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作者： daniel rueda guerra 山东大学

学位级别：硕士

Even though in Costa Rica the solar energy industry is incipient,over the years the number of micros,small and medium-sized companies（MSMEs）,grouped in the Costa Rican Solar Energy Association（Acesolar）,has been *** the import of photovoltaic systems to offer services through consulting projects,marketing,and installation of solar panels so organizations and families can take advantage of solar energy as an alternative source to replace conventional electric *** because of the characteristics of solar energy and the technologies involved,MSMEs are obliged to innovate permanently and,for this reason,they need to promote a culture of innovation that involves technical,managerial and corporate *** companies have managed to maintain their competitiveness,it is unknown what are the factors of the culture of innovation that have allowed these companies to remain in the market and manage consulting,marketing and panel installation *** this purpose,in this thesis the objective is addressed:Analyze the construction of innovation culture in the project management of Costa Rican solar energy *** on the perceptions that the managers of MSMEs have,it was determined that innovation is present in the daily activities of the companies in the *** this sense,the culture of innovation that they have been introducing allows companies to manage the consulting,marketing and installation projects of solar panel systems and the generation of ideas to incubate innovative concepts in the formulation and execution of the same *** part of the factors of the culture of innovation that were identified in this study,it can be said that companies have participative management styles that promote the incorporation of innovative ideas in *** diversity of thoughts in the construction of new ideas is stimulated,and the positive contributions in the management of the projects are communicated *** is allowed if

关键词： Solar energy companies Project managemen Culture Costa Rican

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Inexpensive and combined technique: Use of suction tracheal catheter and hydrogen peroxide for the evacuation of intravesical clots

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Asian Journal of Urology 2022年第1期9卷 99-100页

作者： Fred Alain Montelongo-Rodriguez Carlos daniel guerra-Catanon Mario Vazquez-Herrera Adrian Gutierrez-Gonzalez Lauro Salvador Gomez-guerra Urology Department Hospital Universitario“Dr.Jose Eleuterio Gonzalez”Universidad Autonoma de Nuevo LeonMonterreyMexico

Dear Editor,Persistent hematuria could trigger urinary retention,leading the patient to the emergency department for abdominal pain,decreased urinary output,anemia,and azotemia[1,2].Conventional bladder clot evacuation requires a three-way catheter with continuous irrigation and aspiration with a syringe or Ellik evacuator[3].Sometimes a large and well-organized hematoma requires an open cystostomy[1,4].We want to introduce a combined method using hydrogen peroxide as well as suction technique with an endotracheal catheter to evacuate intravesical clots.

关键词： urinary bladder catheter

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Maize Gene Regulatory Network for Phenolic Metabolism

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Molecular Plant 2017年第3期10卷 498-515页

作者： Fan Yang Wei Li Nan Jiang Haidong Yu Kengo Morohashi Wilberforce Zachary Oumal daniel E. Morales-Mantilla Fabio Andres Gomez-Canol Eric Mukundi Luis daniel Prada-Salcedo Roberto Alers Velazquez Jasmin Valentin Maria Katherine Mejia-guerra John Gray Andrea I. Doseff Erich Grotewold Center for Applied Sciences (CAPS) Department of Molecular Genetics Department of Physiology and Cell Biology Heart and Lung Research Institute Molecular Cellular and Developmental Biology (MCDB) Graduate Program Success in Graduate Education (SiGuE) Program The Ohio State University Columbus OH 43210 USA Department of Biological Sciences University of Toledo Toledo OH 43560 USA

The translation of the genotype into phenotype, represented for example by the expression of genes encod- ing enzymes required for the biosynthesis of phytochemicals that are important for interaction of plants with the environment, is largely carried out by transcription factors （TFs） that recognize specific cis-regulatory elements in the genes that they control. TFs and their target genes are organized in gene regulatory net- works （GRNs）, and thus uncovering GRN architecture presents an important biological challenge necessary to explain gene regulation. Linking TFs to the genes they control, central to understanding GRNs, can be car- ried out using gene- or TF-centered approaches. In this study, we employed a gene-centered approach uti- lizing the yeast one-hybrid assay to generate a network of protein-DNA interactions that participate in the transcriptional control of genes involved in the biosynthesis of maize phenolic compounds including gen- eral phenylpropanoids, lignins, and flavonoids. We identified 1100 protein-DNA interactions involving 54 phenolic gene promoters and 568 TFs. A set of 11 TFs recognized 10 or more promoters, suggesting a role in coordinating pathway gene expression. The integration of the gene-centered network with informa- tion derived from TF-centered approaches provides a foundation for a phenolics GRN characterized by in- terlaced feed-forward loops that link developmental regulators with biosynthetic genes.

