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Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review

Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 139-145页

作者： Wellington Andraus Francisco Tustumi Alexandre Chagas Santana Rafael soares Nunes Pinheiro daniel Reis Waisberg Liliana Ducatti Lopes Rubens Macedo arantes Vinicius Rocha Santos Rodrigo Bronze de Martino Luiz Augusto Carneiro D’Albuquerque department of Gastroenterology Transplantation UnitUniversidade de São PauloSão PauloBrazil

Background:Perihilar cholangiocarcinoma(phCCC)is a dismal *** is no consensus regard-ing the best treatment for patients with unresectable *** present review aimed to gather the current pieces of evidence for liver transplantation and liver resection as a treatment for phCCC and to build better guidance for clinical *** sources:The search was conducted in PubMed,Embase,Cochrane,and *** related references were searched *** criteria were:reports in English or Portuguese literature that a)patients with confirmed diagnosis of phCCC;b)patients treated with a curative intent;c)patients with the outcomes of liver resection and liver *** reports,reviews,letters,editorials,conference abstracts and papers with full-text unavailability were excluded from the ***:Most of the current literature is based on observational retrospective studies with low grades of *** resection has better long-term outcomes than systemic chemotherapy or palliation ther-apy and liver transplantation is a good alternative for selected patients with unresectable *** candidates for resection or transplantation should be medically fit and free of intrahepatic or extrahep-atic *** a general rule,patients presenting with a tumor having a longitudinal size>3 cm or extending below the cystic duct,lymph node disease,confirmed extrahepatic dissemination;intraoper-atively diagnosed metastatic disease;a history of other malignancies within the last five years,and did not complete chemoradiation regimen and were medically unfit should not be considered for *** of these criteria should be individually *** transplantation or resection should only be considered in highly experienced hepatobiliary centers,and any decision-making must be based on a multidisciplinary ***:phCCC is a complex condition with high *** therapies,including hepatec-tomy and liv

关键词： Liver transplantation Cholangiocarcinoma Liver neoplasms

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Morbid Obesity: A Review on the Reasons for Impediments to Physical Exercises and Social Activities

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Modern Plastic Surgery 2020年第3期10卷 93-100页

作者： josé Humberto Cardoso Resende Mattheus Duarte da Veiga Jardim Brena Thamyres de Andrade Irineu Leydeane Rosa Gomes Gontijo Lucas Radi Cruvinel Zeno Augusto de Sousa Neto Rodrigo Gonç alves de Oliveira daniel soares de araújo Emídio Silva Falcã o Brasileiro UNIFAN Work Coordinator Aparecida de Goi&#226 nia Brazil UNIFAN Academics of Medicine Aparecida de Goi&#226 nia Brazil UNIFAN Research Coordinator Aparecida de Goi&#226 nia Brazil

Morbid obesity is regarded as a disease due to excess body weight, causing a silence of life as a whole and entailing the most varied disabilities for the person, such as: physical, social, psychological, affective, etc. It represents cases of “public health”, thereby involving competent bodies in the development of solutions that encompass various medical specialties and other health fields, in addition to influencing the mind of these people, causing depression that, due to metabolic involvement, can evolve to the death of the individual. The participation of multidisciplinary health focuses on weight loss, freely and spontaneously, or on the indication of bariatric surgery. We know how difficult it is to lose weight. In order to achieve successful procedures, we recommend the “Obese Workshop” or pre- and post-surgical follow-ups close to the patients, with a view to avoiding recurrences or the “accordion effect” (very common), which can interfere with the Body Mass Index (BMI). Everyone, males and females, complained of tiredness and the impossibility of any physical exercise, even the lightest and simplest to be performed, in addition to the fact that they cannot attend gyms and are unable to open a simple door handle.

