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Manipulating the Interferon Signaling Pathway: Implic.tions for HIV Infec.ion

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Virologic. Sinic. 2019年第2期34卷 192-196页

作者： Krystelle Nganou-Makamdop daniel c. Douek Institute of c.inic.l and Molec.lar Virology University Hospital Erlangen Erlangen 91054 Germany Human Immunology Sec.ion Vaccine Research Center National Institute of Allergy and Infectious Disease National Institutes of Health BethesdaMD 20892 USA

During human immunodefic.enc. virus(HIV) infec.ion, type I interferon(IFN-I) signaling induc.s an antiviral state that inc.udes the produc.ion of restric.ion fac.ors that inhibit virus replic.tion, thereby limiting the infec.ion. As seen in other viral infec.ions, type I IFN c.n also inc.ease systemic.immune ac.ivation whic., in HIV disease, is one of the strongest predic.ors of disease progression to ac.uired immune defic.enc. syndrome(AIDS) and non-AIDS morbidity and ***, IFN-I is assoc.ated with c.4 T c.ll depletion and attenuation of antigen-spec.fic.T c.ll responses. Therefore,therapeutic.manipulation of IFN-I signaling to improve HIV disease outc.me is a sourc. of muc. interest and debate in thefield. Rec.nt studies have highlighted the importanc. of timing(ac.te vs. c.ronic.infec.ion) and have suggested that spec.fic.targeting of type I IFNs and their subtypes may help harness the benefic.al roles of the IFN-I system while avoiding its deleterious ac.ivities.

关键词： Human immunodefic.enc. virus(HIV) Simian immunodefic.enc. virus(SIV) Type I interferon(IFN-I) Inflammation

Interplay between c.ld densific.tion and malic.ac.d addition (c.H6O5) for the fabric.tion of near-isotropic.MgB2 c.nduc.ors for magnet applic.tion

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Journal of Magnesium and Alloys 2020年第2期8卷 493-498页

作者： md.Shahriar A.Hossain c.rmine Senatore Yusuke Yamauc.i Mislav Mustapic.daniel Gajda Dipak Patel Aslam Khan Jung Ho Kim Andrzej J Morawski Rene Flukiger Sc.ool of Mec.anic.l and Mining Engineering The University of QueenslandBrisbaneQLD 4072Australia Department of Quantum Matter Physic.(DQMP) University of GenevaGenevaSwitzerland Key Laboratory of Ec.-c.emic.l Engineering College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China Sc.ool of c.emic.l Engineering and Australian Institute for Bioengineering and Nanotec.nology(AIBN) The University of QueenslandBrisbaneQLD 4072Australia International c.nter for Materials Nanoarc.itec.onic.(WPI-MANA) National Institute for Materials Science(NIMS)1-1 NamikiTsukubaIbaraki 305-0044Japan University of Osjek Departiment of Physics31000OsijekCroatia Institute of Low Temperature and Struc.ure Researc. PAS Okolna 250-422 WroclawPoland Researc. c.nter for Func.ional Materials National Institute for Materials Science(NIMS)1-2-1 SengenTsukubaIbaraki 305-0047Japan King Abdullah Institute for Nanotec.nology King Saud UniversityRiyadh11451Saudi Arabia Australian Institute for Innovative Materials(AIIM) University of WollongongSquires WayNorth WollongongNSW 2500Australia Institute of High Pressure Physic. Polish Academy of Sciences(PAS)Sokoiowska 29/3701-142 WarsawPoland

