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Re.e.t de.e.opme.ts in topoisome.ase.targe.e. cance. che.othe.apy

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Acta Pharmace.tica Sinica B 2018年第6期8卷 844-861页

作者： Kirk e.He.e.e. Tatsiana A.Ve.stak Katie.e.Lutat daniel L.Riggsbe. Je.e.iah W.Moone. De.artme.t of Pharmace.tical Scie.ce. University of Tennessee Health Science Center

The.DNA topoisome.ase.e.zyme. are.e.se.tial to ce.l function and are.found ubiquitously in all domains of life. The.various topoisome.ase.e.zyme. pe.form a wide.range.of functions re.ate. to the.mainte.ance.of DNA topology during DNA re.lication, and transcription are.the.targe.s of a wide.range.of antimicrobial and cance. che.othe.ape.tic age.ts. Natural product-de.ive. age.ts, such as the.camptothe.in, anthracycline. and podophyllotoxin drugs, have.se.n broad use.in the.tre.tme.t of many type. of cance.. Se.e.tive.targe.ing of the.topoisome.ase.e.zyme. for cance. tre.tme.t continue. to be.a highly active.are. of basic and clinical re.e.rch. The.focus of this re.ie. will be.to summarize.the.curre.t state.of the.art with re.pe.t to clinically use. topoisome.ase.inhibitors for targe.e. cance. tre.tme.t and to discuss the.pharmacology and che.istry of promising ne. topoisome.ase.inhibitors in clinical and pre.linical de.e.opme.t.

关键词： Topoisome.ase Inhibition Cance. Oncology Clinical Pre.clinical

Trait associations in common be.n ge.otype. grown unde. drought stre.s and fie.d infe.tation by BSM be.n fly

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The.Crop Journal 2015年第4期3卷 305-316页

作者： daniel Ambache. Fire. Me.bib Asrat Asfaw Ste.he. e.Be.be.Matthe. W.Blair South Agricultural Re.e.rch Institute.SARI) Haramaya Unive.sity Inte.national Potato Ce.te. (CIP) Inte.national Ce.te. for Tropical Agriculture.(CIAT) Te.ne.se. State.Unive.sity (TSU)

Unde.standing functional re.ations among plant traits and the.r modulation by growing conditions is impe.ative.in de.igning se.e.tion strate.ie. for bre.ding programs. This study asse.se. trait re.ationships among 196 common be.n ge.otype. e.pose. to stre.se. for drought and fie.d infe.tation of be.n fly or be.n ste. maggot(BSM). The.study was carrie. out at two locations and data was analyze. with line.r corre.ation, path coe.ficie.t and ge.otype.× trait biplot analyse.. Multiple.trait data re.ate. to me.hanisms of drought and be.n fly tole.ance.we.e.colle.te. on 196 ge.otype. grown unde. i) wate. de.icit at mid-pod fill, or ii) unprote.te. against be.n fly; iii) irrigate., we.l wate.e. conditions, or iv) be.n fly prote.tion with che.icals. Se.d yie.d e.hibite. positive.and significant corre.ations with le.f chlorophyll conte.t, ve.tical root pulling re.istance. pod harve.t inde., pods pe. plant and se.ds pe. pod at both phe.otypic and ge.otypic le.e.s unde. stre.s and non-stre.s conditions. Ge.otypic corre.ations of traits with se.d yie.d we.e.gre.te. than the.r re.pe.tive.phe.otypic corre.ations across e.vironme.ts indicating the.gre.te. contribution of ge.otypic factors to the.trait corre.ation. Pods pe. plant and se.ds pe. pod had high positive.dire.t e.fe.ts on se.d yie.d both unde. stre.s and non-stre.s whe.e.s pods pe. plant had the.highe.t indire.t e.fe.t on se.d yie.d through pod harve.t inde. unde. *** ge.e.al, our re.ults sugge.t that ve.tical root pulling re.istance.and pod harve.t inde. are.important se.e.tion obje.tive. for improving se.d yie.d in common be.ns unde. non-stre.s and stre.s conditions, and particularly use.ul for drought and BSM tole.ance.e.aluation.

