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Journal of Environmental Protection 2017年第5期8卷 650-661页

作者： Lidmary P. Alves daniela S. P. Vieira Luís Sérgio S. Nunes Lícia P. S. Cruz Ana Caroline S. Reis ícaro V. S. Gomes Sameque R. Luz Akácia V. S. Santos Mabel B. Esteves Center of Biomedical Research Professional Masters in Bioenergy College of Technology and Science—FTC Salvador Brazil Analytical Chemistry Department Chemistry Institute Federal University of Bahia—UFBA Salvador Brazil

To show the risks and harm caused by the occupational exposure to the benzene, toluene, ethylbenzene and xylenes compounds (BTEX), the working conditions of 113 persons employed at gas stations in the cities of Riach?o do Jacuipe, Feira de Santana and Salvador in the state of Bahia, Brazil were investigated by experts who correlated protection measures required by law and those applied to the workers. Data collection was performed by help of a questionnaire and non-participant observation record. The age groups of the workers in the three cities surveyed were between 18 to 25 years (30.08%) and 26 to 33 years (34.51%) of the total. The study revealed an association between occupational habits of workers at gas stations and the prevalence of symptoms due to the exposure to the BTEX compounds. Regarding the use of Personal Protective Equipment (PPE) most workers wear boots. The data show that these workers reported symptoms such as headache, rhinitis, leg pain, drowsiness, cough, fatigue, insomnia, tremors and palpitations. These disorders are related back to previous exposure to BTEX compounds which is associated with inadequate occupational habits of the workers which potentiate chemical contamination in their respective environment.

关键词： BTEX Gas Stations Occupational Exposure Symptoms

Prevalence and risk distribution of schistosomiasis among adults in Madagascar:a cross-sectional study

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Infectious Diseases of Poverty 2023年第2期12卷 136-136页

作者： Sarah Katharina Gruninger Tahinamandranto Rasamoelina Rivo Andry Rakotoarivelo Anjarasoa Ravo Razafindrakoto Zaraniaina Tahiry Rasolojaona Rodson Morin Rakotozafy Patrick Richard Soloniaina Njary Rakotozandrindrainy Pia Rausche Cheick Oumar Doumbia Anna Jaeger Alexandre Zerbo Heidrun von Thien Philipp Klein Govert van Dam Egbert Tannich Norbert Georg Schwarz Eva Lorenz Jürgen May Raphael Rakotozandrindrainy daniela Fusco Department of Infectious Disease Epidemiology Bernhard Nocht Institute for Tropical Medicine Hamburg Germany German Centre for Infection Research (DZIF) Hamburg-Borstel-Lübeck-Riems Germany Centre d’Infectiologie Charles Mérieux (CICM) University of Antananarivo Antananarivo Madagascar Department of Infectious Diseases University of Fianarantsoa Andrainjato Fianarantsoa Madagascar Department of Microbiology and Parasitology University of Antananarivo Antananarivo Madagascar University Clinical Research Centre (UCRC) University of Sciences Technics and Technologies of Bamako (USTTB) Bamako Mali Department of Parasitology Leiden University Medical Centre Leiden The Netherlands National Reference Centre for Tropical Pathogens (NRC) Hamburg Germany Institute of Medical Biostatistics Epidemiology and Informatics University Medical Centre of the Johannes Gutenberg University Mainz Mainz Germany Department of Tropical Medicine I University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany

Background The goal to eliminate the parasitic disease of poverty schistosomiasis as a public health problem is aligned with the 2030 United Nations agenda for sustainable development goals,including universal health coverage(UHC).Current control strategies focus on school-aged children,systematically neglecting *** aimed at providing evidence for the need of shifting the paradigm of schistosomiasis control programs from targeted to generalized approaches as key element for both the elimination of schistosomiasis as a public health problem and the promotion of *** In a cross-sectional study performed between March 2020 and January 2021 at three primary health care centers in Andina,Tsiroanomandidy and Ankazomborona in Madagascar,we determined prevalence and risk factors for schistosomiasis by a semi-quantitative PCR assay from specimens collected from 1482 adult *** and multivariable logistic regression were performed to evaluate odd *** The highest prevalence of ***,*** and co-infection of both species was 59.5%,61.3%and 3.3%,in Andina and Ankazomborona *** prevalence was observed among males(52.4%)and main contributors to the family income(68.1%).Not working as a farmer and higher age were found to be protective factors for *** Our findings provide evidence that adults are a high-risk group for *** data suggests that,for ensuring basic health as a human right,current public health strategies for schistosomiasis prevention and control need to be re-addressed towards more context specific,holistic and integrated approaches.

