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X-ray imaging of 30 year old wine grape wood reveals cumulative impacts of rootstocks on scion secondary growth and ravaz index

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Horticulture research 2023年第1期10卷 31-44页

作者： ZoëMigicovsky Michelle Y.Quigley Joey Mullins Tahira Ali Joel F.Swift Anita rose Agasaveeran Joseph D.Dougherty Brendan Michael Grant Ilayda Korkmaz Maneesh reddy Malpeddi Emily L.McNichol Andrew W.Sharp Jackie L.Harris danielle r.hopkins Lindsay M.Jordan Misha T.Kwasniewski r.Keith Striegler Asia L.Dowtin Stephanie Stotts Peter Cousins Daniel H.Chitwood Plant Foodand Environmental SciencesFaculty of AgricultureDalhousie UniversityTruroNova ScotiaB2N 5E3Canada Department of Horticulture Michigan State UniversityEast LansingMI48823USA College of Natural Science Michigan State UniversityEast LansingMI48823USA Department of Neuroscience Michigan State UniversityEast LansingMI48823USA Department of Biology Saint Louis UniversitySt.LouisMO63103USA Department of Physics and Astronomy Michigan State UniversityEast LansingMI48823USA Department of Computational Mathematics Science&EngineeringMichigan State UniversityEast LansingMI48823USA College of Engineering Michigan State UniversityEast LansingMI48823USA College of Social Science Michigan State UniversityEast LansingMI48823USA Department of Economics Michigan State UniversityEast LansingMI48823USA Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingMI48823USA College of Arts and Letters Michigan State UniversityEast LansingMI48823USA E.&J.Gallo Winery AcampoCA95220USA Current affiliation:Constellation Brands SoledadCA93960USA Department of Food Science The Pennsylvania State UniversityState CollegePA16803USA Department of Forestry Michigan State UniversityEast LansingMI48823USA Department of Agriculture Foodand Resource SciencesUniversity of Maryland Eastern ShorePrincess AnneMD21853USA Department of Natural Sciences University of Maryland Eastern ShorePrincess AnneMD21853USA E.&J.Gallo Winery ModestoCA95354USA Department of Biology Acadia UniversityWolfvilleNova ScotiaB4P 2R6Canada

Annual rings from 30 year old vines in a California rootstock trial were measured to determine the effects of 15 different rootstocks on Chardonnay and Cabernet Sauvignon *** traits measuring vegetative growth,yield,berry quality,and nutrient uptake were collected at the beginning(1995 to 1999)and end(2017 to 2020)of the lifetime of a vineyard initially planted in 1991 and removed in 2021.X-ray Computed Tomography(CT)was used to measure ring widths in 103 *** width was modeled as a function of ring number using a negative exponential *** and late wood ring widths,cambium width,and scion trunk radius were correlated with 27 *** of annual ring width shows that scions alter the width of the first rings but that rootstocks alter the decay of later rings,consistently shortening ring width throughout the lifetime of the *** index,juice pH,photosynthetic assimilation and transpiration rates,and instantaneous water use efficiency are correlated with scion trunk ***,our research indicates that rootstocks modulate secondary growth over years,altering physiology and agronomic *** act in similar but distinct ways from climate to modulate ring width,which borrowing techniques from dendrochronology,can be used to monitor both genetic and environmental effects in woody perennial crop species.

关键词： rings lifetime removed

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International study of the Complex Stress reaction Syndrome:Implications for transdiagnostic clinical practice

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World Journal of Psychiatry 2023年第10期13卷 803-815页

