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Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917

World Journal of Gastroenterology 2016年第23期22卷 5415-5421页

作者： Elina Manzhalii daniel hornuss Wolfgang Stremmel Department of Propedeutics of Internal Medicine 2 Bogomolets National Medical University Department of Gastroenterology University Hospital of Heidelberg

AIM: To evaluate the effect of oral Escherichia coli (E. coli) Nissle application on the outcome of intestinal-borne ***: In a randomized, controlled, non-blinded prospective clinical trial 82 patients with intestinal-borne facial dermatoses characterized by an erythematous papular-pustular rash were screened. At the initiation visit 37 patients entered the experimental arm and 20 patients constituted the control arm. All 57 patients were treated with a vegetarian diet and conventional topical therapy of the dermatoses with ointments containing tetracycline, steroids and retinoids. In the experimental arm patients received a one month therapy with oral E. coli Nissle at a maintenance dose of 2 capsules daily. The experimental group was compared to a non-treatment group only receiving the diet and topical therapy. The primary outcome parameter was improvement of the dermatoses, secondary parameters included life quality and adverse events. In addition the immunological reaction profile (IgA, interleucin-8 and interferon-α) was determined. Furthermore the changes of stool consistency and the microbiota composition over the time of intervention were ***: Eighty-nine percent of the patients with acne, papular-pustular rosacea and seborrhoic dermatitis responded to E. coli Nissle therapy with significant amelioration or complete recovery in contrast to 56% in the control arm (P 107 CFU/g stool) was observed in 79% and 63%

关键词： Intestinal-borne dermatoses Escherichia coli Nissle 1917 Immunological response IgA Interleukin-8 Interferon-α Gut microbiota

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