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Nonalcoholic fatty liver disease in asymptomatic Brazilian adolescents

World Journal of Gastroenterology 2009年第4期15卷 473-477页

作者： Raquel Rocha Helma Pinchemel Cotrim Almir Galvo Vieira Bitencourt daniel batista valente barbosa Adméia Souza Santos Alessandro de Moura Almeida Bruno Cunha Isabel Guimares Postgraduate Course in Medicine and Health Federal University of BahiaSchool of Medicine Federal University of Bahia School of Medicine NASH Project University Hospital Professor Edgard SantosFederal University of Bahia

AIM： To evaluate the prevalence and clinical characteristics of Nonalcoholic fatty liver disease （NAFLD） among asymptomatic Brazilian adolescents. METHODS： Transversal observational study included asymptomatic adolescents with central obesity from private and public schools in Salvador-Bahia, northeastern Brazil. The children answered a questionnaire that in- cluded age, gender, race, and medical history, and were submitted to a complete physical exam and abdominal ultrasound. Biochemical exams included： ALT, AST, GGT, C reactive protein （CRP）, fasting glucose, insulin, cholesterol and triglycerides. Criteria for NAFLD included： the presence of steatosis in ultrasound and/or high level of ALT, negative or occasional historic of intake of alcohol （4 140 g/wk）, negative investigation for hepatitis A, B, C, auto-immune hepatitis, Wilson disease and ***： From October, 2005 to October, 2006, the study included 1801 subjects between 11 and 18 years of age and a mean age of 13.7± 2.0 years. One hun- dred ninety-nine had central obesity. The prevalence of NAFLD was 2.3%, most of whom were male and white. Insulin resistance （IR） was observed in 22.9% of them and had positive correlations with ALT and GGT （P 〈 0.05）. Elevated CRP was observed in 6.9% of the cases; however, it was not associated with WC, IR or liver enzymes. CONCLUSION： The prevalence of NAFLD in Brazilian adolescents was low. The ethnicity may have influence this frequency in the population studied, which had a large proportion of African descendents.

关键词： Nonalcoholic fatty liver disease Insulinresistance Central obesity Ethnicity Adolescents

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Fatty liver disease in severe obese patients:Diagnostic value of abdominal ultrasound

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World Journal of Gastroenterology 2008年第9期14卷 1415-1418页

作者： Alessandro de Moura Almeida Helma Pinchemel Cotrim daniel batista valente barbosa Luciana Gordilho Matteoni de Athayde Adimeia Souza Santos Almir Galvo Vieira Bitencourt Luiz Antonio Rodrigues de Freitas Adriano Rios Erivaldo Alves Faculdade de Medicina da Bahia Universidade Federal da Bahia SalvadorBahia 41830-020Brasil Faculdade de Medicina da Bahia Universidade Federal da BahiaSalvadorBahia 41830-020Brasil Faculdade de Medicina da Bahia Universidade Federal da Bahia SalvadorBahia 41830-020Brasil Faculdade de Medicina da Bahia Universidade Federal da BahiaSalvadorBahia 41830-020 Brasil Núcleo de Cirurgia da Obesidade SalvadorBahia 41830-020Brasil

AIM:To evaluate the sensitivity and specificity of abdominal ultrasound (US) for the diagnosis of hepatic steatosis in severe obese subjects and its relation to histological grade of steatosis. METHODS: A consecutive series of obese patients, who underwent bariatric surgery from October 2004 to May 2005, was selected. Ultrasonography was performed in all patients as part of routine preoperative time and an intraoperative wedge biopsy was obtained at the beginning of the bariatric surgery. The US and histological findings of steatosis were compared, considering histology as the gold standard. RESULTS: The study included 105 patients. The mean age was 37.2 ± 10.6 years and 75.2% were female. The histological prevalence of steatosis was 89.5%. The sensitivity and specificity of US in the diagnosis of hepatic steatosis were, respectively, 64.9% (95% CI: 54.9-74.3) and 90.9% (95% CI: 57.1-99.5). The positive predictive value and negative predictive value were, respectively, 98.4% (95% CI: 90.2-99.9) and 23.3% (95% CI: 12.3-39.0). The presence of steatosis onUS was associated to advanced grades of steatosis on histology (P = 0.016). CONCLUSION: Preoperative abdominal US in our series has not shown to be an accurate method for the diagnosis of hepatic steatosis in severe obese patients. Until another non-invasive method demonstrates better sensitivity and specificity values, histological evaluation may be recommended to these patients undergoing bariatric surgery.

