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Geo-Spatial Information Science 2019年第4期22卷 251-264,I0003页

作者： Yunzhe Liu Alex Singleton daniel arribas-bel Geographic Data Science Lab Department of Geography and PlanningUniversity of LiverpoolLiverpoolUK

A geodemographic classification aims to describe the most salient characteristics of a small area zonal ***,such representations are influenced by the methodological choices made during their *** particular debate are the choice and specification of input variables,with the objective of identifying inputs that add value but also aim for model *** this context,our paper introduces a principal component analysis(PCA)-based automated variable selection methodology that has the objective of identifying candidate inputs to a geodemographic classification from a collection of *** proposed methodology is exemplified in the context of variables from the UK 2011 Census,and its output compared to the Office for National Statistics 2011 Output Area Classification(2011 OAC).Through the implementation of the proposed methodology,the quality of the cluster assignment was improved relative to 2011 OAC,manifested by a lower total withincluster sum of square *** the UK,more than 70.2%of the Output Areas(OAs)occupied by the newly created classification(***-OAC)outperform the 2011 OAC,with particularly strong performance within Scotland and Wales.

关键词： Geodemographics variable selection UK census spatial data mining principal component analysis

Influence of carbon-based cathodes on biofilm composition and electrochemical performance in soil microbial fuel cells

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Environmental Science and Ecotechnology 2023年第4期16卷 106-116页

作者： Arpita Nandy daniel Farkas belén Pepió-Tárrega Sandra Martinez-Crespiera Eduard Borràs Claudio Avignone-Rossa Mirella Di Lorenzo Department of Chemical Engineering and Centre for Biosensors Bioelectronics&Biodevices(C3Bio)University of BathClaverton DownBA27AYUK Department of Microbial Sciences University of SurreyGuildfordGU27XHUK LEITAT Technological Center C/de la Innovació208225TerrassaBarcelonaSpain

Increasing energy demands and environmental pollution concerns press for sustainable and environmentally friendly *** microbial fuel cell(SMFC)technology has great potential for carbon-neutral bioenergy generation and self-powered electrochemical *** this study,an in-depth assessment on the effect of several carbon-based cathode materials on the electrochemical performance of SMFCs is provided for the first *** innovative carbon nanofibers electrode doped with Fe(CNFFe)is used as cathode material in membrane-less SMFCs,and the performance of the resulting device is compared with SMFCs implementing either Pt-doped carbon cloth(PtC),carbon cloth,or graphite felt(GF)as the *** analyses are integrated with microbial analyses to assess the impact on both electrogenesis and microbial composition of the anodic and cathodic *** results show that CNFFe and PtC generate very stable performances,with a peak power density(with respect to the cathode geometric area)of 25.5 and 30.4 mW m^(−2),*** best electrochemical performance was obtained with GF,with a peak power density of 87.3 mW m^(−2).Taxonomic profiling of the microbial communities revealed differences between anodic and cathodic *** anodes were predominantly enriched with Geobacter and Pseudomonas species,while cathodic communities were dominated by hydrogen-producing and hydrogenotrophic bacteria,indicating H_(2)cycling as a possible electron transfer *** presence of nitrate-reducing bacteria,combined with the results of cyclic voltammograms,suggests microbial nitrate reduction occurred on GF *** results of this study can contribute to the development of effective SMFC design strategies for field implementation.

关键词： Soil microbial fuel cells ORR catalyst Carbon nanofibre Microbial profiling

Comparing techniques for measuring corticosterone in tadpoles

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Current Zoology 2015年第5期61卷 835-845页

作者： Pablo BURRACO Rosa arribas Saurabh S. KULKARNI daniel R. BUCHHOLZ Ivan GOMEZ-MESTRE Department of Wetland Ecology Estacion Biologica de Dofiana (EBD-CSIC) C/Americo Vespucio s/n 41092 Sevilla Spain Department of Pediatrics Yale School of Medicine Yale University New Haven CT 0651 USA Department of Biological Sciences University of Cincinnati Cincinnati OH 45221 USA

