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Acute cholestatic hepatitis caused by amoxicillin/ clavulanate

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World Journal of Gastroenterology 2013年第46期19卷 8789-8792页

作者： daniel Oliveira Beraldo Joanderson fernandes melo Alexandre Vidal Bonfim Andrei Alkmim Teixeira Ricardo Alkmim Teixeira André Loyola Duarte Department of Internal Medicine Hospital Renascentista Escola Paulista de Medicina-UNIFESP Nephrology Department Escola Paulista de Medicina-UNIFESP Cardiology Department Cardiology Department Instituto do Cora o-FMUSP Pathology Department Hospital A.C.CamargoSo Paulo

Amoxicillin/clavulanate is a synthetic penicillin that is currently commonly used,especially for the treatment of respiratory and cutaneous *** general,it is a well-tolerated oral ***,amoxicillin/clavulanate can cause adverse effects,mainly cutaneous,gastrointestinal,hepatic and hematologic,in some *** here is a case report of a 63-yearold male patient who developed cholestatic hepatitis after recent use of amoxicillin/*** 6 wk of prolonged use of the drug,he began to show signs of cholestatic icterus and developed severe hyperbilirubinemia(total bilirubin>300 mg/L).Diagnostic investigation was conducted by ultrasonography of the upper abdomen,serum tests for infection history,laboratory screening of autoimmune diseases,nuclear magnetic resonance(NMR)of the abdomen with bile duct-NMR and transcutaneous liver biopsy guided by *** duration of disease was approximately 4 mo,with complete resolution of symptoms and laboratory changes at the end of that time *** treatment was not instituted,only a combination of anti-emetic(metoclopramide)and cholestyramine for pruritus.

关键词： Hepatology Hepatitis Amoxicillin/Clavula-nate Drug reactions Hyperbilirubinemia

Human osteoclast formation and resorptive function on biomineralized collagen

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Bioactive Materials 2022年第2期7卷 241-252页

作者： daniel de melo Pereira Noel Davison Pamela Habibovic Department of Instructive Biomaterials Engineering MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ERMaastrichtThe Netherlands

Biomineralized collagen composite materials pose an intriguing alternative to current synthetic bone graft substitutes by offering a biomimetic composition that closely resembles native *** hypothesize that this composite can undergo cellular resorption and remodeling similar to natural *** investigate the formation and activity of human osteoclasts cultured on biomineralized collagen and pure collagen membranes in comparison to cortical bone *** monocytes/macrophages from peripheral blood differentiate into multinucleated,tartrate-resistant alkaline phosphatase(TRAP)-positive osteoclast-like cells on all *** cells form clear actin rings on cortical bone,but not on biomineralized collagen or pure collagen *** form resorption pits in cortical bone,resulting in higher calcium ion concentration in cell culture medium;however,osteoclast resorption of biomineralized collagen and collagen membranes does not measurably *** of osteoclast enzymes-TRAP,carbonic anhydrase II(CA-II),and cathepsin-K(CTS-K)-is similar on all substrates,despite phenotypic differences in actin ring formation and *** mesh-like structure,relatively low stiffness,and lack of RGD-containing binding domains are likely the factors responsible for preventing formation of stable actin rings on and resorption of(biomineralized)collagen *** insight helps to guide further research toward the optimized design of biomineralized collagen composites as a more biomimetic bone-graft substitute.

关键词： Osteoclastogenesis Osteoclast resorption Biomineralized collagen Intrafibrillar mineral Bone graft substitute

An evolutionary computational framework for capacity-safety trade-off in an air transportation network

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Chinese Journal of Aeronautics 2019年第4期32卷 999-1010页

作者： md.Murad HOSSAIN Sameer ALAM daniel DELAHAYE School of Engineering and Information Technology University of New South Wales School of Mechanical and Aerospace Engineering Nanyang Technological University MAIAA Laboratory Ecole Nationale de l'Aviation Civile

Airspace safety and airport capacity are two key challenges to sustain the growth in Air Transportation. In this paper, we model the Air Transportation Network as two sub-networks of airspace and airports, such that the safety and capacity of the overall Air Transportation network emerge from the interaction between the two. We propose a safety-capacity trade-off approach,using a computational framework, where the two networks can inter-act and the trade-off between capacity and safety in an Air Transport Network can be established. The framework comprise of an evolutionary computation based air traffic scenario generation using a flow capacity estimation module(for capacity), Collision risk estimation module(for safety) and an air traffic simulation module(for evaluation). The proposed methodology to evolve air traffic scenarios such that it minimizes collision risk for given capacity estimation was tested on two different air transport network topologies(random and small-world) with the same number of airports. Experimental results indicate that though airspace collision risk increases almost linearly with the increasing flow(flow intensity) in the corresponding airport network, the critical flow depend on the underlying network configuration. It was also found that, in general, the capacity upper bound depends not only on the connectivity among airports and their individual performances but also the configuration of waypoints and mid-air interactions among conflicts. Results also show that airport network can accommodate more traffic in terms of capacity but the corresponding airspace network cannot accommodate the resulting traffic flow due to the bounds on collision risk.