关键词： Obesity Hypertension Diabetes Bariatric Illness Physical Exercise

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国际护理知识网络建设的调查研究

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International journal of Nursing Sciences 2024年第3期11卷 374-380,I0004,I0005页

作者： Margareth Santos Zanchetta Suzanne Fredericks Kateryna Metersky Geraldine Martorella Pammla Petrucka Laurie Clune Kelly Graziani Giacchero Vedana Cristina Rosa soares Lavareda Baixinho Cristianne Maria Famer Rocha Sara Campagna Sally Zhang He Márcia Teles de Oliveira Gouveia Marcelo Medeiros denize Bouttelet Munari daniel Gonzalo Eslava Albarracin Carlos Aguilera-Serrano Walterlania Silva Santos Toronto Metropolitan University TorontoCanada Florida State University TallahasseeUSA University of Saskatchewan ReginaCanada University of Regina ReginaCanada State of Sao Paulo University Ribeirao PretoBrazil Lisbon Superior School of Nursing LisbonPortugal Federal University of Rio Grande do Sul Porto AlegreBrazil University of Turin TurinItaly Scarborough Health Network ScarboroughCanada Federal University of Piauí TeresinaBrazil Federal University of Goias GoianiaBrazil Fundacion Universitaria Cafam BogotaColombia University of Malaga MalagaSpain University of Brasília Ceil^andiaBrazil

本文报告了为创建护理知识网络(Nursing Knowledge Network,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及... 详细信息

本文报告了为创建护理知识网络(Nursing Knowledge Network,NKN)对不同国家护理院校进行环境扫描调查所收集到的信息。采用在线方式(2021年2-10月)进行环境扫描,探索研究领域的确定、现有资源、预期收益、教学研究创新、知识传播障碍及网络的预期贡献。目标信息提供者包括来自13个国家63所大学的200名护理教师。要求每所大学有1名参与者回答问卷。共有42所大学(约70%)回复,包括巴西21所,加拿大4所,葡萄牙和西班牙各3所,哥伦比亚、墨西哥、秘鲁和美国各2所,智利、意大利和巴拉圭各1所。其分享了相关信息和见解:通过护理高等教育机构之间的协作和交流,全球可以加强共同创新和研究合作能力;较少被研究的领域是知识网络生成证据、为当地科学实践提供信息的潜在重点。这些信息将为进一步了解护理发展,以及地方、区域和全球护理证据应用和传播相关的政府政策与计划制订提供参考。

关键词：信息网络创新扩散国际教育交流知识管理护理教育护理教师实践护理院校跨文化护理

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Control of inherited structural fabric on the development and exhumation of passive margins-Insights from the araçuaíOrogen(Brazil)

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Geoscience Frontiers 2023年第6期14卷 30-48页

作者： Ana Fonseca Tiago Novo Tobias Fonte-Boa Matheus Kuchenbecker daniel Galvão Carnier Fragoso daniel Peifer Antônio Carlos Pedrosa-soares johan de Grave Laboratory for Mineralogy and Petrology Department of GeologyGhent UniversityKrijgslaan 281 S89000 GhentBelgium Universidade Federal de Minas Gerais Programa de Pós-Graduação em GeologiaCPMTC-IGCCampus PampulhaBelo HorizonteMGBrazil Centro de Pesquisas Professor Manoel Teixeira da Costa Instituto de GeociênciasUniversidade Federal de Minas GeraisBelo HorizonteBrazil Universidade Federal dos Vales do Jequitinhonha e Mucuri Instituto de Ciência e TecnologiaCentro de Estudos em GeociênciasLaboratório de Estudos TectônicosDiamantinaBrazil Petrobras Rio de JaneiroRJBrazil Instituto de Geociências Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil department of Geosciences University of TübingenSchnarrenbergstr.94-9672076 TübingenGermany

