer-related *** SUMMARY The patient was diagnosed with lung cancer with destruction of the brachial plexus and *** 2 mo,the patient experienced progressive severe weakness and pain in the right upper ***,the pain intensity reached an extreme level,particularly when lying supine,even under heavy *** heightened pain response posed a significant challenge;as a result,the patient was unable to undergo further evaluation through magnetic resonance ***,he underwent percutaneous cervical cordotomy for symptom relief,resulting in complete resolution of right arm *** a 3-mo follow-up,the pain did not recur,and only a flurbiprofen local patch was required for mild scapular *** Cordotomy,under careful patient selection,appears to enhance the quality of life of patients with unilateral cancerrelated pain.

关键词： Cordotomy Cancer pain Intractable pain Fluoroscopy Radiofrequency therapy Case report

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Two polyoxovanadoborates with over 100 nuclei assembled from a {VCoB} cluster

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Science China Chemistry 2024年

作者： Shuang-Xue Wu yu-Jiao Dong Yang Yang Chao Qin Chun-Yi Sun Wei Guan Xin-Long Wang Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Northeast Normal University School of Chemistry and Environmental Engineering Changchun University of Science and Technology Key Laboratory of Advanced Materials of Tropical Island Resources Hainan University

Combining theoretical prediction and experimental exploration,the first sandwich-type polyoxovanadoborate (POVB) with an odd number of nuclei,[V11B26O73(OH)10]8-(1),was discovered under hydrothermal ***-functional theory (DFT)gives a rationalization for the existence of this structure and the structural feature is consistent with the{VNB2N+X}(X=2,4,6,8)general ***,when Co and 1,10-phenanthroline (phen) are introduced into the synthesis of vanadoborates system,a 100-nuclei[Co6(phen)10(H2O)8][V14Co12B72O144(OH)20]·28H2O (2) and a 102-nuclei[Co6(phen)14(H2O)4][V14Co12B72O144(OH)20]·23H2O (3) with the same core structure of[V14Co12B72]12-are *** vase-shaped[V14Co12B72]polyanion is a multilayered sandwich-type structure containing seven distinct structural layers and is the largest known ***,2demonstrates exceptional thermal and chemical stability and serves as an efficient and stable catalyst for the photoreduction of carbon dioxide.

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习近平法治思想中的海洋法治要义

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河北法学 2024年第2期42卷 16-34页

作者：白佳玉李晓玉南开大学法学院天津300350

新时代海洋法治建设是我国实现海洋强国战略、参与全球海洋治理的重要路径,它蕴含在习近平法治思想之中,二者相互结合,共同发挥作用。习近平法治思想对海洋法治建设的理论与实践层面均具有重大指导意义。在百年未有之大变局下,海洋法治... 详细信息

新时代海洋法治建设是我国实现海洋强国战略、参与全球海洋治理的重要路径,它蕴含在习近平法治思想之中,二者相互结合,共同发挥作用。习近平法治思想对海洋法治建设的理论与实践层面均具有重大指导意义。在百年未有之大变局下,海洋法治建设能够充分维护国家海洋权益,保障国家海洋安全,推动海洋发展繁荣,实现全球海洋治理理念的伟大创新。习近平法治思想是保障新时代海洋法治稳步推进的理论源泉,在中国式现代化新阶段中,谱写新时代海洋法治建设新篇章可从以下层面逐步进行:首先健全涉海法律体系、进而统筹国内法治与涉外法治,协调国内法治与国际法治,再通过积极参与制定全球海洋治理规则的方式、坚持以国际海洋法治为基础的全球海洋秩序构建,最终在海洋命运共同体理念的指引下促进全球海洋善治的实现,为全人类海洋事业的发展作出更大的贡献。

关键词：海洋治理海洋法治海洋强国中国共产党第二十次全国代表大会中国式现代化

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2SWUNet: small window SWin UNet based on tansformer for building extraction from high-resolution remote sensing images

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Optoelectronics Letters 2024年第10期 599-606页

作者： yu Jiamin CHAN Sixian LEI Yanjing WU Wei WANG yuan ZHOU Xiaolong College of Computer Science and Technology Zhejiang University of Technology Key Laboratory of Meteorological Disaster(KLME) Ministry of Education & Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science &Technology College of Geographic Information Modern Industry Zhejiang University of Technology College of Electrical and Information Engineering Quzhou University

