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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Measuring Causal Effect with ARDL-BART: A macroeconomic Application

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Applied Mathematics 2024年第4期15卷 292-312页

作者： Pegah Mahdavi Mohammad Ali Ehsani daniel Felix Ahelegbey Mehrnaz Mohammadpour Department of Economic and Administrative Sciences University of Mazandaran Babolsar Iran Department of Economics and Management Sciences University of Pavia Pavia Italy Department of Mathematical Sciences University of Mazandaran Babolsar Iran

Modeling dynamic systems with linear parametric models usually suffer limitation which affects forecasting performance and policy implications. This paper advances a non-parametric autoregressive distributed lag model that employs a Bayesian additive regression tree (BART). The performance of the BART model is compared with selection models like Lasso, Elastic Net, and Bayesian networks in simulation experiments with linear and non-linear data generating processes (DGP), and on US macroeconomic time series data. The results show that the BART model is quite competitive against the linear parametric methods when the DGP is linear, and outperforms the competing methods when the DGP is non-linear. The empirical results suggest that the BART estimators are generally more efficient than the traditional linear methods when modeling and forecasting macroeconomic time series.

关键词： BART Model Non Parametric Modeling machine Learning Regression Trees Bayesian Network VAR

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Non-Darcy Flow in Molding Sands

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Open Journal of Applied Sciences 2024年第4期14卷 976-982页

作者： Miguel A. Barron-Meza Joan Reyes-Miranda daniel Flores-Sanchez Departamento de Materiales Universidad Autonoma Metropolitana Azcapotzalco Ciudad de Mexico Mexico

Darcy’s law is widely used to describe the flow in porous media in which there is a linear relationship between fluid velocity and pressure gradient. However, it has been found that for high numbers of Reynolds this law ceases to be valid. In this work, the Ergun equation is employed to consider the non-linearity of air velocity with the pressure gradient in casting sands. The contribution of non-linearity to the total flow in terms of a variable defined as a non-Darcy flow fraction is numerically quantified. In addition, the influence of the shape factor of the sand grains on the non-linear flow fraction is analyzed. It is found that for values of the Reynolds number less or equal than 1, the contribution of non-linearity for spherical particles is around 1.15%.

关键词： Darcy’s Law Molding Sands Non-Darcy Flow Reynolds Number Shape Factor

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Neurotoxicity of tetramethylammonium ion on larval and juvenile zebrafish:Effects on neurobehaviors and multiple biomarkers

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Journal of Environmental Sciences 2024年第9期143卷 138-147页

作者： Ruixin Zhang Rui Wang Jiajun Chang Gdaniel Sheng Daqiang Yin Key Laboratory of Yangtze River Water Environment Ministry of EducationCollege of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Tetramethylammonium hydroxide(TMAH)is an important compound that utilized and released by the rapidly expanding semiconductor industry,which could hardly be removed by the conventional wastewater treatment *** a cholinergic agonist,the tetramethylammonium ion(TMA^(+))has been reported to induce toxicity to muscular and respiratory systems of mammals and human,however the toxicity on aquatic biota remains poorly *** investigated the neurotoxic effects of TMA^(+)exposure on zebrafish,based on neurobehavior tests and a series of *** inhibitions on the swimming distance of zebrafish larvae were observed when the exposure level exceeded 50 mg/L,and significant alterations on swimming path angles(straight and deflective movements)occurred even at 10 mg/*** tested neurobehavioral endpoints of zebrafish larvae were significantly positively correlated with reactive oxygen species(ROS)and malondialdehyde(MDA),significantly negatively related with the activities of antioxidant enzymes,but not significantly correlated with the level of acetylcholinesterase(AChE).Such relationship indicates that the observed neurotoxic effects on swimming behavior of zebrafish larvae is mainly driven by oxidative stress,rather than the alterations of *** the highest exposure concentration(200 mg/L),TMA^(+)evoked more severe toxicity on zebrafish juveniles,showing significantly stronger elevation on the MDA activity,and greater inhibitions on the activities of antioxidant enzymes and ACh E,suggesting juveniles were more susceptible to TMA^(+)exposure than larval zebrafish.

