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Wedelolactone from Eclipta prostrata(L)*** inflammation and improves insulin resistance

Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 253-258页

作者： Trinh Tat Cuong Duong Duc Thien Hoang Hai Yen Nguyen anh Duc Trinh quang Nam Do Viet Khanh Key Laboratory for Enzyme and Protein Technology Vietnam National University University of ScienceHanoiVietnam Faculty of Biology Vietnam National University University of ScienceHanoiVietnam Hanoi University of Pharmacy HanoiVietnam Vinschool HanoiVietnam

Objective:To evaluate the effects of wedelolactone,a major flavonoid from Vietnamese Eclipta prostrata(L)L.,on inflammation and insulin ***:Wedelolactone was extracted from the leaves of Vietnamese Eclipta prostrata(L.)*** methanol by *** effects of wedelolactone on lipopolysaccharide(LPS)-induced cytokine production,reactive oxygen species(ROS)generation,and nicotinamide adenine dinucleotide phosphate(NADPH)oxidase activities in Raw 264.7 cells were measured by enzyme-linked immunosorbent assay(ELISA),specific immunofluorescent dyes and luminometric analysis,*** addition,its effects on glucose uptake and the protein expression of insulin receptor substrate 1(IRS1)and glucose transporter 4(GLUT4)were examined in 3T3-L1 cells by immunofluorescent dyes and Western ***:Wedelolactone at 30μg/mL significantly inhibited LPS-induced production of tumor necrosis factor-α,interleukin(IL)-6,and IL-8(P<0.01)with no noticeable effects on IL-10 *** also reduced ROS generation and NADPH oxidase activities in LPS-stimulated Raw 264.7 cells(P<0.01).Furthermore,wedelolactone showed anti-insulin resistance activity,as evidenced by improved glucose uptake and the upregulated expression of IRS1 and GLUT4 in 3T3-L1 cells(P<0.01).Conclusions:Wedelolactone exhibits anti-inflammation and anti-insulin resistance effects,which may be used for the treatment of diabetes and inflammation-associated diseases.

关键词： Wedelolactone Eclipta prostrata Inflammatory responses Anti-insulin resistance Diabetes IRS1 GLUT4

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Influence of sintering behavior on the microstructure and electrical properties of BaTiO_(3) lead-free ceramics from hydrothermal synthesized precursor nanoparticles

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Journal of Advanced Dielectrics 2021年第2期11卷 42-51页

作者： Do Viet On Le Dai Vuong Truong Van Chuong dao anh quang Ho Van Tuyen Vo Thanh Tung Department of Physics College of Sciences Hue UniversityHue CityVietnam Faculty of Chemical and Environmental Engineering Hue Industrial College Hue CityVietnam Institute of Research and Development Duy Tan University Da Nang CityVietnam Faculty of Natural Sciences Duy Tan University Da Nang CityVietnam

BaTiO_(3) nanoparticles were synthesized by hydrothermal method using amorphous phase TiO_(2) precursor as the *** microstructure and phase structure were determined using XRD,SEM and Raman spectroscopy analysis *** results showed that BaTiO_(3) nanoparticles have tetragonal structure,average size of about 100 nm was obtained at Ba/Ti ratio of 1.5,synthesis temperature of 200℃ and reaction time of 12 *** components of the BaTiO_(3) lead-free ceramic system are fabricated by conventional solid-phase reaction from the average size BaTiO_(3) particles about 100 nm obtained by hydrothermal *** effects of sintering behavior on dielectric,ferroelectric and piezoelectric properties of BT high-density ceramic were *** BaTiO_(3) ceramic composition sintered at 1300℃ has a relative density of 97%,the value of the electromechanical coefficient kp=0.40,k33=0.42,the large piezoelectric coefficient d_(33)=300 pC/N,d_(31)=−125 pC/N.