Models dedicated to building long-range dependencies often exhibit degraded performance when transferred to remote sensing images. Vision transformer(Vi T) is a new paradigm in computer vision that uses multi-head self-attention(MSA) rather than convolution as the main computational module, with global modeling capabilities. However, its performance on small datasets is usually far inferior to that of convolutional neural networks(CNNs). In this work, we propose a small window SWin UNet(2SWUNet) for building extraction from high-resolution remote sensing images. Firstly, the 2SWUNet is trained based on swin transformer by designing a fully symmetric encoder-decoder U-shaped architecture. Secondly, to construct a reasonable U-shaped architecture for building extraction from high-resolution remote sensing images, different forms of patch expansion are explored to simulate up-sampling operations and recover feature map resolution. Then, the small window-based multi-head self-attention(W-MSA) is designed to reduce the computational and memory burden, which is more appropriate for the features of remote sensing images. Meanwhile, the pre-training mechanism is advanced to make up for the lack of decoder parameters. Finally, comparison experiments with other mainstream CNNs and Vi Ts validate the superiority of the proposed model.

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Association of education with cholelithiasis and mediating effects of cardiometabolic factors:A Mendelian randomization study

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World Journal of Clinical Cases 2024年第20期12卷 4272-4288页

作者： Chang-Lei Li yu-Kun Liu Ying-Ying Lan Zu-Sen Wang Department of Hepatobiliary and Pancreatic Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Oncology Medicine The Affiliated Hospital of Qingdao UniversityQingdao 266002Shandong ProvinceChina

BACKGROUND Education,cognition,and intelligence are associated with cholelithiasis occurrence,yet which one has a prominent effect on cholelithiasis and which cardiometabolic risk factors mediate the causal relationship remain *** To explore the causal associations between education,cognition,and intelligence and cholelithiasis,and the cardiometabolic risk factors that mediate the *** Applying genome-wide association study summary statistics of primarily European individuals,we utilized two-sample multivariable Mendelian randomization to estimate the independent effects of education,intelligence,and cognition on cholelithiasis and cholecystitis(FinnGen study,37041 and 11632 patients,respectively;n=486484 participants)and performed two-step Mendelian randomization to evaluate 21 potential mediators and their mediating effects on the relationships between each exposure and *** Inverse variance weighted Mendelian randomization results from the FinnGen consortium showed that genetically higher education,cognition,or intelligence were not independently associated with cholelithiasis and cholecystitis;when adjusted for cholelithiasis,higher education still presented an inverse effect on cholecystitis[odds ratio:0.292(95%CI:0.171-0.501)],which could not be induced by cognition or *** out of 21 cardiometabolic risk factors were perceived as mediators of the association between education and cholelithiasis,including body mass index(20.84%),body fat percentage(40.3%),waist circumference(44.4%),waist-to-hip ratio(32.9%),and time spent watching television(41.6%),while time spent watching television was also a mediator from cognition(20.4%)and intelligence to cholelithiasis(28.4%).All results were robust to sensitivity *** Education,cognition,and intelligence all play crucial roles in the development of cholelithiasis,and several cardiometabolic mediators have been identified for prevention of choleli

关键词： Cholelithiasis Mendelian randomization Mediation analysis Education attainment Cardiometabolic risk factors Cognition Intelligence

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香豆素降低PARP10表达抑制人结肠癌细胞HCT116增殖

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复旦学报（自然科学版） 2024年第2期63卷 246-256页

作者：朱李亮余巍复旦大学生命科学学院上海200438

PARP10是ADP-核糖基转移酶家族PARPs的一员,大量分布于细胞质和细胞核中,在细胞免疫应答、转录调控、DNA损伤修复、周期调节等生理过程中起着重要作用。PARP10可通过影响多种信号通路来促进肿瘤细胞的增殖与侵袭,已被发现参与了包括前... 详细信息

PARP10是ADP-核糖基转移酶家族PARPs的一员,大量分布于细胞质和细胞核中,在细胞免疫应答、转录调控、DNA损伤修复、周期调节等生理过程中起着重要作用。PARP10可通过影响多种信号通路来促进肿瘤细胞的增殖与侵袭,已被发现参与了包括前列腺癌、乳腺癌、胃癌、肝癌等恶性肿瘤的发生过程。本研究通过生物信息学分析以及生化实验证明PARP10在结肠癌细胞的发生发展中也发挥重要作用。敲低PARP10的表达可以显著抑制肿瘤细胞增殖并促进其凋亡。通过筛选,我们发现香豆素(Coumarin)这一天然生物活性化合物可以抑制肿瘤细胞的增殖,并初步证明香豆素通过抑制结肠癌细胞中PARP10蛋白表达而降低结肠癌细胞的增殖能力。本研究为深入理解PARP10在结肠癌中作用以及相关的药物研发提供了新的思路。

关键词：香豆素 PARP10 结肠癌

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