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疯狂英语（初中天地） 2012年第4期 46-48页

作者： daphne Liu 芥子

长期以来，地球——我们的家园一直得不到人类的重视。气候变化继续加剧，每一日地球都在上演不同的环境灾难。在世界地球日到来之际，我们再一次呼吁大家保护资源环境，善待地球。再不行动就来不及了!

关键词：世界地球日资源环境气候变化灾难

Staging accuracy of esophageal cancer by endoscopic ultrasound:A meta-analysis and systematic review

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World Journal of Gastroenterology 2008年第10期14卷 1479-1490页

作者： Srinivas R Puli Jyotsna BK Reddy Matthew L Bechtold daphne Antillon Jamal A Ibdah Mainor R Antillon Division of Gastroenterology and Hepatology University of Missouri-Columbia Columbia Missouri 65212 United States

AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) in the staging of esophageal cancer. METHODS: Only EUS studies confirmed by surgery were selected. Articles were searched in Medline and Pubmed. Two reviewers independently searched and extracted data. Meta-analysis of the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratio. Pooling was conducted by both the Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS: Forty-nine studies (n = 2558) which met the inclusion criteria were included in this analysis. Pooled sensitivity and specificity of EUS to diagnose T1 was 81.6% (95% CI: 77.8-84.9) and 99.4% (95% CI: 99.0-99.7), respectively. To diagnose T4, EUS had a pooled sensitivity of 92.4% (95% CI: 89.2-95.0) and specificity of 97.4% (95% CI: 96.6-98.0). With Fine Needle Aspiration (FNA), sensitivity of EUS to diagnose N stage improved from 84.7% (95% CI: 82.9-86.4) to 96.7% (95% CI: 92.4-98.9). The P value for the χ2 test of heterogeneity for all pooled estimates was > 0.10. CONCLUSION: EUS has excellent sensitivity and specificity in accurately diagnosing the TN stage of esophageal cancer. EUS performs better with advanced (T4) than early (T1) disease. FNA substantially improves the sensitivity and specificity of EUS in evaluating N stage disease. EUS should be strongly considered for staging esophageal cancer.

关键词：食管癌癌症分级内窥镜超声波检查法元分析

Shallow Subsurface Stratigraphy Inferred from the Use of Vertical Electrical Soundings (VES) Survey in Central Chihuahua, Mexico

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Open Journal of Geology 2019年第1期9卷 15-28页

作者： Alejandro Villalobos-Aragón Vanessa V. Espejel-García daphne Espejel-García Lucio Rivas-Lobera Facultad de Ingeniería Universidad Autónoma de Chihuahua Chihuahua México

Vertical Electrical Soundings (VES) provide fast and economical measurements used in geophysical exploration. VES were carried out in El Sauz-Encinillas (ESE) aquifer, in northern Mexico, to determine apparent resistivity and geoelectrical units’ thickness. Despite it being one of the three main aquifers feeding Chihuahua city, a lack of available geophysical data prevails in its northern portion. The main goal of this study was the determination of the geoelectrical units in the subsurface stratigraphy via electrical-resistivity soundings. The ESE’ aquifer is located within alluvial Quaternary sediments, with varying granulometry and reaching from a few meters to more than 600 meters of thickness at the center of the valley. Forty-five vertical electrical resistivity soundings (Schlumberger array, maximum AB/2 distance of 500 m) were performed throughout ESE aquifer’s northern portion. Field data were analyzed using software. Results illustrate a wide variability in resistivity values throughout the study area. Five geoelectrical units were identified: 1) a hardpan topsoil, with resistivity values ranging from 200 - 800 Ω-m;2) an alluvial material mixture (sand/silt) with resistivity values ranging from 25 to 100 Ω-m;3) playa lake-type material (clay/evaporites mixture) with resistivity values ranging from 0.2 to 15 Ω-m;4) a gravel/sand mixture with resistivity values from 100 to 300 Ω-m;and 5) a partly fractured rock or conglomeratic material with resistivity values ranging from 400 to 3500 Ω-m. The electrical resistivity data, therefore gives reasonably accurate results that can be used to understand the subsurface stratigraphy and basement configuration in groundwater exploration.

