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An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-Ha Jeong Jarno Hiemstra Patrick V.Blokzijl Rebeca Damian-Ferrara danilo martins dos santos Jéssica H.L.da Fonseca Min-Ho Kang Jihyun Kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez Jeroen Leijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

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Quantitative hazard assessment system(Has-Q) for open pit mine slopes

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International Journal of Mining Science and Technology 2019年第3期29卷 419-427页

作者： Tatiana Barreto dos santos Milene Sabino Lana Tiago martins Pereira Ismet Canbulat Mining Engineering Department Universidade Estadual de Minas GeraisJoao Monlevade 35930314Brazil Mining Engineering Department Universidade Federal de Ouro PretoOuro Preto 35400000Brazil Statistical Department Universidade Federal de Ouro PretoOuro Preto 35400000Brazil School of Minerals and Energy Resources Engineering University of New South WalesSydneyNSW 2052Australia

Rock slope hazard assessment is an important part of risk analysis for open pit *** main parameters that can lead to rock slope failures are the parameters traditionally used in geomechanical classifications,the slope geometrical parameters and external factors like rainfall and *** paper presents a methodology for a hazard assessment system for open pit mine slopes based on 88 cases collated around the world using principal components analysis,discriminant analysis and confidence *** historical cases used in this study included copper,gold,iron,diamond,lead and zinc,platinum and claystone *** variables used in the assessment methodology are uniaxial compressive strength of intact rock;spacing,persistence,opening,roughness,infilling and orientation of the main discontinuity set;weathering of the rock mass;groundwater;blasting method;and height and inclination of the *** principal component analysis was used to quantify the data,the discriminant analysis was used to establish a rule to classify new slopes about its stability *** provide a practical hazard assessment system,confidence ellipses were used to propose a hazard graph and generate the *** discriminant rule developed in this research has a high discrimination capacity with an error rate of 11.36%.

关键词： Hazard assessment Risk analysis Open pit mine slopes Multivariate statistics

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Molecular approaches for spinal cord injury treatment

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Neural Regeneration Research 2023年第1期18卷 23-30页

作者： Fernanda martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos santos Caio Andrade Prins Fellipe Soares dos santos Cardoso Luiza dos santos Heringer Henrique Rocha Mendonça Ana Maria Blanco Martinez Laboratório de Neurodegeneração e Reparo Programa de Pós-Graduação em Medicina:Anatomia PatológicaDepartamento de PatologiaFaculdade de MedicinaHospital Universitário Clementino Fraga FilhoCentro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Ciências Biomédicas Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Biologia Departamento de NeurobiologiaLaboratório de Regeneração Neural e FunçãoUFFRio de JaneiroBrazil Laboratório Integrado de Morfologia Instituto de Biodiversidade e Sustentabilidade NUPEMPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisCentro Multidisciplinar UFRJ-MacaéUniversidade Federal do Rio de JaneiroMacaéBrazil

Injuries to the spinal cord result in permanent disabilities that limit daily life *** main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic *** decades of research,there is still no efficient treatment for spinal cord *** strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord *** these,molecular compounds are currently being used for neurological recovery,with promising *** molecules target the axon collapsed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost *** this review we focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,growth and neurotrophic factors,enzymes,and *** mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans.

关键词： axonal regeneration drugs enzymes growth factors molecular therapy neurotrophic factors purines spinal cord injury

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Inosine: a novel treatment for sciatic nerve injury

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Neural Regeneration Research 2021年第1期16卷 127-128页

作者： Fellipe Soares dos santos Cardoso Ana Maria Blanco Martinez Fernanda martins de Almeida Laboratório de Neurodegeneração e Reparo–Departamento de Anatomia Patológica–Hospital Universitário Clementino Fraga Filho HUCFF/Universidade Federal do Rio de Janeiro Rio de JaneiroBrazil Instituto de Ciências Biomédicas–ICB/Universidade Federal do Rio de Janeiro Rio de JaneiroBrazil

