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Gastric cancer: Current status of lymph node dissection

World Journal of Gastroenterology 2016年第10期22卷 2875-2893页

作者： Maurizio Degiuli Giovanni De Manzoni Alberto Di Leo Domenico D'Ugo erica Galasso daniele Marrelli Roberto Petrioli Karol Polom Franco Roviello Francesco Santullo Mario Morino Department of Surgery University of TurinCitta della Salute e della Scienza Department of Surgery University of VeronaOspedale Borgo Trento Division of Surgery Ospedale di Arco Department of Surgery University "Cattolica del Sacro Cuore""A.Gemelli" University Hospital Department of Surgery University of Siena Department of Oncology University of Siena Department of Surgery Wielkopolskie Centrum Onkologii

D2 procedure has been accepted in Far east as the standard treatment for both early(eGC) and advanced gastric cancer(AGC) for many decades. Recently eGC has been successfully treated with endoscopy by endoscopic mucosal resection or endoscopic submucosal dissection, when restricted or extended Gotoda's criteria can be applied and D1+ surgery is offered only to patients not fitted for less invasive treatment. Furthermore, two randomised controlled trials(RCTs) have been demonstrating the non inferiority of minimally invasive technique as compared to standard open surgery for the treatment of early cases and recently the feasibility of adequate D1+ dissection has been demonstrated also for the robot assisted technique. In case of AGC the debate on the extent of nodal dissection has been open for many decades. While D2 gastrectomy was performed as the standard procedure in eastern countries, mostly based on observational and retrospective studies, in the west the Medical Research Council(MRC), Dutch and Italian RCTs have been conducted to show a survival benefit of D2 over D1 with evidence based medicine. Unfortunately both the MRC and the Dutch trials failed to show a survival benefit after the D2 procedure, mostly due to the significant increase of postoperative morbidity and mortality, which was referred to splenopancreatectomy. Only 15 years after the conclusion of its accrual, the Dutch trial could report a significant decrease of recur-rence after D2 procedure. Recently the long term survival analysis of the Italian RCT could demonstrate a benefit for patients with positive nodes treated with D2 gastrectomy without splenopancreatectomy. As nowadays also in western countries D2 procedure can be done safely with pancreas preserving technique and without preventive splenectomy, it has been suggested in several national guidelines as the recommended procedure for patients with AGC.

关键词： Gastric cancer Lymph node dissection Lymphadenectomy D2 gastrectomy D1 gastrectomy D1 plus gastrectomy Robot assisted lymphadenectomy Laparoscopic lymphadenectomy

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Acute syndesmotic injuries in ankle fractures:From diagnosis to treatment and current concepts

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World Journal of Orthopedics 2021年第5期12卷 270-291页

作者： Francesco Pogliacomi Massimo De Filippo daniele Casalini Alberto Longhi Fabrizio Tacci Rocco Perotta Francesco Pagnini Silvio Tocco Francesco Ceccarelli Department of Medicine and Surgery Orthopaedic ClinicParma 43126Italy Department of Medicine and Surgery University of ParmaParma 43126Italy Centro Riabilitativo della Mano e Arto Superiore Parma 43121Italy

A stable and precise articulation of the distal tibiofibular syndesmosis maintains the tibiofibular relationship,and it is essential for normal motion of the ankle *** disruption of this joint is frequently accompanied by rotational ankle fracture,such as pronation-external rotation,and rarely occurs without ankle *** diagnosis is not simple,and ideal management of the various presentations of syndesmotic injury remains controversial to this *** restoration and stabilization of the disrupted tibiofibular syndesmosis is essential to improve functional *** such an injury,including inadequately treated,misdiagnosed and correctly diagnosed cases,a chronic pattern characterized by persistent ankle pain,function disability and early osteoarthritis can *** paper reviews anatomical and biomechanical characteristics of this syndesmosis,the mechanism of its acute injury associated to fractures,radiological and arthroscopic diagnosis and surgical treatment.

关键词： Ankle Fracture Injury Distal tibiofibular joint Trauma Syndesmosis

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Genotype-environment interaction in Cordia trichotoma(Vell.)Arrá*** *** in two different soil conditions

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Journal of Forestry Research 2022年第1期33卷 309-319页

作者： Wanderley dos Santos Bruno Marchetti de Souza daniele Fernanda Zulian Gilberto Terra Ribeiro Alves João Bosco Vasconcellos Gomes Mário Luiz Teixeira de Moraes Valderês Aparecida de Sousa Ananda Virginia de Aguiar Faculdade de engenharia de Ilha Solteira Universidade Estadual Paulista“Júlio Mesquita Filho”Ilha Solteira 15385-000Brazil Sucupira Agroflorestas Fazenda SucupiraValença 45400-000Brazil eMBRAPA Florestas Empresa Brasileira de Pesquisa AgropecuáriaColombo 83411-000Brazil

