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Com.lem.nt-dependent neuroinf.am.ation in spinal cord injury:f.om.pathology to therapeutic im.lications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tf.ily f.ras Kobeissy Juanm.rco Gutierrez Gonzalez daniel Ref.i Gerald R.Rodts Christian m.stroph David Gim.el Jonathan Grossberg daniel L.Barrow m.tthew f.Gary Ali m.Alawieh Departm.nt of.Neurosurgery Emory University School of MedicineAtlantaGAUSA Departm.nt of.Neurology Yale UniversityNew HavenCTUSA Center f.r Neurotraum. Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury rem.ins a m.jor cause of.disability in young adults,and beyond acute decom.ression and rehabilitation,there are no pharm.cological treatm.nts to lim.t the progression of.injury and optim.ze recovery in this *** the thorough investigation of.the com.lem.nt system.in triggering and propagating cerebral neuroinf.am.ation,a sim.lar role f.r com.lem.nt in spinal neuroinf.am.ation is a f.cus of.ongoing *** this work,we survey the current literature investigating the role of.com.lem.nt in spinal cord injury including the sources of.com.lem.nt proteins,triggers of.com.lem.nt activation,and role of.ef.ector f.nctions in the *** study relevant data dem.nstrating the dif.erent triggers of.com.lem.nt activation af.er spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to dam.ge-associated m.lecular *** ef.ector f.nctions of.com.lem.nt have been im.licated in spinal cord injury,and we critically evaluate recent studies on the dual role of.com.lem.nt anaphylatoxins in spinal cord injury while em.hasizing the lack of.pathophysiological understanding of.the role of.opsonins in spinal cord *** this pathophysiological review,we system.tically review the dif.erent translational approaches used in preclinical m.dels of.spinal cord injury and discuss the challenges f.r f.ture translation into hum.n *** review em.hasizes the need f.r f.ture studies to dissect the roles of.dif.erent com.lem.nt pathways in the pathology of.spinal cord injury,to evaluate the phases of.involvem.nt of.opsonins and anaphylatoxins,and to study the role of.com.lem.nt in white m.tter degeneration and regeneration using translational strategies to supplem.nt genetic m.dels.

关键词： com.lem.nt neuroinf.am.ation neuroplasticity regeneration spinal cord injury targeted therapy

Recovery of.valuable m.tals f.om.waste cables by em.loying m.chanical processing f.llowed by spouted bed elutriation

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Particuology 2019年第4期17卷 74-80页

作者： Eduardo H. Tanabe Roger m. silva Daliom.r L. Oliveira Junior daniel A. Bertuol Environm.ntal Processes Laboratory (LAPAm. Chemical Engineering Department Federal University of Santa Maria - UFSM Santa Maria RS Brazil

Cables and wires, which are essential parts of.equipm.nt f.r the transm.ssion of.both inf.rm.tion and electricity, contain valuable m.terials including copper (Cu) and alum.num.(Al). This experim.ntal work evaluates the use of.m.chanical processing (grinding and sieving), f.llowed by spouted bed elutriation, f.r separation of.the valuable m.terials (steel-coated copper, copper, and alum.num. present in waste coaxial and internet cables. A recovery ef.iciency of.approxim.tely 90% was achieved f.r the steel-coated copper in coaxial cables. f.r in ternet cables, the copper recovery ef.iciency was approxim.tely 87%. These f.ndings dem.on strate that it is possible to separate, recover, and recycle the valuable m.terials (m.tals) present in waste cables using sim.le, low-cost, and ef.icient m.chanical processing f.llowed by spouted bed elutriation.

关键词： Waste cable Elutriation Copper Recycling m.chanical process

A phased approach to enable hybrid sim.lation of.com.lex structures

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Earthquake Engineering and Engineering Vibration 2014年第S1期13卷 63-77页

作者： Billie f.Spencer Jr. Chia-m.ng Chang Thom.s m.f.ankie daniel A.Kuchm. Pedro f.silva Adel E.Abdelnaby Departm.nt of.Civil Engineering University of Illinois at Urbana-Champaign Nathan m.& Anne m.Newm.rk Endowed Chair Earthquake Engineering Research &Test Center Guangzhou University Associate Prof.ssor Wiss JanneyElstner AssociatesInc. Departm.nt of.Civil and Environm.ntal Engineering University of Illinois at Urbana-Champaign Departm.nt of.Civil and Environm.ntal Engineering George Washington University Departm.nt of.Civil Engineering University of Memphis Assistant Prof.ssor

