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Proteomics analysis of coronary atherosclerotic heart disease with different Traditional Chinese Medicine syndrome types before and after percutaneous coronary intervention

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Journal of Traditional Chinese Medicine 2024年第3期44卷 554-563页

作者： wang Zhibo LI Ying wang daoping MA Bo MIAO Lan REN Junguo LIU Jinghua LIU Jianxun Beijing Key Laboratory of Pharmacology of Chinese Materia Region Institute of Basic Medical SciencesXiyuan HospitalChina Academy of Chinese Medical SciencesNational Clinical Research Center of Cardiovascular Disease of Traditional Chinese MedicineBeijing 100000China the National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop ScienceChinese Academy of Agricultural ScienceBeijing 100098China Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

OBJECTIVE: To investigate the underlying protein molecular mechanisms of "Qi stagnation and blood stasis syndrome"(QS) and "Qi deficiency and blood stasis syndrome"(QD), as two subtypes of coronary artery disease(CAD) in Traditional Chinese Medicine(TCM),following percutaneous coronary intervention(PCI).METHODS: In this study, a total of 227 CAD patients with QS and 211 CAD patients with QD were enrolled;all participants underwent PCI. Label-free quantification proteomics were employed to analyze the changes in serum in two subtypes of CAD patients before and 6 months after PCI, aiming to elucidate the intervention mechanism of PCI in treating CAD characterized by two different TCM ***: Biochemical analysis revealed significant changes in tumor necrosis factor-α, high density lipoprotein cholesterol, blood stasis clinical symptoms observation, and Gensini levels in both patient groups post-PCI;Proteomic analysis identified 79 and 95 differentially expressed proteins in the QS and QD patient groups, respectively, compared to their control *** C8 alpha chain, complement factor H,apolipoprotein H, apolipoprotein B, plasminogen,carbonic anhydrase 2, and complement factor Ⅰ were altered in both comparison groups. Furthermore,enrichment analysis demonstrated that cell adhesion and connectivity-related processes underwent changes in QS patients post-PCI, whereas lipid metabolism-related pathways, including the peroxisome proliferator-activated receptor signaling pathway and extracellular matrix receptor interaction, underwent changes in the QD *** protein-protein interaction network analysis further enriched 52 node proteins, including apolipoprotein B,lipoprotein(a), complement C5, apolipoprotein A4,complement C8 alpha chain, complement C8 beta chain,complement C8 gamma chain, apolipoprotein H,apolipoprotein A-Ⅱ, albumin, complement C4-B,apolipoprotein C3, among others. The functional network of these proteins is posited to contribute to

关键词： percutaneous coronary intervention proteomics peptide mapping coronary atherosclerotic heart disease Traditional Chinese Medicine syndrome

Fintech, Macroprudential Supervision and Systematic Risk in China’s Banks

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China Finance and Economic Review 2022年第4期11卷 110-129页

作者： daoping wang Yangjingzhuo Liu Yuxuan Xu Linlin Liu School of Finance Nankai University School of Economics Peking University

In recent years,the rapid development of fi ntech has brought far-reaching changes to the fi nancial *** the same time,fi ntech may cause potential systemic risk in the fi nancial sector,which has aroused special concerns from fi nancial regulatory *** on the micro data of China’s listed banks from 2013 to 2020,this paper analyzes the impact of fi ntech development on systemic risk in China’s banking industry and its *** reveals that for a micro bank,fintech progress increases its risk-taking and enhances inter-bank linkages,which results in signifi cantly amplifi ed systemic risk,and the impact is time-lagged and *** addition,the heterogeneity analysis shows that the impacts of fi ntech on state-owned banks and other banks are heterogeneous and the margining risk of state-owned banks is lower when the fi ntech *** is also found that enhancing macroprudential supervision can reduce the systemic risk spillover of *** analyses including GMM regression and the method of instrumental variables prove that the conclusion is *** paper is of theoretical and policy signifi cance for the prevention of systemic risk in the banking industry as China develops fi ntech.

关键词： fi ntech macroprudential supervision systemic risk

Global mitigation efforts cannot neglect emerging emitters

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National Science Review 2022年第12期9卷 82-89页

作者： Can Cui Dabo Guan daoping wang Jing Meng Vicky Chemutai Paul Brenton Shaohui Zhang Yuli Shan Qiang Zhang Steven J.Davis Department of Earth System Science Tsinghua University The Bartlett School of Sustainable Construction University College London Department of Computer Science and Technology University of Cambridge Centre for Nature and Climate World Economic Forum School of Urban and Regional Science Shanghai University of Finance and Economics The World Bank School of Economics and Management Beihang University International Institute for Applied Systems Analysis School of Geography Earth and Environmental Sciences University of Birmingham Department of Earth System Science University of California Irvine Department of Civil and Environmental Engineering University of California Irvine

