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Effectiveness of bNT162b2 and CoronaVac vaccines against omicron in children aged 5 to 11 years

World Journal of Pediatrics 2023年第10期19卷 949-960页

作者： Eduardo A.Oliveira Maria Christina L.Oliveira Ana Cristina Simões e Silva Enrico A.Colosimo Robert H.Mak Mariana A.Vasconcelos Ludmila R.Silva daniella b.martelli Clara C.Pinhati Hercílio martelli-Júnior Department of Pediatrics Health Sciences Postgraduate ProgramSchool of MedicineFederal University of Minas Gerais(UFMG)R.Engenheiro Amaro Lanari 389/501Belo HorizonteMG30130-100Brazil Department of Statistics Federal University of Minas GeraisBelo HorizonteMGBrazil Department of Pediatrics Rady Children’s HospitalUniversity of CaliforniaLa JollaSan DiegoCAUSA Health Science/Postgraduate Program in Nursing.School of Nursing Federal University of Minas Gerais(UFMG)Belo HorizonteMG30130-100Brazil Health Science/Primary Care Postgraduate Program State University of Montes Claros(Unimontes)Montes ClarosMG39401-089Brazil

background This study aimed to estimate vaccine effectiveness(VE)against omicron variant infection and severe corona virus disease 2019(COVID-19)in children aged 5–11 years hospitalized with acute respiratory *** A test-negative,case–control analysis was conducted from February 2022 to June *** enrolled 6950 eligible children,including 1102 cases and 5848 *** was calculated after immunization with one and two doses of bNT162b2 or *** outcomes were hospitalization with acute respiratory symptoms and detection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and severe *** adjusted odds ratio for the association of prior vaccination and outcomes was used to estimate *** For fully vaccinated children,the overall estimated VE against hospitalization with SARS-CoV-2 infection was 42%[95%confidence interval(CI)26 to 54].VE peaked at 29–42 days(67%,95%CI 40%to 82%)and then declined to 19%(95%CI,−20%to 45%)at 57–120 days after the second *** bNT162b2 vaccine had a similar VE against hospitalization with SARS-CoV-2 infection(45%,95%CI,20 to 61)compared to the CoronaVac vaccine(40%,95%CI,17%to 56%).Among cases,56(5%)children died;53(94.6%)were not fully *** cases,the two-dose schedule effectiveness against ICU admission,need for invasive ventilation,severe illness,and death were 10%(95%CI,−54%–45%),22%(95%CI−70%–68%),12%(95%CI,−62%–52%),and 16%(95%CI,−77%–75%),*** For hospitalized children aged 5–11 years during the omicron-predominant period in brazil,two doses of both vaccines had moderate effectiveness against hospitalization with acute respiratory symptoms and SARS-CoV-2 infection and offered limited protection against endpoints of COVID-19 severity.

关键词： Children COVID-19 Effectiveness Omicron Vaccine

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Comprehensive lumped parameter and multibody approach for the dynamic simulation of agricultural tractors with tyre–soil interaction

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IET Cyber-Systems and Robotics 2023年第3期5卷 1-23页

作者： Massimo martelli Damiano Chiarabelli Silvia Gessi Pietro Marani Emiliano Mucchi Marco Polastri Institute of Sciences and Technologies for Sustainable Energy and Mobility CNR‐STEMSNational Research CouncilFerraraItaly Department of Engineering University of FerraraFerraraItaly

Modern agricultural tractors are complex systems,in which multiple physical(and technological)domains interact to reach a wide set of competing goals,including work operational performance and energy *** complexity translates to the dynamic,multi‐domain simulation models implemented to serve as digital twins,for rapid prototyping and effective pre‐tuning,prior to bench and on‐field ***,a suitable simulation framework should have the capability to focus both on the vehicle as a whole and on individual *** each of the latter,multiple options should be available,with different levels of detail,to properly address the relevant phenomena,depending on the specific focus,for an optimal balance between accuracy and computation *** methodology proposed here by the authors is based on the lumped parameter approach and integrates the models for the following subsystems in a modular context:internal combustion engine,hydromechanical transmission,vehicle body,and tyre–soil *** model is completed by a load cycle module that generates stimulus time histories to reproduce the work load under real operating *** capability is affected by vertical load on the wheels,which is even more relevant if the vehicle is travelling on an uncompacted soil and subject to a variable drawbar pull force as it is when *** vertical load is,in turn,heavily affected by vehicle dynamics,which can be accurately modelled via a full multibody *** presented lumped parameter model is intended as a powerful simulation tool to evaluate tractor performance,both in terms of fuel consumption and traction dynamics,by considering the cascade phenomena from the wheel–ground interaction to the engine,passing through the dynamics of vehicle bodies and their mass *** capabilities and numerical results are presented for the simulation of a realistic ploughing operation.

