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Post-Occupancy Evaluation (POE) Using Space Syntax: A Case Study of Urban Parks in the South of Brazil

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Journal of Civil Engineering and Architecture 2020年第11期14卷 609-616页

作者： Alcindo Neckel Laércio Stolfo Maculan Anaise Breda daniela Maroni Edilaine Cristina Becker Isabelle Risson Laura Pasa Cambrussi Michele Bianchini Julian Grub Postgraduate Program in Architecture and Urbanism(PPGArq-IMED) Group of Studies and Research on Urban Mobility(NEPMOUR)Passo Fundo/RS99070-220Brazil Postgraduate Program in Architecture and Urbanism(PPG Arq e Urb—UNISINOS) São Leopoldo/RS93022-750Brazil

This study is based on strategies for reading and representing the environment,associated with the theory of social logic of space(space syntax).The general objective of this study is to understand and compare the use of space syntax in relation to connectivity,integration and choice of axial routes of the urban parks of Porto Alegre,in the state of Rio Grande do Sul,south of *** method applied was the capture of georeferenced images for data analysis by using the Theory of Space Syntax(TSE).Thus,three variables were considered for interpretation:choice,connectivity and integration,and they were correlated to statistical data on urban *** results demonstrated the possibility of obtaining significant improvements in the studied urban parks due to the need to create guidelines related to connection and integration that directly impact users'choice strategies when they move around the city.

关键词： Walkability choice connectivity integration urban parks space syntax

移民管理中的腐败问题研究:基于网络分析的视角

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国际行政科学评论（中文版） 2020年第1期86卷 166-183页

作者：丹妮拉·皮涅齐朱塞佩·格罗西吴帅(译) 王东芳(审校) 英国埃塞克斯大学挪威诺德大学商学院不详

本文探讨了公共治理兴起的网络治理模式与腐败之间的关系。本文以行动者网络理论(actor-network theory)为视角,检验了一起意大利米内奥移民收容中心(Mineo’s CARA),这所欧洲最大的移民收容中心管理合同授予的腐败案件。分析表明,由于... 详细信息

本文探讨了公共治理兴起的网络治理模式与腐败之间的关系。本文以行动者网络理论(actor-network theory)为视角,检验了一起意大利米内奥移民收容中心(Mineo’s CARA),这所欧洲最大的移民收容中心管理合同授予的腐败案件。分析表明,由于治理系统中行动者的多样性、相互作用和碎片化所造成的模糊性,治理网络可能会沦为滥用权力的腐败网络。

关键词：行动者网络理论治理网络移民转译

Sonographic markers for early diagnosis of fetal malformations

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World Journal of Radiology 2013年第10期5卷 356-371页

作者： Maria daniela Renna Paola Pisani Francesco Conversano Emanuele Perrone Ernesto Casciaro Gian Carlo Di Renzo Marco Di Paola Antonio Perrone Sergio Casciaro National Council of Research Institute of Clinical Physiology c/o Campus Universitario Ecotekne Department of Ob-stetrics and Gynecology University of Perugia Santa Maria della Misericordia University Hospital Obstetrics and Gynecology Department "Vito Fazzi" Hospital Piazza Filippo Muratore

Fetal malformations are very frequent in industrialized *** advanced maternal age may affect pregnancy outcome adversely,80%-90%of fetal malformations occur in the absence of a specific risk factor for *** only effective approach for prenatal screening is currently represented by an ultrasound ***,ultrasound methods present two important limitations:the substantial absence of quantitative parameters and the dependence on the sonographer *** recent years,together with the improvement in transducer technology,quantitative and objective sonographic markers highly predictive of fetal malformations have been *** markers can be detected at early gestation(11-14 wk)and generally are not pathological in themselves but have an increased incidence in abnormal ***,prenatal ultrasonography during the second trimester of gestation provides a"genetic sonogram",including,for instance,nuchal translucency,short humeral length,echogenic bowel,echogenic intracardiac focus and choroid plexus cyst,that is used to identify morphological features of fetal Down’s syndrome with a potential sensitivity of more than 90%.Other specific and sensitive markers can be seen in the case of cardiac defects and skeletal *** the future,sonographic markers could limit even more the use of invasive and dangerous techniques of prenatal diagnosis(amniocentesis,etc.).

关键词： Prenatal diagnosis Prenatal sonography Chromosome abnormalities nuchal translucency Fetal echocardiography Skeletal dysplasia

Targeted molecular therapy (modified RIST regimen) in relapsed high risk stage Ⅳ neuroblastoma: two cases report

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Theory and Clinical Practice in Pediatrics 2018年第1期2卷 2-4页

作者： Paolo Indolfi Selim Corbacioglu Silverio Perrotta Francesca Rossi Antonio Marte Elvira Pota Martina Di Martino daniela Di Pinto Cristiana Indolfi Fiorina Casale Unit of Pediatric Oncology Pediatric DepartmentSecond University of Naplesvia Luigi De Crecchio 280138 NaplesItaly Department of Pediatrics and Adolescent Medicine University of RegensburgRegensburgGermany Unit of Pediatric Oncology Department of Women-Children and General and Specialistic SurgeryUniversity of Campania “Luigi Vanvitelli”NaplesItaly Department of Pediatric Surgery University of Campania “Luigi Vanvitelli”NaplesItaly