Trauma to the peripheral nervous system often results in loss of motor and sensory functions of the affected area of the body,leading to a series of functional impairments(Allodi et al.,2012).Injuries to peripheral nerves initiate a series of complex events,known as Wallerian degeneration,which allows the injured axons to regenerate and reinnervate their targets(Allodi et al.,2012).Damage to a nerve induces multiple alterations,which include:axonal degeneration,breakdown of myelin sheath,Schwann cells(SC)proliferation and conversion to a repair phenotype which express cytokines and chemokines that allow the infiltration and activation of macrophages(Mietto et al.,2015;Jessen and Mirsky,2016).

关键词： al. degeneration alterations

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Soil properties characterization for land-use planning and soil management in watersheds under family farming

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International Soil and Water Conservation Research 2022年第1期10卷 119-128页

作者： Jose Miguel Reichert Paulo Ivonir Gubiani danilo Rheinheimer dos santos Dalvan Jose Reinert Celso Aita Sandro Jose Giacomini Soils Department Universidade Federal de Santa Maria(UFSM)Santa MariaRSBrazil

Environmental monitoring of small,rural watersheds was one of the components of the Natural Re-sources Management and Rural Poverty Alleviation Program(RS-Rural)in southern *** purpose of the monitoring was to assess the impact of promoting soil conservation and environment manage-ment practices adopted by farmers and funded by the *** four small monitored watersheds,in a total of 95 plots representing distinct land use and soil management,surface soil was collected to characterize ground-zero of the Program by determining several soil physical,chemical and microbio-logical *** component analysis(PCA)shows soil physical,chemical and biological properties were decisive in defining the agricultural soils in the rural watersheds with family *** sensitivity to chemical properties provides an opportunity to improve soil quality if soil management focuses on altering those *** management practiced by tobacco farmers leads to rapid,intense degradation of some natural soil properties,especially those related to the dynamics of soil organic matter,compared with more conservationist uses(forest,regrowth,and grassland).Thus,soil management must be reoriented to avoid the progress of degradation and recover soil physical and biological *** crops and by land-abandonment to allow natural vegetation are important management strategies for the degraded soils used for tobacco production,increasing soil organic matter,nutrients and microbial activity and thus allowing further crop *** conclusion,wa-tersheds with tobacco cropping have soils with lower quality than when under no-tillage grain pro-duction,requiring changes in land use and soil management.

关键词： Natural resources management Environmental monitoring Soil conservation Soil quality Alleviating poverty

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J-A formulation: A finite element methodology for simulating superconducting devices

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Superconductivity 2023年第2期6卷 64-73页

作者： Gabriel dos santos Bárbara Maria Oliveira santos Felipe Sass Flávio Goulart dos Reis martins Guilherme Gonçalves Sotelo Rubens de Andrade Junior Federal Fluminense University Brazil State University of Rio de Janeiro Brazil Federal University of Rio de Janeiro Brazil

High‐temperature superconductors are a powerful technological option to be applied in the current scenario of energy *** applications include fault current limiters,power electrical cables,and electrical machines,for *** to the non‐linearities of superconductors,it is computationally costly to run real models of superconducting ***,it is of paramount importance to have a reliable and fast formulation to model superconducting *** paper proposes a new hybrid J‐A formulation to simulate superconducting *** new formulation is validated with 5 case studies,some of which are *** J‐A formulation agrees in all cases and has a smaller computation time when compared with the T‐A ***,due to the simple implementation,the proposed formulation allows the possibility of running the J and A formulations in the same order and presents itself as a potential feature to speed up and help the design of the superconducting devices.