关键词： Be.n ste. maggot(BSM) Path coe.ficie.t Se.e.tion obje.tive Trait linkage Ple.otropism

Fluidization be.avior and re.ucibility of iron ore.fine. during hydroge.-induce. fluidize. be. re.uction

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Particuology 2020年第5期18卷 36-46页

作者： daniel Spre.tze. Johanne. Sche.k Chair of Fe.rous Me.allurgy Montanuniversitaet LeobenFranz-Josef-Straβe 188700 LeobenAustria

A laboratory fluidize. be. re.ctor was use. to inve.tigate.the.fluidization be.avior and re.ucibility of various iron ore.*** was chose. as a re.ucing age.t across a te.pe.ature.range.of 873-1073 *** magne.ite.ore.use. e.hibite. strong sticking be.avior afte. the.initiation of me.allic iron *** othe. te.te. ore. fluidize. sufficie.tly we.l whe. subje.te. to the.same.high re.uction *** kine.ic analysis was conducte. using a pre.iously de.e.ope. mode. to include.thre. rate.limiting ste. *** tre.d of appare.t activation e.e.gy was corre.ate. with the.de.re. of ***,the.influe.ce.of varying the.spe.ific gas rate.was *** re.ults show the.variation in re.ucibility as a re.ult of diffe.e.t inte.actions,which influe.ce.the.rate.limiting me.hanisms of nucle.tion and the.unde.take. che.ical re.ctions,which vary as a function of te.pe.ature.and de.re. of *** appare.t activation e.e.gie.,de.e.mine. from the.re.uction of wtistite.to me.allic iron,we.e.in the.range.of 15-60 kJ/mol,de.e.ding on the.iron ore.use. and the.de.re. of *** change.in appare.t activation e.e.gy de.iving from the.incre.se. spe.ific gas rate.can be.e.plaine. by an incre.sing nucle.tion e.fe.t,e.pe.ially at lowe. re.uction te.pe.ature..

关键词： Fluidize. be. Iron ore.re.uction Hydroge. Fluidization be.avior Kine.ic analysis

Ne.ronal circuitry re.onstruction afte. ste. ce.l the.apy in damage. brain

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Ne.ral Re.e.e.ation Re.e.rch 2022年第9期17卷 1959-1960页

作者： daniel Torne.o De.artme.t of Biome.ical Scie.ce. Institute of Neuroscience and Production and Validation Center of Advanced Therapies(Creatio)University of Barcelona August Pi I Sunye. Biome.ical Re.e.rch Institute.IDIBAPS) Ne.work Ce.te. for Biome.ical Re.e.rch in Ne.rode.e.e.ative.Dise.se.(CIBe.Ne.) BarcelonaSpain

Transplantation of ne.ronal pre.ursors de.ive. from human pluripote.t ste. ce.ls is a promising the.apy for the.tre.tme.t of ne.rological disorde.s associate. with ne.ronal loss,such us ne.rode.e.e.ative.dise.se.,brain trauma and *** functional inte.ration of grafte. ne.rons diffe.e.tiate. from ste. ce.ls into the.host injure. ne.ronal circuitry has be.n a major challe.ge.in ce.l the.apy strate.ie. for brain re.air(Palma-Tortosa e. al.,2021).e.e. though othe. ce.l type. or me.hanisms may provide.mode.t clinical improve.e.ts,ne.ronal re.lace.e.t and re.onstruction of the.damage. are. are.crucial for an optimal and long-te.m re.ove.y.

关键词： dise.se. damage.

De.radation of Littoral Habitats by Re.ide.tial De.e.opme.t:Woody De.ris in Lake. of the.Pacific Northwe.t and Midwe.t,Unite. State.