Hybrid sim.lation has been shown to be a cost-ef.ective approach f.r assessing the seism.c perf.rm.nce of.structures. In hybrid sim.lation,critical parts of.a structure are physically tested,while the rem.ining portions of.the system.are concurrently sim.lated com.utationally,typically using a f.nite elem.nt m.del. This com.ination is realized through a num.rical tim.-integration schem.,which allows f.r investigation of.f.ll system.level responses of.a structure in a cost-ef.ective m.nner. However,conducting hybrid sim.lation of.com.lex structures within large-scale testing f.cilities presents signif.cant challenges. f.r exam.le,the chosen m.deling schem. m.y create num.rical inaccuracies or even result in unstable sim.lations; the displacem.nt and f.rce capacity of.the experim.ntal system.can be exceeded; and a hybrid test m.y be term.nated due to poor com.unication between m.dules(e.g.,loading controllers,data acquisition system.,sim.lation coordinator). These problem. can cause the sim.lation to stop suddenly,and in som. cases can even result in dam.ge to the experim.ntal specim.ns; the end result can be f.ilure of.the entire experim.nt. This study proposes a phased approach to hybrid sim.lation that can validate all of.the hybrid sim.lation com.onents and ensure the integrity largescale hybrid sim.lation. In this approach,a series of.hybrid sim.lations em.loying num.rical com.onents and sm.ll-scale experim.ntal com.onents are exam.ned to establish this preparedness f.r the large-scale experim.nt. This validation program.is incorporated into an existing,m.ture hybrid sim.lation f.am.work,which is currently utilized in the m.lti-Axial f.ll-Scale Sub-Structuring Testing and Sim.lation(m.ST-SIm. f.cility of.the George E. Brown Network f.r Earthquake Engineering Sim.lation(NEES) equipm.nt site at the University of.Illinois at Urbana-Cham.aign. A hybrid sim.lation of.a f.ur-span curved bridge is presented as an exam.le,in which three piers are experim.ntally controlle

关键词： hybrid sim.lation seism.c perf.rm.nce evaluation phased approach curved bridge m.ST-SIm.f.cility

Phylogenetic Analysis of.RhoGAP Dom.in-Containing Proteins

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Genom.cs, Proteom.cs & Bioinf.rm.tics 2006年第3期4卷 182-188页

作者： m.rcelo m. Brando Karina L. silva-Brando f.rnando f. Costa Sara T.O. Saad Hem.tology and Hem.therapy Center State University of Campinas 13083-970 Campinas SP Brazil Departm.nt of.Zoology Institute of Biology State University of Campinas 13083-970 Campinas SP Brazil.

Proteins containing an Rho GTPase-activating protein （RhoGAP） dom.in work as m.lecular switches involved in the regulation of.diverse cellular f.nctions. The ability of.these GTPases to regulate a wide num.er of.cellular processes com.s f.om.their interactions with m.ltiple ef.ectors and inhibitors, including the RhoGAP f.m.ly, which stim.lates their intrinsic GTPase activity. Here, a phylogenetic approach was applied to study the evolutionary relationship am.ng 59 RhoGAP dom.in-containing proteins. The sequences were aligned by their RhoGAP dom.ins and the phylogenetic hypotheses were generated using m.xim.m.Parsim.ny and Bayesian analyses. The character tracing of.two traits, GTPase activity and presence of.other dom.ins, indicated a signif.cant phylogenetic signal f.r both of.them.

关键词： Bayesian analysis character tracing parsim.ny phylogenom.cs protein dom.in,RhoGAP

f.od,polyphenols and neuroprotection

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Neural Regeneration Research 2017年第4期12卷 582-583页

作者： Rui f.m.silva Lea Pogacnik Research Institute f.r m.dicines(im.d.ULisboa)and Departm.nt of.Biochem.stry and Hum.n Biology(DBBH) Faculty of PharmacyUniversidade de LisboaLisboaPortugal Departm.nt of.f.od Science and Technology Biotechnical FacultyUniversity of LjubljanaLjubljana Slovenia

