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Candidate genes for male and female reproductive traits in Canchim beef cattle

Journal of Animal Science and Biotechnology 2018年第1期9卷 59-68页

作者： Marcos Eli Buzanskas daniela do amaral grossi Ricardo Vieira Ventura Flavio Schramm Schenkel Tatiane Cristina Seleguim Chud Nedenia Bonvino Stafuzza Luciana Diniz Rola Sarah Laguna Conceio Meirelles Fabiana Barichello Mokry Maurício de Alvarenga Mudadu Roberto Hiroshi Higa Marcos Vinícius Gualberto Barbosa da Silva Maurício Mello de Alencar Luciana Correia de Almeida Regitano Danísio Prado Munari Departamento de Zootecnia Universidade Federal da Paraíba(UFPB)AreiaParailba 58397-000Brazil Fast Genetics SaskatoonSK S7K 2K6Canada Beef Improvement Opportunities(BIO) GuelphON N1K 1ESCanada Department of Animal and Poultry Science University of GuelphCentre for Genetic Improvement of Livestock(CGIL)GuelphON N1G 2W1Canada Departamento de Ciencias Exatas Faculdade de Ci6ncias Agrarias e VeterinariasUniversidade Estadual Paulista(Unesp)JaboticabalSao Paulo 14884 900Brazil Departamento de Zootecnia Nucleo de Pesquisa e Conservacao de CervMeosFaculdade de Ciencias Agrarias e VeterinariasUniversidade Estadual Paulista(Unesp)JaboticabalSao Paulo 14884 900Brazil Department of Animal Science Federal University/of Lavras(UFLA)LavrasMinas Gerais 37200 000Brazil Department of Genetics and Evolution Federa University of Sao Carlos(UFSCar)Sao CarlosSao Paulo 13565-905Brazil Embrapa Agricultural Informatics Campinas55o Paulo 13083 886Brazil Embrapa Dairy Cattle Juiz de ForaMinas Gerais 36038 330Brazil Embrapa Southeast Livestock Sao CarlosSao Paulo 13560 970Brazil

Background： Beef cattle breeding programs in Brazil have placed greater emphasis on the genomic study of reproductive traits of males and females due to their economic importance. In this study, genome-wide associations were assessed for scrotal circumference at 210 d of age, scrotal circumference at 420 d of age, age at first calving, and age at second calving, in Canchim beef cattle. Data quality control was conducted resulting in 672,778 SNPs and 392 ***： Associated SNPs were observed for scrotal circumference at 420 d of age（435 SNPs）, followed by scrotal circumference at 210 d of age（12 SNPs）, age at first calving（six SNPs）, and age at second calving（four SNPs）. We investigated whether significant SNPs were within genic or surrounding regions. Biological processes of genes were associated with immune system, multicellular organismal process, response to stimulus, apoptotic process, cellular component organization or biogenesis, biological adhesion, and ***： Few associations were observed for scrotal circumference at 210 d of age, age at first calving, and age at second calving, reinforcing their polygenic inheritance and the complexity of understanding the genetic architecture of reproductive traits. Finding many associations for scrotal circumference at 420 d of age in various regions of the Canchim genome also reveals the difficulty of targeting specific candidate genes that could act on fertility; nonetheless,the high linkage disequilibrium between loci herein estimated could aid to overcome this issue. Therefore, al relevant information about genomic regions influencing reproductive traits may contribute to target candidate genes for further investigation of causal mutations and aid in future genomic studies in Canchim cattle to improve the breeding program.

关键词： Animal breeding Composite breed Genome-wide association Genomic data Single nucleotide polymorphism

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Bernard-Soulier Syndrome in Pregnancy: A Case Report

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Open Journal of Obstetrics and Gynecology 2019年第6期9卷 838-844页

作者： Amanda Vilaverde Perez Cilomar Martins de Oliveira Filho Tássia Cividanes Pazinato Mariana Sbaraini Edimárlei Gonsales Valério Sheila Nogueira do amaral Fernanda grossi daniela Vanessa Vettori Janete Vettorazzi Obstetrics and Gynecology Hospital de Clínicas de Porto Alegre Porto Alegre Brazil Postgraduation Program in Health Sciences: Gynecology and Obstetrics Universidade Federal do Rio Grande do Sul Porto Alegre Brazil Hematology Hospital de Clínicas de Porto Alegre Porto Alegre Brazil

Background: Bernard-Soulier Syndrome (BSS) is a rare autosomal recessively inherited bleeding disorder of platelet function. Pregnancy in BSS is associated with a high risk of serious bleeding for both mother and neonate, and current data show no consensual approach. Aim: To report the case of a pregnant woman with BSS, in order to provide more information about management of these cases. Case Presentation: This case report describes a successful pregnancy outcome in a woman with BSS who was closely monitored throughout pregnancy and postpartum period, and had a judiciously planned birth. Conclusion: Management of BSS during pregnancy is still unclear. However, it is important to strictly control platelet counts and plan the birth in advance.

