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阻塞性睡眠呼吸暂停(OSA)是患者在睡眠过程中反复出现的气流中断,持续时间至少10 s,呼吸暂停导致的间歇性低氧与大脑皮层微觉醒及血氧饱和度下降有关。北京大学第三医院风湿免疫科,北京100191OSA患者临床上可表现为打鼾、鼾声大且不规律、夜间常有窒息感或憋醒、睡眠节律紊乱、清晨口干、头晕、白天嗜睡、记忆力下降。

关键词：阻塞性睡眠呼吸暂停窒息感间歇性低氧风湿免疫科血氧饱和度打鼾微觉醒白天嗜睡

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Anti-Neutrophil Cytoplasmic Antibody Vasculitis in Pediatric Patients: Is the Incidence Rising?

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Open Journal of Nephrology 2012年第2期2卷 19-22页

作者： Christine Sethna Rachel Frank Lulette Infante Beth gottlieb Anne Eberhard Xiaotong Wang Howard Trachtman Department of Pathology North Shore University Hospital of the North Shore—LIJ Health System New York USA Department of Pediatrics Division of Nephrology Cohen Children’s Medical Center of New York New York USA Department of Pediatrics Division of Nephrology NYU Langone Medical Center New York USA Department of Pediatrics Division of Rheumatology Cohen Children’s Medical Center of New York New York USA

Objectives: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disease usually seen in middle-aged and older adults but which is rare in children and adolescents. We sought to determine if there has been a change in the incidence of this disorder. Methods: Single-center, retrospective review. Results: Over the last 2 years, we have encountered a striking increase in the frequency of this disease in pediatric patients. All eight patients seen during this period had renal involvement and 5 patients rapidly progressed to end stage kidney disease. The prognosis was worse in younger patients, those with microscopic polyangiitis, and those with chronic kidney damage in the diagnostic renal biopsy. Conclusions: We report these observations to highlight this change in the epidemiology of ANCA-associated vasculitis and to promote earlier recognition and treatment of this severe form of glomerulonephritis.

关键词： Anti-Neutrophil Cytoplasmic Antibody (ANCA) Vasculitis Epidemiology

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玩具厂家定价策略分析

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中外玩具制造 2007年第9期 47-48页

作者： Richard gottlieb 赵明（译）不详 Richard Gottheb＆Associates LLC公司的总裁

当我走在去健身房的路上，才突然想起需要一件训练衫。因此我跑到一家商店从柜台上随便抓起一件来到收款处，拿出信用卡要付款时我才注意到价格-40．50美元。“哇!”我叫了起来，把它放了回原处，然后去其他的地方看了。

关键词：定价策略厂家玩具健身房信用卡商店美元价格

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Pneumocystis Pneumonia——Los Angeles

Pneumocystis Pneumonia——Los Angeles

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临床科研常用方法及进展培训班

作者： MS gottlieb HM Schanker PT Fan A Saxon JD Weisman I Pozalski Div of Clinical Immunology-Allergy Dept of MedicineUCLA School of Medicine

*** paper,from the Morbidity and Mortality Weekly Report of June 5,1981,is reprinted in its *** the period October 1980-May 1981,5 young men,all active homosexuals,were treated for biopsy-confirmed Pneumocystis carinii pneumonia at 3 different hospitals in Los Angeles,*** of the patients *** 5 patients had laboratory-confirmed previous or current cytomegalovirus(CMV)infection and candidal mucosal *** reports of these patients follow.

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慢性中耳疾病和听觉缺陷

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国际耳鼻咽喉头颈外科杂志 1981年第1期 44-45页

作者： gottlieb MI 张子征

慢性中耳疾患常伴有语言发育延迟、学习障碍和行为异常。在语言和听觉发育的关键时期如发生听力障碍,可影响听功能的成熟并产生接受教育和社会活动能力的变态。因此对有听觉缺陷的患儿需用各种方法作早期鉴别并及时补救。作者们对下列... 详细信息

慢性中耳疾患常伴有语言发育延迟、学习障碍和行为异常。在语言和听觉发育的关键时期如发生听力障碍,可影响听功能的成熟并产生接受教育和社会活动能力的变态。因此对有听觉缺陷的患儿需用各种方法作早期鉴别并及时补救。作者们对下列问题进行了研究:(1)听觉中枢性缺陷儿童的发育、教育和行为概况;(2)慢性中耳疾患与学习障碍、行为异常之间可能存在的关系;和(3)因复发性中耳炎致使以后不能入学的幼儿的后期特征。研究所选择的对象均具备以下标准:(1)曾经内科、精神科和言语/语

关键词：听觉中枢性儿童中耳疾病慢性中耳炎语言发育听觉障碍者

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