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Composition,function,and timing:exploring the early‑life gut microbiota in piglets for probiotic interventions

Journal of Animal Science and Biotechnology 2024年第2期15卷 659-678页

作者： Jianping Quan Cineng Xu Donglin Ruan Yong Ye Yibin Qiu Jie Wu Shenping Zhou Menghao Luan Xiang Zhao Yue Chen danyang lin Ying Sun Jifei Yang Enqin Zheng Gengyuan Cai Zhenfang Wu Jie Yang College of Animal Science and National Engineering Research Center for Breeding Swine Industry South China Agricultural UniversityGuangzhouGuangdongPeople’s Republic of China Guangdong Provincial Key Laboratory of Agro‑Animal Genomics and Molecular Breeding South China Agricultural UniversityGuangzhouGuangdongChina Yunfu Subcenter of Guangdong Laboratory for lingnan Modern Agriculture YunfuGuangdongChina National Engineering Research Center for Breeding Swine Industry Wens Foodstuff Group Co.Ltd.YunfuGuangdongPeople’s Republic of China

Background The establishment of a robust gut microbiota in piglets during their early developmental stage holds the potential for long-term advantageous ***,the optimal timeframe for introducing probiotics to achieve this outcome remains *** In the context of this investigation,we conducted a longitudinal assessment of the fecal microbiota of 63 piglets at three distinct pre-weaning time ***,we gathered vaginal and fecal samples from 23 *** 16S rRNA gene and metagenomic sequencing methodologies,we conducted a comprehensive analysis of the fluctuation patterns in microbial composition,functional capacity,interaction networks,and colonization resistance within the gut microbiota of *** the piglets progressed in age,discernible modifications in intestinal microbial diversity,composition,and function were observed.A source-tracking analysis unveiled the pivotal role of fecal and vaginal microbiota derived from sows in populating the gut microbiota of neonatal *** D21,the microbial interaction network displayed a more concise and efficient configuration,accompanied by enhanced colonization resistance relative to the other two time ***,we identified three strains of Ruminococcus *** D10 as potential candidates for improving piglets’weight gain during the weaning *** The findings of this study propose that D10 represents the most opportune juncture for the introduction of external probiotic interventions during the early stages of piglet *** investigation augments our comprehension of the microbiota dynamics in early-life of piglets and offers valuable insights for guiding forthcoming probiotic interventions.

关键词： Colonization resistance Intestinal microbiota Piglet Weaning Weight gain

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Deformation mechanism of Cu-Al-Ni shape memory alloys fabricated via laser powder b e d fusion:Tension-compression asymmetry

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Journal of Materials Science & Technology 2023年第36期167卷 14-26页

作者： Yankun Zhang Lianyong Xu Lei Zhao danyang lin Minqian Liu Wei Chen Yongdian Han School of Materials Science and Engineering Tianjin UniversityTianjin 300350China Tianjin Key Laboratory of Advanced Joining Technology Tianjin 300350China State Key Laboratory of Engines Tianjin UniversityTianjin 300350China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

Introducing the unique advantage of additive manufacturing technology into copper-based shape memory alloys(SMAs)to fabricate high-performance alloys has garnered great attention in recent years,but the intrinsic relationships between microstructure and mechanical properties need to be further *** this paper,the microstructural evolution of ternary CuAlNi SMAs fabricated by laser powder bed fusion(LPBF)under the tensile-compressive loading was investigated to determine the underlying mechanism of tension-compression asymmetry,that is,excellent compressive but poor tensile *** characterization of the different deformation stages revealed the numerous activated deformation mech-anism on the 18R martensite matrix.A twin-related transformation dominated the main plastic defor-mation process due to lower stacking faults energy and high-density pre-existing planer defects in the CuAlNi *** twinning nucleated at prior austenite boundaries and developed into parallel and network structures inside the parent grain of different *** addition,the preferred orientation in different stages,the stress-inducedγphase transformation,and the interaction between dislocations and stacking faults are *** results not only provide significant insights to understand the detwinning and deformation twinning process of SMAs but also establish the essential framework of mi-crostructure and mechanical properties of Cu-based SMAs fabricated by LPBF.

