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Vascular medicine in the 21st century:Embracing comprehensive vasculature evaluation and multidisciplinary treatment

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World Journal of Clinical Cases 2024年第27期12卷 6032-6044页

作者： Yoram Chaiter daniel Lyon Fink Yossy Machluf The Israeli Center for Emerging Technologies in Hospitals and Hospital-Based Health Technology Assessment Shamir(Assaf Harofeh)Medical CenterZerifin 7030100Israel Department of pediatric Cardiology Unit HaEmek Medical CenterAfula 1834111Israel Shamir Research Institute University of HaifaKazerin 1290000Israel

The field of vascular medicine has undergone a profound transformation in the 21st century,transforming our approach to assessment and ***-sclerosis,a complex inflammatory disease that affects medium and large arteries,presents a major challenge for researchers and healthcare *** condition,characterized by arterial plaque formation and narrowing,poses sub-stantial challenges to vascular health at individual,national,and global *** repercussions are far-reaching,with clinical outcomes including ischemic heart disease,ischemic stroke,and peripheral arterial disease—conditions with esca-lating global *** detection of vascular changes caused by athero-sclerosis is crucial in preventing these conditions,reducing morbidity,and averting *** article underscored the imperative of adopting a holistic approach to grappling with the intricacies,trajectories,and ramifications of *** stresses the need for a thorough evaluation of the vasculature and the implementation of a multidisciplinary treatment *** consi-dering the entire vascular system,healthcare providers can explore avenues for prevention,early detection,and effective management of this condition,ultima-tely leading to improved patient *** discussed current practices and proposed new directions made possible by emerging diagnostic modalities and treatment ***,we considered healthcare expenditure,resour-ce allocation,and the transformative potential of new innovative treatments and technologies.

关键词： Vascular medicine Vasculature assessment Holistic approach prevention avenues Healthcare transformation

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Existence Results for a Class of periodic Evolution Variational Inequalities

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Chinese Annals of Mathematics,Series B 2007年第6期28卷 629-650页

作者： Samir ADLY daniel GOELEVEN Michel THra DMI-XLIM UMR-CNRS 6172Université de Limoges123 Avenue A.Thomas87060 Limoges CedexFrance. IREMIA Université de La Réunion97400 Saint-DenisFrance.

In this paper, using the Brouwer topological degree, the authors prove an existence result for finite variational inequalities. This approach is also used to obtain the existence of periodic solutions for a class of e... 详细信息

关键词： Variational inequalities Differential inclusions Topological degree Guiding functions periodic solutions

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Solar-driven photothermal catalytic CO_(2) conversion:a review

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rare Metals 2024年第7期43卷 2913-2939页

作者： Bachirou guene Lougou Bo-Xi Geng Ru-Ming pan Wei Wang Tian-Tian Yan Fang-Hua Li Hao Zhang Oraléou SanguéDjandja Yong Shuai Meisam Tabatabaei daniel Sabi Takou School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090China School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150001China Guangdong provincial Key Laboratory of Distributed Energy Systems Engineering Research Center of None-Food Biomass Efficient Pyrolysis and Utilization Technology of Guangdong Higher Education InstitutesDongguan University of TechnologyDongguan 523808China Higher Institution Centre of Excellence(HICoE) Institute of Tropical Aquaculture and Fisheries(AKUATROP)Universiti Malaysia Terengganu21030 Kuala NerusMalaysia Department of Biomaterials Saveetha Dental CollegeSaveetha Institute of Medical and Technical SciencesChennai600077India école polytechnique d'Abomey-Calavi University of Abomey-Calavi2009CotonouBenin

It is highly desirable to seek green and sustainable technologies,such as employing photo thermal effects to drive energy catalysis processes to address the high energy demand and associated environmental impacts induced by the current *** photothermocatalysis process is an emerging research area with great potential in efficiently converting solar energy through various catalytic ***,achieving simultaneously high conversion efficiency,cyclability,and durability is still a daunting ***,tremendous work is still needed to enhance solar photo thermal catalytic conversion and promote its large-scale *** review developed the principles of coupling solar photon and thermal fields underlying the photothermal effect,exploration of efficient nanocatalysts,development of optofluidic reactor model,and photo thermal synergistic-driven CO_(2) reduction *** ultimate goal was to provide an effective approach that can effectively convert solar energy into photocarriers/hot-electrons and heat,and importantly,can couple them to regulate catalysis reaction pathways toward the production of value-added fuel and chemical energy.