关键词： BaTiO_(3)nanoparticles lead-free ceramics piezoelectric ferroelectric properties

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Effect of Freeze-Thaw and Urea in Solubility of GPC3-Csub Protein Expressed in Escherichia coli

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Journal of Biosciences and Medicines 2024年第4期12卷 288-297页

作者： Xuan-Truc Chu-dao Kim-Tuyen Huynh-Dam Dang-Thuc Ngo-Luong quang-Luan Le Thanh-Thao Vo-Nguyen Department of Medical Biotechnology Biotechnology Center of Ho Chi Minh City Ho Chi Minh City Vietnam

Glypican-3 is a protein encoded by the Glypican-3 gene located on human X chromosome (Xq26), composed of two subunits, a 40 kDa N-terminal subunit, and a 30 kDa C-terminal subunit. Glypican-3 is a currently potential target molecule for liver cancer treatments because of its over-expression and growth effects on hepatocellular carcinoma (HCC). This study examined the expression and purification of a C-terminal subunit of Glypican-3 protein (GPC3-Csub) due to its application in both diagnosis and therapy for hepatocellular carcinoma. The gene encoding for GPC3-Csub was successfully cloned into plasmid pET28a fused with an affinity tag composed of six consecutive histidine residues (His-tag). Recombinant protein GPC3-Csub was expressed in Escherichia coli BL21 (DE3) in the condition of adding 3% ethanol with IPTG induction. GPC3-Csub was extracted using repeated freeze-thaw cycles with lysozyme, and inclusion bodies were solubilized by 8M Urea, SDS 10% in pH 12. His-tag fused GPC3-Csub proteins allowed it to be purified by affinity chromatography method using the Nickel-nitrilotriacetic acid (Ni-NTA) column. High expression of GPC3-Csub was confirmed by Coomassie staining and western-blot. GPC3-Csub could be isolated with a Ni-NTA column and have a purity of about 90%.

关键词： Glypican-3 Affinity Chromatography Inclusion Body Liver Cancer

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Prevalence, risk factors, and BRAF mutation of colorectal sessile serrated lesions among Vietnamese patients

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World Journal of Clinical Oncology 2024年第2期15卷 290-301页

作者： Nhu Thi Hanh Vu Huy Minh Le Diem Thi-Ngoc Vo Hoang anh Vu Nhan quang Le Dung Dang Quy Ho Duc Trong Quach Department of Internal Medicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam GI Endoscopy Department University Medical Center at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Department of Histology-Embryology and Pathology University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Center for Molecular Biomedicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Department of Endoscopy Cho Ray HospitalHo Chi Minh 700000Viet Nam

BACKGROUND Sessile serrated lesions(SSLs)are considered precancerous colorectal lesions that should be detected and removed to prevent colorectal *** studies in Vietnam mainly investigated the adenoma pathway,with limited data on the serrated *** To evaluate the prevalence,risk factors,and BRAF mutations of SSLs in the Vietnamese *** This is a cross-sectional study conducted on patients with lower gastrointestinal symptoms who underwent colonoscopy at a tertiary hospital in *** were diagnosed on histopathology according to the 2019 World Health Organi-zation *** mutation analysis was performed using the Sanger DNA sequencing *** multivariate logistic regression model was used to determine SSL-associated *** There were 2489 patients,with a mean age of 52.1±13.1 and a female-to-male ratio of 1:*** prevalence of SSLs was 4.2%[95%confidence interval(CI):3.5-5.1].In the multivariate analysis,factors significantly associated with SSLs were age≥40[odds ratio(OR):3.303;95%CI:1.607-6.790],male sex(OR:2.032;95%CI:1.204-3.429),diabetes mellitus(OR:2.721;95%CI:1.551-4.772),and hypertension(OR:1.650,95%CI:1.045-2.605).The rate of BRAF mutations in SSLs was 35.5%.CONCLUSION The prevalence of SSLs was 4.2%.BRAF mutations were present in one-third of *** risk factors for SSLs included age≥40,male sex,diabetes mellitus,and hypertension.

关键词： Colorectal cancer Sessile serrated lesion BRAF mutation Risk factors Diabetes mellitus Hypertension

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Hardy factorization in terms of fractional commutators in Lorentz spaces

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Frontiers of Mathematics in China 2022年第5期17卷 853-873页

作者： Nguyen anh dao Institute of Applied Mathematics University of Economics Ho Chi Minh CityHo Chi Minh CityVietnam

We provide a constructive proof of H^(1)(R^(d))(the classical Hardy space)factorization in terms of fractional commutators in Lorentz *** a direct application,we obtain a characterization of functions in BMO ***,we al... 详细信息

关键词： BMO CMO Lorentz space commutator Hardy space Riesz potentia

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Emotion Recognition with Capsule Neural Network

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Computer Systems Science & Engineering 2022年第6期41卷 1083-1098页

