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Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43

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World Journal of Gastroenterology 2025年第8期31卷 82-95页

作者： Wei yang Rui Liu feng Xu Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Medical School Xiangyang Vocational and Technical CollegeXiangyang 441021Hubei ProvinceChina

BACKGROUND Colonic motility dysfunction is a common symptom of ulcerative colitis(UC),significantly affecting patients’quality of *** suggests that glial cell line-derived neurotrophic factor(GDNF)plays a role in restoring colonic *** To investigate whether GDNF enhances aberrant colonic motility in mice with experimental colitis via connexin 43(Cx43).METHODS An experimental colitis model was induced in male C57BL/6 mice using dextran sodium sulfate(DSS).The measurement of colonic transit time was conducted,and colon tissues were evaluated through transmission electron microscopy and hematoxylin and eosin *** mice were treated with exogenous GDNF and Gap 19,a selective Cx43 *** Cx43 and GDNF levels were detected via immunofluorescence,immunohistochemistry,and real-time polymerase chain *** levels of inflammatory markers,including interleukin-1β,tumor necrosis factor-α,interleukin-6,and C-reactive protein,were quantified using enzyme-linked immunosorbent *** Experimental colitis was successfully induced using DSS,and the findings exhibited that the colonic transit time was significantly delayed in colitis mice relative to the UC group(P<0.01).GDNF treatment improved colonic transit time and alleviated intestinal inflammation in DSS-induced colitis mice(P<0.05).In the UC+Gap19+GDNF group,colitis symptoms,colonic transit time,and inflammatory marker levels remained comparable to those in the UC group,indicating that the therapeutic effects of GDNF in UC mice were blocked by Gap *** GDNF improves colonic motility in mice with experimental colitis through a partially Cx43-mediated *** holds promise as a therapeutic option for improving colonic motility in patients with colitis.

关键词： Glial cell line-derived neurotrophic factor Ulcerative colitis Colonic motility Connexin 43 Dextran sodium sulfate model

Tetraphenylethylene-derived organic cages with persistent photogenic radicaloids and efficient photothermal conversion

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Science China Chemistry 2025年第2期68卷 661-669页

作者： Suqiong Yan Bo yang Fanda feng Yuan Zhang Shirong Ban Hui Ma Wei Huang State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China Shenzhen Research Institute of Nanjing University Shenzhen 518057China

Transformation of the electronic spin states has received significant interest in recent years because of its applications in the magnetic information storage materials and optical response ***,it can be formidably challenging to use ultraviolet(UV)light as a contactless stimulus to alter the electronic spin states of the supramolecular *** by the approach on the radical cation mechanism of the Scholl reaction and the photocyclization reactivity of tetraphenylethylene(TPE)derivatives,we report two photochromic cages(cage-TPE-1 and cage-TPE-2)that can be photochemically transformed from electron paramagnetic resonance(EPR)-silent to EPR-active form via UV irradiation due to the photo-induced electron transfer process at the TPE *** provided a strong single-electron signal with a g value of 2.003 in cage-TPE-1 and cage-TPE-2 but no signal was detected for the pristine samples without the *** transformation can be monitored by ultraviolet–visible–near-infrared(UV–vis–NIR)and photoluminescence(PL)*** photogenic radical cage intermediate was unstable in solution resulting in the degradation and intramolecular cyclization of the reactive species,while the radicals were found to be stable and persistent in the solid state due to the spin delocalization,the steric protection of confined cavities,and the oxygen *** theoretical calculations and spectral measurements suggest that the photogenic radical cage-TPE-2(•+)experiences photocyclization on the TPE *** with the close-shell cage,the radical cage-TPE-1(•+)and cage-TPE-2(•+)exhibit better photothermal conversion performance due to the incubated infrared absorption from open-shell electron feature and reduced band gap.

关键词： supramolecular cage photogenic radical photocyclization photothermal conversion

RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-Yao Wang Bang Liu yang-Pu Jia Zhao-Xiong Zhang Xin Liu dao-Han Wang Yong-Jia Yan Wei-Hua Fu feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

Auxiliary ligand-induced assembly of atomically precise silver clusters

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Science China Chemistry 2025年第2期68卷 580-589页

作者： Yeqin feng Xuemeng Jing Fangyu Fu Mengyun Zhao Manzhou Chi Hongjin Lv Guo-Yu yang MOE Key Laboratory of Cluster Science Beijing Key Laboratory of Photoelectroic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 102488China

