检索结果-南通市图书馆

Effects of a remote,YouTube-delivered exercise intervention on young adults’physical activity,sedentary behavior,and sleep during the COVID-19 pandemic:Randomized controlled trial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Sport and Health Science 2022年第2期11卷 145-156,I0002页

作者： daniel j.McDonough Melina A.Helgeson Wenxi Liu Zan Gao School of Kinesiology University of Minnesota-Twin CitiesMinneapolisMN 55455USA Carlson School of Management University of Minnesota-Twin CitiesMinneapolisMN 55455USA

Background:Public health guidelines have called for innovative and flexible physical activity(PA)intervention strategies to promote PA and health amid the coronavirus disease 2019(COVID-19)***,this study’s purpose was to examine the effects of a home-based,YouTube-delivered PA intervention grounded in self-determination theory on young adults’free-living PA,sedentary behavior,and sleep quality(NCT04499547).Methods:Sixty-four young adults(48 females;age=22.8±3.4 years,mean±SD;body mass index=23.1±2.6 kg/m^(2))were randomized(1:1)into the intervention group,which received weekly aerobic and muscle-strengthening PA videos,or control group,which received weekly general health education videos,for 12 *** primary outcome was free-living moderate-to-vigorous PA(MVPA)and our secondary outcomes were sedentary behavior,light PA,and sleep quality(measured using ActiGraph accelerometers)along with muscle-strengthening PA frequency,self-determination theory-related motivation(non-regulation,external regulation,introjected regulation,identified regulation,integrated regulation,and intrinsic regulation),and perceived PA barriers(assessed using validated questionnaires).Repeated measures analysis of variances(ANOVAs)examined between-group differences at an adjusted significance level of 0.004 and effect sizes as partial eta-squared(η;).Results:We observed statistically significant interaction effects for MVPA,sleep efficiency,muscle-strengthening PA frequency,non-regulation,integrated regulation,intrinsic regulation,and perceived PA barriers(F(1,62)=10.75-77.67,pjected,and identified regulations after 12 weeks(F(1,62)=1.11-3.64,p=0.06-0.61).Conclusion:With national COVID-19 restrictions still in place and uncertainty regarding post-pandemic PA envir

关键词： High-intensity interval training Resistance-training Self-determination theory Social media Video

Towards maximized utilization of iridium for the acidic oxygen evolution reaction

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano Research 2019年第9期12卷 2275-2280页

作者： Marc Ledendecker Simon Geiger Katharina Hengge joohyun Lim Serhiy Cherevko Andrea M. Mingers daniel Gohl Guilherme V. Fortunato daniel jalalpoor Ferdi Schuth Christina Scheu Karl j. j. Mayrhofer Department of Interface Chemistry and Surface Engineering Nanoanalytics and Interfaces Max-Planck-Institut fur Eisenforschung GmbH40237 DusseldorfGermany Department of Heterogeneous Catalysis Max-Planck-Institut fur KohlenforschungKaiser- Wilhelm-Platz 145470 Mulheim an der RuhrGermany Helmholtz-Institute Erlangen-Nurnbergfar Renewable Energy (IEK-11) Forschungszentrum Jillich91058 ErlangenGermany Department of Chemical and Biological Engineering Friedrich-Alexander- Universitat Erlangen -Nurnberg91058 ErlangenGermany Institute of Chemistry Universidade Federal de Mato Grosso do SulAv. Senador Filin to Muller1555Campo GrandeMS 79074-460Brazil

The reduction in noble metal content for efficient oxygen evolution catalysis is a crucial aspect towards the large scale commercialisation of polymer electrolyte membrane *** catalytic stability and activity are inversely related,long service lifetime still demands large amounts of low-abundant and expensive *** this manuscript we elaborate on the concept of maximizing the utilisation of iridium for the oxygen evolution *** combining different tin oxide based support materials with liquid atomic layer deposition of iridium oxide,new possibilities are opened up to grow thin layers of iridium oxide with tuneable noble metal ***-situ,time-and potential-resolved dissolution experiments reveal how the stability of the substrate and the catalyst layer thickness directly affect the activity and stability of deposited iridium *** on our results,we elaborate on strategies how to obtain stable and active catalysts with maximized iridium utilisation for the oxygen evolution reaction and demonstrate how the activity and durability can be tailored *** results highlight the potential of utilizing thin noble metal films with earth abundant *** for future catalytic applications in the energy sector.