关键词： Geophysics Vertical Electric Soundings Geoelectrical Sections

Groundwater Quality and Its Impact on Health: A Preliminary Evaluation of Dental Fluorosis in Julimes, Chihuahua, Mexico

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Journal of Water Resource and Protection 2020年第7期12卷 545-557页

作者： Aida Verónica Ontiveros-Terrazas Alejandro Villalobos-Aragón Vanessa Verónica Espejel-García daphne Espejel-García Facultad de Ingeniería Universidad Autónoma de Chihuahua Chihuahua México

Medical Geology can be defined as the branch of geology dealing with the relationship between natural geological aspects and health in organisms (humans and animals), trying to determine the influence of ordinary environmental factors on the geographical distribution of health issues. The main goals of this research were: 1) to evaluate the severity of dental fluorosis (DF) and fluoride concentration in groundwater, used for human consumption, as an indicator of overexposure to fluorides, 2) to estimate the Community Fluorosis Index (CFI) in the Julimes municipality in Chihuahua, Mexico. Nine water samples were collected in four locations in the Julimes area: Hacienda Humboldt, La Regina, Colonia San Jose, and Julimes. Samples were collected and stored in accordance with the Mexican standard (NOM-014-SSA1-1993). All the samples exceeded the maximum permissible limit established in the modified Mexican standard (NOM-127-SSA1-1994) of 1.5 mgL-1 for fluoride in water for human consumption. Average concentrations of 2.74 mgL-1 were found in Colonia San Jose, 2.19 mgL-1 in La Regina, 2.17 mgL-1 in Julimes and 2.06 mgL-1 in Hacienda Humboldt. Dental Fluorosis diagnosis was evaluated using the Dean Index and the CFI applied to residents. A total of 100 inhabitants were examined, with interviews and oral examinations also carried out. Dental Fluorosis prevalence was 92% overall for the municipality, while for Colonia San Jose was of 100%, of 88.89% for Hacienda Humboldt, 88.24% for Julimes and 96% for La Regina. Dental Fluorosis’ severity for the Julimes municipality was distributed as follows: 2% normal, 6% questionable, 8% very mild, 13% mild, 19% moderate, and 52% severe. An average CFI was found for the four localities of 3.02 points, with a very notable impact on public health.

关键词： Dental Fluorosis Dean Index Community Fluorosis Index Chihuahua

乌司奴单抗改善中、重度斑块状银屑病患者健康相关生活质量和临床疗效观察

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临床皮肤科杂志 2014年第9期43卷 521-526页

作者：朱学骏郑敏 Michael Song Chenglong Han daphne Chan Y.K.Shen 王宝玺北京大学第一医院皮肤科北京100034 浙江大学医学院附属第二医院皮肤科浙江杭州310009 Janssen研发有限责任公司美国宾夕法尼亚州19415 Janssen全球服务有限责任公司美国宾夕法尼亚州19415 中国医学科学院北京协和医学院皮肤病研究所江苏南京210042

目的:评估乌司奴单抗对中国3期、双盲、安慰剂对照临床(LOTUS)研究患者健康相关生活质量(HRQoL)的影响。方法:共322例患者,在第0周和第4周随机接受乌司奴单抗45mg(n=160)或安慰剂(n=162);第12周和第16周安慰剂组交叉使用乌司奴单抗,而... 详细信息