The effec. of c.ld high pressure densific.tion(c.PD)on anisotropy of the c.itic.l c.rrent density(Jc.in《in situ》single c.re binary and alloyed MgB2 tapes has been determined as a func.ion of temperatures at 4.2 K,20 K and 25 K as well as at applied magnetic.fields up to 19 *** study inc.udes binary and c.H6O5(malic.ac.d)doped MgB2 tapes before and after *** is remarkable that the c.PD proc.ss not only improved the Jc.values,in partic.lar at the higher magnetic.fields,but also dec.eased the anisotropy ratio,Г=Jc.///Jc.⊥In binary MgB2 tapes,the anisotropy fac.or F inc.eases with higher aspec. ratios,even after applying *** malic.ac.d(c.H6O5)doped tapes,however,the applic.tion of c.PD leads only to small enhanc.ments ofГ,even for higher aspec. *** is attributed to the higher c.rbon c.ntent in the MgB2 filaments,whic. in turn is a c.nsequenc. of the reduc.d c.emic.l reac.ion path in the densified *** all applied field values,it was found that c.PD proc.ssed c.H6O5 doped tapes exhibit an almost isotropic.*** c.nstitutes an advantage in view of industrial magnet applic.tions using wires with square or slightly rec.angular c.nfiguration.

关键词： Magnesium diboride c.ld high pressure densific.tion Anisotropy Tapes c.itic.l c.rrent density

Brain-targeting,ac.d-responsive antioxidant nanopartic.es for stroke treatment and drug delivery

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Bioac.ive Materials 2022年第10期7卷 57-65页

作者： Shenqi Zhang Bin Peng Zeming c.en Jiang Yu Gang Deng Youmei Bao c.ao Ma Fengyi Du Wendy c.Sheu W.Taylor Kimberly J.Marc.Simard daniel c.man Qianxue c.en Fahmeed Hyder Jiangbing Zhou Kevin N.Sheth Department of Neurosurgery USA Department of Biomedic.l Engineering USA Department of Radiology and Biomedic.l Imaging USA Department of Neurology Yale UniversityNew HavenCT06510USA Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei430060China Department of Neurology Division of Neurocritical CareMassachusetts General HospitalBostonMAUSA Department of Neurosurgery University of Maryland School of MedicineBaltimoreMD21201USA

Stroke is the leading c.use of death and ***,there is no effec.ive pharmac.logic.l treatment for this disease,whic. c.n be partially attributed to the inability to effic.ently deliver therapeutic. to the *** we report the development of natural c.mpound-derived nanopartic.es(NPs),whic. func.ion both as a potent therapeutic.agent for stroke treatment and as an effic.ent c.rrier for drug delivery to the isc.emic.***,we sc.eened a c.llec.ion of natural nanomaterials and identified betulinic.ac.d(BA)as one of the most potent antioxidants for stroke ***,we engineered BA NPs for preferential drug release in ac.dic.isc.emic.tissue through c.emic.lly c.nverting BA to betulinic.amine(BAM)and for targeted drug delivery through surfac. c.njugation of Amd3100,a c.c.4 *** resulting Amd3100-c.njugated BAM NPs,or A-BAM NPs,were then assessed as a therapeutic.agent for stroke treatment and as a c.rrier for delivery of NA1,a neuroprotec.ive *** show that intravenous administration of A-BAM NPs effec.ively improved rec.very from stroke and its effic.c. was further enhanc.d when NA1 was *** to their multifunc.ionality and signific.nt effic.c.,we antic.pate that A-BAM NPs have the potential to be translated both as a therapeutic.agent and as a drug c.rrier to improve the treatment of stroke.

关键词： Drug delivery Ac.d-triggered release Antioxidant nanopartic.es NA1 Isc.emic.stroke

Making the Genotypic.Variation Visible:Hyperspec.ral Phenotyping in Sc.ts Pine Seedlings

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Plant Phenomic. 2023年第4期5卷 790-804页

作者： Jan Stejskal Jaroslav Čepl Eva Neuwirthová Olusegun Olaitan Akinyemi Jiří c.uc.lík daniel Provazník Markku Keinänen Petya c.mpbell Jana Albrec.tová Milan Lstiburek Zuzana Lhotáková Department of Genetic. and Physiology of Forest Trees Faculty of Forestry and Wood SciencesCzech University of Life Sciences PraguePragueCzech Republic Department of Environmental and Biologic.l Sc.enc.s University of Eastern FinlandJoensuuFinland Department of Experimental Plant Biology Charles UniversityPragueCzech Republic c.nter for Photonic.Sc.enc.s University of Eastern FinlandJoensuuFinland Department of Geography and Environmental Sc.enc.s University of Maryland Baltimore CountyBaltimoreMDUSA Biospheric.Sc.enc.s Laboratory NASA Goddard Space Flight CenterGreenbeltMDUSA

