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Achieving work hardening by forming boundaries on the nanoscale in a Ti-based metallic glass matrix composite

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journal of Materials Science & Technology 2020年第15期47卷 192-203页

作者： jing Fan Wei Rao junwei Qiao PKLiaw daniel Sopu daniel Kiener jürgen Eckert Guozheng Kang Yucheng Wu College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan University of TechnologyTaiyuan030024China Key Laboratory of Advanced Technologies of Materials School of Mechanics and EngineeringSouthwest Jiaotong UniversityMinistry of Education of ChinaChengdu610031China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN37996-2200USA Technische Universitat Darmstadt Institut fiir MaterialwissenschaftFachgebiet MaterialmodellierungOtto-Bemdt-Strasse 3D-64287DarmstadtGermany Erich Schmid Institute of Materials Science Austrian Academy of SciencesJahnstra'e 12A-8700LeobenAustria Department of Materials Science Montanuniversitat LeobenJahnstra'e 12A-8700LeobenAustria

Achieving work hardening in metallic glass matrix composites(MGMCs) is the key to the extensive use of these attractive materials in structural and functional *** this study,we investigated the formation of nanoscale boundaries resulted from the interaction between matrix and dendrites,which favors the work-hardening deformation in an in-situ Ti41Zr32Ni6 Ta7 Be14 MGMC with β-Ti dendrites in a glassy matrix at room *** microstructures of samples after tension were observed by highresolution transmission electron microscopy(HRTEM) and X-ray diffraction(XRD).The work-hardening mechanism of the present composites involves:(1) appearance of dense dislocation walls(DDWs),(2)proliferation of shear bands,(3) fo rmation of boundaries on the nanoscale,and(4) interactions between hard and soft phases.A theoretical model combined with experimental data reveals the deformation mechanisms in the present work,proving that the in-situ dendrites with outstanding hardening ability in the glass matrix can provide the homogeneous deformation under tensile loading at room temperature.

关键词： Metallic glass matrix composites Plastic deformation Work hardening Dense dislocation walls Nanoscale boundaries

Glial cell line-derived neurotrophic factor as a treatment after spinal cord injury

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Neural Regeneration Research 2018年第10期13卷 1733-1734页

作者： stephen d.ortmann daniel j.hellenbrand department of neurological surgery university of wisconsinmadisonwiusa

Spinal cord injury（SCI）is a devastating trauma that currently affects 54 people out of every million,which is approximately 270,000people in the United States（National Spinal Cord Injury Statistical Center,2013）.The effects of such an injury can cause a loss of both motor and sensory function below the injury site,normally leaving the patient unable to care for themselves entirely and relying on family and friends to provide personal *** there are no.

关键词： Glial cell line-derived neurotrophic factor as a treatment after spinal cord injury GFR SCI

The practice of mine ventilation engineering

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International journal of Mining Science and Technology 2015年第2期25卷 165-169页

作者： Wallace Keith Prosser Brian Stinnette j.daniel Mine Ventilation Services Inc.

The practice of ventilation is continually evolving with new technological advances developed in the mining *** recent years the advances in diesel engine technologies,ventilation modeling software,and ventilation management capacities have redefined the historical methods used to evaluate *** advances re-evaluate previous methods used to calculate the airflow requirements for the dilution of diesel exhaust *** software has become an integral part of planning and developing ventilation systems in partnership with graphical mine design software packages to generate realistic representations of the *** advances in ventilation control strategies through remote sensors and monitoring capabilities have been developed to results in cost *** there has been much advancement in mine ventilation technology,the practices and basic ventilation principals enacted through the ventilation engineer cannot be placated with technological advances only.