关键词： oxygen evolution reaction liquid atomic layer depositi on catalysis iridium core-shell nano particles

Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2019年第1期4卷 636-647页

作者： Eliseos j.Mucaki jonathan Z.L.Zhao daniel j.Lizotte Peter K.Rogan Department of Biochemistry Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada Department of Computer Science Faculty of ScienceWestern UniversityLondonON N6A 2C1Canada Department of Epidemiology&Biostatistics Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada Cytognomix Inc.LondonON N5X 3X5Canada Department of Oncology Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada

The selection of effective genes that accurately predict chemotherapy responses might improve cancer *** compare optimized gene signatures for cisplatin,carboplatin,and oxaliplatin responses in the same cell lines and validate each signature using data from patients with *** support vector machine learning is used to derive gene sets whose expression is related to the cell line GI 50 values by backwards feature selection with *** genes and functional pathways distinguishing sensitive from resistant cell lines are identified by contrasting signatures obtained at extreme and median GI 50 *** of gene signatures at different thresholds are combined to reduce the dependence on specific GI 50 values for predicting drug *** most accurate gene signatures for each platin are:cisplatin:BARD1,BCL2,BCL2L1,CDKN2C,FAAP24,FEN1,MAP3K1,MAPK13,MAPK3,NFKB1,NFKB2,SLC22A5,SLC31A2,TLR4,and TWIST1;carboplatin:AKT1,EIF3K,ERCC1,GNGT1,GSR,MTHFR,NEDD4L,NLRP1,NRAS,RAF1,SGK1,TIGD1,TP53,VEGFB,and VEGFC;and oxaliplatin:BRAF,FCGR2A,IGF1,MSH2,NAGK,NFE2L2,NQO1,PANK3,SLC47A1,SLCO1B1,and *** from The Cancer Genome Atlas(TCGA)patients with bladder,ovarian,and colorectal cancer were used to test the cisplatin,carboplatin,and oxaliplatin signatures,resulting in 71.0%,60.2%,and 54.5%accuracies in predicting disease recurrence and 59%,61%,and 72%accuracies in predicting remission,*** cisplatin signature predicted 100%of recurrence in non-smoking patients with bladder cancer(57%disease-free;N=19),and 79%recurrence in smokers(62%disease-free;N=35).This approach should be adaptable to other studies of chemotherapy responses,regardless of the drug or cancer types.

关键词： bladder chemotherapy signature

A preliminary study of sperm identification in microdissection testicular sperm extraction samples with deep convolutional neural networks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian journal of Andrology 2021年第2期23卷 135-139页

作者： daniel j Wu Odgerel Badamjav Vikrant V Reddy Michael Eisenberg Barry Behr Department of Computer Science Stanford UniversityStanfordCA 94305USA Department of Urology University of Utah HealthSalt Lake CityUT 84108USA Department of Obstetrics and Gynecology Stanford Children’s HealthStanfordCA 94305USA Department of Urology Stanford University School of MedicineStanfordCA 94305USA

Sperm identification and selection is an essential task when processing human testicular samples for in vitro *** and identifying sperm cell(s)in human testicular biopsy samples is labor intensive and time *** developed a new computer-aided sperm analysis(CASA)system,which utilizes deep learning for near human-level performance on testicular sperm extraction(TESE),trained on a custom *** system automates the identification of sperm in testicular biopsy samples.A dataset of 702 de-identified images from testicular biopsy samples of 30 patients was *** image was normalized and passed through glare filters and diffraction *** data were split 80%,10%,and 10%into training,validation,and test sets,***,a deep object detection network,composed of a feature extraction network and object detection network,was trained on this *** model was benchmarked against embryologists’performance on the detection *** deep learning CASA system achieved a mean average precision(mAP)of 0.741,with an average recall(AR)of 0.376 on our *** proposed method can work in real time;its speed is effectively limited only by the imaging speed of the *** results indicate that deep learning-based technologies can improve the efficiency of finding sperm in testicular biopsy samples.