Glucocorticoids play a key role in mediating stress responses in vertebrates. Corticosterone （CORT） is the main glucocorticoid produced in amphibians, birds, and reptiles, and regulates several metabolic functions. The most common methods for quantifying CORT are competitive binding immunoassays： radioimmunoassay （RIA） and enzyme immunoassay （EIA）. RIA has been broadly used since the 1980＇s but it requires radioactivity. Commercial EIA kits permit quantifying hormone levels without radioactivity although the requirement for a larger sample volume may be a strong limitation for measurements involving larval amphibians. Here we used Xenopus laevis tadpoles to compare the performance of three commonly used procedures for determination of CORT： RIA on a chloroform extract of whole-body homogenate, EIA on plasma, and EIA on supematant of whole-body homogenate. We treated tadpoles with exogenous CORT at 0, 25, 50, and 100 nM. RIA could distinguish between 0 and 25 nM, and EIA on plasma between 0 and 50 nM, whereas whole-body homogenate EIA only detected significant differences between 0 and 100 riM. Each procedure presents advantages and disadvantages regarding sensitivity, the use of radioactivity, sample size, handling time, and economic cost. RIA is preferred when studying small-bodied animals from which blood samples cannot be obtained. When CORT level differences are intermediate and blood sampling is possible, EIA on plasma is a good non-radioactive alternative. EIA on whole-body homogenates may be useful to assess qualitative changes in CORT levels when considerable differences are expected. Finally, we discuss our findings in the context of previous studies on CORT in amphibians [Current Zoology 61 （5）： 835-845, 2015].

关键词： Corticosterone Radioimmunoassay Enzyme immunoassay Glucocorticoids Amphibians Stress

Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration

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Translational Neurodegeneration 2019年第1期8卷 111-125页

作者： José Aguareles Juan Paraíso-Luna belén Palomares Raquel Bajo-Grañeras Carmen Navarrete Andrea Ruiz-Calvo daniel García-Rincón Elena García-Taboada Manuel Guzmán Eduardo Muñoz Ismael Galve-Roperh Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS) Ctra.Colmenar Viejokm9100 MadridSpain Departamento de Bioquímica y Biología Molecular and Instituto Universitario de Investigación Neuroquímica Universidad ComplutenseMadridSpain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED) MadridSpain Instituto Maimónides de Investigación Biomédica de Córdoba(IMIBIC) CórdobaSpain Departamento de Biología Celular Fisiología e InmunologíaUniversidad de CórdobaCórdobaSpain Hospital Universitario Reina Sofía CórdobaSpain Emerald Health Pharmaceuticals San DiegoUSA

Background:The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular *** cannabinoid actions in the nervous system are mediated by CB1 receptors,which can elicit psychotropic effects,but other targets devoid of psychotropic activity,including CB2 and nuclear PPARγreceptors,can also be the target of specific ***:We investigated the pro-neurogenic potential of the synthetic cannabigerol derivative,VCE-003.2,in striatal neurodegeneration by using adeno-associated viral expression of mutant huntingtin in vivo and mouse embryonic stem cell differentiation in ***:Oral administration of VCE-003.2 protected striatal medium spiny neurons from mutant huntingtin-induced damage,attenuated neuroinflammation and improved motor ***-003.2 bioavailability was characterized and the potential undesired side effects were evaluated by analyzing hepatotoxicity after chronic ***-003.2 promoted subventricular zone progenitor mobilization,increased doublecortin-positive migrating neuroblasts towards the injured area,and enhanced effective ***,we demonstrated the proneurogenic activity of VCE-003.2 in embryonic stem ***-003.2 was able to increase neuroblast formation and striatal-like CTIP2-mediated ***:The cannabigerol derivative VCE-003.2 improves subventricular zone-derived neurogenesis in response to mutant huntingtin-induced neurodegeneration,and is neuroprotective by oral administration.