关键词： Schistosomiasis Schistosoma haematobium Schistosoma mansoni Universal health coverage Madagascar

Epigenetic and Transcriptional Modulator Potential of Epigallocatechin-3-gallate and Genistein on Fetal Hemoglobin Reactivators Genes

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Clinical Complementary Medicine and Pharmacology 2022年第2期2卷 39-49页

作者： Edna Ribeiro Mariana Delgadinho Elisabete Matos Raquel Santos daniela Sousa Heloísa Galante Miguel Britoa H&TRC-Health and Technology Research Center ESTeSL-Escola Superior de Tecnologia da SaúdeInstituto Politécnico de LisboaAv.D.João IILote 4.69.01Parque das NaçõesLisboa 1990-096Portugal Faculty of Sciences of the University of Lisbon Universidade de LisboaCampo Grande 016Lisboa 1749-016Portugal

Background:𝛽-hemoglobinopathies are one of the most common recessive genetic diseases worldwide,with limited treatments available,particularly in developed countries where the prevalence is *** reactivation of Fetal Hemoglobin(HbF)is a promising therapeutic ***,approximately 25%of the patients do not respond to Hydroxyurea(HU),the first and most commonly used HbF inducing agent approved by the ***:Here,we performed an in vitro assessment of transcriptional effects induced by natural bioactive compounds,namely Epigallocatechin-3-gallate(EGCG)and genistein(GN)in globin genes(HBA1,HBB,HBG1 and HBG2)in HbF regulators/silencer genes(KLF1,BCL11A,MYB and BGLT3)and in epigenetic regulator genes(DNMT1,DNMT3A,DNMT3B,HDAC1,HDAC2,HDAC3 and HDAC8).Moreover,we evaluated EGCG’s in vivo effects in hematological parameters of healthy ***:K562 cells were exposed for 72 and 96 h to GN and EGCG at 100,250 and 500 ng/*** proliferation and viability were measured,and transcriptional levels were evaluated by *** in vivo assay,complete blood count was determined by flow cytometry and HbF level was determined through HPLC in 30 healthy individuals before and after 225 mg EGCG ingestion per day during a 90-day ***:Both compounds impact cellular metabolism and proliferation with no cytotoxic *** GN and EGCG effects in globin and BGLT3 expression levels suggest the involvement of divergent signaling *** for the epigenetic potential,EGCG particularly affects HDAC2 and HDAC8 transcription,whereas GN signifi-cantly affects expression patterns of methylation and acetylation *** appears to have time divergent effects,with greater impact in methylation at 72 h(overregulates DNTM3A)while affecting acetylation mostly at 96 h(downregulates HDAC1 and HDAC8).Additionally,in vivo,EGCG demonstrated a modulator effect in hematopoiesis and HbF ***:Our results advocate EGCG and GN

关键词： Epigenetic modulators Fetal hemoglobin Genistein Epigallocatechin-3-gallate In vitro transcriptional effects In vivo hematologic effects

播期和种植密度对冬小麦新品种‘衡6632’产量及其构成因素的影响

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中国农学通报 2017年第2期33卷 1-6页

作者：乔文臣赵明辉李会敏孙书娈孟祥海魏建伟李丁李强赵凤梧 Pavol Hauptvogel Edita Gregova daniela Benedikova 河北省农林科学院旱作农业研究所、河北省农作物抗旱研究重点实验室河北衡水053000 斯洛伐克植物生产研究所斯洛伐克皮斯坦尼92168

为了明确冬小麦新品种‘衡6632’的高产高效栽培技术措施,为该品种大面积应用提供理论依据,进行了不同播期和种植密度对该品种产量及其构成因素影响的研究。试验采用裂区设计,设5个播期和6个种植密度处理,于2014—2015年在河北省深州市... 详细信息

为了明确冬小麦新品种‘衡6632’的高产高效栽培技术措施,为该品种大面积应用提供理论依据,进行了不同播期和种植密度对该品种产量及其构成因素影响的研究。试验采用裂区设计,设5个播期和6个种植密度处理,于2014—2015年在河北省深州市护驾迟镇旱作节水试验站进行试验。结果表明:(1)播期对单位面积穗数、千粒重及产量有显著影响,但对穗粒数影响不显著;种植密度对产量及其构成因素均有显著影响。(2)产量随着播期的推迟和种植密度增加呈现先升高后降低的趋势。在一定范围内,‘衡6632’单位面积穗数随着播期的推迟而减少,随密度的增加而增加;穗粒数、千粒重随播期的推迟而增加。穗粒数在种植密度300万/hm^2以上时随种植密度增加而减少。千粒重随种植密度的增加而降低。研究分析表明:‘衡6632’在春一水条件下,适宜播期为10月7—19日,最佳播期为10月10—15日,相应的种植密度为225万~300万/hm^2。