关键词： phenylpropanoid flavonoid yeast one-hybrid chromatin immunoprecipitation

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The role of natural killer cells in the uterine microenvironment during pregnancy

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Cellular & Molecular Immunology 2018年第11期15卷 941-943页

作者： Julia P.Andreotti Ana E.Paiva Pedro H.D.M.Prazeres daniel A.P.guerra Walison N.Silva Rogerio S.Vaz Akiva Mintz Alexander Birbrair Department of Pathology Federal University of Minas GeraisBelo HorizonteMGBrazil Department of Biotechnology and Bioprocess Engineering Federal University of ParanaCuritibaPRBrazil Department of Radiology Columbia University Medical CenterNew YorkNYUSA

Pregnancy is a choreographed physiological phenomenon that involves maternal-fetal *** the cellular and molecular mechanisms involved in this communication will allow us to develop therapies for gestational *** is known about the role of natural killer(NK)cells in the uterine *** a recent study,Fu et al.(2017)used state-of-art technologies and showed that NK cells stimulate fetal growth via growth-promoting factors.

关键词： killer fetal uterine

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Silver Nanoparticles Produced by Magnetron Sputtering and Selective Nanodecoration onto <i>α</i>-Cyclodextrin/Carboxylic Acid Inclusion Compounds Crystals

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Advances in Nanoparticles 2013年第2期2卷 112-119页

作者： Bárbara Herrera Tamara Bruna daniel guerra Nicolás Yutronic Marcelo J. Kogan Paul Jara Department of Chemistry Faculty of Sciences University of Chile Santiago Chile Department of Pharmacology and Toxicology Faculty of Chemical nd Pharmaceutical Sciences University of Chile Santiago Chile

In this work, we report the preparation of silver nanoparticles (AgNPs) and the nanodecoration of α-cyclodextrin inclusion compounds (α-CD IC) microcrystals that contain palmitic (PAc) and stearic acids (SAc) like guest molecules. These IC provide a suitable environment for nucleation, epitaxial growth and immobilization of AgNPs that were obtained by the magnetron sputtering technique. The use of α-CD IC substrates with a specific surface morphology in which the functional group of the guest molecule faces outward preferentially from a crystal plane, is an efficient method for the preparation of AgNPs with a low size dispersion, which is probably due to the high affinity between the functional group of the surfactant carboxylic acid guest with the metal nanoparticles.

关键词： Silver Nanoparticles Nanodecoration Cyclodextrin Inclusion Compounds Magnetron Sputtering

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Functional promoter rs189037 variant of ATM is associated with decrease in lung diffusing capacity after irradiation for nonesmall-cell lung cancer

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Chronic Diseases and Translational Medicine 2018年第1期4卷 59-66页

作者： Jose Luis Lopez guerra Yi-Peng Song Quynh-Nhu Nguyen daniel R. Gomez Zhongxing Liao Ting Xu Department of Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Radiation Oncology Virgen del Rocío University HospitalSeville 41013Spain Department of Radiation Oncology Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantaiShandong 264000China

Objective: Single-nucleotide polymorphisms (SNPs) in the ataxia telangiectasiaemutated gene ATM have been linked with pneumonitis after radiotherapy for lung cancer but have not been evaluated in terms of pulmonary function impairment. Here we investigated potential associations between SNPs in ATM and changes in diffusing capacity of the lung for carbon monoxide (DLCO) in patients with nonesmall-cell lung cancer (NSCLC) after radiotherapy. Methods: From November 1998 through June 2009, 448 consecutive patients with inoperable primary NSCLC underwent definitive (≥60 Gy) radiotherapy, with or without chemotherapy. After excluding patients with a history of thoracic surgery, ra-diation, or lung cancer; without DNA samples available for analysis; or without pulmonary function testing within the 12 months before and the 12 months after radiotherapy, 100 patients were identified who are the subjects of this study. We genotyped two SNPs of ATM previously found to be associated with radiation-induced pneumonitis (rs189037 and rs228590) and evaluated potential correlations between these SNPs and impairment (decreases) in DLCO by using logistic regression analysis. Results: Univariate and multivariate analyses showed that the AA genotype of ATM rs189037 was associated with decreased DLCO after definitive radiotherapy than the GG/AG genotypes (univariate coefficient, -0.122; 95％ confidence interval (CI),-0.236 to -0.008; P = 0.037; and multivariate coefficient, -0.102; 95％ CI, -0.198 to -0.005; P = 0.038)No such correlations were found for rs228590 (univariate coefficient, -0.096; 95％ CI, -0.208 to 0.017; P = 0.096). Conclusions: The AA genotype of ATM rs189037 was associated with higher risk of lung injury than were the GG/AG genotypes in patients with NSCLC treated with radiotherapy. This finding should be validated prospectively with other patient populations.

