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Efficacy of infliximab in acute severe ulcerative colitis:A single-centre experience

World Journal of Gastroenterology 2013年第7期19卷 1091-1097页

作者： Stephen J Halpin P john Hamlin daniel P Gree Lisa Warren Alexander C Ford Leeds Gastroenterology Institute St.James's University HospitalLeedsWest Yorkshire LS9 7TFUnited Kingdom Leeds Gastroenterology Institute St.James's University HospitalLeedsWest Yorkshire LS9 7TFUnited Kingdom r Leeds Institute of Molecular Medicine University of LeedsLeedsWest Yorkshire LS9 7TFUnited Kingdom

AIM:To suggest infliximab(IFX) is effective for acute severe ulcerative colitis,from real-life clinical ***:All patients receiving IFX for the treatment of acute severe ulcerative colitis in a single centre were *** were extracted from clinical records in order to assess response to IFX *** primary endpoint was colectomy-free survival,and secondary outcomes included glucocorticosteroid-free remission and safety,which was evaluated by recording deaths and adverse *** and clinical characteristics of those who underwent colectomy and those who were colectomy-free,both at discharge from their index admission,and during follow-up after an initial response to IFX were ***:Forty-four patients(16 females,mean age 36 years) received IFX between May 2006 and January 2012 for acute severe ulcerative *** median duration of follow-up post-first infusion was 396 d(interquartile range = 173-828 d).There were 21(47.7%) patients with 2 years of follow-up post-first infusion of ***,35(79.5%) responded to IFX,avoiding colectomy during their index admission,29(65.9%) were colectomyfree at last point of follow-up(median follow-up 396 d),and 25(56.8%) were in glucocorticosteroid-free remission at end of *** was one death from post-operative sepsis,20 d after a single IFX *** rates were generally lower among those "bridging" to *** 18 patients "bridged" to thiopurine therapy,17(94.4%) were colectomyfree,and 15(83.3%) were in glucocorticosteroid-free remission at study *** predictors of response were ***:IFX is effective for acute severe ulcerative colitis in real-life clinical ***-thirds of patients avoided colectomy,and more than 50% were in glucocorticosteroid-free remission.

关键词： Ulcerative colitis Severe Azathioprine Infliximab Remission

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Evaluation of conflict-resolution policies on controller taskload

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Chinese Journal of Aeronautics 2021年第5期34卷 315-330页

作者： Adan Ernesto VELA William SINGHOSE Karen FEIGH john-Paul CLARKE Eric FERON Department of Industrial Engineering and Management System University of Central FloridaOrlandoFL 32816USA George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA daniel Guggenheim School of Aerospace Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

In an effort to maintain safety while satisfying growing air traffic demand,air navigation service providers are considering the inclusion of advisory systems to identify potential conflicts and propose resolution commands for the air traffic controller to verify and issue to *** understand the potential workload implications of introducing advisory conflict-detection and resolution tools,this paper examines a metric of controller taskload:how many resolution commands an air traffic controller issues under the guidance of an advisory *** a simulation study,the research presented here evaluates how the underlying protocol of a conflict-resolution tool affects the controller taskload(system demands)associated with the conflict-resolution process,and implicitly the controller workload(physical and psychological demands).Ultimately,evidence indicates that there is significant flexibility in the design of conflict-resolution algorithms supporting an advisory system.

