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Bigger or long-winged male common crossbills exhibit redder carotenoid-based plumage coloration

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Current Zoology 2023年第2期69卷 165-172页

作者： Blanca Fernandez-eslava daniel Alonso David Galicia Juan Arizaga Carlos Alonso-Alvarez Biologia Ambiental Universidad de NavarraFacultad de CienciasC/Irunlarrea1 Pamplona31008 NavarraSpain Ornitologia Sociedad de Ciencias de AranzadiZorroagagaina 1120014 DonostiaSan SebastianSpain Ecologia Evolutiva Museo Nacional de Ciencias Naturales(CSiC)Edificio Pinar 2528006 MadridSpain

Carotenoid-based ornaments are often considered reliable(honest)individual condition signals because their expression implies physiological costs unaffordable for low-quality animals(handicap signals).Recently,it has been suggested that efficient cell respiration is mandatory for producing red ketocarotenoids from dietary yellow *** implies that red colorations should be entirely unfalsifiable and independent of expression costs(index signals).In a precedent study,male common crossbills,Loxia curvirostra,showing a red plumage reported higher apparent survival than those showing yellowish-orange *** plumage redness in this species is due to ketocarotenoid accumulation in ***,we correlated the male plumage redness(a 4-level visual score:yellow,patchy,orange,and red)and the body morphology in more than 1,ooo adult crossbills captured in 3 Iberian localities to infer the mechanisms responsible for color evolution.A principal component analysis summarized morphometry of 10 variables(beak,wing,tarsus length,etc.).The overall body size(PC1)and the length of flight feathers regarding body size(Pc3)showed significant positive relationships with plumage *** redness was barely correlated with bill shape measures,suggesting no constraint in acquiring carotenoids from pine ***,large body sizes or proportionally long flying feathers could help carotenoid acquisition via social competition or increased foraging *** longer flight feathers might also be associated with a specific cell respiration profile that would simultaneously favor flying capacities and enzymatic transformations needed for ketocarotenoid *** a phenotypic profile would agree with the hypothesis of ketocarotenoid-based colors acting as individual quality index signals.

关键词： avian carotenoids color and biometrics Loxia genus Mediterranean crossbills resource allocation trade-offs shared pathway hypothesis

Complications during multiorgan retrieval and pancreas preservation

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World Journal of Transplantation 2020年第12期10卷 381-391页

作者： daniel Casanova gonzalo Gutierrez Monica Gonzalez Noriega Federico Castillo Department of Surgery University Hospital Marques de ValdecillaUniversity CantabriaSantander 39008CantabriaSpain Department of Surgery University Hospital Marques de ValdecillaSantander 39008CantabriaSpain

In pancreas transplantation, complications can arise at each step of the process,from the initial selection of donors and recipients through the surgical techniqueitself and the post-operative period, when lifelong immunosuppression isrequired. In the early steps, careful retrieval and preservation of the pancreas arecrucial for the viability of the organ and ultimate success of the transplant. Thepancreas is a low-flow gland, making it highly sensitive to transplantationconditions and presenting risk of pancreatitis due to periods of ischemia. The twogroups of donors - after brain death (DBD) or after cardiac arrest (DCD) - requiredifferent strategies of retrieval and preservation to avoid or reduce the risk ofcomplications developing during and after the transplantation. For DBD donortransplantation, multiorgan retrieval and cold preservation is the conventionaltechnique. Asystole donor (DCD) transplantation, in contrast, can benefit from thenewest technologies, such as hypothermic and especially normothermicpreservation machines (referred to as NECMO), to optimize organ *** latter has led to an increase in the pool of donors by facilitating recuperationof organs for transplantation that would have been discarded otherwise.