关键词： Bariatric surgery Obesity Hepatic steatosis Abdominal ultrasound diagnosis Fatty liver

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Fabry Disease: Update, Focusing on Heart Disease by Multimodal Imaging

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World Journal of Cardiovascular Diseases 2024年第6期14卷 351-362页

作者： Adrian Espejel-Guzman Emily Rodríguez valente Fernandez-Badillo Javier Serrano-Roman Aldo Cabello-Ganem Alexis daniel Aparicio-Ortiz Alberto Ramon-Rios Mariali Palacios-Cruz Nilda Espinola-Zavaleta Department of Nuclear Cardiology. National Institute of Cardiology Ignacio Chavez Mexico City Mexico ABC Medical Center IAP Department of Echocardiography Mexico City Mexico

Fabry disease (FD) is a rare X-linked lysosomal accumulation disorder caused by a deficiency in the enzyme alpha-galactosidase A (Gal A), resulting in excessive storage of glycosphingolipids, particularly globotriaosylceramide (Gb3). This leads to cellular dysfunction in various organs, with cardiovascular compromise being the major cause of morbidity and mortality. This study aimed to provide a comprehensive overview of FD focusing on its genetic, epidemiological, clinical, diagnostic, and therapeutic aspects. This study explored the genetic mutations associated with FD, its epidemiology, clinical phenotypes, cardiac manifestations, diagnostic approaches, and current treatment options. Background: FD is caused by mutations in GLA on the X chromosome, with over 1000 identified variants. Neonatal screening and specific studies have shown an increased incidence of FD. The clinical presentation varies between classic and late phenotypes, with cardiac involvement being a major concern, particularly in late-onset FD. Purpose: This study aimed to summarize the current knowledge on FD, emphasizing cardiac involvement, diagnostic modalities, and treatment options. Methods: A literature review of relevant studies on FD, including genetics, epidemiology, clinical presentation, diagnostic methods, and treatment options, was conducted. Results: Cardiac manifestations of FD included left ventricular hypertrophy (LVH), heart failure, arrhythmias, and sudden death. Diagnostic approaches such as electrocardiography, echocardiography, and cardiac magnetic resonance imaging play crucial roles in the early detection and monitoring of cardiac involvement. Enzyme replacement therapy (ERT) and emerging treatments have shown promise in managing FD, although challenges remain. Conclusions: FD remains a challenging condition in cardiology, with under-diagnosis being a concern. Early detection and specific therapy are essential to improve patient outcomes. Echocardiography and cardiac MRI ar

关键词： Fabry Disease Hypertrophic Cardiomyopathy Echocardiography Cardiac Magnetic Resonance Imaging Enzyme Replacement Therapy

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Temporal and phenological profiles of open and dense Caatinga using remote sensing:response to precipitation and its irregularities

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Journal of Forestry Research 2021年第3期32卷 1067-1076页

作者： Janisson batista de Jesus Tatiana Mora Kuplich íkaro daniel de Carvalho Barreto Cristiano Niederauer da Rosa Fernando Luis Hillebrand Postgraduate Program in Remote Sensing Federal University of Rio Grande Do SulAv.Bento GoncalvesCEP 91501-970Porto AlegreRio Grande do Sul 9500Brazil National Institute for Space Research(INPE)Southern Regional Centre(CRS) CEP 97105-970Santa MariaRio Grande do SulBrazil Postgraduate Program in Applied Biometrics and Statistics Rural Federal University of PernambucoDom Manuel de Medeiross/nDois IrmaosCEP 52171-900RecifePernambucoBrazil