关键词： Air traffic control Air traffic management Conflict detection and resolution Decision-support tools Simulation analysis

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Domestication and Sustainable Use of Genetic Resources of a Native Tree with High Economic Potential in Ghana

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Open Journal of Forestry 2015年第7期5卷 678-685页

作者： Theresa Peprah Kwame Antwi Oduro daniel E. Kwaku Addo Siaw Joseph Rexford Cobbinah Zacharia Tchoundjeu Anthony john Simons Ramni Jamnadass daniel Aninagyei Ofori CSIR-Forestry Research Institute of Ghana Kumasi Ghana College of Agriculture and Natural Resources Faculty of Renewable Natural Resources Sunyani Ghana World Agroforestry Centre (ICRAF) Yaounde Cameroon World Agroforestry Centre (ICRAF) Nairobi Kenya

Allanblackia parviflora A. Chev., an underutilized fruit tree species commonly found in tropical rainforest of West Africa, has potential for integration into agroforestry systems for economic and environmental benefits. The seed oil of A. parviflora is considered economically important but wild fruits collection produces an average of 40 tons of oil annually. However, over 100,000 tons of Allanblackia seed oil is needed annually by food and cosmetics industries. The need to domesticate and conserve A. parviflora to ensure adequate sustainable supply of seed oil and to sustainably manage the genetic resources is therefore critical. This paper reviews the current state-of-the art on domestication and sustainable use efforts of Allanblackia. Propagation methods have been developed to encourage large scale commercial cultivation, include grafting, rooting of stem cuttings and research into improved seed germination. Range-wide germplasm collection has been undertaken leading to establishment of 140 accessions in a gene bank for future source of germplasm. Mother blocks, i.e. established plots consisting of grafts, seedlings and cuttings, have been established at Rural Resource Centres with 58 elite clones, which have been recommended for distribution to farmers. The diversification of cropping systems to include A. parviflora trees is projected to contribute to community livelihoods development and poverty reduction through large-scale production and supply chain development of the species. Furthermore, the integration of A. parviflora into agroforestry systems is important for the conservation of the genetic resources of the species.

关键词： Agroforestry Conservation Germplasm Supply Chain Propagation

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Compressively sampling the optical transmission matrix of a multimode fibre

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Light(Science & Applications) 2021年第5期10卷 916-930页

作者： Shuhui Li Charles Saunders daniel J.Lum john Murray-Bruce Vivek K Goyal TomášČižmár David B.Phillips School of Physics and Astronomy University of ExeterExeterEX44QLUK Wuhan National Laboratory for Optoelectronics School of Optical and Electronic InformationHuazhong University of Science and TechnologyWuhan430074HubeiChina Department of Electrical and Computer Engineering Boston UniversityBostonMA02215USA Department of Physics and Astronomy University of Rochester500 Wilson BlvdRochesterNY14618USA Department of Computer Science and Engineering University of South FloridaTampaFL33620USA Leibniz Institute of Photonic Technology Albert-Einstein-Straße 907745JenaGermany Institute of Scientific Instruments of CAS Královopolská14761264BrnoCzech Republic

The measurement of the optical transmission matrix(TM)of an opaque material is an advanced form of space-variant aberration *** imaging,TM-based methods are emerging in a range of fields,including optical communications,micro-manipulation,and *** many cases,the TM is very sensitive to perturbations in the configuration of the scattering medium it ***,applications often require an up-to-the-minute characterisation of the fragile TM,typically entailing hundreds to thousands of probe ***,we explore how these measurement requirements can be relaxed using the framework of compressive sensing,in which the incorporation of prior information enables accurate estimation from fewer measurements than the dimensionality of the TM we aim to *** of such priors include knowledge of a memory effect linking the input and output fields,an approximate model of the optical system,or a recent but degraded TM *** demonstrate this concept by reconstructing the full-size TM of a multimode fibre supporting 754 modes at compression ratios down to∼5%with good *** show that in this case,imaging is still possible using TMs reconstructed at compression ratios down to∼1%(eight probe measurements).This compressive TM sampling strategy is quite general and may be applied to a variety of other scattering samples,including diffusers,thin layers of tissue,fibre optics of any refractive profile,and reflections from opaque *** approaches offer a route towards the measurement of high-dimensional TMs either quickly or with access to limited numbers of measurements.