关键词： Tetramethylammonium Zebrafish Oxidative stress Acetylcholinesterase Neurobehavior

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Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 139-145页

作者： Wellington Andraus Francisco Tustumi Alexandre Chagas Santana Rafael Soares Nunes Pinheiro daniel Reis Waisberg Liliana Ducatti Lopes Rubens macedo Arantes Vinicius Rocha Santos Rodrigo Bronze de Martino Luiz Augusto Carneiro D’Albuquerque Department of Gastroenterology Transplantation UnitUniversidade de São PauloSão PauloBrazil

Background:Perihilar cholangiocarcinoma(phCCC)is a dismal *** is no consensus regard-ing the best treatment for patients with unresectable *** present review aimed to gather the current pieces of evidence for liver transplantation and liver resection as a treatment for phCCC and to build better guidance for clinical *** sources:The search was conducted in PubMed,Embase,Cochrane,and *** related references were searched *** criteria were:reports in English or Portuguese literature that a)patients with confirmed diagnosis of phCCC;b)patients treated with a curative intent;c)patients with the outcomes of liver resection and liver *** reports,reviews,letters,editorials,conference abstracts and papers with full-text unavailability were excluded from the ***:Most of the current literature is based on observational retrospective studies with low grades of *** resection has better long-term outcomes than systemic chemotherapy or palliation ther-apy and liver transplantation is a good alternative for selected patients with unresectable *** candidates for resection or transplantation should be medically fit and free of intrahepatic or extrahep-atic *** a general rule,patients presenting with a tumor having a longitudinal size>3 cm or extending below the cystic duct,lymph node disease,confirmed extrahepatic dissemination;intraoper-atively diagnosed metastatic disease;a history of other malignancies within the last five years,and did not complete chemoradiation regimen and were medically unfit should not be considered for *** of these criteria should be individually *** transplantation or resection should only be considered in highly experienced hepatobiliary centers,and any decision-making must be based on a multidisciplinary ***:phCCC is a complex condition with high *** therapies,including hepatec-tomy and liv

关键词： Liver transplantation Cholangiocarcinoma Liver neoplasms

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Study of the Management and Disposal Practices of Unused or Out-of-Date Medicines by Households in the Municipality of Ouagadougou, Burkina Faso

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Journal of Biosciences and Medicines 2024年第3期12卷 291-302页

作者： daniel Dori Adama Guembré Kampadilemba Ouoba Nicolas Méda Rasmané Semdé Drug Development Laboratory African Center of Excellence for Training Research and Expertise in Pharmaceutical Sciences (CEA-CFOREM) Sciences and Health Doctoral School Training and Research Unit in Health Sciences Joseph KI-ZERBO University Ouagadougou Burkina Faso Charles De Gaulle University Children's Hospital (CHUP-CDG) Ouagadougou Burkina Faso National Agency for Pharmaceutical Regulation (ANRP) Ministry of Health Ouagadougou Burkina Faso Public Health Laboratory Sciences and Health Doctoral School Joseph KI-ZERBO University Ouagadougou Burkina Faso

Introduction: Not all medicines that pass-through consumers’ hands are used, and some often expire in households. These health products can be sources of accidental risks and pollution when they are not properly disposed of. In Burkina Faso, there are as yet no guidelines for the disposal of unused medicines in households. The aim of this study was to estimate the extent of household possession of unused or expired medicines, and to describe attitudes and disposal practices. Methods: This was a descriptive cross-sectional study covering households in the Ouagadougou commune conducted from June to August 2021. Two-stage stratified sampling was used: selection of Enumeration Zones (EZs) and selection of households, with each EZ comprising several households. Data collection was based on direct interviews using a structured questionnaire. Data were processed using Epi Info software version 7.***.4.0. Results: In total, 417 household residents were surveyed out of the planned 423 households, corresponding to a completion rate of 98.58% compared with the initial sample. Among the respondents, 79.62% had unused and/or expired medicines in their household. A total of 2562 drug packaging units were counted, for a total weight of 121.90 kg. Nearly 75% were aware that improper disposal was a danger to the environment. Some respondents kept their unused medicines at home until they expired (43.41%), and disposed of them mainly by throwing them in the household garbage (75.58%). The majority (79%) were in favor of the government setting up a take-back program for these medicines. Conclusion: The introduction of a take-back program for unused or out-of-date medicines will ensure safer disposal of medicines, and better protection for households and the environment.