Caatinga is a typical biome of Brazil's semiarid regions and subject to climate *** is needed on the relation of its features to climate *** study analyzed the infl uence of rainfall and its irregularities in open and dense woody Caatinga *** curves were generated by means of Normalized Difference Vegetation Index(NDVI)time profiles in the Grota do Angico Conservation Unit study area in Sergipe *** data from 2000 to 2018 were collected and phenological curves generated using various estimate methods that produced the following variables:[start of season,end of season,peak of season position,length of season,mean growing season and maximum seasonal].Rainfall showed a standard intra-annual behavior,with inter-annual variations related to irregularities infl uencing Caatinga *** Caatinga vegetation had higher values of NDVI in all periods,even in anomalous years compared to open Caatinga,in addition to having longer leaf coverage over the year,with an anticipated start and a more extended seasonal *** analysis of the rainfall regime made it possible to assess its infl uence on the Caatinga and phenological profiles proved to be fundamental to understand periods of physiological change of open and dense *** results indicate that dense Caatinga maintains physiological activity longer,which may be associated with greater moisture maintenance in a semiarid *** addition,because it has a greater leaf cover for longer periods,the soil may be preserved and maintain its characteristics longer,reducing the effects of *** results may be associated with the type of forest management and conservation in this *** total or partial suppression of individual remnants of Caatinga should be avoided,since the most open areas have lower photosynthetic capacity,affected to a considerable extent from the effects of adverse climatic ***,open Caatinga has a reduced cap

关键词： Semiarid Tropical dry forest NDVI MODIS Phenopix

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Metastasis-associated lung adenocarcinoma transcript 1 molecular mechanisms in gastric cancer progression

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World Journal of Gastrointestinal Oncology 2023年第9期15卷 1520-1530页

作者： daniel Mateus de Oliveira batista Jessica Manoelli Costa da Silva Carolina de Oliveira Gigek Marilia de Arruda Cardoso Smith Paulo Pimentel de Assumpcao danielle Queiroz Calcagno Nucleo de Pesquisas em Oncologia Universidade Federal do ParaBelem 66073-000ParaBrazil Departamento de Patologia Universidade Federal de São PauloSao Paulo 04023-062São PauloBrazil Disciplina de Genetica Departamento de Morfologia e GeneticaUniversidade Federal de São PauloSão Paulo 04023-900Sao PauloBrazil

Gastric cancer(GC)remains among the most common cancers worldwide with a high mortality-to-incidence *** evidence suggests that long noncoding RNAs(lncRNAs)are involved in gastric *** transcripts are longer than 200 nucleotides and modulate gene expression at multiple molecular levels,inducing or inhibiting biological processes and ***-associated lung adenocarcinoma transcript 1(MALAT1)is one of the best-studied lncRNAs with comprehensive actions contributing to cancer *** lncRNA regulates gene expression at the transcriptional and posttranscriptional levels through interactions with microRNAs and *** the present review,we discussed the molecular mechanism of MALAT1 and summarized the current knowledge of its expression in ***,we highlighted the potential use of MALAT1 as a biomarker,including liquid biopsy.

关键词： Long noncoding RNA Gastric carcinogenesis Transcriptional levels Posttranscriptional levels Prognostic biomarker Liquid biopsy

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Remnant gastric cancer:An ordinary primary adenocarcinoma or a tumor with its own pattern?

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World Journal of Gastrointestinal Surgery 2021年第4期13卷 366-378页

作者： Marcus Fernando Kodama Pertille Ramos Marina Alessandra Pereira Andre Roncon Dias Anna Carolina batista Dantas daniel Jose Szor Ulysses Ribeiro Jr Bruno Zilberstein Ivan Cecconello Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão PauloSão Paulo 01249000Brazil

BACKGROUND Remnant gastric cancer(RGC)is defined as a tumor that develops in the stomach after a previous gastrectomy and is generally associated with a worse ***,there little information available regarding RGCs and their prognostic factors and *** To evaluate the clinicopathological characteristics and prognosis of RGC after previous gastrectomy for benign *** Patients who underwent curative resection for primary gastric cancer(GC)at our institute between 2009 and 2019 were retrospectively *** RGC resections with histological diagnosis of gastric adenocarcinoma were enrolled in this *** proximal GC(PGC)who underwent total gastrectomy was selected as the comparison *** and pathological data were collected from a prospective medical *** A total of 41 patients with RGC and 120 PGC were *** age(P=0.001),lower body mass index(P=0.006),hemoglobin level(P<0.001),and number of resected lymph nodes resected(LN)(P<0.001)were associated with the RGC *** type,pathological tumor-node-metastasis,and perioperative morbimortality were similar between RGC and *** was no difference in disease-free survival(P=0.592)and overall survival(P=0.930)between *** status was the only independent factor related to *** RGC had similar clinicopathological characteristics to *** the lower number of resected LN,RGC had a similar prognosis.

