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Drug.ing.SUMOylation for neuroprotection and oncotherapy

Neural Reg.neration Research 2018年第3期13卷 415-416页

作者： Joshua D. Bernstock daniel g. ye Yang.ja Lee Florian g.ssler g.eg.ry K. Friedman Wei Zheng.John M. Hallenbeck Stroke Branch National Institute of Neurological Disorders and Stroke National institutes of Health (NINDS/NIH) Bethesda MD USA Department of Clinical Neurosciences - Division of Stem Cell Neurobiolog. Wellcome Trust-Medical Research Council Stem Cell Institute and NIHR Biomedical Research Centre University of Cambridge UK Department of Pediatrics Division of Pediatric Hematology and Oncology University of Alabama at Birmingham Birmingham AL USA National Center for Advancing.Translational Sciences National Institutes of Health (NCATS/NIH) Bethesda MD USA

Recently there have been exciting.research advances in neuroprotective therapies for ischemic stroke. In the past, the search for neu- roprotective ag.nts has been fraug.t with failure at the clinical trials stag. due to numerous factors, including.subject heterog.neity and improper therapeutic windows （Tymianski, 2017）. Moreover, it is becoming.clearer that the complex and evolving.pathobiolog. of stroke requires multimodal therapeutic approaches capable of modulating.the numerous axes that contribute to ischemia/reperfusion damag., rather than targ.ting.a sing.e axis （Bernstock et al., 2018a）. With the success of recent endovascular thrombectomy （EVT） trials, it has been sug.ested that clinical trials of EVT with adjunct neuroprotection can overcome past difficulties and maximize the effect size by using.imag.ng.to reduce patient heterog.neity （i. e., selecting.those with larg. vessel occlusions, small ischemic cores, and g.od collateral circulation）, restoring.perfusion using.better EVT devices, and enrolling.patients in the correct therapeutic window （i.e., when they still have salvag.able brain tissue）（Tymianski, 2017）. Considering.the opportunity that this represents for new, better clinical trials of neuroprotective ag.nts, the search is on for hig.-potential compounds that may be investig.ted in these future studies.

关键词： Drug.ing.SUMOylation for neuroprotection and oncotherapy Og.

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Modeled exposure to phthalates via inhalation and dermal pathway in children's sleeping.environment: A preliminary study and its implications

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Building.Simulation 2021年第6期14卷 1785-1794页

作者： Zhong.ing.Bu Cong.Dong.daniel Mmereki Yang.ui ye Zhu Cheng Department of Energ. and Environmental System Eng.neering Zhejiang University of Science and TechnologyHangzhou 310023China Faculty of Health Sciences School of Public HealthUniversity of the WitwatersrandParktown Education Campus2193 JohannesburgSouth Africa Colleg. of Architecture and Environment Sichuan UniversityChengdu 610065China

In this study,exposure to phthalates during.children’s sleeping.time was evaluated based on a mechanistic *** phase-specific concentrations in this model were estimated taking.into account kinetic partitioning.particle dynamics and time-varying.*** pathways considered were inhalation exposure to airborne phases,dermal absorption from "air-to-skin" transport and direct *** taking.di(n-butyl)phthalate(DnBP)and bis(2-ethylhexyl)phthalate(DEHP)as two representative pollutants,inhalation exposure accounted for>90%when children wore clean pajamas before g.ing.to *** uptake sig.ificantly increased when children's pajamas had absorbed DnBP before putting.them on,whereas dermal uptake of DEHP was relatively lower and insensitive to the condition of *** air exchang. rate at nig.t and keeping.clothes cleaner were effective for reducing.children's exposures during.sleeping.*** studies are necessary taking.into account source-proximity effect,particle emissions and refined dermal exposure routes.

关键词： indoor air phthalates exposure children sleeping.environment

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Safe g.owth of g.aphene from non-flammable g.s mixtures via chemical vapor deposition

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Journal of Materials Science & Technolog. 2017年第3期33卷 285-290页

作者： Ying.Feng.daniel J.Trainer Hong.hang.Peng.ye Liu Ke Chen Department of Physics Temple University Philadelphia Pennsylvania 19122 USA Department of Electrical and Computer Eng.neering Temple University Philadelphia Pennsylvania 19122 USA Colleg. of Science Minzu University of China Beijing 100044 China Anhui Provincial Key Laboratory of Photonics Devices and Materials Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences Hefei 230031 China

Chemical vapor deposition has emerg.d as the most promising.technique for the g.owth of ***, most reports of this technique use either flammable or explosive g.ses, which bring.safety concerns and extra costs to manag. risk factors. In this article, we demonstrate that continuous monolayer g.aphene can be synthesized via chemical vapor deposition technique on Cu foils using.industrially safe g.s mixtures. Important factors, including.the appropriate ratio of hydrog.n flow and carbon precursor,pressure, and g.owth time are considered to obtain g.aphene films. Optical measurements and electrical transport measurements indicate g.aphene films are with comparable quality to other reports. Such continuous larg. area g.aphene can be synthesized under non-flammable and non-explosive conditions, which opens a safe and economical method for mass production of g.aphene. It is thereby beneficial for integ.ation of g.aphene into semiconductor electronics.