关键词： Modern ventilation Ventilation on demand Diesel Airflow evaluation Monitoring system

Superconvergence and the Numerical Flux: a Study Using the Upwind-Biased Flux in Discontinuous Galerkin Methods

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Communications on Applied Mathematics and Computation 2020年第3期2卷 461-486页

作者： daniel j.Frean jennifer K.Ryan School of Mathematics University of East AngliaNorwichUK Applied Mathematics and Statistics Colorado School of MinesGoldenCOUSA

One of the beneficial properties of the discontinuous Galerkin method is the accurate wave propagation *** is,the semi-discrete error has dissipation errors of order 2k+1(≤Ch2k+1)and order 2k+2 for dispersion(≤Ch2k+2).Previous studies have concentrated on the order of accuracy,and neglected the important role that the error constant,C,plays in these *** this article,we show the important role of the error constant in the dispersion and dissipation error for discontinuous Galerkin approximation of polynomial degree k,where k=0,1,2,*** gives insight into why one may want a more centred flux for a piecewise constant or quadratic approximation than for a piecewise linear or cubic *** provide an explicit formula for these error *** is illustrated through one particular flux,the upwind-biased flux introduced by Meng et al.,as it is a convex combination of the upwind and downwind *** studies of wave propagation are typically done through a Fourier *** higher order Fourier information can be extracted using the smoothness-increasing accuracy-conserving(SIAC)*** SIAC filter ties the higher order Fourier information to the negative-order norm in physical *** show that both the proofs of the ability of the SIAC filter to extract extra accuracy and numerical results are unaffected by the choice of flux.

关键词： Discontinuous Galerkin Smoothness-increasing accuracy-conserving(SIAC)filtering Superconvergence

Treating spinal cord injury via sustained drug delivery from calcium phosphate coatings

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Neural Regeneration Research 2016年第8期11卷 1236-1237页

作者： daniel j.Hellenbrand Amgad Hanna Department of Neurological Surgery University of Wisconsin

Spinal cord injury（SCI）is a devastating trauma that leaves approximately 10,000 to 20,000 people paralyzed every year in the United *** majority of these cases are young people that will live to almost a full life expectancy,however,their quality of life is significantly *** SCI there is loss of both sensory and motor function below the level of injury.

关键词： sustained devastating sensory young coated trauma dissolution kinetics probably axonal

RULEMAKING POSSIBILITIES： EFFORTS OF THE UNITED STATES jUDICIAL CONFERENCE ADVISORY COMMITTEE ON EVIDENCE RULES TO ADDRESS THE CHALLENGES TO FORENSIC EXPERT TESTIMONY

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Frontiers of Law in China-Selected Publications from Chinese Universities 2018年第1期13卷 34-42页

作者： daniel j. Capra School of Law University of California Berkeley USA Reed Professor School of Law Fordharn University New York 10023 USA

This piece is an echo to one of the main subjects of the Sixth International Conference on Evidence Law and Forensic Science which is to determine what evidentiary reforms are necessary for regulating forensic expert testimony, and how those reforms might be implemented. In United States, the predominant way of evidentiary reform is through rulemaking. As the Reporter of judicial Conference Advisory Committee on the Federal Rules of Evidence since 1996, the author, with a pragmatic spirit throughout the article, examines such an effort at the federal level of U.S. in six parts （levels）, starting from the most general, abstract level till fmishing with the most detailed and substantive points. Part I begins with a brief introduction of the hierarchies of evidentiary rulemaking authorities at the federal level of the United States, various interested groups and their interesting interactions in the rulemaking process. The author then shifts to the general topic of writing rules with a specific focus on the level of detail that is to be provided in doing so; Part II further narrows down the scrutiny into writing a rule on forensic expert testimony with an emphasis on the necessity of making such a rule change to the current general standards of FRE; Part III directly addresses the challenges of drafting a rule on forensic evidence in FRE, including a comparation of various alternative drafting models; Part IV and Part V respectively discusses the Reporter＇s comments and the justice Department＇s concerns over the drafted rules; and Part VI briefly discusses the feasibility and effectiveness of a Best Practices Manual on forensic evidence in lieu of rulemaking.