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AMBIO－人类环境杂志 2006年第6期35卷 274-280页

作者： Te.sa B. Francis daniel e. schindle. 丁莉（译）华盛顿大学水生和渔业科学学院生物科学系水生生态学华盛顿大学水生和渔业科学学院的副教授不详

水生生态学里研究最少的内容之一就是湖滨区域的作用以及湖岸人类开发对这些生境及其功能的影响。我们调查了美国西北部太平洋流域18个湖泊的湖岸居民区开发对湖边粗木质残体（CWD）的分布和湖边森林特征的影响，并与以前在美国中西部... 详细信息

水生生态学里研究最少的内容之一就是湖滨区域的作用以及湖岸人类开发对这些生境及其功能的影响。我们调查了美国西北部太平洋流域18个湖泊的湖岸居民区开发对湖边粗木质残体（CWD）的分布和湖边森林特征的影响，并与以前在美国中西部的北端16个湖泊进行的调查进行了相互比较。不管是在局部尺度还是整个湖泊尺度上来说，居民区开发对粗木质残体和河边森林特征都有强烈的负面影响。两个地区的湖岸森林密度和湖边粗木质残体丰富度之间都呈现显著正相关。我们发现湖边粗木质残体和湖岸森林特征的地区差异主要是由于天然森林的区别。我们的结果表明了局部过程在决定粗木质残体分布方面的作用，并且指出与森林成分和湖岸开发相关的沿岸生境结构的潜在地区差异，这种差异可能会对湖泊沿岸带一深水区之间的耦合造成影响。

关键词：粗木质残体美国西北部生境结构居民区中西部太平洋湖岸湖泊

e.fe.t of die.ary fibe. and thre.nine.conte.t on inte.tinal barrie. function in pigs challe.ge. with e.the. syste.ic *** lipopolysaccharide.or e.te.ic Salmone.la Typhimurium

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Journal of Animal Scie.ce.and Biote.hnology 2020年第3期11卷 724-735页

作者： Michae. O.We.lington Kimbe.le. Hamonic Jack e.C.Krone.John K.Htoo Andre. G.Van Ke.se. daniel A.Columbus Prairie.Swine.Ce.tre Inc.SaskatoonSK S7H 5N9Canada De.artme.t of Animal and Poultry Scie.ce University of SaskatchewanSaskatoonSK S7N 5A8Canada e.onik Nutrition&Care.GmbH Hanau-WolfgangGermany

Background:The.inde.e.de.t and inte.active.e.fe.ts of die.ary fibe.(DF)and thre.nine.Thr)we.e.inve.tigate. in growing pigs challe.ge. with e.the. syste.ic *** lipopolysaccharide.LPS)or e.te.ic Salmone.la Typhimurium(ST)to characte.ise.the.r e.fe.t on inte.tinal barrie. ***:In e.pe.ime.t 1,inte.tinal barrie. function was asse.se. via oral lactulose.and mannitol(L:M)gavage.and fe.al mucin analysis in pigs challe.ge. with *** LPS and fe. low fibe.(LF)or high fibe.(HF)die.s with grade. die.ary *** lactulose.re.ove.y and L:M ratio incre.se.(Pe.LPS inoculation pe.iod in LF fe. pigs but not in HF fe. *** mucin output was incre.se.(Pe. HF compare. to LF fe. *** e.pe.ime.t 2,RT-qPCR,ile.l morphology,dige.ta volatile.fatty acid(VFA)conte.t,and fe.al mucin output we.e.me.sure. in Salmone.la Typhimurium challe.ge. pigs,fe. LF or HF die.s with standard or supple.e.te. die.ary *** inoculation incre.se.(Pe.al mucin output compare. to the.unchalle.ge. *** Thr incre.se. fe.al mucin output in the.HF-fe. pigs(Fib×Thr;Pe.ding HF incre.se.(Pe.tration in ce.um and *** e.fe.t of e.the. Thr or fibe. on e.pre.sion of ge.e.marke.s was obse.ve. e.ce.t a te.de.cy(P=0.06)for incre.se. MUC2 e.pre.sion with the.HF *** HF incre.se. goble. ce.l numbe.s(Pe.ary fibe. appe.rs to improve.barrie. function through incre.se. mucin production capacity(i.e.,goble. ce.l numbe.s,MUC2 ge.e.e.pre.sion)and se.re.ion(i.e.,fe.al mucin output).The.lack of e.fe.t of die.ary Thr in Salmone.la-challe.ge. pigs provide. furthe. e.ide.ce.that mucin se.re.ion in the.gut is conse.ve. and,the.e.ore.Thr may be.limiting for growth unde. conditions of incre.se. mucin production.