关键词： Cannabinoid Huntingtin Neurodegeneration Neurogenesis PPAR

Petrography and tectonic provenance of the Permian Tunas Formation:Implications on the paleotectonic setting during the ClaromecóForeland Basin evolution,southwestern Gondwana margin,Argentina

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Journal of Palaeogeography 2022年第3期11卷 427-447页

作者： María belén Febbo Renata N.Tomezzoli Nora N.Cesaretti Giselle Choque Natalia B.Fortunatti Guadalupe Arzadún Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Argentina Dpto.de Geología Universidad Nacional del SurAvenida Alem 1253B8000ICPBahía BlancaArgentina Centro de Geología Aplicada y Medio Ambiente(CGAMA CIC–UNS)Dpto.de GeologíaUniversidad Nacional del SurBahía BlancaArgentina Laboratorio de Paleomagnetismo“daniel A.Valencio” Instituto de Geociencias BásicasAplicadas y Ambientales de Buenos Aires(IGEBA)Departamento de Ciencias GeológicasFacultad de Ciencias Exactas y Naturales(FCEyN)Universidad de Buenos Aires(UBA)Pabellón II(1428)CABAArgentina Laboratorio de Termocronología(La.Te Andes–CONICET) Las Moreras 310A4401XBAVaquerosSaltaArgentina

The Claromec o Basin is located at the south-western sector of the Buenos Aires province,*** basin is considered a foreland basin closely related to the evolution of the southwestern Gondwana *** contribution focuses on the provenance analysis of the Tunas Formation(Permian,Pillahuinc o Group),which represents the last filling stage for the Claromec o Foreland *** and tectonic provenance analyses were performed in sandstones recovered from subsurface(PANG 0001 and PANG0003 exploration wells)and outcrops located close to the basin center(Gonzales Chaves locality).In the subsurface,the analyzed succession is composed of medium-to fine-grained sandstones interbedded with tuffs,mudrocks,carbonaceous mudrocks and coal *** outcrops,the succession is dominated by mediumto fine-grained sandstones interbedded with *** composition patterns are distributed into the recycled orogen and transitionally recycled to mixed *** analyses,in addition to provenance and sedimentological studies,confirm that sedimentary material was derived from a mixed source,which largely comes from the Sierras Australes fold and thrust belt,located towards the W-SW,where the sedimentary succession is interbedded with volcanic *** Tunas Formation shows clear differences in its modal composition,paleocurrent direction and paleoenvironmental conditions with respect to the underlying units of the Pillahuinc o Group(Sauce Grande,Piedra Azul and Bonete formations).Source areas changed from cratonic to mixed fold belt/arc-derived material,suggesting variations in the Claromec o Basin configuration during the Late *** in the paleotectonic scenario during the deposition of the Tunas Formation have been interpreted as a consequence of a compressive post-collisional deformation event,the product of adjustment,accommodation and translation of terrains towards the equator during the Permian-Triassic to form Pangea.

关键词： Provenance area Petrography Tunas Formation ClaromecóForeland Basin Southwestern Gondwana margin Permian Upper Paleozoic

Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： Javier Martin-Broto Jeronimo Martinez-Garcia David SMoura Andres Redondo Antonio Gutierrez Antonio Lopez-Pousa Javier Martinez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio Carnero Marco Perez David Marcilla Jesus Garcia-Foncillas Pablo Romero Javier Fernandez-Jara daniel Lopez-Lopez Ivan arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de Sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 *** median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRNA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4

Donkey pericardium as a select sourcing to manufacture percutaneous heart valves:Decellularization has not yet demonstrated any clear cut advantage to glutaraldehyde treatment

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Medicine in Novel Technology and Devices 2019年第4期4卷 38-46页