关键词： artificial intelligence computer vision male infertility microdissection testicular sperm extraction sperm

Estimation of cotton yield with varied irrigation and nitrogen treatments using aerial multispectral imagery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International journal of Agricultural and Biological Engineering 2013年第2期6卷 37-41页

作者： Yanbo Huang Ruixiu Sui Steven j.Thomson daniel K.Fisher Crop Production Systems Research Unit Agricultural Research ServiceUnited States Department of AgricultureStonevilleMS 38776USA

Cotton yield varies spatially within a *** variability can be caused by various production inputs such as soil properties,water management,and fertilizer *** multispectral imaging is capable of providing data and information to study effects of the inputs on yield qualitatively and quantitatively in a timely and cost-effective fashion.A 10-ha cotton field with irrigation and non-irrigation 2×2 blocks was used in this *** nitrogen application treatments were randomized with two replications within each *** plant canopy was closed,airborne multispectral images of the field were acquired using a 3-CCD MS4100 *** images were processed to generate various vegetation *** vegetation indices were evaluated for the best performance to characterize *** effect of irrigation on vegetation indices was *** for yield estimation were developed and verified by comparing the estimated and actual *** indicated that ratio of vegetation index(RVI)had a close relationship with yield(R^(2)=0.47).Better yield estimation could be obtained using a model with RVI and soil electrical conductivity(EC)measurements of the field as explanatory variables(R^(2)=0.53).This research demonstrates the capability of aerial multispectral remote sensing in estimating cotton yield variation and considering soil properties and nitrogen.

关键词： remote sensing multispectral imagery cotton yield nitrogen irrigation soil properties

Upregulation of 25-hydroxyvitamin D_3-1α-hydroxylase by butyrate in Caco-2 cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2005年第45期11卷 7136-7141页

作者： Oliver Schr(o|¨)der Sinan Turak Carolin daniel Tanja Gaschott jürgen Stein Ⅰst Department of Internal Medicine

AIM： To investigate the possible involvement of 25-hydroxyvitamin D3-1cx-hydroxylase [1α-25（OH）2D3] in butyrate-induced differentiation in human intestinal cell line Caco-2 cells. METHODS： Caco-2 cells were incubated either with 3 mmol/L butyrate and 1 umol/L 25（OH）2D3 or with 1 umol/L 1α-25（OH）2D3 for various time intervals ranging from 0 to 72 h. Additionally, cells were co-incubated with butyrate and either 25（OH）2D3 or 1α-25（OH）2D3. 1α-25（OH）2D3 mRNA was determined semi-quantitatively using the fluorescent dye PicoGreen. Immunoblotting was used for the detection of 1α-25（OH）2D3 protein. Finally, enzymatic activity was measured by ELISA. RESULTS： Both butyrate and 1α-25（OH）2D3 stimulated differentiation of Caco-2 cells after a 48 h incubation period, while 25（OH）2D3 had no impact on cell differentiation. Synergistic effects on differentiation were observed when cells were co-incubated with butyrate and vitamin D metabolite. Butyrate transiently upregulated 1α-25（OH）2D3 mRNA followed by a timely delayed protein upregulation. Coincidently, enzymatic activity was enhanced significantly. The induction of the enzyme allowed for comparable differentiating effects of both vitamin D metabolites. CONCLUSION： Our experimental data provide a further mechanism for the involvement of the vitamin D signaling pathway in colonic epithelial cell differentiation by butyrate. The enhancement of 1α-25（OH）2D3 followed by antiproliferative effects of the vitamin D prohormone in the Caco-2 cell line suggest that 25（OH）2D3 in combination with butyrate may offer a new therapeutic approach forthe treatment of colon cancer.