关键词： Nonesmall-cell lung cancer Radiation therapy Ataxia telangiectasia-mutated gene Single-nucleotide polymorphisms

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PIK3CA mutation in non-metastatic triple-negative breast cancer as a potential biomarker of early relapse:A case report

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World Journal of Clinical Oncology 2021年第8期12卷 702-711页

作者： Guillermo Arturo Valencia Patricia Rioja Zaida Morante Jhajaira M Araujo Heberth daniel Vallejos Henry guerra Henry L Gomez Department of Medical Oncology Instituto Nacional de Enfermedades NeoplásicasLima 15000Peru Escuela de Medicina Humana Universidad Privada San Juan BautistaLima 15067Peru Department of Medical Oncology Russian Scientific Center of Radiology and RadiotherapyKonkovo 117485MoscowRussia Department of Pathology Instituto Nacional de Enfermedades NeoplásicasLima 15000Peru

BACKGROUND Currently,the detection of PIK3CA mutations is of special interest in personalized medicine because it is frequently found in triple-negative breast cancer(TNBC).The PI3KCA mutation is an independent negative prognostic factor for survival in metastatic breast cancer,and its prognostic value in liquid biopsy as a biomarker of treatment and early relapse is under investigation,both for metastatic disease and neoadjuvant scenario with curative *** SUMMARY A 54-year-old female patient with TNBC clinical stage IIIA,who,after receiving neoadjuvant chemotherapy(based on anthracyclines and taxanes),surgery,radiotherapy,and adjuvant capecitabine,was detected with a PI3KCA mutation in tissue and peripheral blood(ctDNA in liquid biopsy).After 10 mo,the patient had disease relapse of left cervical node *** The detection of PIK3CA mutation in TNBC after neoadjuvant treatment might be associated with early relapse or rapid disease progression.

关键词： Triple-negative breast cancer PIK3CA mutation Liquid biopsy Early relapse Biomarker Case report

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Diversity and host assemblage of avian haemosporidians in different terrestrial ecoregions of Peru

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Current Zoology 2022年第1期68卷 27-40页

作者： Luz GARCIA-LONGORIA Jaime MURIEL Sergio MAGALLANES Zaira Hellen VILLA-GALARCE Leonila RICOPA Wilson Giancarlo INGA-DIAZ Esteban FONG daniel VECCO Cesar guerra-SALDANA Teresa SALAS-RENGIFO Wendy FLORES-SAAVEDRA Kathya ESPINOZA Carlos MENDOZA Blanca SALDANA Manuel GONZALEZ-BLAZQUEZ Henry GONZALES-PINEDO Charlene LUJAN-VEGA Carlos Alberto Del AGUILA Yessica VILCA-HERRERA Carlos Alberto PINEDA Carmen REATEGUI Jorge Manuel CARDENAS-CALLIRGOS JoseAlberto IANNACONE Jorge Luis MENDOZA Ravinder NMSEHGAL Alfonso MARZAL Departamento de Anatomia Biologia Celular y ZoologiaUniversidad de ExtremaduraBadajoz E-506071Spain Molecular Ecology and Evolution Lab Department of BiologyLund UniversitySolvegatan 37SE-22362 LundSweden Instituto Pirenaico de Ecologıa-IPE(CSIC) Avda.Nuestra Senora de la Victoria 16Jaca 22700Spain DIRESA Direccion Regional de SaludLoreto 16001Peru Departamento Academico de Microbiologia y Parasitologia.Facultad de Ciencias Biologicas Universidad Nacional de la Amazonia PeruanaIquitos 16001Peru Facultad de Ciencias Agropecuarias Universidad Alas PeruanasLima 15823Peru EverGreen Institute-San Rafael Distrito de IndianaLoreto 16200Peru Observatorio de Aves Loreto(LBO) Distrito de San JuanLoreto 16008Peru Centro Urku de Estudios Amazonicos Tarapoto 22200Peru Servicio Nacional de Areas Naturales Protegidas por el Estado 15036Peru Sanidad Animal-Facultad de Zootecnia Universidad Nacional Agraria La MolinaLima 15012Peru Laboratorio de Microbiologia Facultad de Medicina Veterinaria y ZootecniaUniversidad CientUfica del SurLima 15067Peru Laboratorio de Analisis Clinico Moraleslab SAC MoralesSan Martin 22201Peru Asociacion Ecosistemas Andinos(ECOAN) Cuzco 08002Peru Pharmacology and Toxicology Graduate Group University of CaliforniaDavisDA 95616USA Global Health Initiative Wabash CollegeCrawfordsvilleIN 47933USA Facultad de Ciencias Biologicas Universidad Nacional Mayor de San MarcosLima 15081Peru Facultad de Medicina Veterinaria Universidad Nacional Hermilio ValdizanHuanuco10160Peru Asociacion Peruana de Helmintologia e Invertebrados Afines Lima 15054Peru Laboratorio de Ecologia y Biodiversidad Animal Universidad Nacional Federico VillarrealEl AgustinoLima 15007Peru Laboratorio de Invertebrados Universidad Ricardo Palma-Santiago de SurcoLima 15537Peru Department of Biology San Francisco State UniversitySan FranciscoCA 94132USA