关键词： scattering fibre matrix

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Research advances on internal processes affecting tropical cyclone intensity change from 2018–2022

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Tropical Cyclone Research and Review 2023年第1期12卷 10-29页

作者： Xiaomin Chen Christopher M.Rozoff Robert F.Rogers Kristen L.Corbosiero Dandan Tao Jian-Feng Gu Falko Judt Eric A.Hendricks Yuqing Wang Michael M.Bell daniel P.Stern Kate D.Musgrave john A.Knaff john Kaplan NOAA/OAR/Atlantic Oceanographic and Meteorological Laboratory MiamiUSA University of Alabama in Huntsville HuntsvilleUSA National Center for Atmospheric Research BoulderUSA University at Albany/State University of New York AlbanyUSA University of Bergen BergenNorway Nanjing University NanjingChina University of Reading ReadingUK University of Hawaii at Manoa HonoluluUSA Colorado State University Fort CollinsUSA University Corporation for Atmospheric Research MontereyUSA NOAA Center for Satellite Applications and Research Fort CollinsUSA Department of Atmospheric and Earth Science University of Alabama in HuntsvilleHuntsvilleUSA

This contribution summarizes the significant progress in a variety of topic areas related to internal tropical cyclone(TC)intensity change processes over 2018–2022 from the WMO Tenth International Workshop on Tropical Cyclones(IWTC-10).These topic areas include surface and boundary layer processes;TC internal structure and microphysical processes;and,radiation interactions with *** studies better frame the uncertainty in the surface drag and enthalpy coefficients at high wind *** parameters greatly impact TC intensity and it is therefore important that more direct measurements of these boundary layer parameters are *** significant scientific strides have been made in TC boundary *** advancements have been achieved through improved coupled models,large-eddy simulations,theoretical advance-ments,and detailed *** is now clear that the research field needs to better represent the eddy viscosity throughout the depth of the boundary ***,detailed study of coherent structures in TC boundary layers will likely be a propitious direction for the research ***,in-depth observational field campaigns and assiduous data analysis have made significant headway into verifying theory and modeling studies of intensification processes related to TC vortex alignment,efficient latent heating distributions,and overall 3D *** efforts have also been made to better understand the intricate roles radiative processes play in TC evolution and intensity ***,some promising progress has been made in the development of time-dependent theories of TC intensification and the predictability of internal TC intensity ***,there have been well-earned gains in the understanding of intensity change processes intrinsic to the TC system,but the journey is not *** paper highlights some of the most relevant and important research areas that are still shedding new light into internal fa

关键词： Tropical cyclone Intensity Internal dynamics Boundary-layer processes Observations Predictability

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Advances in surgical management for locally recurrent rectal cancer: How far have we come?

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World Journal of Gastroenterology 2017年第23期23卷 4170-4180页

作者： daniel Jin-Keat Lee Peter M Sagar Gaitri Sadadcharam Kok-Yang Tan Department of Surgery Khoo Teck Puat Hospital john Goligher Colorectal Surgery Unit St James’s University Hospital

Locally recurrent rectal cancer(LRRC) is a complex disease with far-reaching implications for the patient. Until recently, research was limited regarding surgical techniques that can increase the ability to perform an en bloc resection with negative margins. This has changed in recent years and therefore outcomes for these patients have improved. Novel radical techniques and adjuncts allow for more radical resections thereby improving the chance of negative resection margins and outcomes. In the past contraindications to surgery included anterior involvement of the pubic bone, sacral invasions above the level of S2/S3 and lateral pelvic wall involvement. However, current data suggests that previously unresectable cases may now be feasible with novel techniques, surgical approaches and reconstructive surgery. The publications to date have only reported small patient pools with the research conducted by highly specialised units. Moreover, the short and long-term oncological outcomes are currently under review. Therefore although surgical options for LRRC have expanded significantly, one should balance the treatment choices available against the morbidity associated with the procedure and select the right patient for it.