Neuron loss and neurodegeneration are the com.on denom. inators of.what are known as neurodegenerative diseases. Although the clinical m.nif.stations of.som. neurodegenerative diseases are m.inly associated with ageing, it is believed that onset of.disease and neuronal death occurs progressively through lif., well betore the f.rst sym.tom. appear. So, one of.the m.in dilem.as regarding neurodegenerative disease ther-apies is that treatm.nt of.en starts long af.er the neurodegeneration has occurred, when a great num.er of.neurons have already been lost. f.rtherm.re,

关键词： f.od EGCG

m.chanical stim.lation devices f.rm.chanobiology studies:a m.rket,literature,and patents review

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Bio-Design and m.nuf.cturing 2023年第3期6卷 340-371页

作者： f.m.lo-f.nseca O.Carvalho m.Gasik G.m.randa f.S.silva Center f.r m.croElectrom.chanical System. University of Minho(CMEMS-UMinho)Campus de Azurém4800-058 GuimarãesPortugal LABBELS–Associate Laboratory BragaGuimarãesPortugal International Iberian Nanotechnology Laboratory(INL) 4715-330 BragaPortugal School of.Chem.cal Engineering Aalto University Foundation00076 EspooFinland Seqvera Ltd. HelsinkiFinland Departm.nt of.m.terials and Ceram.c Engineering CICECOAveiro Institute of MaterialsUniversity of Aveiro3810-193 AveiroPortugal

Signif.cant advancem.nts in various research and technological f.elds have contributed to rem.rkable f.ndings on the physiological dynam.cs of.the hum.n *** closely m.m.c the com.lex physiological environm.nt,research has m.ved f.om.two-dim.nsional(2D)culture system. to m.re sophisticated three-dim.nsional(3D)dynam.c *** bioreactors or m.crof.uidic-based culture m.dels,cells are typically seeded on polym.ric substrates or incorporated into 3D constructs which are m.chanically stim.lated to investigate cell response to m.chanical stresses,such as tensile or *** review f.cuses on the working principles of.m.chanical stim.lation devices currently available on the m.rket or custom.built by research groups or protected by patents and highlights the m.in f.atures still open to *** are the f.atures which could be f.cused on to perf.rm.in the f.ture,m.re reliable and accurate m.chanobiology studies.

关键词： Biom.terials Polym.rs Actuators m.chanical stress m.chanotransduction

Coating independent cytotoxicity of.citrate-and PEG-coated silver nanoparticles on a hum.n hepatom. cell line

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Journal of.Environm.ntal Sciences 2017年第1期29卷 191-201页

作者： Veronica Bastos Jose m.P.f.rreira-de-Oliveira Joana Carrola Ana L.daniel-da-silva Iola f.Duarte Conceicao Santos Helena Oliveira CESAm.Laboratory of.Biotechnology and Cytom.cs Department of BiologyUniversity of Aveiro3810-193 AveiroPortugal CICECO-Aveiro Institute of.m.terials Department of ChemistryUniversity of Aveiro3810-193 AveiroPortugal Departm.nt of.Biology Faculty of SciencesUniversity of Porto4169-007 PortoPortugal

The antibacterial potential of.silver nanoparticles（AgNPs） resulted in their increasing incorporation into consum.r,industrial and biom.dical ***,hum.n and environm.ntal exposure to AgNPs（either as an engineered product or a contam.nant）supports the em.rgent research on the f.atures conf.rring them.dif.erent toxicity *** this study,30 ran AgNPs coated with citrate or poly（ethylene glycol）（PEG） were used to assess the inf.uence of.coating on the ef.ects produced on a hum.n hepatom. cell line（HepG2）,nam.ly in term. of.viability,apoptosis,apoptotic related genes,cell cycle and cyclins gene *** types of.coated AgNPs decreased cell prolif.ration and viability with a sim.lar toxicity *** the concentrations used（11 and 5 μg/m. corresponding to IC50 and-IC10 levels,respectively） the am.unt of.cells undergoing apoptosis was not signif.cant and the apoptotic related genes BCL2（anti-apoptotic gene）and BAX（pro-apoptotic gene） were both ***,both AgNPs af.ected HepG2 cell cycle progression at the higher concentration（11 μg/m.） by increasing the percentage of.cells in S（synthesis phase） and G2（Gap 2 phase） *** the cell-cycle related genes,the expression of.cyclin B1 and cyclin E1 genes were ***,this work has shown that citrate- and PEG-coated AgNPs im.act on HepG2 apoptotic gene expression,cell cycle dynam.cs and cyclin regulation in a sim.lar *** research is needed to determ.ne the properties that conf.r AgNPs at lower toxicity,since their use has proved helpf.l in several industrial and biom.dical contexts.