作者： Loan Trinh Van quang H.Nguyen Thuy dao Thi Le School of Information and Communication Technology Hanoi University of Science and TechnologyHanoi10000Vietnam Faculty of Information Technology University of Transport and CommunicationsHanoi10000Vietnam

For human-machine communication to be as effective as human-tohuman communication, research on speech emotion recognition is *** the models and the classifiers used to recognize emotions, neural networks appear to be promising due to the network’s ability to learn and the diversity in configuration. Following the convolutional neural network, a capsuleneural network (CapsNet) with inputs and outputs that are not scalar quantitiesbut vectors allows the network to determine the part-whole relationships thatare specific 6 for an object. This paper performs speech emotion recognition basedon CapsNet. The corpora for speech emotion recognition have been augmented byadding white noise and changing voices. The feature parameters of the recognition system input are mel spectrum images along with the characteristics of thesound source, vocal tract and prosody. For the German emotional corpus EMODB, the average accuracy score for 4 emotions, neutral, boredom, anger and happiness, is 99.69%. For Vietnamese emotional corpus BKEmo, this score is94.23% for 4 emotions, neutral, sadness, anger and happiness. The accuracy scoreis highest when combining all the above feature parameters, and this scoreincreases significantly when combining mel spectrum images with the featuresdirectly related to the fundamental frequency.

关键词： Emotion recognition CapsNet data augmentation mel spectrum image fundamental frequency

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Discrete-time sliding mode control with power rate exponential reaching law of a pneumatic artificial muscle system

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Control Theory and Technology 2022年第4期20卷 514-524页

作者： Quy-Thinh dao Trung-Kien Le Tri Van-anh Nguyen Manh-Linh Nguyen School of Electrical and Electronic Engineering Hanoi University of Science and TechnologyDai Co VietHanoi 11615Vietnam

This paper develops a discrete-time sliding mode controller with a power rate exponential reaching law approach to enhance the performance of a pneumatic artificial muscle system in both reaching time and chattering *** proposed method dynamically adapts to the variation of the switching function,which is based on an exponential term and a power rate term of the sliding ***,the controlled system can achieve high tracking performance while still obtain chattering-free ***,the effectiveness of the proposed method is validated through multiple experimental tests,focused on a dual pneumatic artificial muscle ***,experimental results show the effectiveness of the proposed approach in this paper.

关键词： Pneumatic artificial muscle Discrete-time sliding mode control Exponential reaching law Chattering

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Profiling of Urban Noise Using Artificial Intelligence

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Computer Systems Science & Engineering 2023年第5期45卷 1309-1321页

作者： Le quang Thao Duong Duc Cuong Tran Thi Tuong anh Tran Duc Luong Ph.D.Faculty of Physics VNU University of ScienceHanoi100000Vietnam University of Science Vietnam National UniversityHanoi100000Vietnam The International School of Penang(Uplands) PenangMalaysia Alpha School Hanoi100000Vietnam

Noise pollution tends to receive less awareness compared to other types of pollution,however,it greatly impacts the quality of life for humans such as causing sleep disruption,stress or hearing *** urban sound through the identification of noise sources in cities could help to benefit livability by reducing exposure to noise pollution through methods such as noise control,planning of the soundscape environment,or selection of safe living *** this paper,we proposed a self-attention long short-term memory(LSTM)method that can improve sound classification compared to previous *** attention mechanism will be designed solely to capture the key section of an audio data *** is practical as we only need to process important parts of the data and can ignore the rest,making it applicable when gathering information with long-term *** dataset used is the Urbansound8k dataset which specifically pertains to urban environments and data augmentation was applied to overcome imbalanced data and dataset *** audio sources in the dataset were normalized to mono *** the dataset above,an experiment was conducted to confirm the suitability of the proposed model when applied to the mel-spectrogram and MFCC(Mel-Frequency Cepstral Coefficients)datasets transformed from the original *** the classification accuracy depends on the machine learning models as well as the input data,therefore we have evaluated different class models and extraction methods to find the best *** combining data augmentation techniques and various extraction methods,our classification model has achieved state-of-the-art performance,each class accuracy is up to 98%.