关键词： Airport network Airspace capacity Airspace safety Collision risk Flow intensity

Particles dispersion on fluid-liquid interfaces

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Particuology 2011年第1期9卷 1-13页

作者： Sathish Gurupatham Bhavin Dalal md.Shahadat Hossain Ian S.Fischer Pushpendra Singh daniel D.Joseph Department of Mechanical Engineering New Jersey Institute of Technology Department of Aerospace Engineering and Mechanics University of Minnesota Department of Mechanical and Aerospace Engineering University of California Irvine

This paper is concerned with the dispersion of particles on the fluid-liquid interface. In a previous study we have shown that when small particles, e.g., flour, pollen, glass beads, etc., contact an air-liquid interface, they disperse rapidly as if they were in an explosion. The rapid dispersion is due to the fact that the capillary force pulls particles into the interface causing them to accelerate to a large velocity. In this paper we show that motion of particles normal to the interface is inertia dominated; they oscillate vertically about their equilibrium position before coming to rest under viscous drag. This vertical motion of a particle causes a radially-outward lateral （secondary） flow on the interface that causes nearby particles to move away. The dispersion on a liquid-liquid interface, which is the primary focus of this study, was relatively weaker than on an air-liquid interface, and occurred over a longer period of time. When falling through an upper liquid the particles have a slower velocity than when falling through air because the liquid has a greater viscosity. Another difference for the liquid-liquid interface is that the separation of particles begins in the upper liquid before the particles reach the interface. The rate of dispersion depended on the size of the particles, the densities of the particle and liquids, the viscosities of the liquids involved, and the contact angle. For small particles, partial pinning and hysteresis of the three-phase contact line on the surface of the particle during adsorption on liquid-liquid interfaces was also important. The frequency of oscillation of particles about their floating equilibrium increased with decreasing particle size on both air-water and liquid-liquid interfaces, and the time to reach equilibrium decreased with decreasing particle size. These results are in agreement with our analysis.

关键词： Adsorption Interfacial tension Particle dispersion Fluid–liquid interface Capillary force Viscous drag

Recent progress in MgB_(2)superconducting joint technology

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Journal of Magnesium and Alloys 2023年第7期11卷 2217-2229页

作者： Hao Liang Dipak Patel Mahboobeh Shahbazi Andrzej Morawski daniel Gajda Matt Rindfleisch Richard Taylor Yusuke Yamauchi md Shahriar A.Hossain School of Mechanical and Mining Engineering The University of QueenslandSt LuciaQueensland 4072Australia QUT Centre for Materials Science and School of Chemistry and Physics Queensland University of TechnologyBrisbaneQueensland 4001Australia Institute of High Pressure Physics Polish Academy of Sciences(PAS)Sokolowska 29/37Warsaw 01-142Poland Institute of Low Temperature and Structure Research Polish Academy of Sciences(PAS)Okólna 2Wrocław 50-422Poland Hyper Tech Research Inc.539 Industrial Mile RdColumbusOhio 43228USA Applied Superconductivity Laboratory Queensland University of TechnologyBrisbaneQueensland 4001Australia Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandSt LuciaQueensland 4072Australia Department of Materials Process Engineering Graduate School of EngineeringNagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan The Commonwealth Scientific and Industrial Research Organisation(CSIRO) LindfieldNew South Wales 2070Australia

Magnesium diboride(MgB_(2))magnets have the potential to be the next-generation liquid-helium-free magnet for magnetic resonance imaging(MRI)application due to their relatively high superconducting transition temperature,high current density and low raw material cost compared with current commercial niobium-titanium(Nb-Ti)magnets.A typical superconducting magnet includes several *** produce an ultra-stable magnetic field for imaging in MRI,a superconducting electromagnet operating in a persistent mode is *** coils of the electromagnet in MRI are short-circuited to operate in the persistent mode by connecting coils with superconducting ***-sistent joints have been demonstrated for in-situ and ex-situ wires of both mono-and multi-filamentary structures,made predominantly by PIT techniques similar to those used in wire *** realise further engagement of MgB_(2)in MRI applications,enhancing the performance of MgB_(2)superconducting joints is *** literature review summarises research and development on MgB_(2)superconducting joining technology.