关键词： High‐temperature superconductors Finite element method J‐A formulation

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Magnetic bearings with double crossed loops modelled with T-A formulation and electric circuits

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Superconductivity 2023年第3期7卷 65-74页

作者： Bárbara Maria Oliveira santos Gabriel dos santos Flávio Goulart dos Reis martins Felipe Sass Guilherme Gonçalves Sotelo Rubens de Andrade Junior Francesco Grilli Electrical Engineering Department Rio de Janeiro State UniversityRio de Janeiro20550-900Rio de JaneiroBrazil Electrical Engineering Department Universidade Federal FluminenseNiterói24210-240Rio de JaneiroBrazil Electrical Engineering Department Universidade Federal do Rio de JaneiroRio de Janeiro21941-909Rio de JaneiroBrazil Institute for Technical Physics Karlsruhe Institute of TechnologyKarlsruhe76131Germany

The application of High‐Temperature Superconductor(HTS)coils made of coated conductors has been investigated for many years.A possible configuration for such coils is the jointless loop,also known as the ring *** double crossed loop coil(DCLC)has been successfully applied in superconducting magnetic bearings(SMBs).The design of SMBs with DCLCs requires flexible modelling to allow all parts of the device to be *** work proposes the T‐A formulation with a thin‐film approximation for modelling SMB with DCLCs in the finite element analysis framework.A 2D representation of the system is coupled with an external electric circuit to model the continuity of the lines that represent the parts of each jointless *** couple the T‐A formulation and the circuit,an average of the total electric field,with both resistive and inductive components,is applied to the *** total current computed by the circuit is applied to the T‐A *** proposed methodology was validated by comparison with levitation force experimental *** types of tests were simulated:five levitation force tests and three guidance force *** is shown that there is a limit to the behaviour of the levitation force related to the high‐loss *** this limit,the stack of DCLCs behaves as an equivalent *** this limit,a high‐loss state appears as a linear growth of the levitation *** is also shown that this high‐loss state in vertical displacement influences the lateral force.

关键词： Coated conductors Jointless loops T‐A formulation

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Injection of bone marrow mesenchymal stem cells by intravenous or intraperitoneal routes is a viable alternative to spinal cord injury treatment in mice

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Neural Regeneration Research 2018年第6期13卷 1046-1053页

作者： Bruna dos santos Ramalho FernANDa martins de Almeida Conrado Mendonca Sales Silmara de Lima Ana Maria Blanco Martinez Laboratorio de Neurodegeneracao e Reparo Departamento de Patologia - Faculdade de Medicina HUCFF Universidade Federal do Rio de Janeiro Rio de laneiro Brazil

In spite of advances in surgical care and rehabilitation, the consequences of spinal cord injury （SCI） are still challenging. Several experimental therapeutic strategies have been studied in the SCI field, and recent advances have led to the development of therapies that may act on the inhibitory microenvironment. Assorted lineages of stem cells are considered a good treatment for SCI. This study investigated the effect of systemic transplantation of mesenchymal stem cells （MSCs） in a compressive SCI model. Here we present results of the intraperitoneal route, which has not been used previously for MSC administration after compressive SCI. We used adult female C57BL/6 mice that underwent laminectomy at the T9 level, followed by spinal cord compression for 1 minute with a 30-g vascular clip. The animals were divided into five groups： sham （anesthesia and laminectomy but without compression injury induction）, MSC i.p. （intraperitoneal injection of 8×10^5 MSCs in 500 μL of DMEM at 7 days after SCI）, MSC i.v. （intravenous injection of 8 × 10^5 MSCs in 500μL of DMEM at 7 days after SCI）, DMEM i.p. （intraperitoneal injection of 500μL of DMEM at 7 days after SCI）, DMEM i.v. （intravenous injection of 500 μL of DMEM at 7 days after SCI）. The effects of MSCs transplantation in white matter sparing were analyzed by luxol fast blue staining. The number of preserved fibers was counted in semithin sections stained with toluidine blue and the presence of trophic factors was analyzed by immunohistochemistry. In addition, we analyzed the locomotor performance with Basso Mouse Scale and Global Mobility Test. Our results showed white matter preservation and a larger number of preserved fibers in the MSC groups than in the DMEM groups. Furthermore, the MSC groups had higher levels of trophic factors （brain-derived neurotrophic factor, nerve growth factor, neurotrophin-3 and neurotrophin-4） in the spinal cord and improved locomotor performance. Our results indicate that injection of MSC