关键词： Stomach neoplasms Gastric remnant Gastric cancer Remnant gastric cancer Peptic ulcer Gastric stump

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On the Study of Autonomous Underwater Vehicles by Computational Fluid-Dynamics

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Open Journal of Fluid Dynamics 2020年第1期10卷 63-81页

作者： Joao Victor Nunes de Sousa Antonio Gilson barbosa de Lima Francisco Alves batista Edna Cordeiro de Souza daniel Cesar de Macedo Cavalcante Paulo de Morais Pessoa Joao Evangelista Franco do Carmo Department of Mechanical Engineering Federal University of Campina GrandeCampina GrandeBrazil Department of Physics State University of ParaibaCampina GrandeBrazil Department of Physics and Mathematical Federal University of Campina GrandeCampina GrandeBrazil Federal Institute of Education Science and Technology of the Sertao PernambucanoSerra TalhadaBrazil

Autonomous Underwater Vehicles (AUV’s) are considered as advanced classes of vehicles, capable of performing pre-established missions without physical communication with the ground or human assistance. The research and development of this type of vehicles have been motivated, due to its excellent characteristics, ideal to the military, scientific and industrial sectors. Thus, the objective of this paper is to study fluid flow behavior past over AUV’s, without and with control surfaces (rudders), by Computational Fluid-Dynamics (CFD), aiming to obtain information about the impact of the operating depth and control surfaces on the vehicle's hydrodynamics, in order to help researchers and designers of this class of vehicles. Results of the drag coefficient, pressure, velocity and streamlines distribution around the vehicles are presented and analyzed.

关键词： Autonomous Underwater Vehicle Fluid Flow Computational Fluid-Dynamics Drag Coefficient

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Effects of Gaseous Drinks in Wistar Rats Esophagus

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Journal of Biosciences and Medicines 2017年第5期5卷 32-43页

作者： Thiago Dornelas de Oliveira Marcelli Elioterio Gaspar Larissa Menezes Viana Braga Joice Meire Rodrigues Rebeca Nogueira Falcao Santos Suelen Gaudino Moura Nayara barbosa Bicalho Lamara Laguardia valente Rocha daniel Almeida da Costa Marcus Vinicius de Mello Pinto Academic of the Graduate Course in Medicine of the University Center of Caratinga CaratingaBrazil Religious Sciences from the Pontifical Catholic University of Sao Paulo-PUC/SP Sao PauloBrazil University Center of Caratinga CaratingaBrazil The Institute of Health Sciences at UNEC CaratingaBrazil The Medical School at the Center of Higher Education of Valenca ValencaBrazil The Cellurare Institute Center of Laser Treatment and Cell Therapy PetropolisBrazil

The consumption of beverages and processed foods, mainly soft drinks, has been incorporated into the usual diet of children, adolescents and adults frequently in recent years. The present study aimed to study the effects of carbonated drinks on Wistar rats, based on the macroscopic and histological morphology of the esophagus. Fifteen Wistar rats were divided into three groups: control group;group fed with ration and cola-type refrigerant ad libitum and group fed with ration and gas industrialized water ad libitum, for a trial period of 90 days. For histopathology and morphology, the esophagus was removed, prepared in slides and stained with hematoxylineosin. Images of the sections were captured for analysis and classification of the inflammatory infiltrate. For morphometry, ten grid fields of 100 points were evaluated in the 40x eyepiece, totaling 3000 points per animal. The results demonstrate that the refrigerant treatment induced the following structural changes in the rats: significant reduction of weight in relation to the control group;inflammatory infiltrate predominantly diffuse mild to moderate and tissue edema. The rats treated with carbonated water had similar results to the control, besides signs of healing and tissue repair.