关键词： agricultural tractor digital twin lumped parameter simulation,multibody powertrain tyre-soil interaction

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MULTIPLE SCLEROSIS AFTER HEPATITIS b VACCINATION IN A 16-YEAR-OLD PATIENT

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Chinese Medical Journal 2006年第1期119卷 77-79页

作者： daniella TERNEY SáNDOR bENICZKY PéTER bARSI ISTVáN KONDáKOR JóZSEF PERéNYI béLA FALUDI MAGDOLNA SZAPPER LáSZLó VéCSEI DEPARTMENT OF NEUROLOGY ALBERT SZENT-GYRGYI MEDICAL AND PHARMACEUTICAL CENTRE UNIVERSITY OF SZEGED P.O. BOX 427 H-6701 SZEGED HUNGARY DEPARTMENT OF RADIOLOGY OPNI HüVSVLGYI úT 116 H-1021 BUDAPEST HUNGARY DEPARTMENT OF NEUROLOGY UNIVERSITY OF PéCS RéT U. 2 H-7623 PéCS HUNGARY DEPARTMENT OF NEUROLOGY OPNI HüVSVLGYI úT 116 H-1021 BUDAPEST HUNGARY NEUROLOGY RESEARCH GROUP OF THE HUNGARIAN ACADEMY OF SCIENCES AND UNIVERSITY OF SZEGED SEMMELWEIS U. 6 H-6725 SZEGED HUNGARY

Since the first description of multiple sclerosis （MS）, it has been known that relapse of the disease may be triggered by febrile infections. Although the prevention of febrile illness is therefore clearly advantageous for those with MS there is considerable controversy as to whether vaccine should be administered to such individuals. A further subject of debate is the possibility that vaccination （against influenza,

关键词： hepatitis b vaccination encephalomyelitis multiple sclerosis

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A method for microbial decontamination of Acanthamoeba cultures using the peritoneal cavity of mice

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Asian Pacific Journal of Tropical biomedicine 2015年第10期5卷 796-800页

作者： daniella de Sousa Mendes Moreira Alves Rodrigo Gurgel-Goncalves Patrícia Albuquerque César Augusto Cuba-Cuba Maria Imaculada Muniz-Junqueira Selma Aparecida Souza Kückelhaus Institute of Tropical Pathology and Public Health Federal University of Goias Laboratory of Medical Parasitology and Vector biology Pathology University of Brasilia Faculty of Ceilandia University of Brasilia Laboratory of Cellular Immunology Pathology Faculty of Medicine University of Brasilia Area of Morphology Faculty of Medicine University of Brasilia

Objective: To evaluate whether the inoculation of contaminated cultures in the peritoneal cavity of mice could implement decontamination of Acanthamoeba ***: Suspensions of Acanthamoeba, Acanthamoeba polyphaga ATCC 30461, or Acanthamoeba spp. isolated from soil(Un b13 strain) were inoculated in the peritoneal cavity of Swiss mice(n = 24). After 1, 6, 12, or 24 h of exposure the peritoneal cavity was washed and assessed for the presence of bacteria, fungi, and ***: After 1 h of intraperitoneal inoculation at least 97% of the bacteria and 96% of the fungi(P bacteria(P b13 strain, respectively. This method also allowed the recovery of most trophozoites and cysts from both Acanthamoeba cultures at the end of 24 ***: Our data demonstrated that this technique has great potential for decontamination of Acanthamoeba cultures in a short period of time.