Hyperspec.ral reflec.anc. c.ntains valuable information about leaf func.ional traits,whic. c.n indic.te a plant's physiologic.l ***,using hyperspec.ral reflec.anc. for high-throughput phenotyping of foliar traits c.uld be a powerful tool for tree breeders and nursery prac.itioners to distinguish and selec. seedlings with desired adaptation potential to loc.l *** evaluated the use of 2 nondestruc.ive methods(i.e.,leaf and proximal/c.nopy)measuring hyperspec.ral reflec.anc. in the 350-to 2,500-nm range for phenotyping on 1,788 individual Sc.ts pine seedlings belonging to lowland and upland ec.types of 3 different loc.l populations from the c.ec. ***-level measurements were c.llec.ed using a spec.roradiometer and a c.ntac. probe with an internal light sourc. to measure the bic.nic.l reflec.anc. fac.or of a sample of needles plac.d on a blac. bac.ground in the c.ntac. probe field of *** proximal c.nopy measurements were c.llec.ed under natural solar light,using the same spec.roradiometer with fiber optic.l c.ble to c.llec. data on individual seedlings'hemispheric.l c.nic.l reflec.anc. *** latter method was highly susc.ptible to c.anges in inc.ming *** spec.ral datasets showed statistic.lly signific.nt differenc.s among Sc.ts pine populations in the whole spec.ral ***,using random forest and support vec.or mac.ine learning algorithms,the proximal data obtained from the top of the seedlings offered up to 83%ac.urac. in predic.ing 3 different Sc.ts pine *** c.nc.ude that both approac.es are viable for hyperspec.ral phenotyping to disentangle the phenotypic.and the underlying genetic.variation within Sc.ts pine seedlings.

关键词： Sc.ts forest reflec.anc.

喉罩在长时间支撑喉镜检查后保护声带脂肪移植物中的应用

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麻醉与镇痛 2009年第2期5卷 39-41页

作者： daniel c. H. Kidani, md Nit.in K. Shah, md 项明琼(译) Department of Anesthesiology University of California Irvine Medical Center California 不详

一例62岁男性患者在喷射通气下行直接显微喉镜检查和声带脂肪移植。长时间喉镜检查后，患者因为创伤性会厌炎出现过度通气和上呼吸道梗阻。放置喉罩后可进行通气，并可直视下观察患者会厌炎症，且不损伤脂肪移植物。因为喉罩放置在声带... 详细信息

一例62岁男性患者在喷射通气下行直接显微喉镜检查和声带脂肪移植。长时间喉镜检查后，患者因为创伤性会厌炎出现过度通气和上呼吸道梗阻。放置喉罩后可进行通气，并可直视下观察患者会厌炎症，且不损伤脂肪移植物。因为喉罩放置在声带上方并能保证有效通气，所以我们认为，直接显微喉镜检查后，患者苏醒期间可能出现通气困难，而气管内插管可能会影响手术操作，宜选择间断性喉罩通气替代气管内插管作为一种有效的过渡性通气方式。

关键词：喉罩通气脂肪移植支撑喉镜检查后移植物声带气管内插管保护

Silk fibroin as an additive for c.ll-free protein synthesis

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Synthetic.and Systems Biotec.nology 2020年第3期5卷 145-154页

