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Earthquake Engineering and Engineering Vibration 2002年第1期1卷 152-158页

作者： daniel j.Alesch William j.Petak Department of Public and Environmental Affairs University of Wisconsin-Green BayGreen BayWisconsin54311USA Professor School of Policy Planning and DevelopmentUniversity of Southern California650 Childs WayRoom 201eLos AngelesCalifornia90089-0626USA Professor

This project is aimed at bridging the three planes,from basic research,through enabling processes,to engineered *** the basic research plane,we have been working to improve our collective understanding about obstacles to implementing mitigation practices,owner decision processes (in connection with other MCEER projects),and public policy *** the level of enabling processes,we have been seeking to develop an understanding of how obstacles to greater mitigation can be overcome by improved policy design and *** the engineered systems plane, our work is intended to result in practical guidelines for devising policies and programs with appropriate motivation and incentives for implementing policies and programs once *** phase of the research has been aimed,first,at a thorough,multidisciplinary review of the literature concerning obstacles to ***,the research has focused on advancing the state of the art by developing means for integrating the insights offered by diverse perspectives on the implementation process from the several social,behavioral,and decision *** research establishes a basis for testing our understanding of these processes in the case of hospital retrofit decisions.

关键词： earthquake mitigation earthquake mitigation policies earthquake losses

Psychiatric comorbidities in epilepsy:population co-occurrence,genetic correlations and causal effects

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General Psychiatry 2024年第1期37卷 103-111页

作者： Viktor H Ahlqvist Christina Dardani Paul Madley-Dowd Harriet Forbes jessica Rast Caichen Zhong Renee M Gardner Christina Dalman Kristen Lyal cRAIG Newschaffer Torbjorn Tomson Michael Lundberg daniel Berglind Neil M Davies Brian K Lee Cecilia Magnusson Dheeraj Rai Department of Global Public Health Karolinska InstitutetStockholmSweden Medical Research Council Integrative Epidemiology Unit Bristol Medical SchoolUniversity of BristolBristolUK Centre for Academic Mental Health Population Health SciencesBristol Medical SchoolUniversity of BristolBristolUK Faculty of Epidemiology and Population Health London School of Hygiene and Tropical MedicineLondonUK A.j.Drexel Autism Institute Drexel UniversityPhiladelphiaPAUSA Department of Epidemiology and Biostatistics School of Public HealthDrexel UniversityPhiladelphiaPAUSA College of Health and Human Development Pennsylvania State UniversityState CollegePAUSA Department of Clinical Neuroscience Karolinska InstitutetStockholmSweden Centre for Epidemiology and Community Medicine Region StockholmStockholmSweden K.G jebsen Center for Genetic Epidemiology Department of Public Health and NursingNorwegian University of Science and TechnologyTrondheimNorway Division of Psychiatry University Collge LondonLondonUK Department of Statistical Sciences University Cllge LondonLondonK NIHR Biomedical Research Centre University of BristoBristolUK Avon and Wiltshire Partnership NHS Mental Health TrustBristolUK

Background Psychiatric comorbidities are common in patients with *** for the co-occurrence of psychiatric conditions and epilepsy remain poorly *** We aimed to triangulate the relationship between epilepsy and psychiatric conditions to determine the extent and possible origins of these *** Using nationwide Swedish health registries,we quantified the lifetime prevalence of psychiatric disorders in patients with *** then used summarydata from genome-wide association studies to investigate whether the identified observational associations could be attributed to a shared underlying genetic aetiology using cross-trait linkage disequilibrium score ***,we assessed the potential bidirectional relationships using two-sample Mendelian *** In a cohort of 7628495 individuals,we found that almost half of the 94435 individuals diagnosed with epilepsy were also diagnosed with a psychiatric condition in their lifetime(adjusted lifetime prevalence,44.09%;95%confidence interval(Cl)43.78%to 44.39%).We found evidence for a genetic correlation between epilepsy and some neurodevelopmental and psychiatric *** example,we observed a genetic correlation between epilepsy and attention-deficit/hyperactivity disorder(r,=0.18,95%Cl 0.09 to 0.27,p<0.001)—a correlation that was more pronounced in focal epilepsy(r=0.23,95%CI 0.09 to 0.36,p<0.001).Findings from Mendelian randomisation using common genetic variants did not support bidirectional effects between epilepsy and neurodevelopmental or psychiatric *** Psychiatric comorbidities are common in patients with *** correlations may partially explain some comorbidities;however,there is little evidence of a bidirectional relationship between the genetic liability of epilepsy and psychiatric *** findings highlight the need to understand the role of environmental factors or rare genetic variations in the origins of psy

关键词： epilepsy Psychiat lifetime

Design of synthetic materials for intracellular delivery of RNAs： From siRNA-mediated gene silencing to CRISPR/Cas gene editing

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Nano Research 2018年第10期11卷 5310-5337页

作者： jason B. Miller daniel j. Siegwart Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas TX 75390 USA Department of Biochemistry University of Texas Southwestern Medical Center Dallas TX 75390 USA

Ribonucleic acids （RNAs） possess great therapeutic potential and can be used to treat a variety of diseases. The unique biophysical properties of RNAs, such as high molecular weight, negative charge, hydrophilicity, low stability, and potential immunogenicity, require chemical modification and development of carriers to enable intracellular delivery of RNAs for clinical use. A variety of nanornaterials have been developed for the effective in vivo delivery of short/ small RNAs, messenger RNAs, and RNAs required for gene editing technologies including clustered regularly interspaced palindromic repeat （CRISPR）/Cas. This review outlines the challenges of delivering RNA therapeutics, explores the chemical synthesis of RNA modifications and carriers, and describes the efforts to design nanomaterials that can be used for a variety of clinical indications.