关键词： peritoneal fungi contaminated assessed microbial e

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维生素C有助于克服黄曲霉素中毒

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国外畜牧学（猪与禽） 2001年第4期21卷 14-17页

作者：胡少昶 daniella Tudor 法国全国农业研究院动物生物学和营养研究所

笔者在以前在《国际家禽》杂志中发表的一篇文章中阐述了赖氨酸在免疫系统中的重要作用 ,但在 1 998年召开于以色列的第十届欧洲家禽会议之前 ,未见任何关于维生素C有助于解决霉菌毒素中毒问题的报告。现在 ,许多研究人员和农民都在认... 详细信息

笔者在以前在《国际家禽》杂志中发表的一篇文章中阐述了赖氨酸在免疫系统中的重要作用 ,但在 1 998年召开于以色列的第十届欧洲家禽会议之前 ,未见任何关于维生素C有助于解决霉菌毒素中毒问题的报告。现在 ,许多研究人员和农民都在认真地探索这个问题。笔者坚信 ,在日粮中添加一定水平的维生素C ,再加上适当水平的氨基酸 ,是克服黄曲霉毒素中毒的有效方法。维生素C可阻断黄曲霉毒素b1的环氧化作用从而阻止其转化为活性形式的毒性物质。

关键词：动物饲料黄曲霉毒素中毒维生素C

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漂流的别墅

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室内设计与装修 2006年第7期 56-61页

作者： Lazzarini Pickering Architetti Samuele martelli 周洋

一个多世纪以来,Tuscan b enetti造船厂是意大利航海界最具声望的名字之一。他们所生产的船舶永远是优雅、技术与力量的完美集合体。简言之,Tuscan b enetti就是无可挑剔的绝对象征。因此,他们的产品一直是船主与造船厂选择时的参照。2... 详细信息

一个多世纪以来,Tuscan b enetti造船厂是意大利航海界最具声望的名字之一。他们所生产的船舶永远是优雅、技术与力量的完美集合体。简言之,Tuscan b enetti就是无可挑剔的绝对象征。因此,他们的产品一直是船主与造船厂选择时的参照。2004年,b enetti造船厂投入下水的SaiRam号?（共6页)

关键词：别墅漂流造船厂意大利集合体

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高雅运动

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室内设计与装修 2006年第7期 82-85页

作者： Fulvio De Simoni Samuele martelli 许科

Pershing115’号第一次亮相就赢得满堂喝彩,在2004热那亚(意大利西北名城)国际船只展上,首次向公众展示的Pershing115’号就获得了室内设计特别奖。紧接着,在2005年摩纳哥久负盛名的航海展上它又获得大会的最高奖“Show b oats Aw ard2... 详细信息

Pershing115’号第一次亮相就赢得满堂喝彩,在2004热那亚(意大利西北名城)国际船只展上,首次向公众展示的Pershing115’号就获得了室内设计特别奖。紧接着,在2005年摩纳哥久负盛名的航海展上它又获得大会的最高奖“Show b oats Aw ard2005”。应该说,所有的奖项都不仅仅因为Per（共4页)

关键词：运动 Award 室内设计意大利造船所

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Influence of Photoperiod over Morphometric and Hematological Parameters of Juvenile Piracanjubas （brycon orbygnianus）

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Journal of Agricultural Science and Technology(b) 2016年第5期6卷 350-359页

作者： Monica Rodrigues Ferreira Machado] Eliane Aparecida de Andrade Estefania de Souza Andrade daniella Aparecida de Jesus Paula Julia Alvarenga Oliveira Adriano Carvalho Costa Ana Paula Peconick Luis David Solis Murgas Department of biological Science Federal University of Goias (UFG) Campus Cidade Universitaria CEP 75801-615 JataiGoias Brazil Department of Veterinary Medicine Cdmpus Universitario Federal University of Lavras (UFLA) Lavras Minas Gerais CEP3 7200-000 Brazil Department of Animal Science Federal Institute of Rio Verde (IFR V) Rio Verde Goias CEP 75901-970 Brazil

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The Hemochromatosis Distribution in Matera Province： A New SNP to Explain the Low Genotype-Phenotype Correlation

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Journal of Life Sciences 2012年第5期6卷 469-475页

作者： Maria Carmela Padula Marilena Larocca Rocco Rossano Luigi Milella Domenico Dell'Edera Giuseppe martelli Department of biology University of Basilicata Potenza Viale dell 'Ateneo Lucano 85100 Italy