Investment in silvicultural techniques is noticeably lacking,especially in breeding programs for non-conventional wood *** genotype×environment interaction(G×e)is essential to the development of breeding ***,this study aimed to estimate genetic diversity of and the effects of G×e interaction on two progeny tests of Cordia trichotoma,including the estimation of genetic gain and genetic diversity after *** the experiment,30 progenies of *** were tested at two sites with differing soil *** at breast height(1.30 m above soil surface,dbh-cm),total height,diameter at 30 cm from the soil,first branch height,and survival were all monitored for four *** deviance,best linear unbiased estimator,and harmonic mean of relative performance of genetic values(MHPRVG)were all calculated to predict breeding values,estimate genetic parameters,and analyze *** quantified traits varied significantly among progenies by soil type,with greatest variation recorded for genetic *** of the progenies led to predictions of genetic gain,ranging from 7.73 to 15.45%,for dbh at four years of *** calculated decrease in genetic diversity after selection showed that this parameter should be monitored in subsequent breeding cycles.G×e was low for all *** best-performing progenies proved most stable and best adapted to the different environmental conditions tested.

关键词： effective population number Native species Productivity Stability and adaptability Tree improvement

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基于时间序列SAR影像分析方法的三峡大坝稳定性监测

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中国科学：地球科学 2011年第1期41卷 110-123页

作者：王腾 daniele PeRISSIN Fabio ROCCA 廖明生武汉大学测绘遥感信息工程国家重点实验室武汉430079 Politecnico di Milano Dipartimento di Elettronica e InformazioneMilan 20133Italy 香港中文大学太空与地球信息科学研究所中国香港

本文提出了结合永久散射体和准永久散射体干涉测量技术的时间序列合成孔径雷达(SAR)影像几何信息提取方案,利用2003～2008年获取的40景SAR影像量测并分析了三峡大坝运行时的稳定性问题及其周边区域的形变规律.我们发现在数据获取期间,... 详细信息

本文提出了结合永久散射体和准永久散射体干涉测量技术的时间序列合成孔径雷达(SAR)影像几何信息提取方案,利用2003～2008年获取的40景SAR影像量测并分析了三峡大坝运行时的稳定性问题及其周边区域的形变规律.我们发现在数据获取期间,三峡大坝左段的时效沉降基本停止,大坝形变受水位的影响较大,季节性变化也有一定体现.该实验结果和已发表的该坝段形变监测结果十分吻合.在数据处理结果中我们还在大坝上游秭归县附近堤坝发现一处形变异常.研究结果表明了时间序列SAR影像信息提取技术在大坝稳定性监测及坝区形变参数获取中的应用潜力.

关键词：三峡工程形变监测合成孔径雷达干涉测量永久散射体技术

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Gut microbiota and nutrient interactions with skin in psoriasis:A comprehensive review of animal and human studies

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World Journal of Clinical Cases 2020年第6期8卷 1002-1012页

作者： Giovanni Damiani Nicola Luigi Bragazzi Thomas S McCormick Paolo daniele Maria Pigatto Sebastiano Leone Alessia Pacifico Danica Tiodorovic Sveva Di Franco Aniello Alfieri Marco Fiore Department of Dermatology Case Western Reserve UniversityClevelandOH 44106United States Clinical Dermatology IRCCS Istituto Ortopedico GaleazziMilan 20122Italy Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20122Italy Postgraduate School of Public Health Department of Health SciencesUniversity of GenoaGenoa 16132Italy Department of Medicine Division of Infectious diseases“San Giuseppe Moscati”HospitalAvellino 83100Italy San Gallicano Dermatological Institute IRCCSRome 00144Italy Dermatology Clinic Medical FacultyNis UniversityNis 18000Serbia Department of Women Child and General and Specialized SurgeryUniversity of Campania"Luigi Vanvitelli"Naples 80138Italy

The intestinal tract(i.e.,the gut),is where the body’s nutrients are absorbed,and is simultaneously inhabited by numerous *** increasing body of literature suggests a crucial role for the gut microbiome in modulating systemic inflammatory *** is a chronic systemic inflammatory disease and its pathogenesis is related to the interaction between genetic susceptibility,immune response and environmental *** omics era has allowed physicians to assess different aspects of psoriasis pathogenesis such as the microbiome,infectome,and ***,diet appears to play an important role in modulating disease activity,perhaps by influencing gut *** these observations,we aimed to summarize the current knowledge regarding skin-microbiome-gut-nutrients and psoriasis.