关键词： Shape memory alloys Cu-based Laser powder bed fusion Microstructural evolution Deformation mechanism

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Process-microstructure-properties of CuAlNi shape memory alloys fabricated by laser powder bed fusion

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Journal of Materials Science & Technology 2023年第21期152卷 1-15页

作者： Yankun Zhang Lianyong Xu Lei Zhao danyang lin Minqian Liu Xueyan Qi Yongdian Han School of Materials Science and Engineering Tianjin UniversityTianjin 300350China Tianjin Key Laboratory of Advanced Joining Technology Tianjin 300350China State Key Laboratory of Engines Tianjin UniversityTianjin 300350China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

Cu-based shape memory alloys(SMAs)show great potential in the application of high temperature,but their performance improvement combining with additive manufacturing is still *** this paper,nearly defect-free(99.7%relative density)CuAlNi SMAs with two types of thermal-induced martensites,18R and 2H,were successfully fabricated by laser powder bed fusion(LPBF).The remelting printing strat-egy with systematic optimization framework including densification and printability analysis was used to get optimal process *** twin-related self-accommodation structure with long period stacking order substructure was formed during additive manufacturing *** as-build samples show excel-lent mechanical properties(ultimate compressive strength of 1593±10 MPa and large fracture strain of 23.0%±0.1%)with double-yielding,and outstanding shape memory effect,with maximum recoverable strain of 3.39% and nearly 100%recovery rate under compressive strain not exceeding 6%.Furthermore,the microstructural evolution in LPBF involving remelting,martensitic transformation,and 2H marten-site was *** result not only builds the microstructure framework involving high reflectivity alloys and martensitic transformation but also provides insight into the applicability of LPBF process in producing Cu-based SMAs.

关键词： Shape memory alloys Cu-based Laser powder bed fusion Martensitic transformation Microstructural evolution

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Improving tensile-shear properties of friction stir lap welded dissimilar Al/Mg joints by eliminating hook defect and controlling interfacial reaction

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Chinese Journal of Aeronautics 2023年第7期36卷 257-267页

作者： Yuqing MAO Ping YANG Wenyan ZHANG Ning LI Hao NIE danyang lin Liming KE National Defence Key Discipline Laboratory of Light Alloy Processing Science and Technology Nanchang Hangkong UniversityNanchang 330063China

To improve tensile-shear properties of fiction stir lap welded(FSLW) dissimilar Al/Mg joints, pin-tip profiles were innovatively designed and welding speed was optimized, and effects of them on formation, interface microstructure and mechanical properties of different FSLW joints were investigated. With increasing the welding speed, the tensile-shear load of FSLW joints produced by three pins presents an increasing firstly and then decreasing trend. Compared with Rpin, the hook and hole defect in the joints made by S-pin and T-pin are eliminated owing to additional eccentric force. Moreover, the joints obtained by T-pin at 75 mm/min have the highest tensile-shear load, and a maximum value of 3.425 kN is produced, which increases by 96.8%.Meanwhile, the pin-tip profile improves significantly the interface reaction depending on the welding temperature. For R-pin, thick brittle intermetallic compounds of about 6.9 μm Al3Mg2and 13.3 μm Al12Mg17layers at the welding interface derived from diffusion reaction are formed, resulting in continuous cracks. However, using T-pin can raise the interface temperature, and which makes the interface liquefy locally to generate only 2.2 μm Al3Mg2layer and dispersive(Al12-Mg17+Mg) eutectic structure. This can release high residual stress and remove welding crack, consequently enhancing the interface properties of T-pin joints.

