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Endoscopic ultrasound-guided through-the-needle microforceps biopsy and needle-based confocal laser-endomicroscopy increase detection of potentially malignant pancreatic cystic lesions:A single-center study

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World Journal of Gastrointestinal Endoscopy 2022年第3期14卷 129-141页

作者： Carlos Robles-Medranda Juan I Olmos Miguel Puga-Tejada Roberto Oleas Jorge Baquerizo-Burgos Martha Arevalo-Mora Raquel Del Valle Zavala Joao Autran Nebel daniel calle loffredo Hannah Pitanga-Lukashok Gastroenterology and Endoscopy Division Instituto Ecuatoriano de Enfermedades DigestivasGuayaquil 090505Ecuador

BACKGROUND Currently,there is insufficient data about the accuracy in the diagnosing of pancreatic cystic lesions(PCLs),especially with novel endoscopic techniques such as with direct intracystic micro-forceps biopsy(mFB)and needle-based confocal laser-endomicroscopy(nCLE).AIM To compare the accuracy of endoscopic ultrasound(EUS)and associated techniques for the detection of potentially malignant PCLs:EUS-guided fine needle aspiration(EUS-FNA),contrast-enhanced EUS(CE-EUS),EUS-guided fiberoptic probe cystoscopy(cystoscopy),mFB,and *** This was a single-center,retrospective *** identified patients who had undergone EUS,with or without additional diagnostic techniques,and had been diagnosed with *** determined agreement among malignancy after 24-mo follow-up findings with detection of potentially malignant PCLs via the EUSguided techniques and/or EUS-guided biopsy when available(EUS malignancy detection).RESULTS A total of 129 patients were included, with EUS performed alone in 47/129. In 82/129 patients,EUS procedures were performed with additional EUS-FNA (21/82), CE-EUS (20/82), cystoscopy(27/82), mFB (36/82), nCLE (44/82). Agreement between EUS malignancy detection and the 24-mo follow-up findings was higher when associated with additional diagnostic techniques thanEUS alone [62/82 (75.6%) vs 8/47 (17%);OR 4.35, 95%CI: 2.70-7.37;P < 0.001]. The highestmalignancy detection accuracy was reached when nCLE and direct intracystic mFB were bothperformed, with a sensitivity, specificity, positive predictive value, negative predictive value andobserved agreement of 100%, 89.4%, 77.8%, 100% and 92.3%, respectively (P < 0.001 comparedwith EUS-alone).CONCLUSIONThe combined use of EUS-guided mFB and nCLE improves detection of potentially malignantPCLs compared with EUS-alone, EUS-FNA, CE-EUS or cystoscopy.

关键词： Pancreatic cysts Endoscopic ultrasound-guided fine-needle aspiration Confocal microscopy Image-guided biopsy

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Common molecular subtypes among Asian hepatocellular carcinoma and cholangiocarcinoma

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Cancer Biology & Medicine 2018年第S1期15卷 10-11页

作者： Jittiporn Chaisaingmongkol Anuradha Budhu Hien Dang Siritida Rabibhadana Benjarath Pupacdi So Mee Kwon Marshonna Forgues Yotsawat Pomyen Vajarabhongsa Bhudhisawasdi Nirush Lertprasertsuke Anon Chotirosniramit Chawalit Pairojkul Chirayu UAuewarakul Thaniya Sricharunrat Kannika Phornphutkul Suleeporn Sangrajrang Maggie Cam Ping He Stephen M.Hewitt Kris Ylaya Xiaolin Wu Jesper B.Andersen Snorri S.Thorgeirsson Joshua J.Waterfall Yuelin J.Zhu Jennifer Walling Holly S.Stevenson daniel Edelman Paul S.Meltzer Christopher A.loffredo Natsuko Hama Tatsuhiro Shibata Robert H.Wiltrout Curtis C.Harris Chulabhorn Mahidol Mathuros Ruchirawat Xinwei Wang Laboratory of Human Carcinogenesis Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Laboratory of Chemical Carcinogenesis Chulabhorn Research InstituteBangkokThailand Center of Excellence on Environmental Health and Toxicology Office of Higher Education CommissionMinistry of EducationBangkokThailand Faculty of Medicine Khon Kaen UniversityKhon KaenThailand Faculty of Medicine Chiang Mai UniversityChiang MaiThailand HRH Princess Chulabhorn College of Medical Science BangkokThailand Chulabhorn Hospital BangkokThailand Rajavej Hospital Chiang MaiThailand National Cancer Institute BangkokThailand Center for Cancer Research National Cancer InstituteBethesdaMarylandUSA FDA Silver SpringMarylandUSA Laboratory of Pathology Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Frederick National Laboratory for Cancer Research FrederickMarylandUSA Biotech Research and Innovation Center(BRIC) Department of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Genetics Branch Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Georgetown University Medical Center WashingtonDCUSA Division of Cancer Genomics National Cancer Center Research InstituteThe University of TokyoTokyoJapan Laboratory of Molecular Medicine Human Genome CenterThe Institute of Medical ScienceThe University of TokyoTokyoJapan Cancer Inflammation Program Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA

Objective:Intrahepatic cholangiocarcinoma(ICC)and hepatocellular carcinoma(HCC)are clinically disparate primary liver cancers with etiological and biological *** Thailand,both cancer types represent the primary cause ... 详细信息

关键词： Common molecular subtypes

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