关键词：冬小麦 ‘衡6632’ 播期种植密度产量产量构成

播期和密度对冬小麦杂交种衡杂102产量及其构成因素的影响

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河北农业科学 2016年第6期20卷 6-12页

作者：乔文臣赵明辉李丁李会敏孙书娈孟祥海魏建伟李强赵凤梧 Pavol Hauptvogel Edita Gregova daniela Benedikova 河北省农林科学院旱作农业研究所河北省农作物抗旱研究重点实验室河北衡水053000 Plant Production Research Institute Piestany 92168Slovakia

为了明确冬小麦杂交种衡杂102的高产高效栽培技术措施,为该品种大面积应用提供理论依据,2014~2015年在河北省农林科学院旱作农业研究所旱作节水试验站进行了不同播期与密度组合的产量试验。采用裂区试验设计,播期设10月5、10、15、20和2... 详细信息

为了明确冬小麦杂交种衡杂102的高产高效栽培技术措施,为该品种大面积应用提供理论依据,2014~2015年在河北省农林科学院旱作农业研究所旱作节水试验站进行了不同播期与密度组合的产量试验。采用裂区试验设计,播期设10月5、10、15、20和25日5个水平,密度(基本苗数量)设150万、225万、300万、375万、450万株/hm^2以及对照(石4185)6个处理,研究了不同播期与密度组合对衡杂102产量以及产量构成因素的影响;并对不同播期与密度组合的产量进行了回归分析,根据回归方程,对10月5~25日播种,在10月5日播种基本苗数量150万株/hm^2的基础上,每晚播1 d、基本苗数量增加15万株/hm^2条件下,进行了产量模拟,以探索适宜的播期及其相应的种植密度。结果表明:播种期和种植密度均对产量以及产量构成因素具有显著影响,其中,产量随着播期的推迟、种植密度的增加呈先升高后降低的趋势。在一定的播期和密度范围内,衡杂102单位面积穗数随着播期的推迟而减少,随着密度的增加而明显增多;穗粒数和千粒重随着播期的推迟而增加,随着密度的增加而降低,其中,播期和密度对千粒重的影响大于对穗粒数的影响。冬小麦新品种衡杂102的适宜播种期为10月5~16日,相应的种植密度为150万~315万株/hm^2,产量模拟结果与实际测定结果相吻合。

关键词：冬小麦杂交种衡杂102 播种期种植密度产量产量构成因素

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逆转衰老:修补大脑漏洞

环球科学 2021年第11期 38-45页

作者：丹妮拉·考费尔阿隆·弗里德曼庄凌(译) 加利福尼亚大学伯克利分校海伦·威尔斯神经科学研究所整合生物学系达尔豪西大学医疗神经科学系古里安大学认知与脑科学系不详

那是1994年,耶路撒冷一个寒冷的深夜,我们(考费尔和弗里德曼)两个人蹲在希伯来大学实验室的一池冷水旁仔细盯着小鼠游泳。实验室里很冷,长时间的弯腰i上我们背部感到酸痛,而且多个晚上的重复实验早已让我们疲惫不堪。当然,小鼠的感觉和... 详细信息

那是1994年,耶路撒冷一个寒冷的深夜,我们(考费尔和弗里德曼)两个人蹲在希伯来大学实验室的一池冷水旁仔细盯着小鼠游泳。实验室里很冷,长时间的弯腰i上我们背部感到酸痛,而且多个晚上的重复实验早已让我们疲惫不堪。当然,小鼠的感觉和我们一样,因为它们不喜欢游泳,尤其是在冷水里游泳,但是我们不得不让它们承受这样的压力。

关键词：弗里德曼希伯来大学实验室游泳耶路撒冷重复实验

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意识起源之争

环球科学 2019年第23期 48-55页

作者：达妮埃拉·奥瓦迪亚冯盈哲(翻译) 意大利帕维亚大学不详

哲学家认为意识是外源的,一切意识都是人类与世界互动的产物。而在神经科学家看来,意识是内源的,是神经活动与神经信号造就了我们的意识体验。让我们环顾四周,思考一下周围的世界:我们能闻到气味、看见色彩、感受得到太阳带给皮肤的热量。

关键词：神经科学家神经活动神经信号意识体验

Viral hepatitis:A brief introduction,review of management,advances and challenges

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World Journal of Meta-Analysis 2021年第2期9卷 139-152页