关键词： nucleic acid therapeutics nanoparticles synthetic nanomaterials RNA interference (RNAi) messenger RNA (mRNA) clustered regularly inter-spaced palindromic repeat(CRISPR)/Cas

Current applications of artificial intelligence for intraoperative decision support in surgery Allison

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Frontiers of Medicine 2020年第4期14卷 369-381页

作者： j.Navarrete-Welton daniel A.Hashimoto Surgical Artificial Intelligence and Innovation Laboratory Massachusetts General HospitalBostonMA 02114USA Harvard Medical School BostonMA 02114USA

Research into medical artificial intelligence(AI)has made significant advances in recent years,including surgical *** scoping review investigated AI-based decision support systems targeted at the intraoperative phase of surgery and found a wide range of technological approaches applied across several surgical *** the twenty-one(n=21)included papers,three main categories of motivations were identified for developing such technologies:(1)augmenting the information available to surgeons,(2)accelerating intraoperative pathology,and(3)recommending surgical *** many of the proposals hold promise for improving patient outcomes,important methodological shortcomings were observed in most of the reviewed papers that made it difficult to assess the clinical significance of the reported performance *** limitations,the current state of this field suggests that a number of opportunities exist for future researchers and clinicians to work on AI for surgical decision support with exciting implications for improving surgical care.

关键词： artificial intelligence decision support clinical decision support systems intraoperative deep learning computer vision machine learning surgery

Periodic Orbits in Rotating Second Degree and Order Gravity Fields

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Chinese journal of Astronomy and Astrophysics 2008年第1期8卷 108-118页

作者： Wei-Duo Hu daniel j. Scheeres School of Astronautics BeiHang University Beijing 100083 Department of Aerospace Engineering The University of Michigan Ann Arbor MI48109 USA

Periodic orbits in an arbitrary 2nd degree and order uniformly rotating gravity field are studied. We investigate the four equilibrium points in this gravity field. We see that close relation exists between the stability of these equilibria and the existence and stability of their nearby periodic orbits. We check the periodic orbits with non-zero periods. In our searching procedure for these periodic orbits, we remove the two unity eigenvalues from the state transition matrix to find a robust, non-singular linear map to solve for the periodic orbits. The algorithm converges well, especially for stable periodic orbits. Using the searching procedure, which is relatively automatic, we find five basic families of periodic orbits in the rotating second degree and order gravity field for planar motion, and discuss their existence and stability at different central body rotation rates.

关键词： celestial / orbital mechanics - asteroid - periodic orbit - resonance

Adaptive immunity at the crossroads of autophagy and metabolism

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Cellular & Molecular Immunology 2021年第5期18卷 1096-1105页

作者： Shree Padma Metur daniel j.Klionsky University of Michigan Life Sciences Institute and Department of MolecularCellular and Developmental BiologyAnn ArborMIUSA

The function of lymphocytes is dependent on their plasticity,particularly their adaptation to energy availability and environmental stress,and their protein synthesis *** are constantly under metabolic stress,and macroautophagy/autophagy is the primary metabolic pathway that helps cells overcome *** intrinsic role of autophagy in regulating the metabolism of adaptive immune cells has recently gained increasing *** this review,we summarize and discuss the versatile roles of autophagy in regulating cellular metabolism and the implications of autophagy for immune cell function and fate,especially for T and B lymphocytes.

关键词： Immunology Lysosome Macroautophagy Stress

Autophagy gets in on the regulatory act

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分子细胞生物学报:英文版 2011年第2期3卷 76-77页

作者： Steven K.Backues daniel j.Klionsky Life Sciences Institute University of MichiganAnn ArborMI 48109-2216USA

Autophagy down-regulates the Wnt signal transduction pathway via targeted degradation of a key signaling *** may provide an explanation for autophagy’s role in tumor *** eukaryotic cell has at its disposal two primar... 详细信息

关键词： Autophagy targeted explanation

Forces and energetics of intermittent swimming

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Acta Mechanica Sinica 2017年第4期33卷 725-732页

作者： daniel Floryan Tyler Van Buren Alexander j.Smits Department of Mechanical and Aerospace Engineering Princeton University Princeton NJ 08544 USA

Experiments are reported on intermittent swimming motions. Water tunnel experiments on a nominally two-dimensional pitching foil show that the mean thrust and power scale linearly with the duty cycle, from a value of 0.2 all the way up to continuous motions, indicating that individual bursts of activity in intermittent motions are independent of each other. This conclusion is corroborated by particle image velocimetry（PIV） flow visualizations, which show that the main vortical structures in the wake do not change with duty cycle. The experimental data also demonstrate that intermittent motions are generally energetically advantageous over continuous motions. When metabolic energy losses are taken into account, this conclusion is maintained for metabolic power fractions less than 1.