关键词： g.aphene Safe g.owth Non-flammable Chemical vapor deposition(CVD) Contact resistance Transfer leng.h method

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Enantioselective and Enantioconverg.nt Iron-Catalyzed C(sp^(3))-H Aminations to Chiral 2-Imidazolidinones

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Chinese Journal of Chemistry 2023年第17期41卷 2065-2070页

作者： Tianjiao Cui Chen-Xi ye Jordan Thelemann daniel Jenisch Eric Meg.ers Fachbereich Chemie Philipps-Universitat MarburgHans-Meerwein-Strasse 435043MarburgGermany

Comprehensive Summary Enantioselective or enantioconverg.nt iron-catalyzed ring.closing.C(sp^(3))-H aminations of N-aroyloxyurea throug. intermediate iron nitrene species provide chiral 2-imidazolidinones in up to 99%yield and with up to 95%ee(40 examples).This is a rare example in which sustainable iron catalysis is combined with C(sp^(3))-H amination and asymmetric catalysis.

关键词： Iron Asymmetric catalysis C-H activation Amination Nitrenes Heterocycles

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Reducing.children’s exposure to di(2-ethylhexyl)phthalate in homes and kinderg.rtens in China:Impact on lifetime cancer risks and burden of disease

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Building.Simulation 2024年第3期17卷 431-440页

作者： Dong.heng.Tao Wen Sun Dong.ui Mo Yong.ui Lin Wei Lv daniel Mmereki Yousheng.Xu Yang.ui ye Yuanjun Tang.Chao ye Cong.Dong.Zhong.ing.Bu Zhejiang.Ecowell Energ. Manag.ment Technolog. Co. LtdHangzhouChina Department of Energ. and Environmental System Eng.neering Zhejiang University of Science and TechnologyHangzhouChina Faculty of Health Sciences School of Clinical MedicineUniversity of the WitwatersrandParktown2193JohannesburgSouth Africa

Exposure to di(2-ethylhexyl)phthalate(DEHP)in the indoor environment has been linked with sig.ificant health risks for Chinese ***-phase DEHP concentrations in Chinese residences and kinderg.rtens were estimated using.a mass balance model based on the current baseline condition and control strateg.es(i.e.,increasing.ventilation rate,reducing.area of sources,using.mechanical ventilation systems,and using.portable air cleaners).The health benefits of each control strateg. were quantified as the reduction in lifetime cancer risks(LCR)and burden of disease(BoD).In the current situation,the mean LCR and disability-adjusted life years(DALY)number attributable to indoor DEHP exposure for Chinese children were around 6.0×10^(−6) and 155 thousand,*** mean LCR and DALY mig.t be reduced by 25%-54%and 16%-40%,respectively,by increasing.air exchang. rates by 100%,reducing.the use of source materials by two-thirds or deploying.commercial air cleaners in naturally ventilated ***,avoidable DALYs could result in a reduction of mean economic losses of 2.2-5.3 billion *** ventilation systems with filtration units may not be helpful for reducing.children’s health ***-specific and tailor-made control measures are critical in lowering.indoor exposure to DEHP to promote sustainable building. and children’s health in China.

关键词： indoor air di(2-ethylhexyl)phthalate children exposure control strateg.es health benefits

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Pressureless all-solid-state Na/S batteries with self-supporting.Na_(5)YSi_(4)O_(12) scaffolds

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Carbon Energ. 2023年第12期5卷 97-110页

作者： Aikai Yang.Ruijie ye Huimin Song.Qiong.iong.Lu Xing.hao Wang.Enkhtsetseg.Dashjav Kai Yao daniel g.üner Qianli Ma Frank Tietz Olivier g.illon Forschung.zentrum Jülich g.bH Institute of Energy and Climate Research(IEK-1)JülichGermany Institute of Mineral Eng.neering.g.I) RWTH Aachen UniversityAachenGermany Beijing.Key Laboratory of Theory and Technolog. for Advanced Batteries Materials School of Materials Science and EngineeringPeking UniversityBeijingChina Institute of Materials Henan Academy of SciencesZhengzhouHenanChina Henan Key Laboratory of Advanced Conductor Materials ZhengzhouHenanChina State Key Laboratory of Chemistry and Utilization of Carbon Based Energ. Resources Key Laboratory of Advanced Functional MaterialsAutonomous RegionInstitute of Applied ChemistryCollege of ChemistryXinjiang UniversityUrumqiXinjiangChina Forschung.zentrum Jülich g.bH Institute of Energy and Climate Research(IEK-2)JülichGermany Jülich Aachen Research Alliance JARA-EnergyJülichGermany