关键词： Unused Medicines Expired Medicines Disposal Household Risk

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Knowledge and Attitudes of Knust Pre-Clinical Dental Students towards Orthodontic Treatment

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Open Journal of Stomatology 2024年第1期14卷 1-13页

作者： Ama Agyeibea Amuasi Ama B. Yeboah daniel K. Sabbah The Department of Child Oral Health and Orthodontics College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana

Background: Orthodontics is a dental specialty focusing on correcting dental irregularities and malocclusion. Knowledge and attitudes towards orthodontic treatment are crucial for promoting oral health and overall well-being. Education and awareness play a vital role in ensuring optimal treatment outcomes and improving quality of life. Aim: This study aims to determine the knowledge and attitudes of Kwame Nkrumah University of Science and Technology (KNUST) pre-clinical dentistry students concerning orthodontic therapy. Methodology: This research is a quantitative descriptive cross-sectional study. The research used a non-random convenience sampling method to form the desired sample. For data collection, an interview-administered questionnaire was used over one month. The study set its sights on pre-clinical dental students in KNUST. A total of 150 questionnaires were printed to meet the sample size. Results: The results of the research showed that the knowledge level of KNUST pre-clinical students on orthodontic treatment and its nuances is quite limited. They however had a fair level of knowledge on the disease or ailment that orthodontic treatments solved (especially malocclusion). Their interest in orthodontic treatments on the other hand was quite significant, with a large number having interest in it. Conclusion: To conclude, KNUST pre-clinical students in Ghana although having a limited level of knowledge on orthodontic treatments have a keen interest in undergoing them regardless of the discomforts or the length of time.

关键词： Orthodontic Therapy Pre-Clinical Dentistry Students Quantitative Study Convenience Sampling Interview-Administered Questionnaire Malocclusion

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Study of Harmful Vaginal Practices of Women in the Municipality of Ouagadougou, Burkina Faso

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Health 2024年第5期16卷 425-438页

作者： daniel Dori Ramata Porgo Hyacinthe Zamané Nicolas Méda Rasmané Semdé Drug Development Laboratory African Center of Excellence for Training Research and Expertise in Pharmaceutical Sciences (CEA-CFOREM) Sciences and Health Doctoral School Training and Research Unit in Health Sciences Joseph Ki-Zerbo University Ouagadougou Burkina Faso Charles De Gaulle University Children’ s Hospital (CHUP-CDG) Ouagadougou Burkina Faso Public Health Laboratory Sciences and Health Doctoral School Joseph Ki-Zerbo University Ouagadougou Burkina Faso Mother and Child Laboratory Sciences and Health Doctoral School Joseph Ki-Zerbo University Ouagadougou Burkina Faso

Introduction: Vaginal practices include washing, altering, cutting, cleaning, enhancing, drying, tightening, lubricating, or loosening of the vagina, labia, clitoris, or hymen. This study aimed to investigate the different vaginal practices of women using non-pharmaceutical products. Methodology: This was a cross-sectional study with descriptive and analytical purposes that took place from January 15 to April 23, 2023, in the four largest markets in the municipality of Ouagadougou. This was performed using the data collection sheet in the KoboCollect application. Epi info 7.***.5.0. software was used for data analysis. For the analysis of associated factors, a p-value Results: In total, 977 women were surveyed. Among them, 43.19% underwent vaginal procedures using non-pharmaceutical products. The female practitioners were 34.34 ± 7.44 years old. The products used included plants, mineral substances, ointments, tablets, and solutions. Among the practicing women, 40.99% were looking for vaginal tightening. The main purpose was to maintain their partners (45.97%). Three-point thirty-two percent (3.32%) of the women who underwent vaginal procedures had reported adverse events. Conclusion: Raising awareness of the consequences of vaginal practices and encouraging women to go to a health center for any gynecological problem could significantly reduce the prevalence of vaginal practices.

关键词： Vaginal Practices Women Adverse Events Products

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Exercise training mode effects on myokine expression in healthy adults:A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第6期13卷 764-779页

作者： Francesco Bettariga Dennis R.Taaffe daniel A.Galvao Pedro Lopez Chris Bishop Anna Maria Markarian Valentina Natalucci Jin-Soo Kim Robert U.Newton Exercise Medicine Research Institute Edith Cowan UniversityJoondalupWA 6027Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia Pleural Medicine Unit Institute for Respiratory HealthPerthWA 6009Australia Medical School Faculty of Health&Medical SciencesUniversity of Western AustraliaPerthWA 6009Australia Grupo de Pesquisa em Exercıcio para Populacoes Clınicas(GPCLIN) Universidade de Caxias do SulCaxias do SulRio Grande do Sul 95070-560Brazil London Sport Institute School of Science and TechnologyMiddlesex UniversityLondonNW44BTUK Department of Pathophysiology and Transplantation University of MilanMilan 20133Italy School of Human Movement and Nutrition Sciences University of QueenslandSt.LuciaQLD 4072Australia