Establishing the correlation between inter-cluster assembly and auxiliary ligands at the atomic level is crucial for the development of metal cluster *** this work,we report the successful preparation and characterization of three Ag clusters,discrete 0-D Ag_(51)S_(6)Cl_(3)(i PrS)_(21)(TsO)_(15)CH_(3)CN(0-D Ag_(51),i PrS–=isopropanethiolate,TsO–=toluenesulfonate),1-D{Ag_(38)S_(4)-(i PrS)_(18)(PhCOO)_(12)}n(1-D Ag_(38),PHCOO–=benzoate),and 2-D{Ag_(2)0(SO_(4))Cl_(2)(i PrS)10(NO_(3))6}n(2-D Ag_(20)),using a delicate auxiliary-ligand-induced *** analyses reveal that the types of auxiliary ligands can readily affect the structure and dimensionality of resulting Ag *** addition of different surface auxiliary ligands from TsO–to PhCOO–and then to NO_(3)–leads to the formation of 0-D Ag_(51) to 1-D Ag_(38) and then to 2-D Ag_(2)0 clusters under otherwise identical reaction conditions,*** resulting Ag clusters exhibited structure-related optical/luminescence properties and distinct bathochromic shifts as revealed by the temperature-dependent luminescence and single-crystal X-ray diffraction studies.

关键词： silver(I)clusters auxiliary ligand effect silver cluster synthesis luminescence

Efficient magnetic capture of PE microplastic from water by PEG modified Fe_(3)O_(4)nanoparticles:Performance,kinetics,isotherms and influence factors

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Journal of Environmental Sciences 2025年第1期147卷 677-687页

作者： Yifan Zhang Jingjing Duan Ruiqian Liu Evangelos Petropoulos Yanfang feng Lihong Xue Linzhang yang Shiying He College of Resources and Environmental Sciences Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Agro-Environment in Downstream of yangze Plain Ministry of Agriculture and Rural AffairsInstitute of Agricultural Resources and EnvironmentJiangsu Academy of Agricultural SciencesNanjing 210014China School of Engineering Newcastle UniversityNewcastle upon Tyne NE17RUUK Stantec UK Newcastle upon Tyne NE13DYUK

Due to their resistance to degradation,wide distribution,easy diffusion and potential uptake by organisms,microplastics(MPs)pollution has become a major environmental *** this study,PEG-modified Fe_(3)O_(4)magnetic nanoparticles demonstrated superior adsorption efficiency against polyethylene(PE)microspheres compared to other adsorbents(bare Fe_(3)O_(4),PEI/Fe_(3)O_(4)and CA/Fe_(3)O_(4)).Themaximumadsorption capacity of PEwas found to be 2203 mg/g by adsorption isotherm ***/Fe_(3)O_(4)maintained a high adsorption capacity even at low temperature(5℃,2163 mg/g),while neutral pH was favorable for MP *** presence of anions(Cl^(-),SO_(4)^(2-),HCO_(3)^(-),NO_(3)^(-))and of humic acids inhibited the adsorption of *** is proposed that the adsorption process was mainly driven by intermolecular hydrogen ***,the study demonstrated that PEG/Fe_(3)O_(4)can potentially be used as an efficient control against MPs,thus improving the quality of the aquatic environment and of our water resources.

关键词： Microplastic removal Adsorption Magnetic nanoparticles Wastewater Surface modification

Down-regulation of SEIPIN transcription attenuated the triacylglycerol accumulation in Nannochloropsis oceanica

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Journal of Oceanology and Limnology 2025年第1期43卷 187-195页

作者： Lixian LIU Li GUO Hang LIU Xiaohui PAN Yanan ZONG Leili feng Guanpin yang College of Marine Life Sciences Ocean University of ChinaQingdao 266003China Institutes of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Key Laboratory of Marine Genetics and Breeding of Ministry of Education Ocean University of ChinaQingdao 266003China MoE Laboratory of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China

Abnormal content of protein SEIPIN causes Berardinelli-Seip congenital lipodystrophy type 2(BSCL2)in *** studies have shown that Arabidopsis thaliana has evolved three SEIPIN homologs,determining the fusion and size of lipid *** oceanica is a model oleaginous microalga with the accumulation potential of fatty *** believe that the SEIPIN homolog if any in *** should function as it does in humans,plant among *** this study,we identified a homologous gene of SEIPIN in ***,constructed a bacterial plasmid containing the elements controlling the transcription of its complete antisense RNA,and integrated the linearized plasmid into the *** *** obtained a transformant in which the abundance of SEIPIN transcript is significantly *** cytometry analysis showed that the triacylglycerol(TAG)content of the transformant is significantly lower than that of the wild type(WT).Transcriptomic analysis showed that the down-regulation of SEIPIN transcript abundance could affect the protein functioning in endoplasmic reticulum(ER),implying that SEIPIN gene can function in *** in a similar way to that in ***.