作者： Aisa Rassoli Yiming Li Xianhao Bao Fabien Kawecki Xinzhe Zhao daniel Chappard Gaetan Le-bel Jiaxuan Feng Benedikt Weber Nasser Fatouraee Ze Zhang Zaiping Jing Lucie Germain Lu Wang Robert Guidoin Department of Surgery Faculty of MedicineUniversite Laval and Regenerative Medicine AxisCHU de Quebec Research CenterQuebecCanada Department of Biomedical Engineering Amirkabir University of TechnologyTehranIran Departnent of Vascular Surgery Changhai Hospital of Naval Military Medical UniversityShanghaiChina Key Laboratory of Textile Sciences and Technology Ministry of EducationColle of TextilesDonghua UniversityShanghaiChina GEROM Institut de Biologie en SanteCHU D'AngersAngersFrance Department of Dermatology Medical University of ViennaViennaAustria

Background:The donkey pericardium is considered a good candidate to manufacture percutaneous heart valves based upon its thinness,low cellularity and undulating collagen bundles and *** represents an avenue worth exploring,should its superiority to glutaraldehyde-treated pericardium be *** and methods:Donkey pericardium was divided into two groups:regular glutaraldehyde fixation and mild *** treated pericardia were observed using scanning electron microscopy,histology and transmission electron *** tests were performed along the axial and perpendicular directions,with the data fitted into both the Gasser–Ogden–Holzapfel(GOH)material model and the Fung’s anisotropic ***:The microstructures of the pericardia processed by the two protocols were similar,showing collagen bundles and laminates free of *** decellularization eliminated most of the cells,however leaving the structure somehow *** collagen filaments in bundles were slightly *** anisotropy rates of the non-decellularized specimens were almost identical to the decellularized *** decellularized pericardium appeared ***:The decellularization proved to be ***,it makes the tissue stiffer,which may lead to higher shear concentration during cardiac cycles and reduce its wavy ***,it appears premature to select decellularized donkey pericardium to manufacture heart valves.

关键词： Donkey pericardium Decellularization Valve leaflet Transcatheter aortic valve implantation Wavy microstructure

Distortions in focusing laser pulses due to spatio-temporal couplings:an analytic description

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High Power Laser Science and Engineering 2024年第3期12卷 20-40页

作者： Klaus Steiniger Fabia Dietrich daniel Albach Michael Bussmann Arie Irman Markus Loeser Richard Pausch Thomas Püschel Roland Sauerbrey Susanne Schöbel Ulrich Schramm Mathias Siebold Karl Zeil Alexander Debus Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany CASUS-Center for Advanced Systems Understanding GörlitzGermany Technische Universität Dresden DresdenGermany

In ultra-short laser pulses,small changes in dispersion properties before the final focusing mirror can lead to severe pulse distortions around the focus and therefore to very different pulse properties at the point of laser±matter interaction,yielding unexpected interaction *** mapping between far-and near-field laser properties intricately depends on the spatial and angular dispersion properties as well as the focal *** a focused Gaussian laser pulse under the influence of angular,spatial and group-delay dispersion,we derive analytical expressions for its pulse-front tilt,duration and width from a fully analytic expression for its electric field in the time±space domain obtained with scalar diffraction *** expression is not only valid in and near the focus but also along the entire propagation distance from the focusing mirror to the *** relating angular,spatial and group-delay dispersion before focusing at an off-axis parabola,where they are well measurable,to the respective values in the pulse’s focus are obtained by a ray tracing ***,these formulas are used to show in example setups that the pulse-front tilts of lasers with small initial dispersion can become several tens of degrees larger in the vicinity of the focus while being small directly in the *** formulas derived here provide the analytical foundation for observations previously made in numerical *** numerically simulating Gaussian pulse propagation and measuring properties of the pulse at distances several Rayleigh lengths off the focus,we verify the analytic expressions.