关键词： Bernard-Soulier Hemostasis Thrombocytopenia Pregnancy Obstetrics Postpartum Hemorrhage

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The Effects of Lichen Sclerosus and Its Treatments on Sexuality: Case Report

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Open Journal of Obstetrics and Gynecology 2019年第6期9卷 755-763页

作者： Janete Vettorazzi Edimárlei Gonsales Valério Amanda Vilaverde Perez Mariana Sbaraini Luciana Segat daniela Vanessa Vetori Fernanda Santos grossi Valentino Antonio Magno Postgraduation Program in Health Sciences: Gynecology and Obstetrics Universidade Federal do Rio Grande do Sul (UFRGS). Rua Ramiro Barcelos Santa Cecilia Porto Alegre RS Brazil Department of Gynecology and Obstetrics Faculty of Medicine (FAMED) UFRGS Rua Ramiro Barcelos Santa Cecilia Porto Alegre RS Brazil FAMED UFRGS Rua Ramiro Barcelos Santa Cecilia Porto Alegre RS Brazil Service of Obstetrics and Gynecology Hospital de Clínicas de Porto Alegre (HCPA) Rua Ramiro Barcelos Santa Cecília Porto Alegre RS Brazil

Lichen sclerosus is a chronic and autoimmune dermatitis that develops in the anogenital region. It is related to genital alterations with repercussions in sexuality. We present a case of a 60-year-old woman who had several chronic diseases and had been diagnosed with vulvar lichen sclerosus for 20 years, with no response to multiple treatments (topical corticosteroids, immunomodulators). She was submitted to vulvectomy;however, it leads to worsening of her condition, presenting obliterated and fibrosed clitoris, atrophic vaginal lips, and anal and vulvar fissures. She remained with dyspareunia, decreased sexual desire and difficulty in orgasm. She underwent sexual therapy, adjustment of antidepressant medication and made intercalated use of topical corticosteroids, topical testosterone and vaginal moisturizers, with partial improvement. From this case we can conclude that, although vulvectomy can be related to some degree of improvement in patients with lichen sclerosus, serious complications can occur.

关键词： Lichen Sclerosus Dyspareunia Corticosteroids Vulvectomy

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Unusual Presentation of COVID-19: Encephalitis and Syndrome of Inappropriate Anti-Diuretic Hormone Secretion

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International Journal of Clinical Medicine 2020年第10期11卷 559-564页

作者： Maresca Andrea Mongiardi Christian Montalbetti Lorenzo Dentali Francesco Ageno Walter Mauri Marco Baj Andreina Grandi Anna Maria grossi Paolo Dalla Gasperina daniela Zerba Francesco Sessa Aurelio Guasti Luigina University of Insubria Varese Italy ASST-Settelaghi Varese Italy

COVID-19 is a new challenge in clinical medicine. Although typical presentations include fever and pneumonia, we describe a case of COVID-19 presenting with neurological symptoms of encephalitis and infectious-related syndrome of inappropriate anti-diuretic hormone secretion. Because of the epidemic health problems, it is crucial to identify these patients as early as possible to follow the isolation procedures. We suggest that unclear neurological clinical presentations of patients should be considered for COVID-19.

关键词： COVID-19 SARS-Cov-2 Encephalitis Syndrome of Inappropriate Anti-Diuretic Hormone Isolation Procedures

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移民管理中的腐败问题研究:基于网络分析的视角

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国际行政科学评论（中文版） 2020年第1期86卷 166-183页

作者：丹妮拉·皮涅齐朱塞佩·格罗西吴帅(译) 王东芳(审校) 英国埃塞克斯大学挪威诺德大学商学院不详

本文探讨了公共治理兴起的网络治理模式与腐败之间的关系。本文以行动者网络理论(actor-network theory)为视角,检验了一起意大利米内奥移民收容中心(Mineo’s CARA),这所欧洲最大的移民收容中心管理合同授予的腐败案件。分析表明,由于... 详细信息

本文探讨了公共治理兴起的网络治理模式与腐败之间的关系。本文以行动者网络理论(actor-network theory)为视角,检验了一起意大利米内奥移民收容中心(Mineo’s CARA),这所欧洲最大的移民收容中心管理合同授予的腐败案件。分析表明,由于治理系统中行动者的多样性、相互作用和碎片化所造成的模糊性,治理网络可能会沦为滥用权力的腐败网络。

关键词：行动者网络理论治理网络移民转译

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