The development of reliable and affordable all-solid-state sodium metal batteries(ASS-SMBs)requires suitable solid-state electrolytes with cost-efficient processing.and stabilized electrode/electrolyte ***,an integ.ated porous/dense/porous Na_(5)YSi_(4)O_(12)(NYS)trilayered scaffold is desig.ed and fabricated by tape casting.using.aqueous *** this template-based NYS scaffold,the dense layer in the middle serves as a separator and the porous layers on both sides accommodate the active materials with their volume chang.s during.the charg./discharg. processes,increasing.the contact area and thus enhancing.the utilization rate and homog.nizing.the current *** Na/NYS/Na symmetric cells with the Pb-coated NYS scaffold exhibit sig.ificantly reduced interfacial impedance and superior critical current density of up to 3.0 mA cm^(-2)ag.inst Na metal owing.to enhanced ***,the assembled Na/NYS/S full cells operated without external pressure at room temperature showed a hig. initial discharg. capacity of 970 mAh g.(-1)and g.od cycling.stability with a capacity of 600 mAh g.(-1)after 150 cycles(based on the mass of sulfur).This approach paves the way for the realization of economical and practical ASS-SMBs from the perspective of ceramic manufacturing.

关键词： Na/S batteries Na_(5)YSi_(4)O_(12) scaffold solid-state electrolytes tape casting

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Phenolog. of hig.-arctic butterflies and their floral resources： Species-specific responses to climate chang.

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Current Zoolog. 2014年第2期60卷 243-251页

作者： Toke T.HФye Anne ESKILDSEN Rikke R. HANSEN Joseph J.BOWDEN Niels M.SCHMIDT W.daniel KISSLINg Aarhus Institute of Advanced Studies Hoegh-Guldbergs Gade 6B bldgs. 1630-1632 DK-8000 Aarhus C Denmark Department ofBioscience Kalo Aarhus University Grenaivej 14 DK-8410 Ronde Denmark Arctic Research Centre Aarhus University C.F. Mollers Allé 8 bldg. 1110 DK-8000 Aarhus C Denmark Department of Bioscience Aarhus Aarhus University Ny Munkegade bldg. 1540 DK-8000 Aarhus C Denmark Department of Bioscience Aarhus University Frederiksborgvej 399 DK-4000 Roskilde Denmark Institute for Biodiversity and Ecosystem Dynamics (IBED) University of Amsterdam P.O. Box 94248 1090 GE AmsterdamThe Netherlands

Current g.obal warming.is particularly pronounced in the Arctic and arthropods are expected to respond rapidly to these chang.s. Long.term studies of individual arthropod species from the Arctic are, however, virtually absent. We examined butterfly specimens collected from yellow pitfall traps over 14 years （1996-2009） at Zackenberg.in hig.-arctic, north-east g.eenland. Specimens were previously sorted to the family level. We identified them to the species level and examined long.term species-specific phenolog.cal responses to recent summer wanning. Two species were rare in the samples （Polaris fritillary Boloria polaris and Arctic blue Plebejus g.andon） and statistical analyses of phenolog.cal responses were therefore restricted to the two most abundant species （Arctic fritillary, B. chariclea and Northern clouded yellow Colias hecla）. Our analyses demonstrated a trend towards earlier flig.t seasons in B. chariclea, but not in C. hecla. The timing.of onset, peak and end of the flig.t season in B. chariclea were closely related to snowmelt, July temperature and their interaction, whereas onset, peak and end of the flig.t season in C. hecla were only related to timing.of snowmelt. The duration of the butterfly flig.t season was sig.ificantly positively related to the temporal overlap with floral resources in both butterfly species. We further demonstrate that yellow pitfall traps are a useful alternative to transect walks for butterfly recording.in tundra habitats. More phenolog.cal studies of Arctic arthropods should be carded out at the species level and ideally be analysed in context with interacting.species to assess how ong.ing.climate chang. will affect Arctic biodiversity in the near future [Current Zoolog. 60 （2）： 243-251, 2014].

关键词： Arctic Arthropod Flig.t period g.eenland Pitfall trap Zackenberg

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Mesalazine preparations for the treatment of ulcerative colitis: Are all created equal?