关键词： Pancreas transplantation Diabetes mellitus Graft thrombosis Compartmental syndrome Pancreas retrieval Pancreas preservation

The spatial variability of actual evapotranspiration across the Amazon River Basin based on remote sensing products validated with flux towers

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Ecological Processes 2019年第1期8卷 67-86页

作者： Victor Hugo da Motta Paca gonzalo E.Espinoza-Dávalos Tim M.Hessels daniel Medeiros Moreira Georges F.Comair Wim G.M.Bastiaanssen IHE Delft Institute for Water Education Westvest 7Delft 2611 AXNetherlands TU Delft DelftNetherlands CPRM-Geological Survey of Brazil Rio de JaneiroBrazil World Bank WashingtonD.C.USA

Actual evapotranspiration(ET)is a major component of the water *** several international flux measurement programs have been executed in the tropical rain forest of the Amazon,those measurements represent the evaporative process at a few selected sites *** aim of this study is to obtain the spatial distribution of ET,using remote sensing techniques,across the entire Amazon River *** from six global ET products based on remote sensing techniques(GLEAM,SEBS,ALEXI,CMRSET,MOD16,and SSEBop)were merged to obtain an ensemble prediction of the ET rates for the complex and in-accessible environment of the Amazon at a spatial resolution of 250 *** study shows that the basinwide average ET is 1316 mm/year with a standard deviation of 192 mm/*** new ET-Amazon product was validated against seven different historic flux tower *** energy balance closure of the in situ measurements varied between 86 and 116%.Only months with more than 70%completeness of in situ measurements were considered for *** procedures for closure correction were included in the *** correlation between measured and remotely sensed ET is good(R2>0.97 for consecutive periods of 2 to 12months),and the bias correction is negligible for the energy balance residual method,which seemed most *** ET values have more *** monthly RMSE values vary between 7.4 and 27.8 mm/month(the average RMSE is 22.2mm/month),and the coefficient of determination(R2)varies between 0.48 and 0.87(the average R2 is 0.53).The ET from the water balance is 1380 mm/year,being−64 mm/year difference and 4.6%less than ET derived from the water *** evaporation from the Amazon basin inside Brazil is 5063 km3/year,followed by Peru with 1165 km3/***-Amazon shows more spatial details and accuracy than alternative global ET products such as LandFlux-EVAL,Model Tree Ensemble(MTE),and *** justifies the development of new regional ET pro

关键词： Amazon River Basin Evapotranspiration Flux towers measurements ET-Amazon product

Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology

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World Journal of Gastroenterology 2017年第36期23卷 6628-6638页

作者： Karen Dubois-Camacho Payton A Ottum daniel Franco-Munoz Marjorie De la Fuente Alejandro Torres-Riquelme David Díaz-Jiménez Mauricio Olivares-Morales gonzalo Astudillo Rodrigo Quera Marcela A Hermoso Innate Immunity Laboratory Immunology ProgramInstitute of Biomedical SciencesFaculty of MedicineUniversidad de Chile Neuroimmunology Laboratory Immunology ProgramInstitute of Biomedical SciencesFaculty of MedicineUniversidad de Chile Division of Research Clínica Las Condes Gastroenterology Department Inflammatory Bowel Disease ProgramClínica Las Condes

Inflammatory bowel diseases(IBDs),such as ulcerative colitis and Crohn's disease,are chronic pathologies associated with a deregulated immune response in the intestinal mucosa,and they are triggered by environmental factors in genetically susceptible *** glucocorticoids(GCs)are widely used as anti-inflammatory therapy in *** the past,patients with moderate or severe states of inflammation received GCs as a first line therapy with an important effectiveness in terms of reduction of the disease activity and the induction of ***,this treatment often results in detrimental side *** downside drove the development of second generation GCs and more precise(non-systemic)drugdelivery *** clinical trials show that most of these new treatments have similar effectiveness to first generation GCs with fewer adverse *** remaining challenge in successful treatment of IBDs concerns the refractoriness and dependency that some patients encounter during GCs treatment.A deeper understanding of the molecular mechanisms underlying GC response is key to personalizing drug choice for IBDs patients to optimize their response to *** this review,we examine the clinical characteristics of treatment with GCs,followed by an in depth analysis of the proposed molecular mechanisms involved in its resistance and dependence associated with *** thorough analysis of current clinical and biomedical literature may help guide physicians in determining a course of treatment for IBDs patients and identifies important areas needing further study.