关键词： MgB_(2) Superconducting joints Persistent-mode magnets MRI application Field-decay measurement

Edible Coatings Based on Apple Pectin,Cellulose Nanocrystals,and Essential Oil of Lemongrass:Improving the Quality and Shelf Life of Strawberries(Fragaria Ananassa)

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Journal of Renewable Materials 2019年第1期7卷 73-87页

作者： Ingrid Souza Vieira da Silva Natália Soares Prado Patrícia Gontijo de melo Danilo Campion Arantes Mara Zeni Andrade Harumi Otaguro daniel Pasquini Instituto de Química Universidade Federal de UberlândiaCampus Santa MônicaAv.João Naves deÁvila2121Uberlândia-MG38400-902Brazil Instituto Federal do Triângulo Mineiro Campus Uberaba Rua João Batista Ribeiro4000Uberaba-MG38064-790Brazil Departamento de Ciências Naturais(DCNAT) Universidade Federal de São João Del-ReiPraça D.Helvécio74São João Del-Rei-MG36301-160Brazil Universidade de Caxias do Sul Rua Francisco Getúlio Vargas1130Caxias do Sul-RS95070-970Brazil

In this work,nine different types of edible coating based on pectin,cellulose nanocrystals,glycerol,and essential oil of lemongrass were prepared and used to coat strawberries with a film formed directly on the surface of the coated *** effects of the different edible coatings on refrigerated fruits in terms of weight loss,titratable acidity,total soluble solids,pH,and anthocyanin content was evaluated after 2 days,4 days,6 days,and 8 days of *** of the edible coatings reduced the weight loss of the coated strawberries and the anthocyanin *** total soluble solids content of or uncoated fruit increase more markedly than that of coated *** contrast,pH was maintained for both coated and uncoated *** edible coatings were effective in minimizing of the weight loss,without worsening the physical chemistry *** treatments T5 and T9 presented the best results.

关键词： Strawberry edible coating cellulose nanocrystals pectin shelf life

Toxicity assessment of polyethylene microplastics in combination with a mix of emerging pollutants on Physalaemus cuvieri tadpoles

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Journal of Environmental Sciences 2023年第5期127卷 465-482页

作者： Amanda Pereira da Costa Araújo Thiarlen Marinho da Luz Mohamed Ahmed Ibrahim Ahmed Mir Mohammad Ali md.Mostafizur Rahman Bojan Nataraj daniela de melo e Silva DamiàBarceló Guilherme Malafaia Post-Graduation Program in Environmental Sciences Federal University of GoiásGoianiaGO 74690-970Brazil Laboratory of Toxicology Applied to the Environment Goiano Federal InstituteUrutaíGO 75790-000Brazil Plant Protection Department Faculty of AgricultureAssiut UniversityAssiut 71526Egypt Department of Aquaculture Faculty of FisheriesAquaculture&Marine ScienceSher-e-Bangla Agricultural UniversityDhaka 1207Bangladesh Department of Environmental Sciences Jahangirnagar UniversitySavar 1342Bangladesh Unit of Toxicology Department of ZoologySchool of Life SciencesBharathiar UniversityCoimbatore 641046India Laboratory of Environmental Mutagenesis Federal University of GoiásGoianiaGO 74690-970Brazil Catalan Institute for Water Research(ICRA-CERCA) H_(2)O BuildingScientific and Technological Park of the University of GironaEmili Grahit 101Girona 17003Spain Water and Soil Quality Research Group Department of Environmental ChemistryInstitute of Environmental Assessment and Water Research(IDAEA-CSIC)JordiGirona 1826Barcelona 08034Spain Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal InstituteUrutaíGO 75790-000Brazil Post-Graduation Program in Ecology Conservationand BiodiversityFederal University of UberlandiaUberlandiaMG 38400-902Brazil Post-Graduation Programa in Biotechnology and Biodiversity Federal University of GoiásGoianiaGO 74605-050Brazil