关键词： forensics rulemaking reliability expert

The arms race between Magnaporthe oryzae and rice: Diversity and interaction of Avr and R genes

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journal of Integrative Agriculture 2017年第12期16卷 2746-2760页

作者： WANG Bao-hua daniel j.Ebbole WANG Zong-hua College of Plant Protection/Fujian University Key Laboratory for Plant-Microbe Interaction Fujian Agriculture and Forestry University Department of Plant Pathology and Microbiology Texas A&M UniversityCollege Station Ocean Institute Minjiang University

Rice blast disease, caused by Magnaporthe oryzae, threatens global food security. The rice blast pathosystem is a longstanding model system for understanding plant-microbe interactions. In order to elucidate the coevolution of the host and pathogen, and provide the appropriate methods for preventing or controlling rice blast disease, researchers have focused on the evolution of virulence factors and resistance genes. Thus far, more than 30 rice blast resistance（R） genes and 12 avirulence（Avr） genes have been cloned. This review summarizes the cloned rice blast R genes, cloned Avr genes of M. oryzae and the interaction between them. This discussion also considers some of the major unanswered questions concerning this pathosystem and the opportunities for future investigations.

关键词： rice Maganporthe oryzae resistance gene avirulence gene co-evolution genetic diversity

Geophysical and orbital environments of asteroid 4692192016 HO3

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Astrodynamics 2023年第1期7卷 31-50页

作者： Xiangyu Li daniel j.Scheeres Dong Qiao Zixuan Liu School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Ann and H.j.Smead Aerospace Engineering Department University of Colorado Boulder429 UCBBoulderCO 80309USA

Asteroid 469219 Kamo'oalewa,also named 2016 HO3,is a small-size fast-rotating near-Earth asteroid,which is a potential target for future *** to its weak gravity and fast spin rate,the dynamics on the surface or in the vicinity of 2016 HO3 are significantly different from those of planets or other small bodies explored in previous *** this study,the geophysical and orbital environments of 2016 HO3 were investigated to facilitate a potential mission ***,the geormnetric and geopotential topographies of 2016 HO3 were examined using difterent shape *** liftoff and escape conditions on its fast-rotating surface were ***,the periodic orbits around 2016 HO3 were studied in the asteroid-fixed frame and the Sun-asteroid frame considering the solar radiation *** stable regions of the terminator orbits were discussed using different ***,the influence of the nonspherical shape on the terminator orbits was *** precise terminator orbits around a real shape model of 2016 HO3 were obtained and verified in the high-fidelity *** study shows that the polar region of 2016 HO3 is the primary region for landing or sampling,and the terminator orbits are well suited for global mapping and measurements of 2016 *** analysis and methods can also serve as references for the exploration of other small fast-rotating bodies.

关键词： asteroid 2016 HO3 geophysical environment solar radiation pressure terminator orbit

The N-terminus of COX-1 and its effect on cyclooxygenase-1 catalytic activity

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journal of Genetics and Genomics 2010年第2期37卷 117-123页

作者： Sean Phipps Michael j. Turner daniel L. Simmons Chemistry and Biochemistry Department Brigham Young University

Cyclooxygenases are encoded by COX-1 and COX-2. They share over sixty percent sequence identity in human and are similar to each other in their crystallographic structures. One major difference in the primary structure of these two isozymes is the presence of eight amino acids in the amino-terminal region of COX-1 that are not present in COX-2. The function of this amino acid sequence is unknown. In this study, a human COX-1 mutant （Δ7aa） with this sequence removed was studied in parallel with COX-1. Signal peptide cleavage, N-linked glycosylation, protein expression, distribution and dimerization were not affected by the mutation. The mutant was enzymati-cally active and showed the same sensitivity toward aspirin. The KM for the enzyme remained the same as COX-1. However, the Vmax of the COX-1 mutant decreased by 3.3-fold. We conclude that the COX-1 specific amino-terminal sequence has a subtle but detectable effect on COX-1 catalysis.

关键词： COX-1 COX-2 dimerization glycosylation aspirin KM Vmax