关键词： Inflammatory bowel diseases Ulcerative colitis Crohn's disease Glucocorticoid dependence Glucocorticoid resistance

高灵敏度液相色谱/串联质谱分析河水中内分泌干扰物

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环境化学 2008年第1期27卷 131-133页

作者： Patricia Revilla-Ruiz Gordon Kearney daniel McMillan Encarnacion Rodriguez-gonzalo 萨拉曼卡大学西班牙萨拉曼卡沃特世公司英国曼彻斯特

来自野生动物和实验室的证据表明,一些化学物质可能对内分泌系统有干扰作用.内分泌干扰物（EDCs）包括农药、多氯联苯（PCBs）、二噁英、呋喃、烷基酚以及甾醇类雌激素（天然生成及人工合成）.由于甾醇类雌激素对人体潜在的干扰性,人们... 详细信息

来自野生动物和实验室的证据表明,一些化学物质可能对内分泌系统有干扰作用.内分泌干扰物（EDCs）包括农药、多氯联苯（PCBs）、二噁英、呋喃、烷基酚以及甾醇类雌激素（天然生成及人工合成）.由于甾醇类雌激素对人体潜在的干扰性,人们对其特别关注.天然的性激素———雌二醇及其代谢产物（雌酮和雌三醇）以及合成的甾醇类乙烯雌二醇是由哺乳动物泌尿排泄,在表层水和地下水中均有发现.其它内分泌干扰物,如烷基酚、壬基酚、双酚A以及五氯酚是工业和家庭活动的代谢产物,在环境水体中也时有发现.[第一段]

关键词：内分泌干扰物质谱分析液相色谱高灵敏度河水串联类雌激素人工合成

Territorial Planning for Coastal Zones in Chile:The Need for Geographical-Environmental and Natural Risk Indicators for Spatial Decision Support Systems

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International Journal of Geosciences 2013年第6期4卷 17-29页

作者： Fernando Pena-Cortes daniel Rozas-Vasquez gonzalo Rebolledo Jimmy Pincheira-Ulbrich Miguel Escalona Enrique Hauenstein Luis Vargas-Chacoff Carlos Bertran Jaime Tapia Marco Cisternas Laboratorio de Planificacion Territorial Nucleo de Investigacion en Estudios AmbientalesUniversidad Catolica de TemucoTemucoChile Programa de Doctorado en Sistematica y Biodiversidad Universidad de ConcepcionConcepcionChile Escuela de Ciencias Ambientales Facultad de Recursos NaturalesUniversidad Catolica de TemucoTemucoChile Instituto de Ciencias Marinas y Limnologicas Universidad Austral de ChileValdiviaChile Instituto de Quimica de Recursos Naturales Universidad de TalcaTalcaChile Escuela de Ciencias del Mar Pontificia Universidad Catolica de ValparaisoValparaisoChile

Coastal zones are very dynamic and fragile environments, constituting a landscape ever more heterogeneous, fragmented and with increasing levels of complexity due to the changing relationship between man and nature. Integrated coastal zone management therefore requires detailed knowledge of the system and its components, based—to a large extent—on technical and scientific information. However, the information generated must be in line with the political requirements necessary for decision-making and planning. Thus the use of indicators to give a simplified view of the many components of the territory, and at the same time to provide important information about patterns or trends, becomes a tool of the utmost importance. These indicators can be understood as measurable characteristics of the environment, which facilitate comprehension of the processes occurring at different scales and serve as a reference to inform the population and support decision-making. The aim of the present note is to demonstrate briefly the need to develop geographical-environmental and natural risk indicators to facilitate comprehension of the dynamic of spatial and temporal landscape patterns, particularly in coastal environments. This approach offers an historical summary of the natural, socio-economic and political processes which currently make up the territory, and which without doubt will continue to influence it in the future. At the same time, it is proposed that information should be integrated on the basis of this framework with a view to generating spatial decision support systems in a context of planning and integrated management of the coastal zones of Chile.