关键词： spinal cord injury mesenchymal stem cells intravenous route intraperitoneal route functional recovery systemic transplantation neural regeneration

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Species richness and similarity of the flora on four lajedos in Boa Nova, Bahia, Brazil

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Journal of Mountain Science 2023年第6期20卷 1526-1539页

作者： Morgana Maria DO CARMO BARBOSA Anderson FERREIRA PINTO MACHADO Andrea Karla ALMEIDA dos santos Raymundo JoséDE Sá-NETO Michele martins CORRêA Graduate Program in Environmental Sciences State University of Southwest BahiaUniversity Campus“Juvino Oliveira”BR 415km 0445700-000ItapetingaBahiaBrazil Secretary of Education of the State of Bahia Military Police College Eraldo TinocoBrasilia Avenue273Kadija45650-120Vitoria da ConquistaBahiaBrazil Mongoyós Herbarium Multidisciplinary Institute in HealthCampus Anísio TeixeiraFederal University of BahiaRua Hormindo Barros58Bairro Candeias45029-094Vitoria da ConquistaBahiaBrazil Department of Natural Sciences State University of Southwest BahiaEstrada do Bem Querers/nBairro Candeias45083-900Vitoria da ConquistaBahiaBrazil

The municipality of Boa Nova,in northeastern Brazil,is in an ecotone zone between the Caatinga and Atlantic Forest phytogeographic *** transition phytophysiognomy is seasonal forest and known locally as mata de cipó.In these phytophysiognomies there are lajedos,which are rock outcrops colonized by vegetation welladapted to extreme microclimatic variation and vegetation diversity is affected by the vegetation types of the surrounding *** to the singularity of these environments and the relevance of floristic studies for conservation,this work aimed to identify the species richness and compare the similarity of the flora on four rock outcrops in Boa *** flora was surveyed during exploratory walks along lajedos between 2016 and *** total,162 species were identified on the Boa Nova *** flora has a composition and structure similar to semiarid outcrops,as well as endemic species that also occur in surrounding *** the proximity,a similarity index revealed there is floristic dissimilarity between the *** new occurrences were recorded for the region,five species are threatened with extinction(Aosa gilgiana,Ficus cyclophylla,Hippeastrum stigmovittatum,Pleroma caatingae and Trixis pruskii),and 43 species are common in anthropogenic *** reinforces the importance of actions to conserve these areas.

关键词： Ecotone Flora Inselberg Rock outcrops Semiarid Similarity

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Mitomycin C in pterygium treatment

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 465-468页

作者： Thiago Goncalves dos santos martins Ana Luiza Fontes de A zevedo Costa Milton Ruiz Alves Roger Chammas Paulo Schor Federal University of Sao Paulo (UNIFESP) Sao Paulo 04023062 Brazil University of Sao Paulo (USP) Sao Paulo 01246903 Brazil

Pterygium is a benign lesion usually growing from the nasal side of the conjunctiva onto the *** cases of pterygium does not cause problem or requires specific *** exact cause of pterygium is not clear yet,but some factors are pointed as causes,being the most important the long-term ultraviolet ray *** surgery is usually considered when there are symptoms that do not respond to conservative *** is the main complication of the surgery,and much has been done to avoid *** C（MMC） has been used as a fibroblast proliferation inhibitor during the surgery to reduce the chance of recurrence of the *** review describes the use of MMC as an adjunctive,the optimal dosage,the duration of administration of MMC and possible complications,when used during,after and before the *** studies suggest that increased exposure（dose or duration） of MMC is associated with a lower recurrence,but with higher risks of complications.

关键词： mitomycin C pterygium surgery recurrence rate

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