关键词： photochemistry photothermal CO_(2)catalytic conversion Nanomaterial Solar fuels and chemicals

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Development of Localized Assessment of Municipal Wastewater Disposal Risks

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Journal of Water Resource and protection 2024年第6期16卷 395-413页

作者： Frederick Bloetscher daniel E. Meeroff Brittanney Adelmann Department of Civil Environmental and Geomatics Engineering Florida Atlantic University Boca Raton USA Department of Mathematics Florida Atlantic University Boca Raton USA

A means to develop a comparative assessment of the risks of available wastewater effluent disposal options on a local scale needs to be developed to help local decision-makers make decisions on options such as direct or indirect potable reuse options. These options have garnered more interest as a result of water supply limitations in many urban areas. This risk assessment was developed from a risk assessment developed at the University of Miami in 2001 and Florida Atlantic University (FAU) in 2023. Direct potable reuse and injection wells were deemed to have the lowest risk in the most recent study by FAU. However, the injection well option may not be available everywhere. As a result, a more local means to assess exposure risk is needed. This paper outlines the process to evaluate the public health risks associated with available disposal alternatives which may be very limited in some areas. The development of exposure pathways can help local decision-makers define the challenges, and support later expert level analysis upon which public health decisions are based.

关键词： potable Reuse Wastewater Effluent Disposal Risk Risk Assessment

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Shear wave velocity prediction:A review of recent progress and future opportunities

Energy Geoscience

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Energy Geoscience 2024年第4期5卷 36-54页

作者： John Oluwadamilola Olutoki Jian-guo Zhao Numair Ahmed Siddiqui Mohamed Elsaadany AKM Eahsanul Haque Oluwaseun daniel Akinyemi Amany H.Said Zhaoyang Zhao State Key Laboratory of petroleum Resources and prospecting CNPC Key Laboratory of Geophysical ExplorationCollege of GeophysicsChina University of PetroleumBeijingChina Center of Excellence in Subsurface Seismic Imaging and Hydrocarbon prediction Department of GeoscienceFaculty of Geoscience&Petroleum EngineeringUniversiti Teknologi PETRONAS(UTP)Malaysia Geology Department Faculty of ScienceAssiut UniversityAssiut71516Egypt

Shear logs,also known as shear velocity logs,are used for various types of seismic analysis,such as determining the relationship between amplitude variation with offset(AVO)and interpreting multiple types of seismic *** log is an important tool for analyzing the properties of rocks and interpreting seismic data to identify potential areas of oil and gas ***,these logs are often not collected due to cost constraints or poor borehole conditions possibly leading to poor data quality,though there are various approaches in practice for estimating shear wave *** this study,a detailed review of the recent advances in the various techniques used to measure shear wave(S-wave)velocity is carried *** techniques include direct and indirect measurement,determination of empirical relationships between S-wave velocity and other parameters,machine learning,and rock physics ***,this study creates a collection of employed techniques,enhancing the existing knowledge of this significant topic and offering a progressive approach for practical implementation in the field.

关键词： Shear wave(S-wave)velocity Direct and indirect measurement Empirical relationship Artificial intelligence(AI) Machine learning Rock physics model

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Estimating geographic variation of infection fatality ratios during epidemics

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Infectious Disease Modelling 2024年第2期9卷 634-643页

作者： Joshua Ladau Eoin L.Brodie Nicola Falco Ishan Bansal Elijah B.Hoffman Marcin p.Joachimiak Ana M.Mora Angelica M.Walker Haruko M.Wainwright Yulun Wu Mirko pavicic daniel Jacobson Matthias Hess James B.Brown Katrina Abuabara Departments of Computational precision Health and Dermatology University of CaliforniaSan FranciscoCA94115USA Arva Intelligence Inc.Salt Lake CityUT84101USA Computational Biosciences Group Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Earth and Environmental Sciences Area Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Graduate Group in Biostatistics University of CaliforniaBerkeleyCA94720USA Biosystems Data Science Environmental Genomics and Systems BiologyLawrence Berkeley National LaboratoryBerkeleyCA94720USA Center for Environmental Research and Community Health(CERCH) School of Public HealthUniversity of CaliforniaBerkeleyCA94720USA Bredesen Center for Interdisciplinary Research and Graduate Education University of TennesseeKnoxvilleTN37996USA Department of Nuclear Science and Engineering Massachusetts Institute of TechnologyBostonMA02139USA Biosciences Oak Ridge National LaboratoryOak RidgeTN37830USA University of California DavisCA95616USA Statistics Department University of CaliforniaBerkeleyCA94720USA Division of Epidemiology and Biostatistics University of California Berkeley School of Public Health2121 Berkeley WayBerkeleyCA94720USA