关键词： 25-Hydroxyvitamin D3-1α-hydroxylase Butyrate Caco-2 cells Colon cancer Differentiation Vitamin D

Optimal decentralized control of large scale systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Control Theory and Technology 2016年第4期14卷 287-313页

作者： Xiao Qi SHI daniel E. DAVISON Raymond KWONG Edward j. DAVISON Systems Control Group Department of Electrical and Computer Engineering University of Toronto Ontario Canada MSS 3G4 Department of Electrical and Computer Engineering University of Waterloo Ontario Canada N2L 3G1

This paper presents a new optimized decentralized controller design method for solving the tracking and disturbance rejection problems for large-scale linear time-invariant systems, using only low-order decentralized controllers. To illustrate the type of results which can be obtained using the new optimized decentralized control design method, the control of a large flexible space structure is studied and compared with the standard centralized LQR-observer controller. The order of the resultant decentralized controller is much smaller than that of the standard centralized LQR-observer controller. The proposed controller also has certain fail-safe properties and, in addition, it can be five orders of magnitude more robust than the standard LQR-observer controller based on their real stability radii. The new decentralized controller design method is applied to a large flexible space structure system with 5 inputs and 5 outputs and of order 24.

关键词： Decentralized control multivariable control PID control robustness optimization large-scale systems flexiblestructures

A limit equilibrium fracture zone model to investigate seismicity in coal mines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International journal of Mining Science and Technology 2018年第5期28卷 745-753页

作者： daniel Malan john Napier Department of Mining Engineering Faculty of Engineering Built Environment and IT University of Pretoria

This paper explores possible synergies between techniques used to minimise seismicity in deep South African gold mines and their applicability to control coal bumps. The paper gives a summary of the techniques used in the deep gold mines and a critical appraisal if these are useful in coal mines. The techniques typically include control of mining rate, preconditioning, optimisation of extraction sequences and centralised blasting. Of particular interest to the coal bump problem is an experimental limit equilibrium fracture zone model implemented in a displacement discontinuity code. This was recently developed for the gold mines to enable the interactive analysis of complex tabular mine layout extraction sequences. The model specifically accommodates energy dissipation computations in the developing fracture zone near the edges of these excavations. This allows the released energy to be used as a surrogate measure of ongoing seismic activity and addresses a number of the weaknesses in the traditional usage of this quantity as a criterion for the design of seismically active layouts. This paper investigates the application of the model to a hypothetical coal longwall layout and the specific problem of coal bumps.

关键词： Coal bumps Limit equilibrium model Mining rate Seismicity

Leaf morphogenesis:The multifaceted roles of mechanics

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2022年第7期15卷 1098-1119页

作者： Kexin Guo Changjin Huang Yansong Miao daniel j.Cosgrove K.jimmy Hsia School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Department of Biology The Pennsylvania State UniversityUniversity ParkPA 16802USA School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore 637459Singapore

Plants produce a rich diversity of biological forms,and the diversity of leaves is especially *** of leaf morphogenesis have been studied in the past two decades,with a growing focus on the interactive roles of mechanics in recent *** of plant organs involves feedback by mechanical stress:growth induces stress,and stress affects growth and *** much attention has been given to potential stress-sensing mechanisms and cellular responses,the mechanical principles guiding morphogenesis have not been well *** we synthesize the overarching roles of mechanics and mechanical stress in multilevel and multiple stages of leaf morphogenesis,encompassing leaf primordium initiation,phyllotaxis and venation patterning,and the establishment of complex mature leaf ***,the roles of mechanics at multiscale levels,from subcellular cytoskeletal molecules to single cells to tissues at the organ scale,are *** highlighting the role of mechanical buckling in the formation of three-dimensional leaf shapes,this review integrates the perspectives of mechanics and biology to provide broader insights into the mechanobiology of leaf morphogenesis.

关键词： leaf morphogenesis cell-wall mechanics phyllotaxis and venation patterning differential and anisotropic growth mechanical buckling