关键词： Silver nanoparticles(AgNPs) Citrate Polyethylene glycol)(PEG) HepG2 cells Cytotoxicity Nanotoxicology

f.acture Loci in Sheet m.tal f.rm.ng: A Review

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Acta m.tallurgica Sinica(English Letters) 2015年第12期28卷 1415-1425页

作者： m.Beatriz silva Kerim.Isik A.Erm.n Tekkaya Paulo A.f.m.rtins IDm.C Instituto Superior Técnico Universidade de Lisboa Institute of.f.rm.ng Technology and Lightweight Construction Technical University of Dortmund

f.acture in sheet m.tal f.rm.ng usually occurs as ductile f.acture, rarely as brittle f.acture, at the operating tem.eratures and rates of.loading that are typical of.real processes in two dif.erent m.des：（1） tensile and（2） in-plane shear（respectively, the sam. as m.des I and II of.f.acture m.chanics）. The circum.tances under which each m.de will occur are identif.ed in term. of.plastic f.ow and ductile dam.ge by m.ans of.an analytical approach to characterize f.acture loci under plane stress conditions that takes anisotropy into consideration. f.acture loci was characterized by m.ans of.the f.acture f.rm.ng lim.t line and by the shear f.acture f.rm.ng lim.t line in the f.acture f.rm.ng lim.t diagram. Experim.nts were perf.rm.d with single point increm.ntal f.rm.ng and double-notched test specim.ns loaded in tension, torsion and in-plane shear give support to the presentation and allow determ.ning the f.acture loci of.AA1050-H111 alum.nium.sheets with1 m. thickness. The relation between f.acture toughness and the f.acture f.rm.ng lim.ts was also investigated by com.aring experim.ntal values of.the strains at f.acture obtained f.om.a truncated conical part produced by single point increm.ntal f.rm.ng and f.om.double-notched test specim.ns loaded in tension.

关键词： Sheet f.rm.ng f.acture f.acture f.rm.ng lim.t diagram

NiTi laser textured im.lants with im.roved in vivo osseointegration:An experim.ntal study in rats

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Journal of.m.terials Science & Technology 2022年第19期114卷 120-130页

作者： m.m.Costa A.m.randa f.Bartolom.u O.Carvalho S.m.tos G.m.randa f.S.silva Center f.r m.croElectrom.chanical System.(Cm.m.-Um.nho) University of MinhoCampus de AzurémGuimarães 4800-058Portugal Lif. and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de GualtarBraga 4710-057Portugal ICVS/3B’s-PT Governm.nt Associate Laboratory Braga/GuimarãesPortugal Center f.r Innovation and Research in Oral Sciences(CIROS) Faculty of MedicineUniversity of CoimbraFMUCPortugal CICECO Aveiro Institute of MaterialsDepartment of Materials and Ceramic EngineeringUniversity of AveiroAveiro 3810-193Portugal

Laser surf.ce texturing is a versatile approach f.r m.nuf.cturing im.lants with suitable surf.ces f.r *** work explores the use of.laser to f.bricate NiTi textured im.lants,testing two dif.f.rent groove-based *** perf.rm.nce was evaluated in vivo through im.lantation in Sprague Dawley rats’f.m.r,being then analyzed af.er 4 and 12 weeks of.***-out experim.nts and histological characterization allowed to assess bone-im.lant bond and osseointegration and to com.are the laser textured solutions with non-textured *** showed that,at 4 weeks of.im.lantation,m.inly im.ature woven bone was present whilst at 12 weeks a m.re m.ture bone had ***-sidering the largest im.lantation tim.(12 weeks),results showed extraction f.rces considerably higher f.r textured im.lants(G2 and G3).m.reover,when com.aring G2 and G3,it was f.und that G2(having the highest textured surf.ce area)displayed the m.xim.m.extraction f.rce am.ng all groups,with an increase of.212%when com.ared to non-textured im.lants(G1).These results prove that the design and m.nuf.cturing technology are ef.ective to prom.te an im.proved bone-im.lant bond,aim.ng the developm.nt of.orthopedic im.lants.

关键词： NiTi Laser surf.ce texturing In vivo studies Osseointegration Im.lants