Objectives We aim to estimate geographic variability in total numbers of infections and infection fatality ratios(IFR;the number of deaths caused by an infection per 1,000 infected people)when the availability and quality of data on disease burden are limited during an *** We develop a noncentral hypergeometric framework that accounts for differential probabilities of positive tests and reflects the fact that symptomatic people are more likely to seek *** demonstrate the robustness,accuracy,and precision of this framework,and apply it to the United States(U.S.)COVID-19 pandemic to estimate county-level SARS-CoV-2 *** The estimators for the numbers of infections and IFRs showed high accuracy and precision;for instance,when applied to simulated validation data sets,across counties,pearson correlation coefficients between estimator means and true values were 0.996 and 0.928,respectively,and they showed strong robustness to model *** the county-level estimators to the real,unsimulated COVID-19 data spanning April 1,2020 to September 30,2020 from across the U.S.,we found that IFRs varied from 0 to 44.69,with a standard deviation of 3.55 and a median of *** The proposed estimation framework can be used to identify geographic variation in IFRs across settings.

关键词： Infection fatality ratio Infection fatality rate Noncentral hypergeometric distribution COVID-19 SARS-CoV-2

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An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads:Experimental studies and molecular dynamics analysis

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Acta pharmaceutica Sinica B 2024年第6期14卷 2669-2684页

作者： Jamie Anne Lugtu-pe Xuning Zhang Sako Mirzaie Hao Han R.Chang Nour AL-Mousawi Kuan Chen Yongqiang Li Anil Kane daniel Bar-Shalom Xiao Yu Wu Advanced pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo pharmatech Company Inc. Mississauga L5N 5M1Canada Department of pharmacy University of CopenhagenCopenhagen DK-2100Denmark patheon by Thermo Fisher Scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution ***,most new chemical entities exhibit poor water solubility,and hence are exempt from such *** combining drug amorphization with controlled release formulation is promising to elevate drug solubility,like other supersaturating systems,the problem of drug recrystallization has yet to be resolved,particularly within the dosage ***,we explored the potential of an emerging,non-leachable terpolymer nanoparticle(TpN)pore former as an internal recrystallization inhibitor within controlled release amorphous solid dispersion(CraSD)beads comprising a poorly soluble drug(celecoxib)reservoir and insoluble polymer(ethylcellulose)*** to conventional pore former,polyvinylpyrrolidone(pVp),TpN-containing membranes exhibited superior structural integrity,less crystal formation at the CraSD bead surface,and greater extent of celecoxib ***-atom molecular dynamics analyses revealed that in the presence of TpN,intra-molecular bonding,crystal formation tendency,diffusion coefficient,and molecular flexibility of celecoxib were reduced,while intermolecular H-bonding was increased as compared to *** work suggests that selection of a pore former that promotes prolonged molecular separation within a nanoporous controlled release membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CraSD.

关键词： Controlled release amorphous solid dispersion poorly soluble drug Internal recrystallization Membrane-reservoir coated beads Molecular dynamics simulation Effect of pore formers Terpolymer nanogel Drug-polymer interactions

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Characterization of Arroyo Verde Epithermal Deposit:paragenesis,Mineral Geochemistry,Geochronology and Fluid Inclusions in Lower Chon Aike Volcanism,Argentina

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Journal of Earth Science 2024年第1期35卷 62-84页

作者： Cecilia pavón pivetta Leonardo Benedini paulo Marcos Ma.Agustina Cócola Mercedes Virginia Barros daniel Gregori Leonardo Strazzere Anderson Costa dos Santos Mauro C.Geraldes Instituto Geologico del Sur(INGEOSUR) Universidad Nacional del Sur(UNS)-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)Bahia Blanca 8000Argentina Dpto.de Geologia Universidad Nacional del Sur(UNS)Bahia Blanca 8000Argentina Universidad Nacional de Rio Negro Instituto de Investigacion en Paleobiologia y GeologiaGeneral Roca 8332Argentina Universidade do Estado do Rio de Janeiro Faculdade de GeologiaDepartamento de Mineralogia e Petrologia igneaRiodeJaneiro20559-900Brazil Geobiotec Departamento de GeocienciasUniversidade de AveiroAveiro 3800-002Portuga

Arroyo Verde epithermal deposit,in the North patagonia region of Argentina,is located within the Lower Chon Aike volcanism and is developed between 192.6±2.5 Ma(mineralization host rock)and 189.5±2.6 Ma(overlying lava).Marifil volcanic complex is the host rock for these veins,veinlets and *** particular small deposit has developed low to intermediate sulphidation characteristics,with gangue mineral textures associated with several ore *** probe microanalysis determines electrum,silver minerals such as acanthite,and tetrahedrite,related Ag-Cu minerals like jalpaite,mckinstryite,stromeyerite,and base metals like chalcopyrite,sphalerite,galena and *** inclusions in quartz of two out of five events indicate that these Low Jurassic veins were formed due to subtle boiling and dilution mechanisms and by low-salinity(3.4 wt.%to 6.7 wt.%NaCl Eq)magmatic-hydrothermal fluid at 225 to 310℃.The fluid inclusion measurements that indicate boiling(Event 3)were plotted,and based on this data,we interpret that the Arroyo Verde deposit has been eroded between 550 and 700 *** particular character has not been previously recorded for other sectors of the eastern north patagonian region.