The araçuaíOrogen,in eastern Brazil,was formed during the Neoproterozoic–Cambrian amalgamation of West *** the Mesozoic–Cenozoic opening of the South Atlantic Ocean,and the associated divergent tectonics,the orogen developed as basement to the passive margin of South America and was progressively covered by thick offshore sedimentary basins,particularly the Espírito Santo,Mucuri,and Cumuruxatiba basins,in which hydrocarbon systems have been *** understanding of the araçuaíOrogen’s passive margin evolution,erosion,and sediment transfer to these basins ultimately depends on constraining the onshore exhumation in response to Mesozoic–Cenozoic ***,new and previously published data from apatite fission-track(AFT)analyses and inverse thermal history modelling of(Pre)Cambrian basement rocks from the araçuaíOrogen resolve three discrete basement cooling and associated erosional exhumation *** the Pre-Rift phase,Jurassic–Hauterivian erosion of the araçuaíOrogen is most likely related to the adjoining intra-continental West Gondwana flexural subsidence,which increased hillslope and river erosion *** the Rift and Transitional phases,Barremian–Albian accelerated phase of erosion is associated with the uplift of the Atlantic rift shoulders and the establishment of an oceanic *** the Drift phase,reactivations in response to far-field stresses likely triggered a Late Cretaceous–Paleocene rapid erosion *** rates at which these events unfolded vary spatially and are controlled by inherited *** araçuaíOrogen experienced slower denudation rates in areas closer to the São Francisco Craton,which suggests that the tectonic reactivation and related surface uplift during the Mesozoic–Cenozoic is in first-order controlled by lithospheric ***,the structural framework of the Paramirim and Pirapora aulacogens and NE-oriented shear zones in the orogen’s southeast facilitated later *** the spati

关键词： Thermal history denudation Tectonic inheritance Reactivations South Atlantic Hydrocarbons

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Apparent soil electrical conductivity in the delineation of management zones for cocoa cultivation

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Information Processing in Agriculture 2022年第3期9卷 443-455页

作者： Samuel de Assis Silva Railton Oliveira dos Santos daniel Marcal de Queiroz Juliao soares de Souza Lima Levi Fraga Pajehua Caique Carvalho Medauar Center for Agricultural Sciences and Engineering Federal University of Espirito SantoAlegre CampusEspirito Santo 29500-000Brazil department of Agricultural Sciences Santa Cruz State UniversityIlheusBahia 45662-900Brazil department of Agricultural Engineering Federal University of Vic¸osaVic¸osaMinas Gerais 36570-900Brazil

Apparent electrical conductivity is an important parameter for describing the spatial vari-ability of physical and chemical attributes of the soil and for the delineation of manage-ment *** objective of this work is to outline management zones for the cocoa cultivation based on the spatial variability of the productivity and the apparent electrical conductivity(ECa)of the *** collection was performed in a regular sample grid con-taining 120 points in an area cultivated with cocoa trees,located in the municipality of Ilhe´us,state of Bahia,*** each sampling point(cocoa tree),soil samples were col-lected to determine chemical *** was measured for one year,counting,monthly,the number of fruits,which were classified into off-season cocoa,harvest and annual *** of the apparent electrical conductivity of the soil were performed at different times of the year using a portable conductivity *** data were analyzed using classical statistics and *** management zones were delin-eated using the fuzzy k-means *** ideal number of class was defined using the fuzziness performance index(FPI)and the entropy of the modified partition(MPE)*** Kappa coefficient was used to validate the management zones,assessing their agreement with the chemical attributes of the *** ECa of the soil values pre-sented moderate temporal variation,with maximum amplitude of 19.37 mS m1 and min-imum of 0.82 mS m1 between measurement periods;higher averages of the ECa coincided with the highest levels of water in the *** measurements of the ECa of the soil carried out in April and October showed greater correlation with the chemical attributes of the soil,with significant values for 11 and 8 of the 17 attributes evaluated,*** man-agement zones from the ECa measured in April showed:a)reduced number of classes;b)spatial continuity between classes,and;c)agreement from reasonable(kappa between

关键词： Theobroma cacao Precision agriculture Spatial variability Fuzzy k-means

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Challenges in developing polymer flocculants to improve bitumen quality in *** extraction processes:an experimental study

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Petroleum Science 2020年第3期17卷 811-821页

作者： daniel V.Dixon Stanislav R.Stoyanov Yuming Xu Hongbo Zeng joao B.P.soares department of Chemical and Materials Engineering University of Alberta9211-116 Street NW.EdmontonAB T6G 1H9Canada CanmetENERGY devon.Natural Resources Canada 1 Oil Patch DriveDevonAB T9G 1A8Canada