作者： Sari Goldstein Ferber Aron Weller Adele M Hayes Tracy D Vannorsdall Yaroup Ajlouni Mo'nes Qudah Gil Zalsman Gal Shoval Tommaso Benedetto Jannini racquel Fiedler Lily X Chen danielle r Shayani Elin Kachuki Dory Dana Stolowicz-Melman Connor Evans Megan Trow Giorgio Di Lorenzo rodolfo rossi Department of Psychological and Brain Sciences University of DelawareNewarkDE 19716United States Department of Psychology Bar Ilan UniversityRamat Gan 5290002Israel Department of Psychology and The Gonda Brain research Center Bar Ilan UniversityRamat Gan 5290002Israel Department of Psychiatry and Behavioral Sciences Department of NeurologyThe Johns Hopkins University School of MedicineBaltimoreMD 21287United States Jordan Health Aid-International Amman 1234Jordan Geha Mental Health Center Petah TiqvaIsrael and Faculty of MedicineTel Aviv UniversityRamat Aviv 6997801Israel Division of Molecular Imaging and Neuropathology Department of PsychiatryColumbia UniversityNew YorkNY 10032United States Department of Neuroscience Princeton UniversityPrincetonNJ 08544United States Department of Systems Medicine Tor Vergata University of RomeRome 00133Italy UNSW School of Psychology UNSW SydneySydney 2052Australia Department of Biology Pacific UniversityForest GroveOR 97116United States Oregon Chapter of Fulbright Association OregonOR 97045United States Department of Systems Medicine Tor Vergata University of RomeRome 00179Italy IrCCS Fondazione Santa LuciaRome 00179Italy

BACKGrOUND The debate regarding diagnostic classification systems in psychiatry(categorial vs dimensional systems)has essential implications for the diagnosis,prevention and treatment of stress *** previously found a unique pattern of stress reaction in a study executed during the coronavirus disease 2019 pandemic using large representative samples in two countries,and termed it the Complex Stress reaction Syndrome(CSrS).AIM To investigate CSrS,Type A(psychiatric symptoms,spanning anxiety,depression,stress symptoms,and posttraumatic stress disorder(PTSD)),with or without long-coronavirus disease(COVID)residuals(CSrS,Type B,neuropsychiatric symptoms spanning cognitive deficits and fatigue,excluding systemic symptoms).Our two-tailed hypothesis was that CSrS is a condition related to an unrecognized type of stress reaction in daily life in the general population(Type A)or that it is related to the severe acute respiratory syndrome coronavirus 2 infection and its long-COVID residuals(Type B).METHODS 977 individuals in four continents(North America,Europe,Australia and the Middle East)completed the online study questionnaire in six languages using the Qualtrics *** study was managed by six teams in six countries that promoted the study on social *** questionnaire assessed anxiety,depression,stress symptoms and PTSD(CSrS,Type A),cognitive deficits and fatigue(CSrS,Type B).The data were analyzed using Proportion Analyses,Multivariate Analysis of Co-Variance(MANCOVA),linear regression analyses and validated clinical cutoff *** The results of the Proportion Analyses showed that the prevalence of 4 symptoms spanning anxiety,depression,stress symptoms,and PTSD was significantly higher than the most prevalent combinations of fewer symptoms across 4 continents,age groups,and *** supports the transdiagnostic argument embedded in the CSrS(Type A).The same pattern of results was found in infected/recovered *** prevalence of the

关键词： Transdiagnostic Complex Stress reaction Syndrome Stress reactivity Affective disorders Debate in psychiatry

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Juvenile polyposis syndrome

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World Journal of Gastroenterology 2011年第44期17卷 4839-4844页

作者： Lodewijk AA Brosens danielle Langeveld W Arnout van Hattem Francis M Giardiello G Johan A Offerhaus Department of Pathology University Medical Centre Utrecht Department of Pathology Academic Medical Centre Division of Gastroenterology Department of Medicine The Johns Hopkins University School of Medicine