The prognosis for children with recurrent or refractory neuroblastoma remains a significant clinical challenge,and currently there are no known curative salvage *** this paper we investigated the effect of imatinib with rapamycin and the chemotherapeutic agents temozolomide and *** treated two children with recurrent neuroblastoma with this so called RIST *** patients,off therapy for 15 and 31 months,respectively are well,and developing normally,without any *** findings suggest that a combination regimen of RIST may provide a therapeutic benefit with a favorable toxicity profile to a unfortunate subset of patients with neuroblastoma.

关键词： RIST therapy Neuroblastoma Pediatric cancer

Methylated PLK2 is a prognostic biomarker in taxane-treated breast cancers

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Discussion of Clinical Cases 2020年第2期7卷 7-12页

作者： Priti Chivers Laura Lattanzio Ornella Garrone daniela Vivenza Nel Syed Marco C.Merlano Tim Crook Helen M.Coley Cristiana Lo Nigro Faculty of Health and Medical Sciences University of SurreyGuildfordSurreyUK Oncology Department S.Croce&Carle Teaching HospitalCuneoItaly Neuro-Oncology Department Imperial CollegeLondonUK Oncology Department Royal Surrey County HospitalGuildfordSurreyUK Laboratory Department Galliera HospitalGenovaItaly

Background:In search of potential biomarkers of drug responsiveness the tumour suppressor PLK2 has been identified as a mediator of taxane sensitivity in some tumour types,based on its role of G2M checkpoint ***:The current study set out to evaluate PLK2 methylation in breast cancer treated with neo-adjuvant chemotherapy including a taxane,as a biomarker of disease ***:Silencing of PLK2 in MCF-7 cells followed by taxane treatment was assessed using apoptotic readout for proof of *** was extracted from 64 cases of diagnostic surgical FFPE *** pyrosequencing,levels of PLK2 promoter methylation were ***:Silencing of PLK2 resulted in a significantly reduced apoptotic response following paclitaxel treatment(compared with scramble transfected controls).An association with higher levels of CpG island promoter methylation was seen for those cases with a progression-free survival(PFS)of less than 12 ***-Meier analysis showed there was an association between overall survival(OS)and level of methylation(p=.06).Conclusions:Thus,based on data obtained from this pilot study,further larger studies evaluating the utility of PLK2 methylation as a potential predictive biomarker in breast cancer are warranted.

关键词： Breast cancer PLK2 DNA methylation Drug resistance Taxanes

Cytomegalovirus reactivation after autologous stem cell transplantation in myeloma and lymphoma patients:A single-center study

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World Journal of Transplantation 2015年第3期5卷 129-136页

作者： Francesco Marchesi Fulvia Pimpinelli Svitlana Gumenyuk daniela Renzi Francesca Palombi Francesco Pisani Atelda Romano Antonio Spadea Elena Papa Marco Canfora Fabrizio Ensoli Andrea Mengarelli Hematology and Stem Cell Transplantation Unit Regina Elena National Cancer Institute Molecular Virology Pathology and Microbiology LaboratorySan Gallicano Dermatological Institute Scientific Direction Regina Elena National Cancer Institute

AIM: To determine the incidence of and the risk factors for cytomegalovirus(CMV) symptomatic infection and end-organ disease after autologous stem cell transplantation(ASCT).METHODS: A total of 327 consecutive non CD34+ selected autografts performed from the Hematology and Stem Cell Transplantation Unit of Regina Elena National Cancer Institute of Rome(Italy) in the period comprised between January 2003 to January 2015, were reviewed. Over the 327 autografts, 201 were performed in patients with multiple myeloma, whereas the remaining 126 in patients affected by non-Hodgkin's lymphoma and Hodgkin's lymphoma. The patients who underwent an ASCT for an acute leukemia(n = 20) in the sameperiod were excluded from this analysis. CMV DNA load in the blood has been determined by polymerasechain reaction in the case of a clinical suspicion of reactivation, therefore, no routine monitoring strategy was adopted. In the presence of signs and symptoms of CMV reactivation an antiviral treatment was ***: Overall, 36 patients(11%) required a specific antiviral treatment for a symptomatic CMV reactivation(n = 32) or an end-organ disease(n = 4). We observed 20 and 16 cases of CMV reactivation among lymphoma(16%) and myeloma patients(8%), respectively. Among cases of end-organ disease, 3 were diagnosed as interstitial pneumonia and one remaining case as hemorrhagic enteritis. All cases of CMV reactivation were observed in Ig G seropositive patients, with no documented cases of primary CMV infection. All patients were treated with a specific antiviral therapy, with a global rate of hospitalization of 55%; four patients received intravenous immunoglobulins. Transplantrelated mortality was significantly higher in patients who experienced a CMV reactivation(8.4% ± 4.7% vs 1.7% ± 0.8%; P = 0.047). In univariate analysis, a pretransplant HBc Ig G seropositivity, a diagnosis of T-cell non-Hodgkin's lymphoma and higher median age at transplant were significantly associated with t