Studies in recent years have shown that aquatic pollution by microplastics(MPs)can be considered to pose additional stress to amphibian ***,our knowledge of how MPs affect amphibians is very rudimentary,and even more limited is our understanding of their effects in combination with other emerging ***,we aimed to evaluate the possible toxicity of polyethylene MPs(PE-MPs)(alone or in combination with a mix of pollutants)on the health of Physalaemus cuvieri *** 30 days of exposure,multiple biomarkers were measured,including morphological,biometric,and developmental indices,behavioral parameters,mutagenicity,cytotoxicity,antioxidant and cholinesterase responses,as well as the uptake and accumulation of PE-MPs in *** on the results,there was no significant change in any of the parameters measured in tadpoles exposed to treatments,but induced stress was observed in tadpoles exposed to PE-MPs combined with themixture of pollutants,reflecting significant changes in physiological and biochemical *** principal component analysis(PCA)and integrated biomarker response(IBR)assessment,effects induced by pollutants in each test group were distinguished,confirming that the exposure of *** tadpoles to the PE-MPs in combination with a mix of emerging pollutants induces an enhanced stress response,although the uptake and accumulation of PE-MPs in these animalswas ***,our study provides newinsight into the danger to amphibians of MPs coexisting with other pollutants in aquatic environments.

关键词： Amphibians Environmental toxicology Micropollutants Emerging pollutants Aquatic pollution Biomarkers

Moldable and transferrable conductive nanocomposites for epidermal electronics

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npj Flexible Electronics 2022年第1期6卷 363-371页

作者： Myeong Namkoong Heng Guo md Saifur Rahman daniel Wang Cassandra Jane Pfeil Sophia Hager Limei Tian Department of Biomedical Engineering and Center for Remote Health Technologies and SystemsTexas A&M UniversityCollege StationTX 77843USA

Skin-inspired soft and stretchable electronic devices based on functional nanomaterials have broad applications such as health monitoring,human-machine interface,and the Internet of ***-processed conductive nanocomposites have shown great promise as a building block of soft and stretchable electronic ***,realizing conductive nanocomposites with high conductivity,electromechanical stability,and low modulus over a large area at sub-100μm resolution remains ***,we report a moldable,transferrable,high-performance conductive nanocomposite comprised of an interpenetrating network of silver nanowires and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate).The stacked structure of the nanocomposite synergistically integrates the complementary electrical and mechanical properties of the individual *** patterned the nanocomposite via a simple,low-cost micromolding process and then transferred the patterned large-area electrodes onto various substrates to realize soft,skin-interfaced electrophysiological *** signals measured using the nanocomposite electrodes exhibit a higher signal-to-noise ratio than standard gel *** nanocomposite design and fabrication approach presented here can be broadly employed for soft and stretchable electronic devices.

关键词： conductive transfer interface

High aluminum concentration and initial establishment of Handroanthus impetiginosus : clues about an Al non-resistant species in Brazilian Cerrado

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Journal of Forestry Research 2020年第6期31卷 2075-2082页

作者： Ane Marcela das Chagas Mendon ca Jean Marcel Sousa Lira Ana Luiza de Oliveira Vilela daniel Amorim Vieira Nayara Cristina de melo Joao Paulo Rodrigues Alves Delfi no Barbosa Programa de Pós-Graduacao em Fisiologia Vegetal Departamento de BiologiaUniversidade Federal de LavrasLavrasMG 37200-000Brazil Programa de Pós-Graduacao em Ciências Ambientais Instituto de Ciências ExatasUniversidade Federal de AlfenasAlfenasMG 37130-001Brazil Programa de Pós-Graduacao em Fitotecnia Departamento de AgriculturaUniversidade Federal de LavrasLavrasMG 37200-000Brazil Instituto Federal de Educacao Ciência e Tecnologia do Pará BelémPA 66093-020Brazil

Cerrado soils are acidic and nutrient-poor,with high content of solubilized Al 3+.Plants growing in these conditions may display adaptations to cope with high aluminum concentrations especially during early developmental *** investigated leaf nutritional status,and photosynthetic and growth characteristics during the initial establishment of Handroanthus impetiginosus(*** Dc.)Mattos,a secondary tree species distributed in the Brazilian *** goal was to understand leaf-level traits related to diff erent aluminum *** plants were cultivated in four diff erent aluminum sulfate concentrations:0,1,2,and 4 mM Al,for 40 *** performed analyses of growth,leaf gas exchange,chloroplast pigment content,and leaf mineral *** observed a linear increase of Al leaf content as a function of Al concentration in the nutrient *** grown in 1 mM Al showed a remarkable increase of K leaf content,net photosynthesis,stomatal conductance,and transpiration,while in 4 mM Al there were reductions of N,P,and K contents,gas exchange characteristics,and *** did not have mechanisms of avoidance,compartmentalization,or resistance to high Al ***,this species showed a hormetic response,with low Al concentrations stimulating and high Al concentrations inhibiting plant responses.

关键词： Hormesis Low Al concentration Al toxicity Cerrado species Carbon assimilation