作者： Olga Fagan Paul Amstrong Kevin Van Der Merwe daniela Crosnoi Chris Steele Julia Sopena-Falco VikrantParihar Department of Gastroenterology Letterkenny University HospitalLetterkenny F92 AE81Ireland Department of Gastroenterology Saint Vincent’s University HospitalDublin 04Ireland

Viral hepatitis represents a major public health hazard and is associated withsignificant global mortality. Over the last decade, there have been significantdevelopments in the prevention and treatment of viral hepatitis. These changeshave led to a situation whereby global elimination has become a realistic goal,fully endorsed by the World Health Organization (WHO). By 2030, the WHOaims to reduce viral hepatitis mortality by 65% and reduce new infections by 90%by 2030. These are ambitious targets and will only be met through a sustainedprogramme. This will require expertise from hepatologists and virologists and thefields of public health and primary care. In this article, we review the causes ofviral hepatitis, its management through prevention and treatments, and the mostpressing challenges and recent advances.

关键词： Viral Hepatitis Management Direct-acting antivirals Advances Challenges

Bacteroides fragilis Supernatant Extracts Enriched in Phenylacetic Acid Induce a Cytotoxic Effect in Mammalian Cells

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Advances in Microbiology 2015年第10期5卷 730-736页

作者： Laís S.Falcao Eduardo N.F.Antunes Eliane O.Ferreira Heidi Pauer Maria Teresa V.Romanos Rossiane C.Vommaro Sérgio H.Seabra daniela S.Alviano Celuta S.Alviano Antonio Jorge R.da Silva Leandro A.Lobo Regina Maria C.P.Domingues Departamento de Ciências Básicas Pólo Universitário de Nova FriburgoUniversidade Federal FluminenseNova FriburgoBrasil Instituto de Microbiologia Prof.Paulo de Góes Universidade Federal do Rio de JaneiroRio de JaneiroBrasil Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de JaneiroRio de JaneiroBrasil Centro Universitário Estadual da Zona Oeste—UEZO Rio de JaneiroBrasil Instituto de Pesquisa Produtos Naturais Universidade Federal do Rio de JaneiroRio de JaneiroBrasil

Bacteroides species are nearly half of the fecal flora community and some are host symbionts crucial to host nutrition and systemic immunity. Among Bacteroides species B. fragilis strains are considered to be the opportunistic ones, being the most isolated anaerobic bacteria in clinical samples. Cell-free supernatants of 65 B. fragilis strains were assayed and they were capable of inducing vacuolating phenotype on Vero cells lineage. The supernatant of the Bacteroides fragilis ATCC 23745 strain was elicited to have the strongest vacuolating effect on Vero cells monolayers and peritoneal macrophages. Some drastic cell alterations were observed, such as a general disorganization of cytoplasm and chromatin condensation, evidencing cell death. By transmission electron microscopy it was confirmed that the vacuoles observed were, in fact, swollen mitochondria. An immunocytochemical assay, TUNEL, was used to confirm this hypothesis and showed that Vero cells and peritoneal macrophages were dying by apoptotic process after exposition of B. fragilis cell-free supernatant. Physical analysis of the apoptotic factor has revealed properties similar to short-chain fatty acids. After gas chromatography and mass spectrometry analysis, phenylacetic acid (PA) was characterized as the major compound present in the most purified active fraction. We believe that the PA is responsible for the pro-apoptotic effect elicited by the supernatant of B. fragilis cultures.

关键词： Bacteroides fragilis Vacuolization Apoptosis Vero cells Lineage Peritoneal Macrophages Phenylacetic Acid

Management of penile urethral strictures: Challenges and future directions

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World Journal of Clinical Urology 2016年第1期5卷 1-10页

作者： Felix Campos-Juanatey Simon Bugeja Stella L Ivaz Anastasia Frost daniela E Andrich Anthony R Mundy Institute of Urology University College London Hospitals Marques de Valdecilla University Hospital

The anatomy of the penile urethra presents additional challenges when compared to other urethral segments during open stricture surgery particularly because of its unsuitability for excision and primary anastomosis and its relatively deficient corpus spongiosum. Stricture aetiology, location, length and previous surgical intervention remain the primary factors influencing the choice of penile urethroplasty technique. We have identified what we feel are the most important challenges and controversies in penile urethral stricture reconstruction, namely the use of flaps vs grafts, use of skin or oral mucosal tissue for augmentation/substitution and when a single or a staged approach is indicated to give the best possible outcome. The management of more complex cases such as panurethral lichen-sclerosus strictures and hypospadias "cripples" is outlined and potential developments for the future are presented.

关键词： Reconstructive surgical procedures Anterior urethral stricture Oral mucosa Tissue transplants Skin grafting Hypospadias Lichen sclerosus