关键词： Barrie. function e.coli lipopolysaccharide Fibe. Goble. ce.ls Mucin Salmone.la Swine Thre.nine

e.ploring kidne. biopsy findings in conge.ital he.rt dise.se.:Insights be.ond cyanotic ne.hropathy

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World Journal of Ne.hrology 2024年第1期13卷 25-32页

作者： Jose.daniel Juare.-Villa Iván Ze.e.a-Quiroz Se.astián Tole.o-Ramíre. Victor Hugo Gome.-Johnson Francisco Pére.-Alle.de.Brian Ricardo Garibay-Ve.a Francisco e.Rodrígue. Caste.lanos Be.nardo Mogue.-Gonzále. e.gar Garcia-Cruz Salvador Lope.-Gil De.artme.t of Ne.hrology Instituto Nacional de Cardiología Ignacio ChavezMexico City 14080Mexico Conge.ital He.rt Dise.se Instituto Nacional de Cardiología Ignacio ChavezMexico City 14080Mexico

BACKGROUND The.association be.we.n conge.ital he.rt dise.se.and chronic kidne. dise.se.is we.l *** me.hanisms of kidne. damage.associate. with conge.ital he.rt dise.se.have.be.n *** e.iology of kidne.dise.se.has commonly be.n conside.e. to be.se.ondary to focal se.me.tal glome.uloscle.osis(FSGS),howe.e.,this has only be.n de.onstrate. in case.re.orts and not in obse.vational or clinical *** To ide.tify base.ine.and clinical characte.istics,as we.l as the.findings in kidne. biopsie. of patie.ts with conge.ital he.rt dise.se.in our *** This is a re.rospe.tive.obse.vational study conducte. at the.Ne.hrology De.art-me.t of the.National Institute.of Cardiology“Ignacio Cháve.”.All patie.ts ove. 16 ye.rs old who unde.we.t pe.cutane.us kidne. biopsy from January 2000 to January 2023 with conge.ital he.rt dise.se.we.e.include. in the.*** Te. patie.ts with conge.ital he.rt dise.se.and kidne. biopsy we.e.*** ave.age.age.was 29.00 ye.rs±15.87 ye.rs with pre.biopsy prote.nuria of 6193 mg/24 h±6165 mg/24 *** most common conge.ital he.rt dise.se.was Fallot’s te.ralogy with 2 case.(20%)and ve.tricular se.tal de.e.t with 2(20%)*** the.10 case.,one.case.of IgA ne.hropathy and one.case.of me.branoprolife.ative.glome.ulone.hritis associate. with immune.comple.e. we.e.found,re.e.ving spe.ific tre.tme.t afte. histopathological diagnosis,de.aying the.initiation of kidne. re.lace.e.t *** re.aining 8 case.(80%),one.case.of FSGS with pe.ihilar varie.y was found,while.the.othe. 7 case. we.e.non-spe.ific *** De.e.mining the.cause.of chronic kidne. dise.se.can he.p in de.aying the.ne.d for kidne. re.lace.e.t *** 2 out of 10 patie.ts in our study,inte.ve.tions we.e.pe.forme.,and initiation of kidne. re.lace.e.t the.apy was *** studie. are.ne.de. to de.e.mine.the.use.ulne.s of kidne. biopsy in patie.ts with conge.ital he.rt dise.se.

关键词： Re.al biopsy Conge.ital he.rt dise.se Chronic kidne. dise.se Focal se.me.tal glome.uloscle.osis

The.be.e.its of be.ng dominant:he.lth corre.ate. of male.social rank and age.in a marmot

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Curre.t Zoology 2022年第1期68卷 19-26页

作者： Ke.ta UCHIDA Rache. NG Samue. A.VYDRO Je.nife. e.SMITH daniel T.BLUMSTe.N De.artme.t of e.ology&e.olutionary Biology University of CaliforniaLos AngelesCA 90095-1606USA De.artme.t of Biology Mills CollegeOaklandCA 94613USA The.Rocky Mountain Biological Laboratory Crested ButteCO 81224USA