Background:The benefits of exercise are well known;however,many of the underlying molecular mechanisms are not fully *** muscle secretes myokines,which mediate muscleorgan *** regulate satellite-cell proliferation and migration,inflammatory cascade,insulin secretion,angiogenesis,fatty oxidation,and cancer *** date,the effects of different exercise modes(namely,aerobic and resistance exercise)on myokine response remain to be *** is crucial considering the clinical implementation of exercise to enhance general health and wellbeing and as a medical ***:A systematic search was undertaken in PubMed,MEDLINE,CINAHL,Embase,SPORTDiscus,andWeb of Science in April *** studies examining the effects of a single bout of exercise on interleukin15(IL-15),irisin,secreted protein acidic and rich in cysteine(SPARC),oncostatinM(OSM),and decorin were included.A random-effects meta-analysis was also undertaken to quantify the magnitude of ***:Sixty-two studies were included(n=1193).Overall,exercise appeared to induce small to large increases in myokine expression,with effects observed immediately after to 60 min post-exercise,although these were mostly not statistically *** aerobic and resistance exercise resulted in changes in myokine levels,without any significant difference between training modes,and with the magnitude of change differing across *** levels returned to baseline levels within 180 min to 24 h ***,owing to potential sources of heterogeneity,most changes were not statistically significant,indicating that precise conclusions cannot be ***:Knowledge is limited but expanding with respect to the impact of overall and specific effects of exercise on myokine expression at different time points in the systemic *** research is required to investigate the effects of different exercise modes at multiple time points on myok

关键词： Myokine Resistance exercise Aerobic exercise Cytokine Systemic circulation

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以芳基重氮盐为芳基前体电化学合成芳基取代的苯并噻吩和菲

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电化学（中英文） 2024年第4期30卷 6-48页

作者：蓝丽媛蒋洋叶 R.daniel Little 曾程初北京工业大学环境与生命学院北京100124 Department of Chemistry&Biochemistry University of CaliforniaSanta BarbaraCalifornia 93106USA

芳基取代的苯并噻吩和菲是药物化学和材料科学中的重要结构单元。尽管已经投入了很多来制备这类化合物,并且已经开发了多种方法来构建2-取代的苯并噻吩核心结构,但仍然需要环境友好且有效的合成方法。基于我们以前的以芳基重氮盐为芳基... 详细信息

芳基取代的苯并噻吩和菲是药物化学和材料科学中的重要结构单元。尽管已经投入了很多来制备这类化合物,并且已经开发了多种方法来构建2-取代的苯并噻吩核心结构,但仍然需要环境友好且有效的合成方法。基于我们以前的以芳基重氮盐为芳基前体的电化学Minisci型芳基化反应,以及来自Konig小组的工作,本文使用成对电解以苯重氮盐为芳基前体来获得2-芳基苯并噻吩和9-芳基菲。首先,选择2-甲硫基苯重氮盐1a和4-甲基苯乙炔2a作为模型底物,通过考察溶剂、支持电解质、电极材料和电流密度来优化反应条件。经过大量的努力,发现在装备有石墨毡阳极、镍片阴极的单室电解池中,使用n-Bu_(4)NBF_(4)作为支持电解质,DMSO作为溶剂,控制在4mA·cm^(-2)条件下恒流电解,获得89%产率的所需产物3a。在最佳条件下,考察该电化学方案和底物范围的普适性。结果表明,烷基乙炔和芳基乙炔都适用于该方法,并成功地得到了一系列芳基取代的苯并噻吩衍生物。考虑到菲类化合物在药物化学和材料科学中的广泛应用,将此方案应用到菲衍生物的合成中,获得了相应的9-芳基菲衍生物。最后,通过循环伏安法分析了可能的机理。2-甲硫基苯重氮盐1a在CH_(3)CN中相对于Ag/Ag^(+)在-0.4 V处产生一个显著的不可逆还原峰,而在扫描电位窗口中没有检测到苯乙炔2a的信号。此外,尽管峰电流略有增加,2a的存在没有改变1a的还原峰电位。这些结果表明1a的还原比2a的还原容易。基于循环伏安分析和光催化结果,我们提出了成对电解机制,即芳基重氮盐1a在阴极的电化学还原产生芳基5a,然后芳基5a加成到苯乙炔上,在分子内环化后产生乙烯基6a和磺酰基7a。最后,7a的阳极氧化,接着用DMSO脱甲基化,生成目标产物3a。总之,我们发展了一种成对电解法来合成2-芳基苯并噻吩衍生物和9-芳基菲衍生物。该方案具有广泛的底物范围和官能团耐受性,进一步证明了芳基重氮盐作为多用途芳基自由基来源通过电化学还原产生芳基自由基的实用性。

关键词：苯并噻吩菲成对电合成芳基重氮盐芳基自由基

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