目的:评估乌司奴单抗对中国3期、双盲、安慰剂对照临床(LOTUS)研究患者健康相关生活质量(HRQoL)的影响。方法:共322例患者,在第0周和第4周随机接受乌司奴单抗45mg(n=160)或安慰剂(n=162);第12周和第16周安慰剂组交叉使用乌司奴单抗,而乌司奴单抗组则在第16周继续使用乌司奴单抗。第12周HRQoL终点包括皮肤病生活质量指数(DLQI)评分较基线的变化、单个DLQI域的变化、DLQI评分为0分或1分的患者比例以及获得有临床意义DLQI改善(评分降低≥5分)的患者比例。结果:乌司奴单抗治疗患者12周时DLQI评分较基线的改善(-9.3分)显著优于安慰剂组(-1.9分)(P<0.001)。同样,乌司奴单抗治疗后DLQI≤1分的患者比例显著高于安慰剂组(42.6%vs 10.7%,P<0.001),乌司奴单抗组和安慰剂组治疗后分别有71.5%和29.6%的患者DLQI降低≥5分(P均<0.001)。乌司奴单抗治疗患者12周时单个DLQI域与安慰剂相比显著改善(P<0.001)。乌司奴单抗组DLQI的改善在治疗28周内持续存在。交叉接受乌司奴单抗的安慰剂组患者,与最初随机接受乌司奴单抗治疗的患者相比,HRQoL改善程度类似。结论:乌司奴单抗显著改善了中国中至重度斑块状银屑病患者的HRQoL。

关键词：银屑病乌司奴单抗健康相关生活质量

婴儿是如何学会看东西的?--根据达夫妮·莫伊雷尔教授在婴幼儿发展与托育国际学术会议上的报告整理

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健康研究 2023年第4期43卷 361-364页

作者：达夫妮·莫伊雷尔麦克马斯特大学加拿大哈密尔顿L8S 4L8

婴儿在出生时,生理上便已经做好看世界的准备。他们可以看到较大条纹,偏爱像面孔那样顶部比重大的事物;他们也可以区分人脸,并很快学会辨认母亲。这些技能会不断完善,直到视觉发展达到成年水平。文章从视敏度、面孔知觉和面孔识别这3种... 详细信息

婴儿在出生时,生理上便已经做好看世界的准备。他们可以看到较大条纹,偏爱像面孔那样顶部比重大的事物;他们也可以区分人脸,并很快学会辨认母亲。这些技能会不断完善,直到视觉发展达到成年水平。文章从视敏度、面孔知觉和面孔识别这3种视觉能力的发展,以及视觉剥夺对视觉发展的影响来阐述婴幼儿的视觉发展。

关键词：婴幼儿视觉剥夺视敏度面孔知觉面孔识别

A Comparison among Manual and Automatic Calibration Methods in VISSIM in an Expressway (Chihuahua, Mexico)

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Open Journal of Civil Engineering 2017年第4期7卷 539-552页

作者： daphne Espejel-Garcia Jose Alejandro Saniger-Alba Gilberto Wenglas-Lara Vanessa Veronica Espejel-Garcia Alejandro Villalobos-Aragon Facultad de Ingenieria Universidad Autonoma de Chihuahua Chihuahua Mexico PTV Group Mexico Ciudad de Mexico Mexico

Traffic microsimulation is an essential tool in urban transportation and road planning. Its calibration is essential to attain representative results validated with real-world conditions. VISSIM (Verkehr in Städten—SIMulationsmodell) operates with the Wiedemann’s psycho-physical car-following model for freeway travel that considers safety distances (standstill and movement) during simulation. Calibration in this paper was achieved by using two different approaches: a) manual and b) genetic algorithm (with the GEH statistic formula) calibration techniques. Calibration and validation of this model were performed at the Periferico de la Juventud expressway in Chihuahua City, in northern Mexico. The Periferico de la Juventud (PDJ) has a N-S orientation and a length of ca. 20 km, with its northern section being its most congested portion. Its highest vehicle volume occurs at noon, with 3700 vehicles per hour, with 95% being passenger cars and the other 5% heavy goods vehicles. PDJ’s speed limit is 70 km·h-1, but the driver’s behavior has a tendency towards the aggressive performance. A total of 82 standstill and 82 look-ahead distances were obtained from unmanned aerial vehicles (UAV) images, with values ranging from 0.8 to 4.7 m and from 0.2 to 28 m, respectively. VISSIM calibrated parameter values were calculated for this expressway, being slightly above than the VISSIM default ones;and was validated with travel times and look-ahead distances. Results contribute information for the city’s future installment of public transportation systems, and should help decision makers deal with future urban planning.