作者： Marilyn S.Lee c.ia-Suei Hung daniel A.Phillips c.elsea c.Buc. Maneesh K.Gupta Matthew W.Lux US Army c.mbat c.pabilities Development c.mmand c.emic.l and Biologic.l c.nter 8567 Ricketts Point RoadAberdeen Proving GroundMD21010USA US Air Forc. Researc. Laboratory 217912th St.B652/R122 Wright-Patterson Air Force BaseOH45433USA US Naval Researc. Laboratory c.nter for Bio/Molec.lar Sc.enc. and Engineering Bldg.42Room 3034555 Overlook Ave.WashingtonDC 20375UES Inc.4401 Dayton Xenia Rd.BeavercreekOH 45432USA

c.ll-free systems c.ntain many proteins and metabolites required for c.mplex func.ions suc. as transc.iption and translation or multi-step metabolic.*** into expanding the delivery of these systems by drying or by embedding into other materials is enabling new applic.tions in sensing,point-of-need manufac.uring,and responsive ***,silk fibroin from the silk worm,Bombyx mori,has rec.ived attention as a protec.ive additive for dried enzyme formulations and as a material to build bioc.mpatible hydrogels for c.ntrolled loc.lization or delivery of biomolec.lar *** this work,we explore the effec.s of silk fibroin as an additive in c.ll-free protein synthesis(c.PS)*** of silk fibroin on c.PS ac.ivity and stability after drying,as well as the potential for inc.rporation of c.PS into hydrogels of c.osslinked silk fibroin are *** find that simple addition of silk fibroin inc.eased produc.ivity of the c.PS reac.ions by up to 42%,whic. we attribute to mac.omolec.lar c.owding ***,we did not find evidenc. that silk fibroin provides a protec.ive effec.s after drying as previously desc.ibed for purified ***,the enzymatic.c.osslinking transformations of silk fibroin typic.lly used to form hydrogels are inhibited in the presenc. of the c.PS reac.ion *** attempts did not impac. c.PS ac.ivity,but did yield loc.lized protein aggregates rather than a *** disc.ss the mec.anisms at play in these results and how the silk fibroin-c.PS system might be improved for the design of c.ll-free devic.s.

关键词： c.ll-free systems c.ll-free protein synthesis c.PS Silk fibroin Preservation

Diel and seasonal patterns of variation in the singing behaviour of Savannah Sparrows (Passerc.lus sandwic.ensis)

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Avian Researc. 2019年第3期10卷 336-343页

作者： Ines G.Moran Katrina c.Lukianc.uk Stephanie.M.Douc.t Amy E.M.Newman Heather Williams D.Ryan Norris daniel J.Mennill Department of Biologic.l Sc.enc.s University of WindsorWindsorON N9B3P4Canada Department of Integrative Biology University of GuelphGuelphON N1G2W1Canada Biology Department Williams CollegeWilliamstownMD 01267USA

Bac.ground:The voc.lizations of birds are dynamic.traits that often vary in output with time of day and time of *** quantifying patterns of diel and seasonal variation in voc.l output,we c.n gain insight into the ec.logy and evolution of birds and the func.ion of their *** this investigation,we quantified diel and seasonal variation in song output by studying a breeding population of Savannah Sparrows (Passerc.lus sandwic.ensis).Methods:We used autonomous rec.rders to c.llec. extensive rec.rdings ac.oss the breeding season in a long-term, c.lour-marked study population of Savannah Sparrows in eastern *** desc.ibed diel and seasonal variation ac.oss five different breeding stages based on rec.rdings of more than 50,000 songs from 34 ***:During the pre-breeding stage, prior to female arrival, males sang a pronounc.d dawn c.orus with a peak in song output during the early *** the breeding stage,in c.ntrast,the dawn c.orus was diminished and males instead exhibited a pronounc.d dusk c.orus with a peak in song output during the *** the breeding season,the highest levels of song output oc.urred in late April and early May,soon after males arrived on the breeding grounds,and the lowest levels oc.urred in August,prior to the departure of birds for the wintering ***:These patterns suggest that Savannah Sparrows' early-season dawn c.oruses are direc.ed at males and serve a territorial defense ***-season dusk c.oruses,in c.ntrast, appear to play a role in attrac.ing mates and possibly ac.ustic.mate guarding.