关键词： Dissimilar Al/Mg alloys Friction stir lap welding Hook defect Interface microstructure Tensile-shear properties

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航天用镍基高温合金粉末床熔融技术研究进展

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航天制造技术 2024年第3期 1-14页

作者：宋晓国胡继旭林丹阳马瑞王亚军石志峰李赛哈尔滨工业大学(威海)材料学院威海264209 北京动力机械研究所北京100074

采用激光粉末床熔融技术(LPBF)制造镍基高温合金具有较大的生产潜力,在航空航天领域有着广泛的应用,因此这一技术受到了高度关注。近年来,为了更好地了解LPBF-镍基高温合金的性能和使用极限,相关学者对其开展了大量的研究工作。本文基... 详细信息

采用激光粉末床熔融技术(LPBF)制造镍基高温合金具有较大的生产潜力,在航空航天领域有着广泛的应用,因此这一技术受到了高度关注。近年来,为了更好地了解LPBF-镍基高温合金的性能和使用极限,相关学者对其开展了大量的研究工作。本文基于近年来多项LPBF-镍基高温合金的研究,阐述了该领域的研究目标和重要发现,并列举了LPBF镍基高温合金在航天工业中的具体应用。总体分析了工艺参数和热处理对镍基高温合金及其复合材料增材构件组织及力学性能的影响,以及LPBF过程中常用的建模方法及研究进展。最后,对LPBF-镍基高温合金的未来发展方向提出了展望。

关键词：激光粉末床熔融技术镍基高温合金微观结构拉伸性能疲劳性能

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GH3230合金选区激光熔化成形工艺对激光焊开裂的影响研究

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航天制造技术 2024年第3期 54-59页

作者：张泽宇闫梦喆罗文睿席鑫路永新林丹阳宋晓国西安石油大学材料科学与工程学院油气田腐蚀防护与新材料陕西省高等学校重点实验室西安710065 哈尔滨工业大学(威海)材料科学与工程学院山东省特种焊接技术重点实验室威海264290

采用选区激光熔化技术(SelectiveLaserMelting,SLM)制备了GH3230镍基高温合金,研究了工艺参数对GH3230镍基高温合金激光焊接开裂的影响。实验表明,随着扫描间距从0.05mm增加至0.09mm的过程中,母材析出的碳化物平均尺寸在增大,母材晶粒... 详细信息

采用选区激光熔化技术(SelectiveLaserMelting,SLM)制备了GH3230镍基高温合金,研究了工艺参数对GH3230镍基高温合金激光焊接开裂的影响。实验表明,随着扫描间距从0.05mm增加至0.09mm的过程中,母材析出的碳化物平均尺寸在增大,母材晶粒尺寸明显减小,晶界角向右偏移,得到的晶界角分布变得更为均匀。在激光焊接后,由于遗传效应的影响,焊缝处的晶粒随着扫描间距的增大也同母材晶粒一起减小,晶界角分布变得更加均匀,提高整体抵抗裂纹能力,焊缝中裂纹总长和最大长度都逐渐降低,裂纹数量逐渐减少。最终得出在扫描间距为0.09mm时,成形的合金试样在多种焊接工艺条件下抵抗开裂的能力最佳。

关键词：选区激光熔化 GH3230合金扫描间距焊接裂纹

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Fasn involved in the nephrotoxicity induced by polystyrene nanoplastics and the intervention of melatonin through intestinal microbiota-mediated lipid metabolism disorder

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Nano Research 2024年第8期17卷 7365-7375页

作者： Huiwen Kang danyang Huang Jiaru Jing Wei Zhang Lei Zhang Jingyu Wang Ziyan Liu lin Han Ziyan Wang Lefeng Zhang Ai Gao Department of Occupational Health and Environmental Health School of Public HealthCapital Medical UniversityBeijing 100069China Beijing Key Laboratory of Environmental Toxicology Capital Medical UniversityBeijing 100069China

Nanoplastics(NPs)can accumulate in the kidney and cause kidney injury,but the multi-organ interaction mechanism and preventive measures of kidney injury are still *** this study,in vivo(60μg/day,42 days)and in vitro(0.4μg/μL,24 h)exposure models of polystyrene nanoplastics(PS-NPs,80 nm)in mice and human kidney cortex proximal tubule epithelial cells(HK-2 cells)were established,*** study revealed that PS-NPs caused obvious pathological changes and impaired renal function in mice,which were related to lipid metabolism disorders mediated by intestinal ***-fatty acid synthase(Fasn)-docosahexaenoic acid(DHA)pathway may be one of the mechanisms of kidney injury in ***,we also found that melatonin attenuates PS-NPs-induced nephrotoxicity by modulating lipid metabolism disorders(represented by DHA)and affects Fasn *** conclusion,our study revealed the important role of intestinal flora-mediated lipid metabolism in PS-NPs-induced nephrotoxicity and preliminarily provided potential key gene targets and effective preventive measures for PS-NPs-induced nephrotoxicity.