Western Canada’s oil sands hold the third-largest hydrocarbon deposits in the ***,a very heavy petroleum,is currently recovered by surface mining with warm water or in *** processes that use organic solvents are being developed to reduce water usage and tailings *** solvent-based methods can effectively extract bitumen,removal of residual fine solids from diluted bitumen product(DBP)to meet the pipeline transport requirement ofjor *** propose a novel area of application of polymer flocculants for fine solids removal from *** principle,polymer flocculants can be applied to help remove these residual solids in conjunction with physical separation processes to increase process effectiveness and energy *** polymers are selected and screened for flocculation behavior using kaolinite suspended in DBP and toluene,as a model *** beam reflectance measurements and force tensiometer techniques are used to determine flocculation and sedimentation in *** observed flocculation and sedimentation rate enhancements indicate that the polymers tested have only minor effects,providing opportunities for advanced polymer *** findings exemplify the challenges in identifying polymers that may be effective as flocculants in heavy petroleum media.

关键词： Non-aqueous extraction Diluted bitumen Oil-soluble polymer flocculants Sedimentation in dark and opaque media Focused beam reflectance measurements

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Technical Evaluation of Hybrid Clones of Corymbia spp. to Produce Market Pulp

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Paper And Biomaterials 2022年第3期7卷 1-6页

作者： Marcelo Moreira da Costa Ricardo de Carvalho Bittencourt Thales Augusto Pinto Coelho Nogueira Larissa soares Silva Weslley Henrique Martins da Silva Sebastião Renato Valverde Gleison Augusto Dos Santos daniel Alexander Fernandes Coelho Claudilene Aparecida Alves Pena department of Forest Sciences Federal University of VicosaVicosaMinas Gerais36570900Brazil Aperam BioEnergia Co. CapelinhaMinas Gerais39680000Brazil

This study presents hybrid clones of Corymbia *** by Aperam BioEnergia as potential substitutes for Eucalyptus wood in the pulp *** biomass of Eucalyptus *** compared with that of Corymbia *** performing modified kraft pulping and basic density *** were made by analyzing their respective mean annual increments of cellulose(MAI_(cel))and specific wood consumption(SWC),estimated using a kappa number of(19±1).The results showed that one of the hybrid clones(Corymbia citriodora×Corymbia torelliana,ID 4)had higher basic wood density,higher screened yield,better MAI_(cel#k19),and lower SWC than the other samples,reaching values of 0.608 t/m^(3),54.1%,24.6 ADt/ha/year(i.e.,air dry ton/hectare/year),and 2.74 m^(3)/ADt,***,clone ID 4 had the highest MAI_(cel)/SWC ratio score(8.98).Given its high forest productivity and low industrial cost compared with other samples,as well as its advantages over Eucalyptus ***,we concluded that clone ID 4 has great potential as an alternative biomass for pulp production.

关键词： Corymbia hybrids modified kraft pulping mean annual increments of cellulose(MAIcel) specific wood consumption(SWC)

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Edible Coatings Based on Apple Pectin,Cellulose Nanocrystals,and Essential Oil of Lemongrass:Improving the Quality and Shelf Life of Strawberries(Fragaria Ananassa)

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journal of Renewable Materials 2019年第1期7卷 73-87页

作者： Ingrid Souza Vieira da Silva Natália soares Prado Patrícia Gontijo de Melo Danilo Campion arantes Mara Zeni Andrade Harumi Otaguro daniel Pasquini Instituto de Química Universidade Federal de UberlândiaCampus Santa MônicaAv.João Naves deÁvila2121Uberlândia-MG38400-902Brazil Instituto Federal do Triângulo Mineiro Campus Uberaba Rua João Batista Ribeiro4000Uberaba-MG38064-790Brazil departamento de Ciências Naturais(DCNAT) Universidade Federal de São João Del-ReiPraça D.Helvécio74São João Del-Rei-MG36301-160Brazil Universidade de Caxias do Sul Rua Francisco Getúlio Vargas1130Caxias do Sul-RS95070-970Brazil

In this work,nine different types of edible coating based on pectin,cellulose nanocrystals,glycerol,and essential oil of lemongrass were prepared and used to coat strawberries with a film formed directly on the surface of the coated *** effects of the different edible coatings on refrigerated fruits in terms of weight loss,titratable acidity,total soluble solids,pH,and anthocyanin content was evaluated after 2 days,4 days,6 days,and 8 days of *** of the edible coatings reduced the weight loss of the coated strawberries and the anthocyanin *** total soluble solids content of or uncoated fruit increase more markedly than that of coated *** contrast,pH was maintained for both coated and uncoated *** edible coatings were effective in minimizing of the weight loss,without worsening the physical chemistry *** treatments T5 and T9 presented the best results.