关键词： Recurrent rectal cancer Sacrectomy Pelvic exenteration Pelvic sidewall Radical resection

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Newly established autonomous adaptive low-power instrument platform(AAL-PIP) chain on East Antarctic Plateau and operation

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Advances in Polar Science 2019年第4期30卷 362-374页

作者： Zhonghua XU Michael DHARTINGER Robert CLAUER daniel WEIMER Kshitija DESHPANDE Hyomin KIM Stephen MUSKO Anna WILLER Thomas EDWARDS Shane COYLE Yuxiang PENG Dong LIN john BOWMAN Bradley Department of Electrical and Computer Engineering Virginia TechBlacksburgVA 24061USA Center for Space Plasma Physics Space Science InstituteBoulderCO 80301USA Department of Physical Sciences Embry-Riddle Aeronautical UniversityDaytona BeachFL 32114USA Center for Solar-Terrestrial Research New Jersey Institute of TechnologyNewarkNJ 07102USA Space Physics Research Laboratory College of EngineeringUniversity of MichiganAnn ArborMI48109USA DTU Space National Space InstituteTechnical University of DenmarkKongens LyngbyDenmark

An autonomous adaptive low-power instrument platform(AAL-PIP)chain of six stations has been newly established on East Antarctic Plateau along the 40°geomagnetic meridian,to investigate interhemispheric geomagnetically conjugate current systems,waves,and other space weather phenomena in Polar *** six stations,PG0 to PG5,which host low-power magnetometers(Fluxgate and Searchcoil),dual frequency GPS receivers,HF radio experiment,and run autonomously with solar power and two-way satellite communication,are designated at the geomagnetically conjugate(based on the International Geomagnetic Reference Field)locations of the West Greenland geomagnetic chain covering magnetic latitudes from 70°to 80°.We present the development,deployment,and operation of this chain,as well as the data collected by the chain and some preliminary scientific results showing evidence of interhemispheric asymmetries,which are important to better understand Solar Wind–Magnetosphere–Ionosphere(SWMI)coupling in Polar *** investigations focus on magnetic impulse(MI)events,traveling convection vortices(TCVs),and ultra-low frequency(ULF)waves in the coupled southern and northern hemispheres.

关键词： magnetometers magnetic perturbation magnetic conjugate

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ZFN,TALEN and CRISPR-Cas9 mediated homology directed gene insertion in Arabidopsis:A disconnect between somatic and germinal cells

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Journal of Genetics and Genomics 2018年第12期45卷 681-684页

作者： Qiwei Shan Nicholas J.Baltes Paul Atkins Elida R. Kirkland Yong Zhang Joshua A.Ballet Levi G.Lowder Aimee A.Malzahn john C.Haugner Ⅲ Burckhard Seelig daniel F. Voytas Yiping Qi Department of Genetics Cell Biology & Development and Center for Genome EngineeringUniversity of MinnesotaMinneapolisMN 55455USA Department of Biology East Carolina UniversityGreenvilleNC 27858USA Department of Biotechnology School of Life Sciences and Technology University of Electronic Science and Technology of ChinaChengdu 610054China Minnesota Supercomputing Institute University of Minnesota MinneapolisMN 55455USA Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA Department of Biochemistry Molecular Biology and Biophysics University of MinnesotaMinneapolisMN 55455USA BioTechnology Institute University of MinnesotaSt.PaulMN 55108 USA Institute for Bioscience and Biotechnology Research University of MarylandRockvilleMD 20850USA

Breakthroughs in the generation of programmable sequence-specific nucleases (SSNs), such as zinc finger nucleases (ZFNs),TAL effector nucleases (TALENs) and the RNA-directed nuclease CRISPR-associated protein 9 (Cas9), have greatly increased the ease of plant genome engineering (Voytas, 2013; Malzahn et al.,2017). Programmable SSNs introduce a DNA double-strand break

关键词： ZFN,TALEN and CRISPR-Cas9 mediated homology directed gene insertion in Arabidopsis GUS A disconnect between somatic and germinal cells

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Optimisation of the Design of Pulverised Coal Injection Lances:From Concept to Full Scale Implementation at BlueScope Steel’s BF6

Optimisation of the Design of Pulverised Coal Injection Lanc...