International efforts to avoid dangerous climate change have historically focused on reducing energy-related CO2emissions from countries with either the largest economies(*** EU and the USA)and/or the largest populations(*** and India).However,in recent years,emissions have surged among a different and much less-examined group of countries,raising concerns that a next generation of high-emitting economies will obviate current mitigation ***,we analyse the trends and drivers of emissions in each of the 59 countries where emissions in 2010-2018 grew faster than the global average(excluding China and India),project their emissions under a range of longer-term energy scenarios and estimate the costs of decarbonization *** emissions from these ’emerging emitters’ reach as much as 7.5 GtCO2/year in the baseline 2.5° scenari—substantially greater than the emissions from these regions in previously published scenarios that would limit warming to 1.5℃ or even 2℃.Such unanticipated emissions would in turn require non-emitting energy deployment from all sectors within these emerging emitters,and faster and deeper reductions in emissions from other countries to meet international climate ***,the annual costs of keeping emissions at the low level are in many cases 0.2%-4.1% of countries’ gross domestic production,pointing to potential trade-offs with poverty-reduction goals and/or the need for economic support and low-carbon technology transfer from historically high-emitting *** results thus highlight the critical importance of ramping up mitigation efforts in countries that to this point have been largely ignored.

关键词： emerging emiters developing countries climate change mitigation CO_2 emissions net zero

Modeling and Robustness of Knowledge Network in Supply Chain

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Transactions of Tianjin University 2014年第2期20卷 151-156页

作者：王道平沈睿芳 Dongling School of Economics and Management University of Science and Technology Beijing College of Information and Technology Hebei University of Economics and Business

The growth and evolution of the knowledge network in supply chain can be characterized by dynamic growth clustering and non-homogeneous degree *** networks with the above characteristics are also known as scale-free *** this paper,the knowledge network model in supply chain is established,in which the preferential attachment mechanism based on the node strength is adopted to simulate the growth and evolution of the *** nodes in the network have a certain preference in the choice of a knowledge *** the basis of the network model,the robustness of the three network models based on different preferential attachment strategies is *** robustness is also referred to as tolerances when the nodes are subjected to random destruction and malicious *** simulation results of this study show that the improved network has higher connectivity and stability.

关键词： knowledge network preferential attachment modeling robustness

A macrocycle-based “Russian doll”: The smallest cucurbit[4]uril in cucurbit[10]uril

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Chinese Chemical Letters 2024年第12期35卷 197-201页

作者： Yu Xia Yangming Jiang Xin-Long Ni Qiaochun wang daoping wang State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Natural Products Research Center of Guizhou Province Key Laboratory of Chemical Biology and Traditional Chinese Medicine Ministry of Educational of China Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province Hunan Normal University Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry & Molecular Engineering East China University of Science &Technology

Host-guest recognition-based macrocycle in macrocycle to form "Russian doll" assemblies remains an interesting topic in supramolecular ***,a macrocycle-in-macrocycle assembly was studied using cucurbit[10]uril（Q[10]） and the smallest cucurbituril-like macrocycle（TD[4]）.X-ray crystal structure analysis revealed that TD[4] was encapsulated in the cavity of Q[10] to form a 1:1 ***,competitive guest studies suggested that TD[4] had the highest binding constant with the Q[10]host among the guests used,including Q[5],Me8TD[4],and amantadine molecules in *** results provided a new cucurbituril-based Russian-doll structure containing both the largest and smallest cavities of the cucurbiturils,which expanded the family of molecular Russian dolls.

关键词： Cucurbituril Cucurbituril Host-guest recognition X-ray structure Macrocycle in macrocycle

基于区块链技术的供应链碳信息披露与共享机制

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系统工程理论与实践 2024年第11期44卷 3666-3680页

作者：田雨王道平郝玫北京科技大学经济管理学院北京100083

本文考虑由供应商、生产商和消费者组成的供应链,供应商和生产商根据市场情况决策碳信息披露度及产品溢价.引入消费者信息信任度、消费者信息敏感度和信息共享收益系数等参数,分别构建了信息不对称下的供应链碳信息披露模型以及基于区... 详细信息

本文考虑由供应商、生产商和消费者组成的供应链,供应商和生产商根据市场情况决策碳信息披露度及产品溢价.引入消费者信息信任度、消费者信息敏感度和信息共享收益系数等参数,分别构建了信息不对称下的供应链碳信息披露模型以及基于区块链技术的供应链碳信息共享模型,比较分析了不同决策模型中的最优决策.研究表明:1)随碳信息披露成本系数的增大,供应链决策分为供应商和生产商碳信息全披露,仅生产商碳信息全披露以及供应商和生产商碳信息部分披露三个阶段,决策主体的最优决策整体呈下降趋势. 2)存在某一碳信息上链成本系数临界阈值,使得供应商的碳信息披露度更高,除此之外,生产商的最优碳信息披露度始终不低于供应商;当产品初始价格小于某阈值时,生产商的最优产品溢价更高;且生产商的最优决策对相关参数的变化更敏感. 3)当碳信息上链成本系数小于一定比例的传统碳信息披露成本系数时,“区块链+碳信息”共享机制下决策主体的利润远高于信息不对称下的利润.