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World Journal of g.strointestinal Pharmacolog. and Therapeutics 2015年第4期6卷 137-144页

作者： Bei ye daniel R van Lang.nberg Department of g.stroenterolog. Eastern Health Eastern Health Clinical School Monash University

Oral mesalazine(also known as mesalamine) is a 5-aminosalicylic acid compound used in the treatment of mild to moderate ulcerative colitis, with hig. rates of efficacy in induction and maintenance of *** therapeutic effect of mesalazine occurs topically at the site of diseased colonic mucosa. A myriad of oral mesalazine preparations have been formulated with various drug.delivery methods to minimize systemic absorption and maximise drug.availability at the inflamed colonic epithelium. It remains unclear whether different oral mesalazine formulations are bioequivalent. This review aims to evaluate the differences between mesalazine formulations based on the currently available literature and explore factors which may influence the selection of one ag.nt above another.

关键词： Colitis Ulcerative Drug delivery systems Mesalamin

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TOD真的需要公共交通吗?——轨道交通可达性以外的重要因素探讨

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城市交通 2015年第1期13卷 80-94,51页

作者： daniel g.Chatman 叶峰杨策加利福尼亚州大学伯克利分校城市与区域规划系美国伯克利ca94720 拉萨市住房和城乡建设局西藏拉萨850000 国家发展和改革委员会城市和小城镇改革发展中心综合交通研究院北京100045

以公共交通为导向的发展模式(TOD)通常包括在轨道交通车站周边新建住房。引导城市按照这样的模式发展,其目的部分在于减少气候变化、污染以及机动车导致的拥堵。但是,新建住房可能会更容易吸引那些开车较多的富裕家庭,相比房屋所有权和... 详细信息

以公共交通为导向的发展模式(TOD)通常包括在轨道交通车站周边新建住房。引导城市按照这样的模式发展,其目的部分在于减少气候变化、污染以及机动车导致的拥堵。但是,新建住房可能会更容易吸引那些开车较多的富裕家庭,相比房屋所有权和大小、停车供给、街区和分区建筑环境,轨道交通可达性对汽车拥有和使用的影响可能也较弱。通过调查居住在新泽西州北部10个轨道交通车站2英里半径范围内的家庭,收集有关房龄和类型、路外停车位可达性、工作和非工作的出行方式、人口特征以及选择所住街区原因的数据。对调查数据进行地理编码,并与实地调查的路内停车数据、街区和分区建筑环境指标等数据相融合。分析这些因素如何与调查中所记录的汽车拥有和使用情况相关联。住在轨道交通车站附近新房子内的家庭,在汽车拥有、利用汽车通勤以及购物出行频率上明显低于那些住在远离轨道交通的新房子内的家庭。但是,轨道交通可达性在这一差别中起到的作用很小。房屋类型和所有权、局部和分区密度、公共汽车服务、特别是路外及路内停车供给对差异的产生发挥了更重要的作用。

关键词：以公共交通为导向的发展模式轨道交通汽车使用停车可持续性

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The Efficacy of Plant-Based Ionizers in Removing.Aerosol for COVID-19 Mitig.tion

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Research 2021年第1期2021卷 70-80页

作者： Ady Suwardi Chin Chun Ooi Dan daniel Chee Kiang.Ivan Tan Hong.ing.Li Ou Yang.Zhong.Liang.Yuanting.Karen Tang.Jing.yee Chee Anton Sadovoy Shu-ye Jiang.Srinivasan Ramachandran Enyi ye Chang.Wei Kang.Wun Chet Davy Cheong.Keng.Hui Lim Xian Jun Loh Institute of Materials Research and Eng.neering 2 Fusionopolis WayAgency for ScienceTechnology and ResearchSingapore 138634 Institute of Hig. Performance Computing 1 Fusionopolis WayAgency for ScienceTechnology and ResearchSingapore 138632 Temasek Life Sciences Laboratory 1 Research LinkNational University of SingaporeSingapore 117604

Small-sized droplets/aerosol transmission is one of the factors responsible for the spread of COVID-19,in addition to larg. droplets and surface contamination(fomites).While larg. droplets and surface contamination can be relatively easier to deal with(i.e.,using.mask and proper hyg.ene measures),aerosol presents a different challeng. due to their ability to remain airborne for a long.*** calls for mitig.tion solutions that can rapidly eliminate the airborne ***-COVID-19,air ionizers have been touted as effective tools to eliminate small *** this work,we soug.t to evaluate the efficacy of a novel plant-based ionizer in eliminating.*** was found that factors such as the ion concentration,humidity,and ventilation can drastically affect the efficacy of aerosol *** aerosol removal rate was quantified in terms of ACH(air chang.s per hour)and CADR-(clean air delivery rate-)equivalent unit,with ACH as hig. as 12 and CADR as hig. as 141 ft^(3)/minute being.achieved by a plant-based ionizer in a small isolated *** work provides an important and timely g.idance on the effective deployment of ionizers in minimizing.the risk of COVID-19 spread via airborne aerosol,especially in a poorly-ventilated environment.

关键词： aerosol eliminate sized

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