Characterizing the diversity and structure of host–parasite communities is crucial to understandingtheir eco-evolutionary *** and related haemosporidian parasites are responsible forfitness loss and mortality in bird species ***,despite exhibiting the greatest ornithologicalbiodiversity,avian haemosporidians from Neotropical regions are quite ***,we analyze the genetic diversity of bird haemosporidian parasites(Plasmodium andHaemoproteus)in 1,336 individuals belonging to 206 bird species to explore for differences in diversityof parasite lineages and bird species across 5 well-differentiated Peruvian *** 70 different haemosporidian lineages infecting 74 bird *** showed that 25 out ofthe 70 haplotypes had not been previously ***,we also identified 81 new host–parasite interactions representing new host records for these haemosporidian *** outcomesrevealed that the effective diversity(as well as the richness,abundance,and Shannon–Weaver index)for both birds and parasite lineages was higher in Amazon basin ***,we also showed that ecoregions with greater diversity of bird species also had highparasite richness,hence suggesting that host community is crucial in explaining parasite *** parasites were found in ecoregions with lower bird diversity,implying that the abundanceand richness of hosts may shape the exploitation strategy followed by haemosporidian *** outcomes reveal that Neotropical region is a major reservoir of unidentified *** studies analyzing host distribution and specificity of these parasites inthe tropics will provide important knowledge about phylogenetic relationships,phylogeography,and patterns of evolution and distribution of haemosporidian parasites.

关键词： Amazonia avian malaria generalist parasite habitat specificity Haemoproteus Plasmodium specialist parasite

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里斯本wonderWALL临时展览空间

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现代装饰 2015年第8期 62-67页

作者： Diogo Aguiar Teresa Otto Joao Jesus Joao Salgueiro daniel Mudrak Fernando guerra(摄) 姜敏华(译) LIK Earchitects 不详

本案是一个位于里斯本科伦坡购物中心的临时展览空间,用于展出Jen Lewin创作的《池塘》艺术装置,由大约两万条黑白织物带组成。设计团队在设计这个临时＂博物馆＂时,通过将一种能够为参观者完全理解的黑色织物,覆盖于整个建筑表面,伴随... 详细信息

本案是一个位于里斯本科伦坡购物中心的临时展览空间,用于展出Jen Lewin创作的《池塘》艺术装置,由大约两万条黑白织物带组成。设计团队在设计这个临时＂博物馆＂时,通过将一种能够为参观者完全理解的黑色织物,覆盖于整个建筑表面,伴随气流的摆动,从而呈现出一种抽象式的外观。圆柱型的空间体意在突显装置艺术品的中心位置,这在展示空间设计中具有一定的重要性。

关键词：展览空间里斯本展示空间设计购物中心建筑表面中心位置色织物艺术品

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First Report on the Presence of Phyllachora sp. in Corn Crops at Toluca, Estado de Mexico

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American Journal of Plant Sciences 2016年第5期7卷 733-739页

作者： Erika Natalia Ríos-Herrera Laila Pamela Partida-Martínez Yisa María Ochoa-Fuentes Ernesto Cerna-Chávez Francisco daniel Hernández-Castillo Alberto Flores-Olivas Víctor Olalde-Portugal Raúl Rodríguez-guerra Universidad Autónoma Agraria Antonio Narro Saltillo México Department of Genetic Engineering CINVESTAV Irapuato México Department of Agricultural Parasitology Universidad Autónoma Agraria Antonio Narro Saltillo México Department of Biotechnology and Biochemistry CINVESTAV Irapuato México General Terán INIFAP General Terán Nuevo León México

Symptoms of Tar Spot Complex (TSC) in corn appear in the form of black spots surrounded by a chlorotic halo known as fish-eye. The crop with these symptoms was found at San Pablo Autopan, Estado de Mexico. The stromal region of foliar lesions was cut longitudinally, showing perithecia, asci and ascospores typical of Phyllachora maydis. The results were confirmed by PCR-ITS with ITS 1 and ITS4 initiators, cloned by pJET, before being sequenced and compared against NCBI’s data base. Phyllachora identity was confirmed. This is the first report where TSC pathogen has been detected under conditions that had not been previously reported, for instance, at 2600 meters above the sea level.

关键词： Phyllachora maydis Tar Spot Complex ITS

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