关键词： Gut Microbiota Nutrients endotypes exposome Psoriasis

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Biodegradable elastomeric circuit boards from citric acid-based polyesters

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npj Flexible electronics 2023年第1期7卷 307-320页

作者： Brendan L.Turner Jack Twiddy Michael D.Wilkins Srivatsan Ramesh Katie M.Kilgour eleo Domingos Olivia Nasrallah Stefano Menegatti Michael A.daniele Joint Department of Biomedical engineering North Carolina State University and University of North CarolinaChapel Hill911 Oval Dr.RaleighNC 27695USA Department of electrical&Computer engineering North Carolina State University890 Oval Dr.RaleighNC 27695USA Department of Chemical and Biomolecular engineering North Carolina State University911 Partners WayRaleighNC 27695USA Biomanufacturing Training and education Center(BTeC) North Carolina State University850 Oval DrRaleighNC 27606USA

Recyclable and biodegradable microelectronics,i.e.,“green”electronics,are emerging as a viable solution to the global challenge of electronic ***,flexible circuit boards represent a prime target for materials development and increasing the utility of green electronics in biomedical *** board substrates and packaging are good dielectrics,mechanically and thermally robust,and are compatible with microfabrication ***(octamethylene maleate(anhydride)citrate)(POMaC)–a citric acid-based elastomer with tunable degradation and mechanical properties–presents a promising alternative for circuit board substrates and ***,we report the characterization of elastomeric Circuit Boards(eCBs).Synthesis and processing conditions were optimized to achieve desired degradation and mechanical properties for production of stretchable *** traces were characterized and exhibited sheet resistance of 0.599Ωcm^(−2),crosstalk distance ofexhibited stable 0%strain resistances after 1000 strain cycles to 20%.Fabrication of single layer and encapsulated eCBs was demonstrated.

关键词： polyester resistance strain

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Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy

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Bioactive Materials 2021年第8期6卷 2629-2642页

作者： Gabriela Graziani Katia Barbaro Inna V.Fadeeva daniele Ghezzi Marco Fosca enrico Sassoni Gianluca Vadalà Martina Cappelletti Francesco Valle Nicola Baldini Julietta V.Rau IRCSS Istituto Ortopedico Rizzoli Laboratory of NanoBiotechnologyvia di Barbiano 1/1040136BolognaItaly Istituto Zooprofilattico Sperimentale Lazio e Toscana“M.Aleandri” Via Appia Nuova 1411-00178RomeItaly A.A.Baikov Institute of Metallurgy and Materials Science Russian Academy of SciencesLeninsky prospect 49119334MoscowRussia Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere100-00133RomeItaly University of Bologna Department of CivilChemicalEnvironmental and Materials Engineeringvia Terracini 2840131BolognaItaly UniversitàCampus Bio-Medico di Roma Research Unit of Orthopaedic SurgeryFaculty of Medicine and SurgeryVia Alvaro del Portillo 2100128RomeItaly University of Bologna Department of Pharmacy and Biotechnologyvia Irnerio 4240126BolognaItaly Institute of Nanostructured Materials National Research Council(ISMN-CNR)Via Piero Gobetti10140129BolognaItaly IRCSS Istituto Ortopedico Rizzoli BST Biomedical Science and Technologies Labvia di Barbiano 1/1040136BolognaItaly University of Bologna Department of Biomedical and Neuromotor SciencesVia Massarenti940128BolognaItaly Sechenov First Moscow State Medical University Institute of PharmacyDepartment of AnalyticalPhysical and Colloid ChemistryTrubetskaya 8build.2119991MoscowRussia

Orthopedic infections pose severe societal and economic burden and interfere with the capability of the implanted devices to integrate in the host bone,thus significantly increasing implants failure *** address infection and promote integration,here nanostructured antibacterial and bioactive thin films are proposed,obtained,for the first time,by Ionized Jet Deposition(IJD)of silver-substituted tricalcium phosphate(Ag-TCP)targets on *** morphology,composition and mechanical properties are characterized and proof-of-concept of biocompatibility is *** efficacy is investigated against four Gram positive and Gram negative bacterial strains and against *** fungus,by investigating the modifications in planktonic bacterial growth in the absence and presence of ***,for all bacterial strains,the capability of the film to inhibit bacterial adhesion is also *** indicate that IJD permits a fine control over films composition and morphology and deposition of films with suitable mechanical *** studies show a good efficacy against escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,enterococcus faecalis and against fungus Candida albicans,with evidences of efficacy against planktonic growth and significant reduction of bacterial cell *** cytotoxic effects are evidenced for equine adipose tissue derived mesenchymal stem cells(ADMSCs),as no reductions are caused to cells viability and no interference is assessed in cells differentiation towards osteogenic lineage,in the presence of ***,thanks to nanostructuration and biomimetic composition,tricalcium phosphate(TCP)coatings favor cells viability,also when *** findings show that silver-substituted nanostructured coatings are promising for orthopedic implant applications.