关键词： Nannochloropsis oceanica antisense RNA SEIPIN neutral lipid

Tuning the ion-dipole interactions between fluoro and carbonyl(EC)by electrolyte design for stable lithium metal batteries

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Chinese Chemical Letters 2025年第1期36卷 579-584页

作者： Guihuang Fang Ying Liu yangyang feng Ying Pan Hongwei yang Yongchuan Liu Maoxiang Wu Faculty of Metallurgy and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Ethylene carbonate(EC)is the conventional and promising solvent to achieve high energy lithium metal ***,the innate low energy level of lowest unoccupied molecular orbital(LUMO)in EC makes it incompatible with lithium metal,causing uncontrolled lithium growth and low Coulombic efficiency(CE).Herein,we introduced bis(2,2,2-trifluoroethyl)carbonate(TFEC),a carbonate with a strong electron-withdrawing effect(-CF_(3)),which enhances the stability of EC at electrode interface by reducing ion-dipole interactions between Li^(+)and *** the interaction between Li and EC weakens,TFEC and more PF_(6)^(-)anions coordinate with Li^(+),promoting the formation of contact ion pairs(CIPs)and aggregates(AGGs),thereby increasing the inorganic composition within the solid electrolyte ***,the distinct solvated sheath structure favors the decomposition of fluorinated solvents and PF_(6)^(-)anions,forming inorganic-rich electrode-electrolyte interfaces(SEI and CEI),thereby ensuring high stability for both the Li anode and high-voltage ***,when applied in the full-cell Li||LiMn_(0.8)Fe_(0.2)PO_(4),it displays consistent cycling performance,exhibiting minimal capacity decay with a retention rate of 62.5%after800 cycles,substantially surpassing that of cells using base electrolytes(29.8%).

关键词： Lithium-ion batteries LiMn_(0.8)Fe_(0.2)PO_(4) High-voltage Solvation structure Ethylene carbonate Bis(2,2,2-trifluoroethyl)carbonate

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong Fei Luan Juanjuan yang feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

Modulation of the octahedral structure and potential superconductivity of La_(3)Ni_(2)O_(7)through strain engineering

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Science China(Physics,Mechanics & Astronomy) 2025年第3期68卷 145-152页

作者： Zihao Huo Zhihui Luo Peng Zhang Aiqin yang Zhengtao Liu Xiangru Tao Zihan Zhang Shumin Guo Qiwen Jiang Wenxuan Chen dao-Xin Yao Defang Duan Tian Cui Key Laboratory of Material Simulation Methods&Software of Ministry of Education State Key Laboratory of Superhard MaterialsCollege of PhysicsJilin UniversityChangchun130012China Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesState Key Laboratory of Optoelectronic Materials and TechnologiesSchool of PhysicsSun Yat-sen UniversityGuangzhou510275China MOE Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter Shaanxi Province Key Laboratory of Advanced Functional Materials and Mesoscopic PhysicsSchool of PhysicsXi’an Jiaotong UniversityXi’an710049China Institute of High Pressure Physics School of Physical Science and TechnologyNingbo UniversityNingbo315211China

The recent transport measurements of La_(3)Ni_(2)O_(7)uncovered a“right-triangle”shape of the superconducting dome in the pressure-temperature(P-T)phase *** by this,we perform theoretical first-principles studies of La_(3)Ni_(2)O_(7)with the pressure ranging from 0 to 100 ***,we reveal a pressure dependence of the Ni-d_(z^(2))electron density at the Fermi energy(n_(z)^(E_(F)))that highly coincides with such *** this basis,we further explore the electronic structure under uniaxial *** tracking the stress response of n_(z)^(E_(F)),we propose that superconductivity can be achieved by applying only ~2GPa of compression along the c *** idea is further exemplified from the perspectives of lattice distortion,band structure,Fermi surface and superconducting phase *** also discuss the possible charge modulation under the stress and provide an insight into the relation between nz E Fand the superconducting T_(c)in La_(3)Ni_(2)O_(7)*** study provides new routes to the search of high-T_(c)superconductors in future experiments.

关键词： nickelate superconductors density functional theory strong correlated systems strain engineering

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