关键词： Urban noise noise classification mel-spectrogram MFCC LSTM self-attention

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Embryonic, genetic and clinical outcomes of fresh versus vitrified oocyte: A retrospective cohort study

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Asian pacific Journal of Reproduction 2023年第6期12卷 266-272页

作者： Phuong dao Thi Son Dang Truong Thuan Nguyen Duc anh Pham Van anh Do Tuan Van Hanh Nguyen HP Fertility-Hai Phong International Hospital of Obstetrics and Pediatrics Haiphong180000Vietnam Graduate University of Science and Technology Vietnam Academy of Science and TechnologyHanoi100000Vietnam Institute of Biotechnology Vietnam Academy of Science and TechnologyHanoi100000Vietnam

Objective:To compare embryonic development,ploidy status and clinical outcomes between fresh and frozen-thawed ***:This retrospective cohort study evaluated 83 fertilization cycles including both fresh and frozen oocytes from 79 patients at the HP Fertility Center of Hai Phong International Hospital of Obstetrics and Pediatrics in *** patient underwent several ovarian stimulation cycles to accumulate a certain number of oocytes that would be *** the last oocyte retrieval,all patient’s oocytes including both frozen and fresh would be *** outcomes included the rates of oocyte survival,cleavage embryo,blastocyst,ploidy status,pregnancy,biochemical pregnancy and clinical ***:The oocyte survival rate after thawing was 96.5%.No statistically significant difference was found when comparing fresh and frozen oocytes regarding fertilization rate(78.1%vs.75.5%,P=0.461),usable cleavage embryo rate(86.9%vs.87.2%,P=0.916)but usable blastocyst rate was found higher statistically in the frozen oocyte group(44.4%vs.54.0%,P=0.049).The percentages of euploid,aneuploid and mosaic embryos between the fresh group and the vitrified group had no significant differences(33.8%vs.31.6%,P=0.682;51.0%vs.54.2%,P=0.569;15.2%vs.12.4%,P=0.787;respectively).The rates of pregnancy,biochemical pregnancy and clinical pregnancy had no statistical difference(68.8%vs.64.8%,P=0.764;12.5%vs.3.6%,P=0.258;37.5%vs.46.4%,P=0.565).17 Mature oocytes are the minimum to have at least one euploid ***:Oocyte vitrification does not affect embryonic,genetic and clinical *** number of mature oocytes should be considered for fertilization in some cases.

关键词： Clinical outcomes Embryonic development Genetic outcomes Human oocyte Oocyte accumulation Oocyte cryopreservation Ploidy status Vitrified oocyte

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Rapid and efficient characterization of cervical collagen orientation using linearly polarized colposcopic images

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Journal of Innovative Optical Health Sciences 2023年第5期16卷 21-31页

作者： Cat Phan Ngoc Khuong Dung Nguyen Huu quang Hai Pham Thanh Long Nguyen Quynh Nguyen Ngoc Duc Le Huynh Tien Tran Van Tu Ly anh Department of Applied Physics Ho Chi Minh City University of Technology 268 Ly Thuong Kiet Street District 10 Ho Chi Minh City 700000Vietnam Quality Management Department Tu Du Hospital 284 Cong QuynhDistrict 1 Ho Chi Minh City 700000Vietnam Department of Biomedical Engineering Nguyen Tat Thanh University 300A Nguyen Tat Thanh District 4Ho Chi Minh City 700000Vietnam Faculty of Science and Technology Jean Monnet University 11 Rue du Docteur Annino Saint Etienne 42000France

Collagen provides tissue strength and structural *** fication of the orientated dispersion of collagen fibers is an important factor when studying the mechanical properties of the *** this study,for the first time,a new method for rapid characterization of the collagen fiber orientations of the cervix using linearly polarized light colposcopy is presented.A total of 24 colposcopic images were captured using a cross-polarized imaging system with white LED light *** the preprocessing stage,the Red channel of the RGB image was chosen,which contains no information of the blood vessels because of the low-absorption of blood cells in the red ***,which is an ImageJ plug-in,was used to estimate the local orientation of the collagen *** result shows that in the nonpregnant cervix,the middle zone(Zone 2)has circumferentially aligned collagen fibers while the inner zone(Zone 1)has randomly *** collagen fiber dispersion in Zone 2 is much smaller than that in Zone 1 at all four quadrants region(anterior,posterior,left,and right quadrant).This new analysis technique could potentially combine with diagnostic tools to provide a quantitative platform of collagen fibers in the clinic.

关键词： Cervix collagen fibers collagen orientation coherency cross-polarized imaging colposcopy

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