关键词： Tricalcium phosphate Silver Nanostructured coatings Antibacterial coatings Orthopedics Antibacterial ceramics

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Possible Multiple Sources of the Strong 1117 Po Plain earthquake, Inferred from the Plio-Quaternary evolution of the Northern Adriatic Area

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International Journal of Geosciences 2021年第4期12卷 381-403页

作者： enzo Mantovani Giuliano Brancolini daniele Babbucci Caterina Tamburelli Marcello Viti Dipartimento di Scienze Fisiche della Terra e dell’Ambiente Università di Siena Siena Italy Istituto Nazionale di Oceanografia e Geofisica Sperimentale—OGS Trieste Italy

The strongest documented seismic disaster ever occurred in the Po Plain area (January 3, 1117, M = 6.5) involved significant damage over a large zone. The genetic mechanism of such an event, most probably caused by more than one earthquake, is still an object of debate. Above all, the sources so far proposed cannot account for significant features of the observed macroseismic field. In this work, we suggest that the damage in the Verona zone was caused by the activation of a fault in the Lessini tectonic district, while damage in the central Po Plain may be related to a thrust fault located beneath the Giudicarie belt. The effects felt in northern Tuscany might derive from the seismic activation of the presumed SW-ward buried prolongation of the Giudicarie fault. The presence of such transpressional lithospheric discontinuity in the Adriatic domain since the upper Miocene and its reactivation (Pliocene-Pleistocenee="font-family:Verdana;">) as a thrust zone is mainly suggested by an accurate analysis of the observed deformation pattern in the central Mediterranean region. The proposed Giudicarie source may also help to explain the damage observed in the central Po Plain on December 25, 1222, which is not compatible with the seismic sources so far proposed.

关键词： Northern Adriatic Tectonics Po Plain Giudicarie Thrust Zone January 3 1117 earthquake Sources

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Femoral artery blowout syndrome after inguinal lymphadenectomy for penile cancer

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Asian Journal of Urology 2023年第3期10卷 379-381页

作者： edoardo Agostini eugenio Pretore Simone Scarcella daniele Castellani emanuele Gatta Lucio Dell’Atti Andrea B.Galosi Faculty of Medicine School of UrologyPolytechnic University of Marche RegionAnconaItaly Urology Unit Civil Hospital“C.e G.Mazzoni”Ascoli PicenoItaly Urology Unit Azienda Ospedaliera“Ospedali riunitiMarche Nord”PesaroItaly Urology Unit Azienda Ospedaliero Universitaria“Ospedali Riuniti”di AnconaAnconaItaly Vascular Surgery Unit Azienda Ospedaliero Universitaria“Ospedali Riuniti”di AnconaAnconaItaly Azienda Ospedaliero Universitaria“Ospedali Riuniti”di Ancona AnconaItaly

Dear editor,Inguinal lymphadenectomy represents a crucial step in both staging and treatment of penile cancer and can be curative in some ***,severe morbidity can be high in up to 50%of *** most-reported complications are skin necrosis,wound infection,lymphoedema,and lymphocele[1].In this setting,artery blowout syndrome(ABS)is a complication rarely described,presenting with vessels exposure through wound dehiscence,leading to arterial wall rupture with potentially life-threatening bleeding(Type III ABS).Reports have been described following radiation treatment of the groins or the neck[2,3].We present the first case of femoral artery wall rupture with severe hemorrhage after iliac and inguinal lymphadenectomy for penile cancer in a patient without previous radiation *** consent for case publication was obtained.

关键词： treatment wound treatment

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Seismotectonics of the Padanian Region and Surrounding Belts: Which Driving Mechanism?

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International Journal of Geosciences 2016年第12期7卷 1412-1451页

作者： Marcello Viti enzo Mantovani daniele Babbucci Caterina Tamburelli Nicola Cenni Dipartimento di Scienze Fisiche Della Terra e dell’Ambiente Università degli Studi di Siena Siena Italy Dipartimento di Fisica ed Astronomia Università degli Studi di Bologna Bologna Italy

It is argued that the complex tectonic pattern observed in the study area can plausibly be explained as an effect of the kinematics of the Iberia and Adria blocks, induced by the NNe ward motion of Africa and the roughly westward motion of the Anatolian-Aegean system with respect to eurasia. These boundary conditions cause the constrictional regime which is responsible for the observed shortening processes in the Padanian region and Western Alps. The proposed dynamic context can plausibly account for the peculiar distribution of major seismic sources, located in the northern Apennines, the Giudicarie fault system, the offshore of the western Ligurian coast and the Swiss Alps. The observed tectonic pattern in Western europe and the study area can hardly be reconciled with the implications of the roughly NWward convergence between Africa and eurasia proposed by global kinematic models, whereas it is compatible with the alternative Africa-eurasia kinematics and plate mosaic proposed by [1].

关键词： Seismotectonics Geodynamics GPS Mediterranean Padanian

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