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Characterization of patients with both alcoholic and nonalcoholic fatty liver disease in a large United States cohort

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World Journal of Hepatology 2019年第10期11卷 710-718页

作者： George Khoudari Amandeep Singh Mazen Noureddin danielle fritze Rocio Lopez Imad Asaad Eric Lawitz Fred Poordad Kris V Kowdley Naim Alkhouri Department of Hospital Medicine Cleveland Clinic FoundationClevelandOH 44195United States Department of Gastroenterology and Hepatology Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology and Hepatology Cedars Sinai Medical CenterLos AngelesCA 90048United States Department of General Surgery Texas Liver Institute and University of Texas HealthSan AntonioTX 78215United States Department of Quantitative Health Sciences Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology Metro Health SystemClevelandOH 44109United States Texas Liver Institute and University of Texas Health San AntonioTX 78215United States Swedish Liver Care Network Swedish Medical CenterSeattleWA 98122United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is the hepatic manifestation of the metabolic syndrome(MetS)and is characterized by steatosis in the absence of significant alcohol ***,MetS and significant alcohol intake coexist in certain individuals which may lead to the development of *** To assess the clinical characteristics of patients with both alcoholic and NAFLD(BAFLD)in a large cohort in the United *** Adults from the National Health and Nutrition Examination Survey between 2003-2014 were *** was diagnosed based on elevated alanine aminotransferase(ALT)and being overweight or obese in the absence of other liver *** patients met the criteria for NAFLD but also had either MetS or type 2 diabetes and consumed excessive amounts of *** and multivariable analysis were performed to assess differences between NAFLD and BAFLD and to compare severity based on a validated fibrosis score(FIB4 index).RESULTS The prevalence of NAFLD was at 25.9%(95%CI;25.1-26.8)and that of BAFLD was 0.84%(0.67,1.02)which corresponds to an estimated 1.24 million Americans affected by *** to NAFLD,patients with BAFLD were more likely to be male,smokers,have higher ALT,aspartate aminotransferase,triglycerides,and lower platelets;P2.67 was 3.2(1.4,7.0),P=0.004].CONCLUSION A significant percentage of the American general population is afflicted by BAFLD and these patients tend to have more advanced liver fibrosis.

关键词： Non-alcoholic fatty liver disease Alcoholic liver disease Fatty liver disease

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