关键词： Strawberry edible coating cellulose nanocrystals pectin shelf life

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A 35-Year-Old Man Presenting Sleep-Related Painful Erections (Erpes): A Case Report and Review of Literature

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Advances in Sexual Medicine 2014年第1期4卷 6-10页

作者： daniel de Freitas G. soares Ernani Luis Rhoden Federal University of Health Sciences (UFCSPA) Porto Alegre Brazil

Introduction: Erectile episodes occurring in the night time are considered normal and are usually related to the REM sleep. Spontaneous painful erections are unusual but they can have a great impact in the patient’s quality of sleep and, for consequence, quality of life. Report: We present a patient who has been presenting painful erections which wake him up almost every night. We discuss the workup and treatment offered to the patient, as well as the short-time response and two months follow-up. Discussion: Although studies still do not explain this relationship, nocturnal erections occur only during rapid eye movement (REM) sleep, which can be confirmed by polysomnography accompanied by Nocturnal Penile Tumescence testing or RigiScan test. However, diagnosis can be established based exclusively on clinical aspects. Based on all literature reviewed, the initial treatment should safely consist in improvement in sleep architecture and pelvis muscles relaxation. Conclusion: After the first suspicion, polysomnography with rigidity measurements of nocturnal erections should be considered although clinical diagnosis and therapeutic test may be acceptable. The management we suggest is usually effective, well tolerated and sustained.

关键词： Painful Erection Priapism Nocturnal Erections REM-Sleep

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Multifunctional Nanostructured Materials Applied in Controlled Radiopharmaceuticals Release

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journal of Biomaterials and Nanobiotechnology 2012年第2期3卷 163-168页

作者： Raquel Cristina de Sousa Azevedo daniel Crístian Ferreira soares Ricardo Geraldo de Sousa Edésia Martins Barros de Sousa Centro de desenvolvimento da Tecnologia Nuclear(CDTN)/CNEN Serviço de NanotecnologiaBelo HorizonteBrazil departa-mento de Engenharia Química Universidade Federal de Minas GeraisBelo HorizonteBrazil

The metaiodobenzylguanidine (MIBG) radiopharmaceutical, an analogue of norepinephrine, has been used to diagnose certain diseases in the cardiovascular system when radiolabeled with 123I. This radiopharmaceutical can also be used to treat tumors, such as neuroblastomas and pheochromocytomas, when radiolabeled with 131I. Its clinical use is often accompanied by a slow intravenous administration, where a significant dose of radiation can directly affect workers in nuclear medicine services. To overcome this problem, the incorporation and controlled release of radiopharmaceuticals from the matrix of mesoporous systems based on silica, such as SBA-15 and hybrid [SBA-15/P(N-iPAAm)], can lead to a significant reduction in radiation doses received by workers. In the present study, silica matrices SBA-15 and hybrid [SBA-15/P(N-iPAAm)] containing the radiopharmaceutical MIBG were prepared and physicochemically characterized through FTIR, SEM, and small angle X-ray diffraction techniques. The release profiles of MIBG from SBA-15 and [SBA-15/P(N-iPAAm)] were studied in a simulated body fluid (SBF) to evaluate their potential application as vehicles for controlled releases. Furthermore, in vitro studies were performed to assess the cytotoxicity of matrices as compared to human lung fibroblast cells (MRC-5). The results revealed that the amount of MIBG incorporated within the studied matrices was indeed quite different, showing that only the hybrid [SBA-15/P(N-iPAAm)] system allowed for a more adequate release profile of MIGB. Taking all results into consideration, it can be concluded that the hybrid matrix [SBA-15/P(N-iPAAm)] can be considered a potential alternative material for the controlled release delivery of radio-pharmaceuticals.

关键词： SAB-15 Hybrid[SBA-15/P(N-iPAAm)] MIGB Radiopharmaceutical Drug Release

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