关键词： nanoplastics nephrotoxicity lipid metabolism fatty acid synthase(Fasn) melatonin

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制度包容性视角下的庇护主义与新兴民主:阿根廷与菲律宾的比较研究

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东南亚研究 2022年第1期 46-63,153-154页

作者：林丹阳中山大学港澳珠江三角洲研究中心、粤港澳发展研究院

庇护主义对新兴民主的作用是多元、复杂、充满张力的。现有研究虽然揭示了庇护主义对新兴民主的双重作用,但无论是从功能主义视角还是政治发展视角的研究,都没有进一步探究导致庇护主义在不同国家发挥不同作用的原因。从制度主义视角出... 详细信息

庇护主义对新兴民主的作用是多元、复杂、充满张力的。现有研究虽然揭示了庇护主义对新兴民主的双重作用,但无论是从功能主义视角还是政治发展视角的研究,都没有进一步探究导致庇护主义在不同国家发挥不同作用的原因。从制度主义视角出发,引入“庇护主义包容性”这一概念,可以识别出两种类型的庇护主义,而庇护主义包容性的差异,则是决定庇护主义给新兴民主带来正面或负面作用的重要因素。在以阿根廷为代表的国家,包容性庇护主义能够在民主化时期与正式制度展开良性、积极的互动,使正式制度能够有效运转,将多元、广泛的社会群体纳入民主体制,从而有助于国家顺利实现民主转型和民主巩固;在以菲律宾为代表的国家,排他性庇护主义则会与民主化时期各项新生的正式制度展开恶性、消极的互动,严重侵蚀和破坏正式制度的功能,无法有效地聚合民意,也无法为民主体制提供必要的秩序与稳定,从而导致政治体系持续衰弱,民主巩固难以完成。

关键词：庇护主义新兴民主制度包容性阿根廷菲律宾

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电气自动化控制中变频调速技术研究

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科技资讯 2023年第10期21卷 51-54页

作者：林丹阳北京新骏商业管理有限公司北京100728

通过围绕电气自动化系统的三相异步电动机,探讨电动机传动设备的变频调速机械特性,包括电机电压、频率变频协调控制的稳态机械特征,并在此基础上提出利用矢量控制技术、脉宽调制技术(Pulse Width Modulation,PWM)、空间矢量脉宽调制算法... 详细信息

通过围绕电气自动化系统的三相异步电动机,探讨电动机传动设备的变频调速机械特性,包括电机电压、频率变频协调控制的稳态机械特征,并在此基础上提出利用矢量控制技术、脉宽调制技术(Pulse Width Modulation,PWM)、空间矢量脉宽调制算法(Space Vector Pulse Width Modulation,SVPWM),进行三电平逆变器结构构建、电压空间矢量生成、交流电压脉宽调制的控制,做出电气系统电动机变频电压、电流、转子调速的矢量控制,可有效保证电动机从负载转矩到额定转矩、给定转速到额定转速的动态平稳变化。

关键词：电气自动化矢量控制变频调速技术仿真研究

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Foreign body granuloma reaction with the use of medical glue and literature review:2 case report

Foreign body granuloma reaction with the use of medical glue...

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2013年浙江省肛肠外科学术年会暨结直肠疾病的微创及综...

作者： Wang danyang Liu FanLong lin JianJiang

In recent years,medical glue is widely used in surgery treatment of colorectal *** reported two cases of postoperative formation of foreign body granuloma reaction after application of medical glue in the foregoing operation,in order to prompt iatrogenic problems caused by the medical *** the increasingly widespread use of medical glue,it is necessary to conduct in-depth evidence-based medical research,and also prompts we should pay more attention to application security,to ensure medical safety.

关键词： medical glue colorectal disease iatrogenic problem foreign body granuloma

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