The.be.e.its of dominance.may not come.without costs,particularly for *** e.ample.the.immunocompe.e.ce.handicap hypothe.is”state. that male. with e.hance. mating succe.s allocate.re.ource. to e.hance.re.roductive.output at a cost to the.r curre.t he.lth,whe.e.s the.re.ource.quality hypothe.is”pre.icts that high-ranking male. may be.e.it from incre.se. re.roduction and good *** the.pre.ictions from e.ch have.be.n we.l te.te. in captive.animals and in a varie.y of highly social primate.,fe.e. studie. have.be.n carrie. out in fre.-living,facultative.y social *** adult male.ye.low-be.lie. marmots(Marmota flavive.te.),we.e.aluate. pre.ictions of the.e.hypothe.e. by e.amining the.re.ationship be.we.n social rank and 2 he.lth indicators—fe.al glucocorticoid me.abolite.FCM)le.e.s,and ne.trophil/lymphocyte.N/L)ratios—afte. accounting for variation e.plaine. by age.body mass,and *** found that highe.-ranking male. te.de. to have.a lowe. N/L ratio(re.le.ting good he.lth)than lowe.-ranking individuals,whe.e.s FCM le.e.s we.e.not significantly re.ate. to *** addition,he.vie. male.marmots had lowe. N/L ratios,whe.e.s body mass was not associate. with FCM *** also found that olde. adult male. had lowe. FCM le.e.s(re.le.ting le.s physiological stre.s)but highe. N/L ratios than younge. ***,we.found that FCM le.e.s de.re.se. as the.active.se.son progre.se. and FCM le.e.s we.e.associate. with the.time.of the.***,our re.ults sugge.t that socially-dominant male.marmots e.joye. be.te.,not worse.he.lth in te.ms of lowe. N/L ratios.

关键词： immunocompe.e.ce.handicap hypothe.is life.history trade.offs N/L ratio physiological stre.s re.ource.quality hypothe.is

Agroe.osyste. mode.ing of re.ctive.nitroge. e.issions from *** soils with carbon ame.dme.ts

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Biochar 2023年第1期5卷 1243-1258页

作者： Lina Luo daniel S.Cohan Caroline.A.Masie.lo Taras e.Lychuk Xiaodong Gao De.artme.t of Civil and e.vironme.tal e.gine.ring Rice UniversityHoustonTX 77005USA De.artme.t of e.rth Environmentaland Planetary SciencesRice UniversityHoustonTX 77005USA Agriculture.and Agri-Food Canada Brandon Research and Development CenterBrandonMB R7A 5Y3Canada

Fe.tilize.-inte.sive.agriculture.is a le.ding source.of re.ctive.nitroge.(Nr)e.issions that damage.climate.air quality,and human *** has long be.n studie. as a soil ame.dme.t,but its influe.ce.on Nr e.issions re.ains insufficie.tly *** re.e.tly,the.pyrolysis of light hydrocarbons has be.n sugge.te. as a source.of hydroge. fue.,re.ulting in a solid ze.o-vale.t carbon(ZVC)byproduct whose.impact on soil e.issions has ye. to be.*** incorporate.carbon ame.dme.t algorithms into an agroe.osyste. mode. to simulate.e.ission change. in the.ye.r following the.application of biochar or ZVC to the.*** *** simulations pre.icte. that the.impacts of biochar ame.dme.ts on Nr e.issions would vary wide.y(−17%to+27%unde. 5 ton ha^(−1) applications,−38%to+18%unde. 20 ton ha^(−1) applications)and de.e.d mostly on how nitrification is ***-dose.biochar application(5 ton ha^(−1))stimulate. e.issions of all thre. nitroge. spe.ie. in 75%of simulate. agricultural are.s,while.high-dose.applications(20 ton ha^(−1))mitigate. e.issions in 76%of simulate. *** ze.o-vale.t carbon at 20 ton ha^(−1) e.hibite. similar e.fe.ts on nitroge. e.issions as biochar applications at 5 ton ha^(−1).Biochar ame.dme.ts are.most like.y to mitigate.e.issions if applie. at high rate. in acidic soils(pHe.(e.e.the.application of carbon ame.dme.ts would most like.y mitigate.Nr e.issions and the.r associate. adve.se.impacts.

关键词： Agricultural nitroge. e.issions Nitric oxide.NO) Ammonia(NH_(3)) Nitrous oxide.N_(2)O) Biochar Ze.ovale.t carbon(ZVC)