关键词：区块链碳信息披露共享机制信息不对称

利率市场化、存款保险制度与系统性银行危机防范

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金融研究 2016年第1期 50-65页

作者：王道平南开大学金融学院天津300350

本文基于全球88个国家1970～2012年的面板数据,研究了利率市场化改革和存款保险制度建设对系统性银行危机发生概率的影响。研究表明,利率市场化将提高系统性银行危机发生几率;存款保险制度对系统性银行危机发生几率的影响,取决于存款保... 详细信息

本文基于全球88个国家1970～2012年的面板数据,研究了利率市场化改革和存款保险制度建设对系统性银行危机发生概率的影响。研究表明,利率市场化将提高系统性银行危机发生几率;存款保险制度对系统性银行危机发生几率的影响,取决于存款保险制度的金融稳定作用和导致的银行道德风险问题;尽管利率市场化完成后存款保险导致的银行道德风险上升、存款保险的金融稳定效应可能并不明显,但若利率市场化时期建有存款保险制度,将有助于降低利率市场化改革时期系统性银行危机发生概率。另外,加强银行监管有助于限制存款保险导致的银行道德风险、增进银行系统稳定性;提高市场约束力和防范道德风险的存款保险制度设计,也有助于防止系统性银行危机发生。

关键词：利率市场化存款保险银行危机系统性风险

考虑制造商声誉和大数据服务商参与的闭环供应链决策

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计算机集成制造系统 2023年第7期29卷 2474-2484页

作者：王道平梁思涵周玉北京科技大学经济管理学院北京100083 黄河水利委员会黄河水利科学研究院河南省智慧水利工程技术研究中心河南郑州450003 辽宁工程技术大学工商管理学院辽宁葫芦岛125105

在闭环供应链中考虑了大数据服务商参与并提供协助回收和协助营销两种服务,引入了制造商声誉,研究了不同的大数据服务对闭环供应链的影响。利用伊藤过程刻画了受多因素扰动的回收率,分析了大数据服务费用的分担比例和支付水平等参数对... 详细信息

在闭环供应链中考虑了大数据服务商参与并提供协助回收和协助营销两种服务,引入了制造商声誉,研究了不同的大数据服务对闭环供应链的影响。利用伊藤过程刻画了受多因素扰动的回收率,分析了大数据服务费用的分担比例和支付水平等参数对闭环供应链成员的影响。研究表明:当回收再造行业达到饱和时,大数据服务商的协助对环境和经济效益的提升都不显著;当大数据服务商协助营销能够有效刺激市场时,回收率、回收努力水平以及企业利润有可能高于协助回收情形;制造商更容易受到不确定因素的干扰,回收努力水平和利润的波动幅度更大,但波动能在一定程度上提升回收努力水平和利润。零售商的价格和利润趋于稳定的时间更短,感知市场变化和应对的速度更快;当大数据服务费用的支付水平高于一定阈值时,会降低企业的利润。

关键词：协助回收协助营销大数据服务商闭环供应链

考虑动态回收率和拆解商参与的闭环供应链合作策略

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计算机集成制造系统 2022年第12期28卷 3981-3992页

作者：王道平梁思涵王婷婷北京科技大学经济管理学院北京100083 黄河水利委员会黄河水利科学研究院河南郑州450003 北京印刷学院经济管理学院北京102600

在闭环供应链中考虑了拆解商参与和受制造商回收努力、时间等多种因素影响的回收率,研究了三方无合作、制造商分别与拆解商和零售商合作三种情形下供应链成员的最优策略和利润的变化情况。通过伊藤过程对动态变化的回收率进行了刻画,分... 详细信息

在闭环供应链中考虑了拆解商参与和受制造商回收努力、时间等多种因素影响的回收率,研究了三方无合作、制造商分别与拆解商和零售商合作三种情形下供应链成员的最优策略和利润的变化情况。通过伊藤过程对动态变化的回收率进行了刻画,分析了不同的合作方式对供应链成员的影响,并进行了灵敏度分析。研究表明:制造商与拆解商合作优于与零售商合作和三方不合作,能够显著提升合作双方的利润。制造商与零售商合作时制造商的利润受以旧换新消费者的比例影响较大,当以旧换新消费者的比例较小时,三方不合作优于与零售商合作。三种情形下以旧换新消费者的比例越大,制造商利润提升越显著。对于废弃电器电子产品的回收,高外部激励和低外部约束不仅能有效提升制造商的利润,还能减小制造商利润的波动。制造商与拆解商合作时,拆解商为制造商分担回收品初步拆解的比例对拆解失败的废弃补偿金额的影响与制造商的利润呈正相关。

关键词：动态回收率拆解商伊藤过程闭环供应链