关键词： Cytomegalovirus Autologous hematopoietic stem cell transplantation Lymphoma Myeloma HBcIgG seropositivity Transplant-related mortality

添加脂肪来源间质细胞的脂肪移植在修复颅面短小患者中的应用

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中国美容整形外科杂志 2013年第11期24卷 I0024-I0024页

作者： daniela Y.S.Tanikawa MeireAguena daniela F.Bueno. Maria Rita Passos.Bueno Nivaldo Alonso 魏峰(译者) 高景恒(译者) 袁继龙(译者) 圣保罗大学医学院整形与再造外科中心巴西圣保罗圣保罗大学生物科学学院人类基因研究中心巴西圣保罗《中国美容整形外科杂志》编辑部辽宁省人民医院整形外科

背景与目的尽管有关脂肪来源间质细胞（adipose—derived stromal cells，ADSCs）临床应用的早期报道提示其在软组织增大方面具有可行性和有效性，但仍缺乏随机性对照的临床研究类文献。因此，本研究旨在探讨一种ADSCs的快速分离方法，... 详细信息

背景与目的尽管有关脂肪来源间质细胞（adipose—derived stromal cells，ADSCs）临床应用的早期报道提示其在软组织增大方面具有可行性和有效性，但仍缺乏随机性对照的临床研究类文献。因此，本研究旨在探讨一种ADSCs的快速分离方法，以及ADSCs联合脂肪组织移植在颅面短小患者治疗中提高移植物长期存活能力的方法。方法本组14例颅面短小患者，采取自体脂肪移植治疗，分为联合ADSCs移植的实验组和未联合ADSCs移植的对照组。对脂肪组织移植物加入ADSCs之前和加入ADSCs之后活性细胞的数量进行估算，并利用流式细胞术对此类间质细胞的表面标记物进行检测。对术前和术后6个月两侧面部的CT图像进行评估。结果脂肪组织移植物加入ADSCs之前和加入ADSCs之后活性细胞的数量分别为5．6X10^5个／ml和9．9X10^5个／ml（P=0．015）。流式细胞术显示ADSCs对间质细胞标记物呈阳性（CD73和CDl05阳性率〉95％）。术后6个月，实验组存活的脂肪体积为88％，而对照组为54％（P=0．003）。结论研究结果提示，这种ADSCs的分离方式和将ADSCs加入到移植脂肪组织中的模式是有效的、安全的，其在颅面短小患者的面部塑形治疗中优于传统的脂肪注射方法。（循证医学证据等级：Ⅱ级，疗法）

关键词：脂肪移植间质细胞临床应用患者短小颅面脂肪组织移植 ADSCs

早产母乳中内源性肽释放量高于其在足月生产母乳中的含量

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早产母乳中内源性肽释放量高于其在足月生产母乳中的含量

Violence Towards Migrants

作者： David C Dallas Christina J Smink Randall C Robinson Tian Tian Andres Guerrero Evan A Parker Jennifer T Smilowitz Kasper A Hettinga Mark A Underwood Carlito B Lebrilla J Bruce German daniela Barile 徐美虹 Department of Food Science and Technology University of CaliforniaDavisDavisCA Foods for Health Institute University of CaliforniaDavisDavisCA Dairy Science and Technology Group Wageningen University and Research Centre Department of Chemistry University of CaliforniaDavisDavisCA

当母亲自己的乳汁不适于婴儿喂养时,捐赠人乳(DHM)是早产儿营养的首选来源。但是DHM通常属于晚期哺乳期乳汁,对于早产儿可能不能提供充足的营养,因此了解足月儿和早产儿不同哺乳期母乳中的成分差异是十分重要的。鉴于肽是一种母乳的替...

当母亲自己的乳汁不适于婴儿喂养时,捐赠人乳(DHM)是早产儿营养的首选来源。但是DHM通常属于晚期哺乳期乳汁,对于早产儿可能不能提供充足的营养,因此了解足月儿和早产儿不同哺乳期母乳中的成分差异是十分重要的。鉴于肽是一种母乳的替代成分,已知足月儿母乳中的总乳蛋白浓度明显高于早产儿,并且随着哺乳期延长而逐渐降低,因此该研究推测在足月儿和早产儿的整个哺乳期,母乳中内生肽的组成、肽的功能和对这些肽负有责任的酶是有差异的。该研究从荷兰人乳库选取22份样本,对其中的总蛋白、肽组成、肽功能和酶进行了分析。分析选取的样本包括了早产儿

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Psychology Research 2018年第8期8卷 355-366页

作者： Patricia Martinez Lanz Maria Domenica Ravelo Ladron de Guevara daniela Ayari Moreno Landeta Maria Fernanda Gen Lortia Ixchel Aditi Gonzalez Gutierrez Elsa Paulina Alanis Cazares Universidad Anauac Mexico Mexico City Mexico