关键词： Soft Drinks Consumption Inflammation Carbonate Beverages

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Towards the Recovery of By-Product Metals from Mine Wastes:An X-Ray Absorption Spectroscopy Study on the Binding State of Rhenium in Debris from a Centennial Iberian Pyrite Belt Mine

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Journal of Minerals and Materials Characterization and Engineering 2014年第2期2卷 135-143页

作者： Maria-Ondina Figueiredo Teresa Pereira da Silva Joao Pedro Veiga daniel de Oliveira Maria Joao batista CENIMAT/I3N Faculty of Sciences and TechnologyNew University of LisbonCampus da CaparicaLisbonPortugal Unit of Mineral Resources and Geophysics National Laboratory for Energy and GeologyAmadoraPortugal

Rhenium is a very scarce element, occurring in the Earth's crust mainly carried by molybdenite (MoS2). Due to a very low availability comparative to actual industrial demand, rhenium is nowadays one of the most expensive mineral commodities and an increased interest is focused on ex- ploring residues resulting from a long-term mining, particularly of sulphide ore deposits. It is therefore noteworthy to assign the presence of rhenium (in a concentration up to 3 ppm) in the waste materials from the old sulphur factory at the abandoned mine of Sao Domingos (Iberian Pyrite Belt, Southeast Portugal), exploited since the Roman occupation of Iberia. Aiming at a potential sustainable recovery of rhenium as a by-product, X-ray near-edge absorption spectroscopy (XANES) was applied to clarify the Re-binding and mode of occurrence by comparing Re L3-edge XANES spectra obtained from mine waste samples (previously fully characterized by X-ray laboratory techniques) with similar spectra collected from Re-rich molybdenites (Mo1-xRexS2) and from Re-O model compounds configuring various valences and coordination environments of rhenium ions. Obtained results are commented, ruling out a possible Re-S binding and rather conforming with the binding of rhenium to oxygen in the analysed mine waste materials.

关键词： Mine Waste Materials By-Products Iberian Pyrite Belt Rhenium XANES Re L_(3)-Edge

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Profile of Patients with Stroke and Disorders of the Vocal Tract

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World Journal of Neuroscience 2017年第1期7卷 82-94页

作者： Lina Claudia Pereira Lopes daniel Almeida da Costa Marcus Vinicius de Mello Pinto Aline Ronis Sampaio Lamara Laguardia valente Rocha Isabela Nardoni Bernardes Rafael batista Ferreira Elias Sobreira Sathler R. R. B. T. Vieira Luiz Gioseffi Jannuzzi School Hospital of the Dom André Arcoverde Foundation Valen&ccedil a Brazil The Medical School at the Center of Higher Education of Valenç a Valen&ccedil a Brazil University of Business and Social Sciences Bueinos Aires Argentina The Cellurare Institute Center of Laser Treatment and Cell Therapy Petrópolis Brazil The Medical School at the Health Sciences Institute of the University Center of Caratinga Caratinga Brazil

Background: The present work aims to characterize the profile of patients with stroke treat at a hospital located in the Region of the Mata of Minas Gerais, Brazil, considering the findings of the clinical vocal tract, kind of stroke, age and gender of such patients. Methodology: To obtain data, the clinical profile of 133 patients with a clinical or tomography diagnosis of stroke was analyzed, and the results were presented in percentage. For quantitative data average and analysis the tests were done with associations that held χ2 test, and for significance it was considered p Results: From the total of patients, 63 were women, accounting for 47.4% and the other 52.6% were males. Clinically, they were characterized with the highest percentage for ischemic stroke (89.4%) compared to the hemorrhagic type (10.6%). Most of them were referred for computed tomography (86.5%) and remained hospitalized for an average of 6.496 ± 7.372 days. Similar percentages were obtained in the analysis of the population in question, when considering if they had (54.1%) or not (49.6%) any damage in their speech, language skills or swallowing. There were different types of disabilities in patients with stroke. Men with an average age of 69.8 ± 13.9 presents mostly ischemic stroke, and the majority of patients with stroke had hemiplegia and abnormalities of the vocal tract, dysphasia, and aphasia. While older patients had an ischemic stroke and were presented with left hemiplegia, the younger ones suffered from hemorrhagic strokes that caused a disability characterized as right hemiplegic. Conclusion: Our results show important conclusions regarding the clinical evolution of the vocal tract of patients who suffered strokes during the period of the analysis, being useful for better comprehension of how the vocal tract from these patients evolved according to the kind of stroke, sex and age also allowing a contraposition with other future statistics periods available in literature. It can al

关键词： Speech Disorders Swallowing Disorders Stroke Vocal Tract

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