Juvenile polyposis syndrome is a rare autosomal dominant syndrome characterized by multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk of colorectal *** cumulative life-time risk of colorectal cancer is 39% and the relative risk is *** polyps have a distinctive histology characterized by an abundance of edematous lamina propria with inflammatory cells and cystically dilated glands lined by cuboidal to columnar epithelium with reactive ***,juvenile polyposis syndrome is defined by the presence of 5 or more juvenile polyps in the colorectum,juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile *** about 50%-60% of patients diagnosed with juvenile polyposis syndrome a germline mutation in the SMAD4 or BMPr1A gene is *** genes play a role in the BMP/TGF-beta signalling *** has been suggested that cancer in juvenile polyposis may develop through the socalled "landscaper mechanism" where an abnormal stromal environment leads to neoplastic transformation of the adjacent epithelium and in the end invasive *** of this rare disorder is important for patients and their families with regard to treatment,follow-up and screening of at risk *** clinician confronted with the diagnosis of a juvenile polyp should therefore consider the possibility of juvenile polyposis *** addition,juvenile polyposis syndrome provides a unique model to study colorectal cancer pathogenesis in general and gives insight in the molecular genetic basis of *** review discusses clinical manifestations,genetics,pathogenesis and management of juvenile polyposis syndrome.

关键词：幼年性综合征肉 SMAD4蛋白分子遗传基础发病机制上皮细胞临床表现

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Systematic review of HPV Prevalence in Penile Cancer and Penile Intraepithelial Neoplasia

Systematic Review of HPV Prevalence in Penile Cancer and Pen...

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24th International Papillomavirus Conference and Clinical Workshop

作者： danielle Backes robert Kurman Jennifer Smith Department of Epidemiology School of Public HealthUniversity of North CarolinaChapel HillNC Departments of Pathology Gynecology and ObstetricsJohns Hopkins Medical InstitutionsBaltimoreMD Department of Epidemiology School of Public HealthUniversity of North CarolinaChapel HillNC

＜正＞Background:Type-specific prevalence data of human papitlomavirus（HPV）DNA in penile carcinoma and penile intraepithelial neoplasia（PIN）are needed to determine the potential impact of HPV prophytactic vaccines...

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Traps and trumps from adjacent-to-tumor samples in gastric cancer research

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Chinese Journal of Cancer research 2018年第5期30卷 564-567页

作者： Paulo Pimentel de Assumpcao Andre Salim Khayat Taissa Maira Thomaz Araujo Williams Fernandes Barra Geraldo Ishak Mine Maria Pereira Cruz ramos Sidney Emanuel Batista dos Santos Andrea Kely Campos ribeiro dos Santos Samia Demachki Paula Barauna de Assumpcao danielle Queiroz Calcagno Ney Pereira Carneiro dos Santos Monica Barauna de Assumpcao Fabiano Cordeiro Moreira Andre Mauricio ribeiro dos Santos Carolina Barauna de Assumpcao Gregory Joseph riggins rommel Mario rodriguez Burbano Oncology research Center Federal University of Para Belem 66075-110 Brazil PhD Program in Genetics and Molecular Biology Federal University of Para Belem 66075-110 Brazil Gastrointestinal Endoscopy Service Joao de Barros Barreto University Hospital Belem 66073-000 Brazil Department of Surgical Oncology Oswaldo Cruz Germany Hospital Sao Paulo 01327-001 Brazil Department of Neurosurgery Johns Hopkins University Baltimore 21287 USA Laboratory of Molecular Biology Ophir Loyola Hospital Belem 66060-281 Brazil

The search for cancer biomarkers is frequently based on comparisons between tumors and adjacent-to-tumor samples. However, even after histological confirmation of been free of cancer cells, these adjacent-to-tumor samples might harbor molecular alterations which are not sufficient to cause them to look like cancer, but can differentiate these cells from normal cells. When comparing them, potential biomarkers are missed, and mainly the opportunity of finding initial aberrations presents in both tumors and adjacent samples, but not in true normal samples from non-cancer patients, resulting in misinterpretations about the carcinogenic process. Nevertheless, collecting adjacent-to-tumor samples brings trumps to be explored. The addition of samples from non-cancer patients opens an opportunity to increase the finds of the molecular cascade of events in the carcinogenic process. Differences between normal samples and adjacent samples might represent the first steps of the carcinogenic process. Adding samples of non-cancer patients to the analysis of molecular alterations relevant to the carcinogenic process opens a new window of opporttmides to the discovery of cancer biomarkers and molecular targets.

关键词： Adjacent-to-tumor trumps traps

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