关键词： intermittent swimming maintained conclusion cycle thrust favorable producing aquatic circles

Avalonia,get bent!–Paleomagnetism from SW Iberia confirms the Greater Cantabrian Orocline

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Geoscience Frontiers 2021年第2期12卷 805-825页

作者： Bruno daniel Leite Mendes daniel Pastor-Galan Mark j.Dekkers Wout Krijgsman Paleomagnetic Laboratory Fort Hoofddijk Department of Earth SciencesUtrecht UniversityBudapestlaan 173584CDthe Netherlands Frontier Research Institute for Interdisciplinary Sciences Tohoku UniversityJapan Department Earth Science Tohoku UniversityJapan Center for North East Asia Studies Tohoku University980-857641 KawauchiAoba-kuSendaiMiyagiJapan

The amalgamation of Pangea formed the contorted Variscan-Alleghanian orogen,suturing Gondwana and Laurussia during the *** all swirls of this orogen,a double curve in Iberia stands out,the coupled Cantabrian Orocline and Central Iberian *** Cantabrian Orocline formed at ca.315–290 Ma subsequent to the Variscan *** formation mechanism of the Cantabrian Orocline is disputed,the most commonly proposed mechanisms include either(1)that south-westernmost Iberia would be an Avalonian(Laurussian)indenter or(2)that the stress field changed,buckling the *** contrast,the geometry and kinematics of the Central Iberian curve are largely *** some authors defend both curvatures are genetically linked,others support they are distinct and formed at different *** uncertainty adds an extra layer of complexity to our understanding of the final stages of Pangea’s *** solve these issues,we study the late Carboniferous–early Permian vertical-axis rotations of SW Iberia with *** results show up to 70counterclockwise vertical-axis rotations during late Carboniferous times,concurring with the anticipated kinematics if SW Iberia was part of the southern limb of the Cantabrian *** results do not allow the necessary penecontemporaneous clockwise rotations in Central Iberia to support a concomitant formation of both Cantabrian and Central Iberian *** coherent rotation of both Gondwanan and Avalonian pieces of SW Iberia discards the Laurussian indenter hypothesis as a formation mechanism of the Cantabrian Orocline and confirms the Greater Cantabrian Orocline *** Greater Cantabrian Orocline likely formed as a consequence of a change in the stress field during the late Carboniferous and extended beyond the Rheic Ocean suture affecting the margins of both Laurussia and Gondwana.

关键词： Pangea Variscan orogeny Greater Cantabrian Orocline Paleomagnetism Central Iberian curve

Ischemic preconditioning-induced hyperperfusion correlates with hepatoprotection after liver resection

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World journal of Gastroenterology 2010年第15期16卷 1871-1878页

作者： Oleg Heizmann Georgios Meimarakis Andreas Volk daniel Matz daniel Oertli Rolf j Schauer Department of Surgery University Hospital Basel Department of Surgery Klinikum of the Ludwig-Maximilians-University-Grosshadern University of Munich Department of Surgery University Hospital of Dresden Department of Surgery Academic Hospital of the Ludwig-Maximilians-University of Munich

AIM:To characterize the impact of the Pringle ma-neuver (PM) and ischemic preconditioning (IP) on total blood supply to the liver following hepatectomies. METHODS: Sixty one consecutive patients who un-derwent hepatic resection under in flow occlusion were randomized either to receive PM alone (n = 31) or IP (10 min of ischemia followed by 10 min of reperfusion) prior to PM (n = 30). Quantification of liver perfusion was measured by Doppler probes at the hepatic artery and portal vein at various time points after reperfusion of remnant livers. RESULTS: Occlusion times of 33 ± 12 min (mean ± SD) and 34 ± 14 min and the extent of resected liver tissue (2.7 segments) were similar in both groups. In controls (PM), on reperfusion of liver remnants for 15 min, portal perfusion markedly decreased by 29% while there was a slight increase of 8% in the arterial blood flow. In contrast, following IP + PM the portal vein flow remained unchanged during reperfusion and a significantly increased arterial blood flow (+56% vs baseline) was observed. In accordance with a better postischemic blood supply of the liver, hepatocellular injury, as measured by alanine aminotransferase (ALT) levels on day 1 was considerably lower in group B compared to group A (247 ± 210 U/I vs 550 ± 650 U/I, P < 0.05). Additionally, ALT levels were significantly correlated to the hepatic artery in ***: IP prevents postischemic flow reduction of the portal vein and simultaneously increases arterial perfusion, suggesting that improved hepatic macrocirculation is a protective mechanism following hepatectomy.

关键词： Ischemic preconditioning Reperfusion injury Liver Surgery Liver blood flow