The present study aims to investigate the genotype-phenotype correlation of the hereditary hemochromatosis (HH), a genetic disorder of iron metabolism, in Matera province (basilicata, Italy). Integrating both epidemiological and molecular approaches, the authors studied: (a) the frequency of the HH main mutations; (b) the association between mutations and HH cases. The majority of patients with HH are homozygous for the C282Y mutation of the HFE gene. A second mutation (H63D) is more widely distributed and its connection with HH isn"t clear, but a low penetrance is attributed to this variant. The population-based study consists of three steps: (1) determination of iron biochemical parameters, (2) genetic test, and (3) sequencing of HFE gene and bioinformatics studies. A case report is presented in a 41-year-old male (genotype: H63D/wt) with biochemical and clinical evidences of HH, in absence of secondary iron overload factors. In the cohort of studied patients (150M:62F), there are 18 homozygous patients; H63D/H63D genotype is found in 11 cases. In the heterozygous group, H63D/wt is the predominant genotype (61/68 subjects). All the H63D/wt residents in the same village (Mont.) show altered biochemical parameter levels. In our case study, a substitution localized into the HFE promoter (nt225A > C) is found. Results show that the H63D genotype is responsible for most cases of HH. The peculiar clinical manifestation found in Mont. suggests a founder effect. In our case, the iron overload is related to a presence of an undetected mutation, critical for the transcriptional regulation of the HFE gene.

关键词：表型相关基因型 SNP 分子生物学方法遗传性疾病血色生化指标临床表现

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Search for the rare decays W^(+)→D_(s)^(+)γ and Z→D^(0)γ at LHCb

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中国物理C:英文版 2023年第9期47卷 14-26页

作者： R.Aaij A.S.W.Abdelmotteleb C.Abellan beteta F.Abudinén T.Ackernley b.Adeva M.Adinolfi P.Adlarson H.Afsharnia C.Agapopoulou C.A.Aidala Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche P.Alvarez Cartelle R.Amalric S.Amato J.L.Amey Y.Amhis L.An L.Anderlini M.Andersson A.Andreianov M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov M.Artuso E.Aslanides M.Atzeni b.Audurier S.bachmann M.bachmayer J.J.back A.bailly-reyre P.baladron Rodriguez V.balagura W.baldini J.baptista de Souza Leite M.barbetti R.J.barlow S.barsuk W.barter M.bartolini F.baryshnikov J.M.basels G.bassi b.batsukh A.battig A.bay A.beck M.becker F.bedeschi I.b.bediaga A.beiter V.belavin S.belin V.bellee K.belous I.belov I.belyaev G.benane G.bencivenni E.ben-Haim A.berezhnoy *** *** Andres D.berninghoff H.C.bernstein C.bertella A.bertolin C.betancourt F.betti Ia.bezshyiko S.bhasin J.bhom L.bian M.S.bieker N.V.biesuz S.bifani P.billoir A.biolchini M.birch F.C.R.bishop A.bitadze A.bizzeti M.P.blago T.blake F.blanc J.E.blank S.blusk D.bobulska J.A.boelhauve O.boente Garcia T.boettcher A.boldyrev C.S.bolognani R.bolzonella N.bondar F.borgato S.borghi M.borsato J.T.borsuk S.A.bouchiba T.J.V.bowcock A.boyer C.bozzi M.J.bradley S.braun A.brea Rodriguez J.brodzicka A.brossa Gonzalo J.brown D.brundu A.buonaura L.buonincontri A.T.burke C.burr A.bursche A.butkevich J.S.butter J.buytaert W.byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini P.Carniti L.Carus A.Casais Vidal R.Caspary G.Casse M.Cattaneo G.Cavallero V.Cavallini S.Celani J.Cerasoli D.Cervenkov A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier C.A.Chavez barajas M.Chefdeville C.Chen S.Chen A.Chernov S.Chernyshenko V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek G.Ciullo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.b.Coelho J.Cogan E.Cognera Centro brasileiro de Pesquisas Físicas(CbPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute Of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie Mont blanc CNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di bari BariItaly INFN Sezione di bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A search for the rare decays W^(+)→D_(s)^(+)γ and Z→D0γis performed using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of 13TeV,corresponding to an integrated luminosity of 2.0fb−*** significant signal is observed for either decay mode and upper limits on their branching fractions are set using W^(+)→D_(s)^(+)γ and Z→μ+μ−decays as normalization *** upper limits are 6.5×10^(−4) and 2.1×10^(−3) at 95% confidence level for the W^(+)→D_(s)^(+)γ and Z→D^(0)γ decay modes,*** is the first reported search for the Z→D^(0)γ decay,while the upper limit on the W+→D+sγbranching fraction improves upon the previous best limit.

关键词： W/Z boson rare decay upper limit of branching fraction

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