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第五届国际炼铁科技大会

作者： daniel Maldonado Paul Zulli Peter Austin Mark Walsh john Mathieson Harold Rogers BlueScope Steel Research Port Kembla BlueScope Steel Ironmaking Department Port Kembla BHP Billiton-Newcastle Technology Centre

Pulverised coal injection started at BlueScope Steel’s Port Kembla blast furnaces in 2002. With significant economic advantages to reduce consumption of coking coal via increasing the quantity of pulverised coal injected to the blast furnaces, a three-dimensional numerical model of the blowpipe/tuyere/raceway has been developed. The model has been applied in various plant-specific investigations of blast parameters, and more recently in the development of alternate coal injection lance tip geometries. The designs with the highest potential for increasing coal burnout included swirl and high dispersive tip designs. The reduction in char load entering the furnace for the best performing alternate designs was due to an increase in coal dispersion compared with the conventional design. A full-scale trial of the swirl lance design was carried out at Port Kembla’s BF6 in mid-2008. The trial delivered promising results, with PCI rates maintained. This was despite unrelated changes to the coke ash content and the burden mix fed to the furnace, which would normally reduce furnace permeability.

关键词： coal combustion modelling injection lance tip design char burnout

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Characteristics and distinct prognostic determinants of individuals with hepatosplenic T-cell lymphoma over the past two decades

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World Journal of Clinical Oncology 2024年第6期15卷 745-754页

作者： Ayrton Bangolo Pierre Fwelo Shraboni Dey Tanni Sethi Sowmya Sagireddy Jawaria Chatta Ashish Goel Sneha Nagpaul Eric Pin-Shiuan Chen Chiranjeeve Saravanan Sheeja Gangan Joel Thomas Sarah Potiguara Vignesh K Nagesh daniel Elias Charlene Mansour Prajakta H Ratnaparkhi Priyanshu Jain Midhun Mathew Taylor Porter Shadiya Sultan Shailaja Abbisetty Linh Tran Megha Chawla Abraham Lo Simcha Weissman Christina Cho Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Epidemiology Human Geneticsand Environmental SciencesUTHealth School of Public HealthHoustonTX 77030United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States Stem Cell Transplantation and Cellular Therapy John Theurer Cancer CenterHackensackNJ 07601United States

BACKGROUND Hepatosplenic T-cell lymphoma(HSTCL)is a rare and aggressive peripheral T-cell lymphoma with historically dismal outcomes,representing less than one percent of non-Hodgkin *** its rarity,the true incidence of HSTCL is unknown and most data have been extrapolated through case *** the best of our knowledge,the largest and most up to date study addressing the epidemiology and outcomes of patients with HSTCL in the United States covered a period from 1996 to 2014,with a sample size of 122 *** To paint the most updated epidemiological picture of *** A total of 186 patients diagnosed with HSTCL,between 2000 and 2017,were ultimately enrolled in our study by retrieving data from the Surveillance,Epidemiology,and End Results *** analyzed demographics,clinical characteristics,and overall mortality(OM)as well as cancer-specific mortality(CSM)of *** with a P value<0.01 in the univariate Cox regression were incorporated into the multivariate Cox model to determine the independent prognostic factors,with a hazard ratio of greater than 1 representing adverse prog-nostic *** Overall,the outlook for this rare malignancy is very *** this retrospective cohort study of the United States population,non-Hispanic blacks and the elderly had a higher *** data highlights the need for larger prospective studies to investigate factors associated with worse prognosis in one ethnic group,such as treatment delays,which have been shown to increase mortality in this racial/ethnic group for other cancers.

关键词： Extra nodal lymphoma Mortality Survival Racial disparity Age

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