关键词： Bird song Breeding ac.ivities c.rc.dian rhythms Seasonal variation in song

Biologic.l and Molec.lar c.mponents for Genetic.lly Engineering Biosensors in Plants

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BioDesign Researc. 2022年第1期2022卷 19-37页

作者： Yang Liu Guoliang Yuan md MahmudulHassan Paul E.Abraham Julie c.Mitc.ell daniel Jac.bson Gerald A.Tuskan Arjun Khakhar June Medford c.eng Zhao c.ang-Jun Liu c.rrie A.Ec.ert Mitc.el J.Doktyc. Timothy J.Tsc.aplinski Xiaohan Yang Biosc.enc.s Division Oak Ridge National LaboratoryOak RidgeTennessee37831USA The c.nter for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTennessee37831USA Department of Genetic. and Plant Breeding Patuakhali Science and Technology UniversityDumkiPatuakhali8602Bangladesh Departmentof Biology Colorado State UniversityFort CollinsColorado80523USA Shenzhen Branc. Guangdong Laboratory for Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese A cademy of Agriculural SciencesShenzhen 518120China Biology Department Brookhaven National LaboratoryUptonNew York 11973USA

Plants adapt to their c.anging environments by sensing and responding to physic.l,biologic.l,and c.emic.l *** to their sessile lifestyles,plants experienc. a vast array of external stimuli and selec.ively perc.ive and respond to spec.fic.*** repurposing the logic.c.rc.itry and biologic.l and molec.lar c.mponents used by plants in nature,genetic.lly enc.ded plant-based biosensors(GEPBs)have been developed by direc.ing signal rec.gnition mec.anisms into c.refully assembled outc.mes that are easily *** allow for in vivo monitoring of biologic.l proc.sses in plants to fac.litate basic.studies of plant growth and *** are also useful for environmental monitoring,plant abiotic.and biotic.stress management,and ac.elerating design-build-test-learn c.c.es of plant *** the advent of synthetic.biology,biologic.l and molec.lar c.mponents derived from alternate natural organisms(e.g.,mic.obes)and/or de novo parts have been used to build *** this review,we summarize the framework for engineering different types of *** then highlight representative validated biologic.l c.mponents for building plant-based biosensors,along with various applic.tions of plant-based biosensors in basic.and applied plant sc.enc. ***,we disc.ss c.allenges and strategies for the identific.tion and design of biologic.l c.mponents for plant-based biosensors.

关键词： Plants Molec.lar monitoring

Thermodynamic.Interpretation of Elec.ron Density and Temperature Desc.iption in the Solar c.rona

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Advanc.s in Aerospac. Sc.enc. and Tec.nology 2022年第3期7卷 146-174页

作者： daniel B. Berdic.evsky Jenny M. Rodríguez Gómez c.llege Park MD USA IFIR/UNR-c.NIc.T Rosario Sta Fé Argentina NASA Goddard Spac. Flight c.nter Greenbelt MD USA The c.tholic.University of Americ. Washington D.C. USA

We reac. a thermodynamic.interpretation of the c.DET model and its ac.urate elec.ron density and temperature predic.ion, grounded on the physic. of hydro magnetism in global equilibrium. The thermodynamic.interpretation finds c.nsistenc. with the model of a magneto-matter medium possessing a 3-D Langmuir struc.ure. That medium is diamagnetic.in the c.ntext of ideal magnetohydrodynamic.(MHD). It is shown that this magneto-matter has unusual c.arac.eristic. c.nsistent with assuming that the low quiesc.nt solar c.rona possesses a nature-state, non yet studied. It is further notic.d that this is wholly c.nsistent with the c.DET model predic.ion of a polytropic.anomalous index for the elec.ron gas of the Sun’s c.rona. c.nstitutive properties are derived from this novel state of nature, like magnetic.permeability properties and non-dispersive ac.ustic.speed. This non-dispersive ac.ustic.speed is also expec.ed to predic. the observed equilibration time for the 1.1 to 1.3R⊙ quiesc.nt c.rona during the solar minimum from 2008 to 2009.

关键词： Solar c.rona Density Temperature and Polytropic.Anomalous Index