关键词： Coastal Zone Territorial Planning Indicators Spatial Decision Support System Chile

Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla David Reyes-Corona Yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio Nava daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico Department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

Current Understanding of Papillary Thyroid Carcinoma

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第3期10卷 184-221页

作者： Rodrigo Arrangoiz Jeronimo Garcialopez De Llano Maria Fernanda Mijares gonzalo Fernandez-Christlieb Vanitha Vasudevan Amit Sastry Adrian Legaspi Jennifer Fernandez Frank de la Cruz Fernando Cordera daniel Margain Center for Advanced Surgical Oncology Florida USA American British Cowdray Medical Center Mexico City Mexico Sociedad Quirurgica S.C. at the American British Cowdray Medical Center Mexico City

The term thyroid neoplasm incorporates tumors that originate from follicular cells and those that arise from parafollicular cells (C cells). Differentiated thyroid cancer, which originates from follicular cells, includes papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), oncocytic cell carcinoma (Hürthle), poorly differentiated carcinoma, and anaplastic thyroid carcinoma (ATC). PTC tends to have an indolent clinical course with low morbidity and mortality. However, this entity has a broad range of biological and clinical behavior that can result in disease recurrence and death, depending on patient and tumor characteristics and the initial treatment approach. PTC is the most common form of well-differentiated thyroid cancer (WDTC) and based on the most recent statistics, accounts for approximately 89.4% of all thyroid malignancies. PTC appears as an irregular solid or cystic nodule in normal thyroid parenchyma. PTC has the propensity for lymphatic invasion, but it is less likely to have hematogenous spread. Around 11% of patients with PTC present with distant metastases outside the neck and mediastinum. This manuscript with review the current understanding of the epidemiology, pathology, molecular characteristics, prognostic factors, and dynamic risk stratification of PTC centered on an evidence-based and personalized approach.

关键词： Thyroid Cancer Papillary Thyroid Cancer Papillary Thyroid Microcarcinoma Thyroid Nodule Thyroid Cancer Treatment Molecular Studies for Thyroid Cancer

Molecular Diagnosis of Thyroid Nodules and Its Future Implications for the Management of Thyroid Cancer

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第5期10卷 398-418页

作者： Rodrigo Arrangoiz Jeronimo Garcialopez De Llano Maria Fernanda Mijares gonzalo Fernandez-Christlieb Vanitha Vasudevan Amit Sastry Adrian Legaspi Jennifer Fernandez Frank de la Cruz Fernando Cordera daniel Margain Center for Advanced Surgical Oncology Steward Health Hialeah FL USA American British Cowdray Medical Center Mexico City Mexico

Molecular testing in thyroid nodules and thyroid cancer is rapidly evolving;care must be used when incorporating molecular testing for thyroid nodules into clinical practice. A clear appreciation of the goals and restraints of molecular testing must be integrated into how physicians use and explain molecular testing to patients. Molecular tests can help rule in cancer for indeterminate thyroid nodules with very specific mutations for thyroid cancer, such as BRAF and RET/PTC, and can help reduce the rates of completion thyroidectomies in this era of de-escalation of the management of thyroid disease. The positive predictive value (PPV) of malignant cytology (Bethesda VI) is 98%;and even though molecular testing improves specificity and PPV, it falls short of this ideal for other mutations. We present a detailed evaluation of the current state of molecular testing and their clinical relevance in the setting of diagnostic utility and their impact on surgical decision-making. By recapitulating the clinical impact of these tests and some of the related drawbacks, we hope to provide adequate up to date information of the appropriate utilization of these tools in the management of indeterminate or suspicious thyroid nodules and highlight future directions on their utilization for the management of thyroid cancer.

关键词： Thyroid Cancer Papillary Thyroid Cancer Papillary Thyroid Microcarcinoma Thyroid Nodule Thyroid Cancer Treatment Molecular Studies for Thyroid Cancer Affirma Thyroseq