关键词： group-delay dispersion pulse-front tilt spatio-temporal couplings third-order dispersion ultra-short laser pulses

Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

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Translational Neurodegeneration 2021年第4期10卷 666-677页

作者： Nuole Zhu Miguel Santos-Santos Ignacio lllán-Gala Victor Montal Teresa Estellés Isabel Barroeta Miren Altuna Javier Arranz Laia Muñoz Olivia belbin Isabel Sala Maria belén Sánchez-Saudinós Andrea Subirana Laura Videla Jordi Pegueroles Rafael Blesa Jordi Clarimón Maria Carmona-Iragui Juan Fortea Alberto Lleó daniel Alcolea Sant Pau Memory Unit Department of NeurologyInstitut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant PauUniversitat Autònoma de Barcelona08041 BarcelonaSpain Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas(CIBERNED) 28031 MadridSpain Autonomous University of Barcelona 08913 BarcelonaSpain Fundación Catalana Sindrome de Down Centre Mèdic Down08029 BarcelonaSpain

Background:Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative *** of glial fibrillary acidic protein(GFAP),an astrocytic damage marker,may help advance our understanding of different neurodegenerative *** this study,we investigated the diagnostic performance of plasma GFAP(pGFAP),plasma neurofilament light chain(pNfL)and their combination for frontotemporal dementia(FTD)and Alzheimer's disease(AD)and their clinical utility in predicting disease ***:pGFAP and pNfL concentrations were measured in 72 FTD,56 AD and 83 cognitively normal(CN)participants using the Single Molecule Array *** the 211 participants,199 underwent cerebrospinal(CSF)analysis and 122 had magnetic resonance *** compared cross-sectional biomarker levels between groups,studied their diagnostic performance and assessed correlation between CSF biomarkers,cognitive performance and cortical *** prognostic performance was investigated,analyzing cognitive decline through group comparisons by ***:Unlike pNfL,which was increased similarly in both clinical groups,pGFAP was increased in FTD but lower than in AD(all P<0.01).Combination of both plasma markers improved the diagnostic performance to discriminate FTD from AD(area under the curve[AUC]:combination 0.78;pGFAP 0.7;pNfL 0.61,all P<0.05).In FTD,pGFAP correlated with cognition,CSF and plasma NfL,and cortical thickness(all P<0.05).The higher tertile of pGFAP was associated with greater change in MMSE score and poor cognitive outcome during follow-up both in FTD(1.40 points annually,hazard ratio[HR]3.82,P<0.005)and in AD(1.20 points annually,HR 2.26,P<0.005).Conclusions:pGFAP and pNfL levels differ in FTD and AD;and their combination is useful for distinguishing between the two *** could also be used to track disease severity and predict greater cognitive decline during follow-up in patients with FTD.

关键词： Glial fibrillary acidic protein Neurofilament Frontotemporal dementia Plasma biomarkers

Allophane as a Nanotechnological Additive in Masonry Materials to Increase Resistance and Waterproofing

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Advances in Materials Physics and Chemistry 2024年第8期14卷 196-212页

作者： Edward H. Jiménez Joao Rivera Juan H. Villalba Paola E. Vera Marlon Cuenca belén Granja Javier Fuentes Sandra Gavilanes daniel Hidalgo Fernando Garcia Jose Bermudez Washington Ruiz Alexis Martial Debut Facultad de Ingeniera Qumica Universidad Central del Ecuador Quito Ecuador Facultad de Arquitectura y Urbanismo Universidad Central del Ecuador Quito Ecuador Nanomaterials Characterization Laboratory Universidad de las Fuerzas Armadas ESPE Sangolqu Ecuador

The constant need for high-strength materials in the construction industry promotes the research of additives that improve the properties of masonry materials. The use of allophane as an additive in concrete and mortar mixtures was implemented to improve their strength and waterproofing, respectively, using compression and water absorption tests according to their corresponding standards (ASTM C1231, ASTM D2938, and ASTM C1585). The samples were evaluated at different concentrations and curing ages. In addition, different sand/cement ratios were considered for the mortar. The results revealed that there was a 9.4% increase in compressive strength in concrete and a 23.7% reduction in water absorption in mortar for the 5:1 ratio. These changes would be the result of the interaction of the nanoporous additive in the atomic crystal structure of the material demonstrating the nanotechnological nature of allophane.

关键词： Allophane Nano Additive Strength Impermeability Concrete Mortar