关键词： VISSIM Genetic Algorithm Calibration Expressway Chihuahua

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"健康的争吵"帮助改善夫妻关系

父母世界 2019年第5期 100-101页

作者： Sonia(译) daphne de Mameffe 不详

就像蹒跚学步的孩子发脾气一样,你有时也会因为积压很久的情绪跟老公发脾气、吵架。不过,这样做才能把矛盾摊开,然后采取措施修复二人的关系,重新拉近夫妻关系。吵架是所有夫妻都会面对的困扰我们都经历过跟伴侣吵架的情况。你需要向伴... 详细信息

就像蹒跚学步的孩子发脾气一样,你有时也会因为积压很久的情绪跟老公发脾气、吵架。不过,这样做才能把矛盾摊开,然后采取措施修复二人的关系,重新拉近夫妻关系。吵架是所有夫妻都会面对的困扰我们都经历过跟伴侣吵架的情况。你需要向伴侣提出问题所在,比如老公总是随处丢东西。有的时候,为了给孩子一个好的休息环境,不得不马上结束争吵,虽然此时问题并没有得到满意的解决。

关键词：夫妻关系争吵健康提出问题发脾气吵架孩子伴侣

Endoscopic ultrasound:It’s accuracy in evaluating mediastinal lymphadenopathy? A meta-analysis and systematic review

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World Journal of Gastroenterology 2008年第19期14卷 3028-3037页

作者： Srinivas R Puli Jyotsna Batapati Krishna Reddy Matthew L Bechtold Jamal A Ibdah daphne Antillon Shailender Singh Mojtaba Olyaee Mainor R Antillon Division of Gastroenterology and Hepatology University of Missouri- Columbia Division of Gastroenterology and Hepatology University of Kansas School of Medicine

AIM:To evaluate the accuracy of endoscopic ultrasound (EUS), EUS-fine needle aspiration (FNA) in evaluating mediastinal lymphadenopathy. METHODS:Only EUS and EUS-FNA studies confirmed by surgery or with appropriate follow-up were selected. Articles were searched in Medline, Pubmed, and Cochrane control trial registry. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratios. Pooling was conducted by both Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS:Data was extracted from 76 studies (n = 9310) which met the inclusion criteria. Of these, 44 studies used EUS alone and 32 studies used EUS-FNA. FNA improved the sensitivity of EUS from 84.7% (95% CI:82.9-86.4) to 88.0% (95% CI:85.8-90.0). With FNA, the specificity of EUS improved from 84.6% (95% CI:83.2-85.9) to 96.4% (95% CI:95.3-97.4). The P forchi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION:EUS is highly sensitive and specific for the evaluation of mediastinal lymphadenopathy and FNA substantially improves this. EUS with FNA should be the diagnostic test of choice for evaluating mediastinal lymphadenopathy.

关键词：内窥镜检查法淋巴结病检查方法诊断方法

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有了宝宝后，夫妻彼此依赖也是一种幸福

父母世界 2018年第9期 96-97页

作者： daphne de Marneffe 张超男(翻译)

有了孩子后，有些夫妻之间不再像以前那样亲密。其实，在养育孩子的同时，我们也应该关注自己亲密的伴侣，给予他/她温柔和体贴。时间不充裕的确，孩子的存在会占据父母的时间，消耗父母的精力。因为生活中，父母需要陪伴孩子玩耍，配... 详细信息

有了孩子后，有些夫妻之间不再像以前那样亲密。其实，在养育孩子的同时，我们也应该关注自己亲密的伴侣，给予他/她温柔和体贴。时间不充裕的确，孩子的存在会占据父母的时间，消耗父母的精力。因为生活中，父母需要陪伴孩子玩耍，配合孩子扮演各种各样的角色。他们渐渐就会发现，时间不够用，成为彼此之间发生冲突以及压力变大的原因。

关键词：夫妻宝宝幸福孩子时间父母玩耍压力