关键词： epithermal deposit Ag minerals mineral geochemistry fluid inclusions Chon Aike geochronology

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Comparative Analysis: Trays versus packed Columns in pressure-Swing Distillation for the Separation of Tetrahydrofuran, Water and Ethanol Azeotropic Mixture

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World Journal of Engineering and Technology 2024年第3期12卷 798-819页

作者： Samuel Oluwaseun Ogunrinde Tolulope daniel Adekoya Thomas A. Orhadahwe Department of Mechanical Engineering Faculty of Engineering Ajayi Crowther University Oyo Nigeria AstraZeneca Boston Massachusetts USA

This paper delves into the comparative study of tray and packed column pressure swing distillation systems, focusing on the separation of a ternary mixture containing ethanol, tetrahydrofuran (THF), and water. The study particularly emphasizes the production of 99.5 w/w% tetrahydrofuran from the downstream product of 1,4-butanediol synthesis via diethyl maleate. pro/II simulation software is utilized to explore various system configurations, including sieve trays, valve trays, and packed columns. Material and energy balances are performed to ascertain stream compositions and energy demands. The investigation encompasses the effects of column operating pressure on condenser and reboiler temperatures, as well as the implications of utility streams. A rigorous distillation model is employed to compare valve tray, sieve tray, and random packing (utilizing Norton Super Intalox) column designs by varying the number of trays, reflux ratio, and second distillation column pressure. Heat exchangers are integrated into the model, and their areas and utility flow rates are computed and integrated into the economic assessment. Economic analysis, guided by Net present Value (NpV) calculations over a 20-year span, drives the selection of the most cost-effective design. Results demonstrate that while all designs are energy-efficient, the packed column system emerges as the most economical choice, offering a comprehensive framework for the separation process. Furthermore, optimal design configurations and operating conditions for both tray and packed column systems are outlined, providing valuable insights for industrial applications.

关键词： Azetrope Tetrahydrofuran Ethanol pressure-Swing Distillation Simulation

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Keemun black tea stems and leaves: Comparison of chemical characterization and anti-inflammatory activities

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Food Science and Human Wellness 2024年

作者： Mengting Zhu Xiaoqing Rong Mingchun Wen piaopiao Long Zongde Jiang Wen Xu daniel Granato Liang Zhang State Key Laboratory of Tea plant Biology and Utilization， Anhui Agricultural University Key Laboratory of Quality Evaluation of Chinese Medicine of the Guangdong provincial Medical products Administration， the Second Clinical College， Guangzhou University of Chinese Medicine International Joint Laboratory on Tea Chemistry and Health Effects of Ministry of Education， Anhui Agricultural University Bioactivity & Applications Lab， Department of Biological Sciences， Faculty of Science and Engineering， University of Limerick

This work aims to compare the chemical composition and anti-inflammatory effects on raW264.7 macrophages of Keemun black tea stems and leaves. Fifty volatile compounds were identified in tea stems and leaves， and aldehydes， alcohols， and esters were the main volatile compound categories. Eleven key volatile compounds， including geraniol， phenylacetaldehyde， methyl salicylate， linalool， etc. contributed to distinguishing the tea stems from the tea leaves. In the quantitative and LC-MS-based metabolomics analysis， higher contents of amino acids， monosaccharides， and quinic acid were found in stems than in leaves. Inversely， higher contents of tea pigments， flavan-3-ols， gallic acid， purine alkaloids， and flavonol glycosides were present in tea leaves than in stems. LC-MS-based metabolomics also revealed that organic acids were the most critical non-volatile compounds responsible for the differences between tea stems and leaves. Furthermore， tea stems had better inhibiting effects of pro-inflammatory cytokines (IL-1β and IL-6) in lipopolysaccharide-challenged raW264.7 macrophages than tea leaves， while no significant differences exist between leaves and stems for inhibiting the secretion of TNF-α and NO. In conclusion， our results support using Keemun black tea stems as a novel source of anti-inflammatory compounds.

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